Abstract:
:Keishibukuryogan (KBG) is one of the traditional herbal formulations widely administered to patients with blood stagnation for improving blood circulation; currently, it is the most frequently prescribed medicine in Japan. KBG has been reported to improve conjunctional microcirculation. The aim of this study was to evaluate the role of KBG and paeoniflorin, a bioactive compound of KBG, in inhibiting the production of inflammatory cytokines using human dermal microvessel endothelial cells (HDMECs). The authors observed that lipopolysaccharide (LPS; 1 μg/mL) stimulated the secretion of proinflammatory cytokines in HDMECs. KBG treatment (10 mg/mL) significantly suppressed the mRNA levels of migration inhibitory factor (MIF), interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α in LPS-stimulated cultured HDMECs. Similarly, paeoniflorin significantly suppressed the mRNA levels of these cytokines in LPS-stimulated cultured HDMECs. ELISA showed that KBG and paeoniflorin suppressed the production of MIF, IL-6, IL-8, and TNF-α in LPS-stimulated HDMECs. Moreover, KBG and paeoniflorin decreased the expression of cyclooxygenase-2 and inducible nitric oxide synthase (iNOS) in these cells. These results suggest that KBG may be useful for improving microvascular inflammation in patients with skin diseases.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Yoshihisa Y,Furuichi M,Ur Rehman M,Ueda C,Makino T,Shimizu Tdoi
10.1155/2010/804298subject
Has Abstractpub_date
2010-01-01 00:00:00pages
804298eissn
0962-9351issn
1466-1861journal_volume
2010pub_type
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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pub_type: 杂志文章,随机对照试验
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pub_type: 已发布勘误
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journal_title:Mediators of inflammation
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pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
pub_type: 杂志文章
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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更新日期:2007-01-01 00:00:00