Abstract:
:Periodontitis is an inflammatory disease caused by pathogenic microorganisms and characterized by the destruction of the periodontium. Obese individuals have an increased risk of periodontitis, and elevated circulating levels of adipokines, such as nicotinamide phosphoribosyltransferase (NAMPT), may be a pathomechanistic link between both diseases. The aim of this in vitro study was to examine the regulation of periodontal ligament (PDL) cells by NAMPT and its production under inflammatory and infectious conditions. NAMPT caused a significant upregulation of 9 genes and downregulation of 3 genes, as analyzed by microarray analysis. Eight of these genes could be confirmed by real-time PCR: NAMPT induced a significant upregulation of EGR1, MMP-1, SYT7, ITPKA, CCL2, NTM, IGF2BP3, and NRP1. NAMPT also increased significantly the MMP-1 and CCL2 protein synthesis. NAMPT was significantly induced by interleukin-1 β and the periodontal microorganism P. gingivalis. NAMPT may contribute to periodontitis through upregulation of MMP-1 and CCL2 in PDL cells. Increased NAMPT levels, as found in obesity, may therefore represent a mechanism whereby obesity could confer an increased risk of periodontitis. Furthermore, microbial and inflammatory signals may enhance the NAMPT synthesis in PDL cells and thereby contribute to the increased gingival and serum levels of this adipokine, as found in periodontitis.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Nokhbehsaim M,Eick S,Nogueira AV,Hoffmann P,Herms S,Fröhlich H,Jepsen S,Jäger A,Cirelli JA,Deschner Jdoi
10.1155/2013/437123subject
Has Abstractpub_date
2013-01-01 00:00:00pages
437123eissn
0962-9351issn
1466-1861journal_volume
2013pub_type
杂志文章abstract::Peritoneal dialysis therapy has increased in popularity since the end of the 1970s. This method provides a patient survival rate equivalent to hemodialysis and better preservation of residual renal function. However, technique failure by peritonitis, and ultrafiltration failure, which is a multifactorial complication ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2012/912595
更新日期:2012-01-01 00:00:00
abstract:STUDY OBJECTIVES:To assess serum amyloid alpha (SAA) pleural fluid levels in parapneumonic effusion (PPE) and to investigate SAA diagnostic performance in PPE diagnosis and outcome. METHODS:We studied prospectively 57 consecutive patients with PPE (empyema (EMP), complicated (CPE), and uncomplicated parapneumonic effu...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2011/237638
更新日期:2011-01-01 00:00:00
abstract::Our understanding of inflammation's role in the pathogenesis of myeloproliferative neoplasm (MPN) is evolving. The impact of chronic inflammation, a characteristic feature of MPN, likely goes far beyond its role as a driver of constitutional symptoms. An inflammatory response to the neoplastic clone may be responsible...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/606819
更新日期:2015-01-01 00:00:00
abstract::The effects of intravenous injection of Porphyromonas gingivalis (Pg) on rabbit inflammatory immune response and atherosclerosis were evaluated by establishing a microamount Pg bacteremia model combined with high-fat diet. Twenty-four New Zealand rabbits were randomly divided into Groups A-D (n = 6). After 14 weeks, l...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/364391
更新日期:2015-01-01 00:00:00
abstract::Particulate matter with an aerodynamic diameter equal or less than 2.5 micrometers (PM2.5) is associated with the development of chronic obstructive pulmonary disease (COPD). The mechanisms by which PM2.5 accelerates disease progression in COPD are poorly understood. In this study, we aimed to investigate the effect o...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/4260204
更新日期:2020-05-08 00:00:00
abstract::Angiostrongylus cantonensis (A. cantonensis) is an important food-borne parasitic disease. Previous study showed that A. cantonensis infection can cause demyelination in the central nerve system, but the mechanism of action has not been understood. To explore the mechanism and to look for effective therapeutic methods...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/3513651
更新日期:2017-01-01 00:00:00
abstract::The serum concentration of two pro-angiogenic cytokines: basic fibroblast growth factor (bFGF) and transforming growth factor beta1 (TGF-beta1), and anti-angiogenic factor endostatin in the serum of 80 never treated B-cell chronic lymphocytic leukemia (CLL) patients and 27 healthy volunteers was measured using an enzy...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/0962935031000134888
更新日期:2003-06-01 00:00:00
abstract::The mechanism of pain reduction involves bidirectional processes of pain blocking (nociception) and reductions in the levels of proinflammatory cytokines in the blood. Does transcutaneous electrical nerve stimulation (TENS) reduce blood levels of proinflammatory cytokines? For this systematic review, we searched in si...
journal_title:Mediators of inflammation
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2018/1094352
更新日期:2018-04-02 00:00:00
abstract::This study was designated to evaluate the influence of behavioral depression on the airway leukocyte recruitment in allergic animals. To achieve this, total and differential cell counts in bronchoalveolar (BAL) fluid of ovalbumin (OVA)-sensitized and depressed rats was evaluated. Inescapable electric footshock, applie...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350124118
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:This study aims to investigate the effect of feeding low-fat diet (LFD) to diet-induced obesity (DIO) mice lacking TLR5 (TLR5(-/-)), which have a tendency to develop glucose intolerance with increased adiposity, compared to that in C57BL/6 mice. RESULTS:TLR5(-/-) and C57BL/6 male mice were divided into thre...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/852126
更新日期:2015-01-01 00:00:00
abstract::Little work is done to develop Aloe vera (AV) using probiotics. To explore the potential benefits, the antioxidant effects and the antibacterial effects on foodborne pathogens of Aloe fermentation supernatant were evaluated in vitro. Our results indicated that the Aloe fermentation supernatant fermented by Lactobacill...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/2945650
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:To assess FGF-β, TGF-β, and COX2 expression and immunocompetent cells in the orbital tissue of patients with severe and mild Graves' orbitopathy. PATIENTS AND METHODS:Orbital tissue was taken from 27 patients with GO: (1) severe GO (n = 18), the mean clinical activity score (CAS) being 8.5 (SD 2.5); and (2) mi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/412158
更新日期:2014-01-01 00:00:00
abstract::Stimulation of phosphoinositide hydrolysis in myocardium from autoimmune myocarditis mice by ThEA and histamine was assayed. Myocardium from autoimmune heart, but not the normal forms, specifically increased phosphoinositide turnover in the presence of histaminergic agonists. This increment was blocked by a specific H...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935193000444
更新日期:1993-01-01 00:00:00
abstract::The aim of this study was to evaluate the relationship between serum transforming growth factor β 1 (TGF- β 1) concentrations and the duration of type 1 diabetes mellitus (T1DM) in children and adolescents. One hundred and sixteen patients with T1DM and 19 healthy controls were examined. Serum TGF- β 1 concentrations ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/849457
更新日期:2013-01-01 00:00:00
abstract::Syndecan-1 (CD138) is a transmembrane heparin sulfate proteoglycan expressed on distinct stages of differentiation of B-lymphoid cells. Its prognostic value in B-cell chronic lymphocytic leukemia (B-CLL) has not been evaluated so far. The serum concentration of sCD138 and some angiogenesis-involved cytokines: vascular...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI/2006/42394
更新日期:2006-01-01 00:00:00
abstract::S. epidermidis is responsible for biofilm-related nonunions. This study compares the response to S. epidermidis-infected fractures in rats systemically or locally injected with vancomycin or bone marrow mesenchymal stem cells (BMSCs) in preventing the nonunion establishment. The 50% of rats receiving BMSCs intravenous...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/9595706
更新日期:2016-01-01 00:00:00
abstract::Early sensing of pathogenic bacteria by the host immune system is important to develop effective mechanisms to kill the invader. Microbial recognition, activation of signaling pathways, and effector mechanisms are sequential events that must be highly controlled to successfully eliminate the pathogen. Host recognizes ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2014/432785
更新日期:2014-01-01 00:00:00
abstract::The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation of the immune system, in patients with allergic bronchial asthma, with those in healthy subjects. Significantly higher levels of soluble IL-2R and soluble CD4 were...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935195000433
更新日期:1995-01-01 00:00:00
abstract::Inflammatory response in Chagas disease is related to parasite and host factors. However, immune system regulation has not been fully elucidated. Thus, this study is aimed at evaluating IL-4 influence on acute phase of Trypanosoma cruzi experimental infection through dosage of cytokine levels in cardiac homogenate of ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/3421897
更新日期:2018-11-28 00:00:00
abstract:Objective:For patients with severe acute pancreatitis (SAP), a high body mass index (BMI) increases the possibility of infection derived from the intestine. In this study, we evaluate whether TAK242 can alleviate severe acute pancreatitis-associated injury of intestinal barrier in high-fat diet-fed rats. Methods:A SAP...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/2512687
更新日期:2019-12-17 00:00:00
abstract::Systemic sclerosis (SSc) is an autoimmune connective tissue disorder of unknown etiology. This disease is characterized by a large variety of clinical patterns, which include the fibrosis of skin and visceral organs causing a variety of clinical manifestations. Genetic and environmental factors participate in the etio...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/389582
更新日期:2014-01-01 00:00:00
abstract::Serine proteinases have been recognized as playing an important role in inflammation via proteinase activated receptors (PARs). However, little is known about the influence of serine proteinases and PARs on TNF secretion from highly purified T cells. We challenged T cells from human peripheral blood with serine protei...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/165453
更新日期:2013-01-01 00:00:00
abstract::Podocyte injury critically contributes to the pathogenesis of obesity-related glomerulopathy (ORG). Recently, lipid accumulation and inflammatory responses have been found to be involved in podocyte injury. This study is to explore their role and relationship in podocyte injury of ORG. In animal experiments, the ORG m...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/3172647
更新日期:2019-04-11 00:00:00
abstract::There is some anecdotal evidence that oxygen-ozone therapy may be beneficial in some human diseases. However so far only a few biochemical and pharmacodynamic mechanisms have been elucidated. On the basis of preliminary data we postulated that controlled ozone administration would promote an oxidative preconditioning ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359890983
更新日期:1998-01-01 00:00:00
abstract:AIM:The aim of this study was to evaluate the presence of the cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in human periapical lesions. SUBJECTS AND METHODS:Samples were obtained from three groups of teeth: symptomatic teeth, asymptomatic lesions, and uninflamed periradicular tissues as a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2007/38210
更新日期:2007-01-01 00:00:00
abstract::Metabolic hormones have been associated with reproductive function modulation. Thus, the aim of this study was: (i) to characterize the immunolocalization, mRNA and protein levels of leptin (LEP), Ghrelin (GHR) and respective receptors LEPR and Ghr-R1A, throughout luteal phase; and (ii) to evaluate the role of LEP and...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/682193
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Icariin (ICA) is an active compound extracted from Epimedium brevicornum Maxim. Previous reports have shown that icariin has a clinically significant therapeutic effect on rheumatoid arthritis. However, little is known about the mechanism by which icariin inhibits cartilage and bone degradation. METHODS:New...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/9529630
更新日期:2016-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2016/3214105.]. ...
journal_title:Mediators of inflammation
pub_type: 已发布勘误
doi:10.1155/2017/2917134
更新日期:2017-01-01 00:00:00
abstract::We recently reported the immune-enhancing effects of a high-molecular-weight fraction (HMF) of CW in macrophages and immunosuppressed mice, and this effect was attributed to a crude polysaccharide. As polysaccharides may also have anti-inflammatory functions, we investigated the anti-inflammatory effects and related m...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/3859856
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Empirical observations have shown that ozonated autohemotherapy markedly improves the symptoms of chronic limb ischemia (muscular pain at rest, intermittent claudication, etc) in atherosclerotic patients, but mechanisms of action remain unclear. AIMS:Human endothelial cells (HUVECs) are known to release nit...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350020027573
更新日期:2000-01-01 00:00:00