Eicosanoids in the innate immune response: TLR and non-TLR routes.

Abstract:

:The variable array of pattern receptor expression in different cells of the innate immune system explains the induction of distinct patterns of arachidonic acid (AA) metabolism. Peptidoglycan and mannan were strong stimuli in neutrophils, whereas the fungal extract zymosan was the most potent stimulus in monocyte-derived dendritic cells since it induced the production of PGE(2), PGD(2), and several cytokines including a robust IL-10 response. Zymosan activated kappaB-binding activity, but inhibition of NF-kappaB was associated with enhanced IL-10 production. In contrast, treatments acting on CREB (CRE binding protein), including PGE(2), showed a direct correlation between CREB activation and IL-10 production. Therefore, in dendritic cells zymosan induces il10 transcription by a CRE-dependent mechanism that involves autocrine secretion of PGE(2), thus unraveling a functional cooperation between eicosanoid production and cytokine production.

journal_name

Mediators Inflamm

authors

Alvarez Y,Valera I,Municio C,Hugo E,Padrón F,Blanco L,Rodríguez M,Fernández N,Crespo MS

doi

10.1155/2010/201929

subject

Has Abstract

pub_date

2010-01-01 00:00:00

eissn

0962-9351

issn

1466-1861

journal_volume

2010

pub_type

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