Culturing Articular Cartilage Explants in the Presence of Autologous Adipose Tissue Modifies Their Inflammatory Response to Lipopolysaccharide.

abstract：:Fluid of artificial blisters from erythromelalgic skin areas in primary thrombocythaemia contained a high amount of prostaglandin-E-like activity. Dazoxiben did not alleviate the erythromelalgia in patients with primary thrombocythaemia despite complete inhibition of platelet malondialdehyde and thromboxane B(2) synth...

journal_title：Mediators of inflammation

authors： Michiels JJ,Zijlstra FJ

更新日期：1993-01-01 00:00:00

abstract：:The effect of exogenous RNA on many cellular functions has been studied in a variety of eukaryotic cells but there are few reports on macrophages. In the present study, it is demonstrated that cytoplasmatic RNA extracted from rat macrophages stimulated with Escherichia coli lipopolysaccharide (LPS), referred to as L-R...

journal_title：Mediators of inflammation

authors： Ribeiro RA,Lucca FL,Flores CA,Cunha FQ,Ferreira SH

更新日期：1993-01-01 00:00:00

abstract：:Cathepsin G is a serine protease secreted by activated neutrophils that play a role in the inflammatory response. Because neutrophils are known to be invading leukocytes in various tumors, their products may influence the characteristics of tumor cells such as the growth state, motility, and the adhesiveness between c...

journal_title：Mediators of inflammation

authors： Kudo T,Kigoshi H,Hagiwara T,Takino T,Yamazaki M,Yui S

更新日期：2009-01-01 00:00:00

abstract：:The effect of L-carnitine and some of its acyl derivatives on serum TNF production and lethality in a murine experimental endotoxin shock model was investigated. In some instances, serum IL-6 production was also evaluated. In this experimental model, C57BL/6 mice received 30 mg/kg LPS (E. cell 055:B5) injected intrape...

journal_title：Mediators of inflammation

authors： Ruggiero V,D'Urso CM,Albertoni C,Campo S,Foresta P,Martelli EA

更新日期：1993-01-01 00:00:00

abstract：:Sanguisorbae Radix (SR) is well known as herbal medicine named "Zi-Yu" in Korea, which is the dried roots of Sanguisorba officinalis L. (Rosacease). We investigated the underlying mechanism on the inhibition of atopic dermatitis (AD) of an ethanol extract of SR (ESR) using 2,4-dinitrochlorobenzene- (DNCB-) induced AD ...

journal_title：Mediators of inflammation

authors： Yang JH,Yoo JM,Cho WK,Ma JY

更新日期：2016-01-01 00:00:00

abstract：:Human periodontal ligament (hPDL) fibroblasts play a major role during periodontitis and orthodontic tooth movement, mediating periodontal inflammation, osteoclastogenesis, and collagen synthesis. The highly COX-2-selective NSAID etoricoxib has a favorable systemic side effect profile and high analgesic efficacy, part...

journal_title：Mediators of inflammation

authors： Kirschneck C,Küchler EC,Wolf M,Spanier G,Proff P,Schröder A

更新日期：2019-03-10 00:00:00

abstract：:Type 2 Diabetes Mellitus (T2DM) is well known to include an inflammatory component that has been considered to be related to diabetic complications. Diabetic nephropathy (DN) is one of the significant complications as it constitutes the most frequent cause of end-stage renal disease. Tumor Necrosis Factor-α (TNF-α) is...

journal_title：Mediators of inflammation

authors： Emara M,El-Edel R,Fathy WM,Aboelkhair NT,Watany MM,Abou-Elela DH

更新日期：2020-07-01 00:00:00

abstract：:Exposure to hog barn organic dust contributes to occupational lung diseases, which are mediated by inflammatory and oxidative stress pathways. Isoprostanes-a family of eicosanoids produced by oxidation of phospholipids by oxygen radicals-are biomarkers of pulmonary oxidative stress. Importantly, 8-isoprostane has been...

journal_title：Mediators of inflammation

authors： Gerald CL,McClendon CJ,Ranabhat RS,Waterman JT,Kloc LL,Conklin DR,Barton KT,Khatiwada JR,Williams LL

更新日期：2019-08-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-α) is a cytokine which plays opposing roles in the context of infectious disease pathogenesis. TNF-α is essential for the development of a protective immune response to some pathogens, for example, Mycobacterium tuberculosis, by synergizing with other cytokines. However, exorbitant or ...

journal_title：Mediators of inflammation

authors： Dirisala VR,Jeevan A,Ly LH,McMurray DN

更新日期：2015-01-01 00:00:00

abstract：:Microcystins (MCs) produced by toxic cyanobacteria cause serious water pollution and public health hazard to humans and animals. However, direct molecular mechanisms of MC-LR in vascular endothelial cells (ECs) have not been understood yet. In this study, we investigated whether MC-LR induces vascular inflammatory pro...

journal_title：Mediators of inflammation

authors： Shi J,Zhou J,Zhang M

更新日期：2015-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic demyelinating disease of the human central nervous system (CNS). The condition predominantly affects young adults and is characterised by immunological and inflammatory changes in the periphery and CNS that contribute to neurovascular disruption, haemopoietic cell invasion of targe...

journal_title：Mediators of inflammation

authors： Bolton C,Paul C

更新日期：2006-01-01 00:00:00

abstract：:Modification of endogenous eicosanoid synthesis by dietary n-3 fatty acid supplementation reduces febrile responses, but the mechanisms underlying these effects in vivo have not been determined. In the present study, local inflammation was induced by intramuscular injection ofturpentine in rats fed control or n-3 supp...

journal_title：Mediators of inflammation

authors： Cooper AL,Turnbull AV,Hopkins SJ,Rothwell NJ

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma. OBJECTIVES:To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma....

journal_title：Mediators of inflammation

authors： Liu Y,Liu T,Wu J,Li T,Jiao X,Zhang H,Zhao J,Wang J,Liu L,Cao L,Li S,Xu J,Xu J,Ma X,Yang L,Dong L

更新日期：2017-01-01 00:00:00

abstract：:Chronic pain has to be considered in all respects a debilitating disease and 10-20% of the world's adult population is affected by this disease. In the most general terms, pain is symptomatic of some form of dysfunction and (often) the resulting inflammatory processes in the body. In the study of pain, great attention...

journal_title：Mediators of inflammation

authors： Vodo S,Bechi N,Petroni A,Muscoli C,Aloisi AM

更新日期：2013-01-01 00:00:00

abstract：:Statins exert pleiotropic effects on endothelial cells in addition to lowering cholesterol. 15-Lipoxygenase-1 (ALOX15) has been implicated in vascular inflammation and disease. The relationship between atorvastatin and ALOX15 was investigated using a rat carotid artery balloon-injury model. Hematoxylin and eosin (HE) ...

journal_title：Mediators of inflammation

authors： Zhang P,Xing X,Hu C,Yu H,Dong Q,Chang G,Qin S,Liu J,Zhang D

更新日期：2016-01-01 00:00:00

abstract：:Thiopurines are extensively used immunosuppressants for the treatment of inflammatory bowel disease (IBD). The polymorphism of thiopurine S-methyltransferase (TPMT) influences thiopurine metabolism and therapy outcome. We used a TPMT knockdown (kd) model of human Jurkat T-lymphocytes cells to study the effects of trea...

journal_title：Mediators of inflammation

authors： Misdaq M,Ziegler S,von Ahsen N,Oellerich M,Asif AR

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Human and rodent leukocytes express high levels of the glucocorticoid-inducible protein annexin 1 (ANXA1) (previously referred to as lipocortin 1). Neutrophils and monocytes have abundant ANXA1 levels. AIM:We have investigated, for the first time, ANXA1 ultrastructural expression in rat eosinophils and comp...

journal_title：Mediators of inflammation

authors： Oliani SM,Damazo AS,Perretti M

更新日期：2002-10-01 00:00:00

abstract：Background:Acute lung injury (ALI) and subsequent pulmonary infection are the most severe and usually fatal complications for elderly hip fracture patients. It is necessary to find some biomarkers for early diagnosis and prognosis of it. Objective:This study is aimed at examining the differential expression of miR-146...

journal_title：Mediators of inflammation

authors： Gan L,Sun T,Li B,Tian J,Zhang J,Chen X,Zhong J,Yang X,Li Q

更新日期：2018-10-28 00:00:00

abstract：:OKT3 , a murine monoclonal antibody specific to the human CD3 complex, induces immunosuppression by depletion of T cells. Administration of OKT3 results in significant release of proinflammatory cytokines, such as TNFalpha and IL1beta. Liver recipients who experience rejection within 3 weeks after transplantation with...

journal_title：Mediators of inflammation

authors： Roayaie S,Sheiner PA,Emre S,Guy S,Schwartz ME,Boros P,Miller CM

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Asthma is a disorder characterized by a predominance of Th2 cells and eosinophilic inflammation. Suppressors of cytokine signaling (SOCS) proteins act as negative regulators of cytokine signaling. In particular, SOCS1 and SOCS3 play an important role in immune response by controlling the balance between Th1 ...

journal_title：Mediators of inflammation

authors： López E,Zafra MP,Sastre B,Gámez C,Lahoz C,del Pozo V

更新日期：2011-01-01 00:00:00

abstract：:Heparanase activity is correlated with the metastatic potential of several cancer cells and is a key enzyme in the breakdown of tissue barriers. It is also involved in the regulation of growth factor and cytokine activity. However, little is known about the factors that induce heparanase in cancer cells. We investigat...

journal_title：Mediators of inflammation

authors： Sasaki M,Ito T,Kashima M,Fukui S,Izumiyama N,Watanabe A,Sano M,Fujiwara Y,Miura M

更新日期：2001-10-01 00:00:00

abstract：:Alcohol-related disorders are one of the challenging current health problems with medical, social, and economic consequences. Endotoxemia, oxidative stress, and release of a variety of inflammatory molecules are established mediators in alcoholic liver injury (ALD). Probiotics like L. plantarum though were reported to...

journal_title：Mediators of inflammation

authors： Arora S,Kaur IP,Chopra K,Rishi P

更新日期：2014-01-01 00:00:00

abstract：:Keishibukuryogan (KBG) is one of the traditional herbal formulations widely administered to patients with blood stagnation for improving blood circulation; currently, it is the most frequently prescribed medicine in Japan. KBG has been reported to improve conjunctional microcirculation. The aim of this study was to ev...

journal_title：Mediators of inflammation

authors： Yoshihisa Y,Furuichi M,Ur Rehman M,Ueda C,Makino T,Shimizu T

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Icariin (ICA) is an active compound extracted from Epimedium brevicornum Maxim. Previous reports have shown that icariin has a clinically significant therapeutic effect on rheumatoid arthritis. However, little is known about the mechanism by which icariin inhibits cartilage and bone degradation. METHODS:New...

journal_title：Mediators of inflammation

authors： Wei CC,Ping DQ,You FT,Qiang CY,Tao C

更新日期：2016-01-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) remains a high morbidity and mortality disease entity in critically ill patients, despite decades of numerous investigations into its pathogenesis. To obtain global protein expression changes in acute lung injury (ALI) lung tissues, we employed a high-throughput proteomics me...

journal_title：Mediators of inflammation

authors： Liu D,Mao P,Huang Y,Liu Y,Liu X,Pang X,Li Y

更新日期：2014-01-01 00:00:00

abstract：:Dysfunctions of the L-arginine (L-arg)/nitric-oxide (NO) pathway are suspected to be important for the pathogenesis of multiple organ dysfunction syndrome (MODS) in septic shock. Therefore plasma concentrations of L-arg and asymmetric dimethylarginine (ADMA) were measured in 60 patients with septic shock, 30 surgical ...

journal_title：Mediators of inflammation

authors： Brenner T,Fleming TH,Rosenhagen C,Krauser U,Mieth M,Bruckner T,Martin E,Nawroth PP,Weigand MA,Bierhaus A,Hofer S

更新日期：2012-01-01 00:00:00

abstract：Background:Systemic inflammation impairs cognitive performance, yet the brain networks mediating this process remain to be elucidated. The purpose of the current study was to use resting-state functional magnetic resonance imaging (fMRI) to explore changes in the functional connectivity in a lipopolysaccharide- (LPS-) ...

journal_title：Mediators of inflammation

authors： Zhu X,Ji MH,Li SM,Li B,Mei L,Yang JJ

更新日期：2019-05-09 00:00:00

abstract：:Tantalum (Ta) is gaining attention as a biomaterial in bone tissue engineering. Although the clinical advantage of Ta-based implants for primary and revision total joint replacement (TJA) has been well documented, few studies investigated the effect of wear products of Ta implants on peri-implant cells, and their pote...

journal_title：Mediators of inflammation

authors： Zhang L,Haddouti EM,Beckert H,Biehl R,Pariyar S,Rüwald JM,Li X,Jaenisch M,Burger C,Wirtz DC,Kabir K,Schildberg FA

更新日期：2020-12-03 00:00:00

abstract：:Increased insulin resistance and inflammatory action are observed in pregnancy-induced hypertension (PIH), but similar insulin resistance is observed also in successful pregnancy. To estimate insulin resistance and inflammatory activity in normal pregnancy and PIH, serum concentrations of free fatty acids (FFA; correc...

journal_title：Mediators of inflammation

authors： Naruse K,Noguchi T,Sado T,Tsunemi T,Shigetomi H,Kanayama S,Akasaka J,Koike N,Oi H,Kobayashi H

更新日期：2012-01-01 00:00:00

abstract：:Procalcitonin (PCT) is one of the best diagnostic and prognostic markers in clinical practice, widely used to evaluate the evolution of bacterial infections. Although it is mainly produced by thyroid, during sepsis almost all the peripheral tissues are involved in PCT production. Parenchymal cells have been suggested ...

journal_title：Mediators of inflammation

authors： Rami D,La Bianca M,Agostinis C,Zauli G,Radillo O,Bulla R

更新日期：2014-01-01 00:00:00