Abstract:
BACKGROUND:In aromatherapy, essential oils are used as anti-inflammatory remedies, but experimental studies on their action mechanisms are very limited. AIMS OF THE STUDY:To assess their anti-inflammatory activities, the effects of essential oils on neutrophil recruitment in mice were examined in vivo. METHOD:The effect of essential oils on leukocyte and neutrophil recruitment induced 6 h after intraperitoneal injection of casein in mice was examined. RESULTS:Leukocyte recruitment into the peritoneal cavity in mice was suppressed by intraperitoneal injections of geranium, lemongrass and spearmint oils at the dose of 5 microl/mouse, but was not by tea tree oil. This recruitment was inhibited dose-dependently by geranium oil. The suppression of leukocyte recruitment resulted from inhibition of neutrophil accumulation. CONCLUSION:Some essential oils used as anti-inflammatory remedies suppress neutrophil recruitment into the peritoneal cavity in mice.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Abe S,Maruyama N,Hayama K,Inouye S,Oshima H,Yamaguchi Hdoi
10.1080/09629350410001664798subject
Has Abstractpub_date
2004-02-01 00:00:00pages
21-4issue
1eissn
0962-9351issn
1466-1861pii
EDVV7R9H4T2JN0TJjournal_volume
13pub_type
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