Abstract:
:Endoglin is a coreceptor of the TGF-β superfamily predominantly expressed on the vascular endothelium and selective subsets of immune cells. We previously demonstrated that Endoglin heterozygous (Eng (+/-)) mice subjected to dextran sulfate sodium (DSS) developed persistent gut inflammation and pathological angiogenesis. We now report that colitic Eng (+/-) mice have low colonic levels of active TGF-β1, which was associated with reduced expression of thrombospondin-1, an angiostatic factor known to activate TGF-β1. We also demonstrate dysregulated expression of BMPER and follistatin, which are extracellular regulators of the TGF-β superfamily that modulate angiogenesis and inflammation. Heightened colonic levels of the neutrophil chemoattractant and proangiogenic factor, CXCL1, were also observed in DSS-treated Eng (+/-) mice. Interestingly, despite increased macrophage and neutrophil infiltration, a gut-specific reduction in expression of the key phagocytic respiratory burst enzymes, NADPH oxidase 2 (Nox-2) and myeloperoxidase, was seen in Eng (+/-) mice undergoing persistent inflammation. Taken together, these findings suggest that endoglin is required for TGF-β superfamily mediated resolution of inflammation and fully functional myeloid cells.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Peter MR,Jerkic M,Sotov V,Douda DN,Ardelean DS,Ghamami N,Lakschevitz F,Khan MA,Robertson SJ,Glogauer M,Philpott DJ,Palaniyar N,Letarte Mdoi
10.1155/2014/767185subject
Has Abstractpub_date
2014-01-01 00:00:00pages
767185eissn
0962-9351issn
1466-1861journal_volume
2014pub_type
杂志文章abstract::The regulatory functions of glycosaminoglycan hyaluronan (HA) are suggested to be dependent on its molecular weight (MW). Proinflammatory and stimulatory effects are proposed mainly for the low MW HA. However, the complex response of blood phagocytes to HA of different MW is unclear. Herein, the effects of highly puri...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/380948
更新日期:2010-01-01 00:00:00
abstract::This study was designated to evaluate the influence of behavioral depression on the airway leukocyte recruitment in allergic animals. To achieve this, total and differential cell counts in bronchoalveolar (BAL) fluid of ovalbumin (OVA)-sensitized and depressed rats was evaluated. Inescapable electric footshock, applie...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350124118
更新日期:2001-08-01 00:00:00
abstract::Enterovirus 71 (EV71) is one of the most common intestinal virus that causes hand, foot, and mouth disease (HFMD) in infants and young children (mostly ≤5 years of age). Generally, children with EV71-infected HFMD have mild symptoms that resolve spontaneously within 7-14 days without complications. However, some EV71-...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2020/9273241
更新日期:2020-01-31 00:00:00
abstract::The mechanism of pain reduction involves bidirectional processes of pain blocking (nociception) and reductions in the levels of proinflammatory cytokines in the blood. Does transcutaneous electrical nerve stimulation (TENS) reduce blood levels of proinflammatory cytokines? For this systematic review, we searched in si...
journal_title:Mediators of inflammation
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2018/1094352
更新日期:2018-04-02 00:00:00
abstract::Daily food intake is crucial to maintain health and determine endogenous fuel to practice endurance exercise. We investigated the association between quantity of macronutrient and micronutrient daily intake and inflammation induced by long-distance exercise. Methods. Forty-four Brazilian male amateurs' marathon finish...
journal_title:Mediators of inflammation
pub_type: 临床试验,杂志文章
doi:10.1155/2019/1537274
更新日期:2019-10-07 00:00:00
abstract::The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) is one of the strongest stimuli of the immune response, and it has been shown that P2X7R activatio...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2011/152625
更新日期:2011-01-01 00:00:00
abstract::Fasting insulin, adiponectin, high-sensitivity C-reactive protein (hs-CRP), and interleukin-1 receptor antagonist (IL-1Ra) were determined in 278 men and 273 women with blood pressure > or = 130 and/or > or = 85 mmHg and/or with antihypertensive medication. Metabolic syndrome (MetS) with the National Cholesterol Educa...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2009/959281
更新日期:2009-01-01 00:00:00
abstract::Infection with dengue virus (DENV) causes an increase in proinflammatory responses, such as nitric oxide (NO) generation and TNF-α expression; however, the molecular mechanism underlying this inflammatory activation remains undefined, although the activation of the transcription factor NF-κB is generally involved. In ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/274025
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Airway smooth muscle (ASM) is considered to be a target for mediators released during airway inflammation. AIMS:To investigate the expression of c-fos, a constituent of the transcription factor activator protein-1, in human ASM cells. In addition, to measure the release of interleukin (IL)-6 into the condit...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350124155
更新日期:2001-06-01 00:00:00
abstract::Causes of mortality from COVID-19 include respiratory failure, heart failure, and sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that recognizes pathogen-associated molecular patterns (PAMPs) including viral proteins and triggers the production of type I interferons and proinflammator...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2021/8874339
更新日期:2021-01-14 00:00:00
abstract:OBJECTIVES:In the present study, the ability of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, to stimulate osteoblast function and inhibit the release of bone-resorbing mediators was investigated in osteoblastic MC3T3-E1 cells. METHODS:Osteoblast function was measured by cell growth, a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/829650
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:We have previously reported a continuous activation of caspase-1 and increased interleukin (IL)-1β levels in early rheumatoid arthritis (RA). These observations raised the hypothesis that drugs targeting the IL-1β pathway, in addition to tumour necrosis factor (TNF), may be particularly effective for early R...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/195327
更新日期:2014-01-01 00:00:00
abstract:Aim:The objective of the current study is to analyze the correlation between cytokine levels and periodontal parameters in aggressive periodontitis patients before and after periodontal treatment that was performed by using two different laser therapies. Materials and Methods:Twenty-six generalized aggressive periodon...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/2780794
更新日期:2019-06-12 00:00:00
abstract::Nitric oxide has enigmatic qualities in inflammation. In order to appreciate the precise contributions of nitric oxide to a pathophysiological process, one must account for enzyme source, coproduction of oxidants and antioxidant defences, time, rate of nitric oxide production, cellular source, peroxynitrite formation ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935195000639
更新日期:1995-01-01 00:00:00
abstract::Interleukin-10 (IL-10) is a cytokine derived from CD4+ T-helper type 2 (T(H2)) cells identified as a suppressor of cytokines from T-helper type 1(T(H1)) cells. Interleukin-12 (IL-12) is produced by B cells, macrophages and dendritic cells, and primarily regulates T(H1) cell differentiation, while suppressing the expan...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1080/09629350120054518
更新日期:2001-04-01 00:00:00
abstract::Maternal immune activation (MIA) is a potential risk factor for autism spectrum disorder (ASD) and schizophrenia (SZ). In rodents, MIA results in changes in cytokine profiles and abnormal behaviors in the offspring that model these neuropsychiatric conditions. Given the central role that mitochondria have in immunity ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/609602
更新日期:2013-01-01 00:00:00
abstract::The causes of retinal hypoxia are many and varied. Under hypoxic conditions, a variety of soluble factors are secreted into the vitreous cavity including growth factors, cytokines, and chemokines. Cytokines, which usually serve as signals between neighboring cells, are involved in essentially every important biologica...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/935301
更新日期:2013-01-01 00:00:00
abstract::Increasing evidence has demonstrated that reactive oxygen species (ROS) induces oxidative stress and plays a crucial role in the pathogenesis of acute pancreatitis (AP). Hydrogen-rich saline (HRS), a well-known ROS scavenger, has been shown to possess therapeutic benefit on AP in many animal experiments. Recent findin...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/930894
更新日期:2014-01-01 00:00:00
abstract::The destruction of joints caused by rheumatoid arthritis and osteoarthritis is characterized by an imbalance of enzyme catalysed cartilage breakdown and regeneration. A complex cytokine network perpetuates joint conditions by direct regulation of metalloproteases, by indirect recruitment of cells that secrete degradat...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935194000359
更新日期:1994-01-01 00:00:00
abstract::The present study investigated the association between the rs12979860 polymorphism in the IL-28B gene and HTLV-1 infection as well as the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1-infected patients (26 HAM/TSP symptomatic and 53 asymptomatic) and 300 seronegative health...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/804167
更新日期:2015-01-01 00:00:00
abstract::Infection by Leishmania takes place in the context of inflammation and tissue repair. Besides tissue resident macrophages, inflammatory macrophages and neutrophils are recruited to the infection site and serve both as host cells and as effectors against infection. Recent studies suggest additional important roles for ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/754965
更新日期:2014-01-01 00:00:00
abstract::Chlamydophila pneumoniae (CPn) is a common respiratory pathogen that causes a chronic and persistent airway infection. The elderly display an increased susceptibility and severity to this infection. However, the underlying mechanisms are not well understood. Dendritic cells (DCs) are the initiators and regulators of i...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/436438
更新日期:2014-01-01 00:00:00
abstract::Neuropathic pain is a serious clinical problem to be solved. This study is aimed at investigating protein kinase A (PKA) expression in neuropathic pain and its possible mechanisms of involvement. A neuropathic pain-related gene expression dataset was downloaded from Gene Expression Omnibus, and differentially expresse...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/6420425
更新日期:2020-03-23 00:00:00
abstract:Background:Over the last 20 years, the prevalence of hepatitis B virus (HBV) infection in China has decreased gradually due to the application of a national HBV vaccination program. In contrast, the prevalence of alcoholic liver disease (ALD), nonalcoholic fatty liver disease, autoimmune liver disease, and drug-induced...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/5605981
更新日期:2017-01-01 00:00:00
abstract:AIM:To determine induced sputum cell counts and interleukin-8 (IL-8), tumor necrosis factor alpha (TNF-alpha) and leukotriene B4 (LTB4) levels as markers of neutrophilic inflammation in moderate persistent asthma, and to evaluate the response to inhaled steroid therapy. METHODS:Forty-five moderate asthmatic patients a...
journal_title:Mediators of inflammation
pub_type: 临床试验,杂志文章
doi:10.1080/09629350400003118
更新日期:2004-08-01 00:00:00
abstract::Fat loss is associated with shorter survival and reduced quality of life in cancer patients. Effective intervention for fat loss in cachexia requires identification of the condition using prognostic biomarkers for early detection and prevention of further depletion. No biomarkers of fat mass alterations have been defi...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/820934
更新日期:2015-01-01 00:00:00
abstract::Many therapies are now available for patients with rheumatoid arthritis (RA) who have an inadequate response to methotrexate including tumor necrosis factor inhibitors, abatacept, tocilizumab, and rituximab. Clinical response to drugs varies widely between individuals. A part of this variability is due to the characte...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2014/386148
更新日期:2014-01-01 00:00:00
abstract::Tumor necrosis factor alpha (TNF-α) is a cytokine which plays opposing roles in the context of infectious disease pathogenesis. TNF-α is essential for the development of a protective immune response to some pathogens, for example, Mycobacterium tuberculosis, by synergizing with other cytokines. However, exorbitant or ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/619480
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma. OBJECTIVES:To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma....
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/7918472
更新日期:2017-01-01 00:00:00
abstract::Inflammatory bowel disease (IBD) describes different illnesses characterized by chronic inflammation of the gastrointestinal tract. Although the pathogenic mechanisms leading to IBD are poorly understood, immune system disturbances likely underlie its development. Sphingolipids (SLs) have been identified as important ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/9890141
更新日期:2016-01-01 00:00:00