Abstract:
OBJECTIVE:Progranulin (PGRN) is implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to assess the relationship between PGRN and disease activity in RA. METHODS:PGRN levels were evaluated in patients with RA (n = 47) and OA (n = 42) and healthy controls (n = 41). Immunohistochemical analysis of PGRN in synovial tissues was performed. The association between PGRN and C-reactive protein (CRP), disease activity score (DAS28-CRP), and health assessment questionnaire (HAQ) was studied. RESULTS:Circulating PGRN was elevated in patients with RA and OA compared to healthy controls (227.1 ± 100.2 and 221.5 ± 102.5 versus 128.1 ± 34.7 ng/mL; P < 0.001). Synovial fluid levels of PGRN were higher in patients with RA compared to OA (384.5 ± 275.3 versus 241.4 ± 165.2 ng/mL; P = 0.002). PGRN expression was significantly upregulated in the synovial tissue of RA patients particularly in the inflammatory infiltrates. Serum PGRN levels correlated with DAS28 (r = 0.327, P = 0.049) and HAQ score (r = 0.323, P = 0.032), while synovial fluid PGRN correlated only with HAQ (r = 0.310, P = 0.043) in patients with RA. PGRN levels were not associated with CRP or autoantibodies. CONCLUSIONS:This study demonstrates increased PGRN expression at local sites of inflammation and association between PGRN levels, disease activity, and functional impairment in patients with RA.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Cerezo LA,Kuklová M,Hulejová H,Vernerová Z,Kaspříková N,Veigl D,Pavelka K,Vencovský J,Šenolt Ldoi
10.1155/2015/740357subject
Has Abstractpub_date
2015-01-01 00:00:00pages
740357eissn
0962-9351issn
1466-1861journal_volume
2015pub_type
杂志文章abstract::High levels of serum long chain saturated fatty acids (LCSFAs) have been associated with inflammation in type 2 diabetes. Dietary SFAs can promote inflammation, the secretion of IgG antibodies, and secretion of the proinflammatory cytokine IL-1β. This study characterizes anti-LCSFA IgG antibodies from patients with ty...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/196297
更新日期:2015-01-01 00:00:00
abstract::The alteration of resting tension (RT) from 0.5 g to 2.5 g increased significantly airway smooth muscle contractions induced by acetylcholine (ACh) in rabbit trachea. The decrease in extracellular calcium concentration [Ca2+]o from 2 mM to 0.2 mM reduced ACh-induced contractions only at 2.5 g RT with no effect at 0.5 ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2007/24174
更新日期:2007-01-01 00:00:00
abstract:Background:Systemic inflammation impairs cognitive performance, yet the brain networks mediating this process remain to be elucidated. The purpose of the current study was to use resting-state functional magnetic resonance imaging (fMRI) to explore changes in the functional connectivity in a lipopolysaccharide- (LPS-) ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/6212934
更新日期:2019-05-09 00:00:00
abstract::Aim. Inflammation is important in heart failure (HF). The role of the immune receptor toll-like receptor 9 (TLR9) in HF is not understood and not investigated in diastolic HF. We investigated the role of TLR9 in a murine diastolic HF model caused by cardiomyocyte SERCA2a excision. Methods and Results. We crossed SERCA...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/9450439
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Production of antibodies that are specific for allergens is an important pathological process in inflammatory allergic diseases. These contain the antibodies against antigens of Candida albicans, one of the normal microbial flora in an intestinal tract. We studied the effects of the prednisolone administrati...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09511920410001713510
更新日期:2004-06-01 00:00:00
abstract::Maternal immune activation (MIA) is a potential risk factor for autism spectrum disorder (ASD) and schizophrenia (SZ). In rodents, MIA results in changes in cytokine profiles and abnormal behaviors in the offspring that model these neuropsychiatric conditions. Given the central role that mitochondria have in immunity ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/609602
更新日期:2013-01-01 00:00:00
abstract::Leukocytosis and thrombocytopenia occur during cardiopulmonary bypass (CPB) with extracorporeal circulation (ECC). Elevated circulating concentrations of macrophage colony-stimulating factor (M-CSF) are reported during thrombocytopenia and leukopenia of different origins. We have assessed M-CSF concentrations in 40 pa...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000518
更新日期:1996-01-01 00:00:00
abstract::Inflammatory response in Chagas disease is related to parasite and host factors. However, immune system regulation has not been fully elucidated. Thus, this study is aimed at evaluating IL-4 influence on acute phase of Trypanosoma cruzi experimental infection through dosage of cytokine levels in cardiac homogenate of ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/3421897
更新日期:2018-11-28 00:00:00
abstract::Platelet activating factor (PAF) is a potent inflammatory lipid. In this study we assessed the ability of PAF to impact lymphatic vessel function by altering prenodal lymphatic resistance. Intralymphatic PAF (7.47 x 10(-6), 7.47 x 10(-5) and 7.47 x 10(-4) M) increased lymphatic perfusion pressure at the two highest in...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935192000590
更新日期:1992-01-01 00:00:00
abstract::The recently discovered IL-33 as an IL-1 cytokine family member has been proved to be specifically released from osteonecrotic bones. We aimed to investigate the potential role of IL-33 in the development of osteonecrosis of femoral head (ONFH). Forty patients diagnosed with ONFH and forty age-, sex-, and body mass in...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/1732638
更新日期:2017-01-01 00:00:00
abstract::Background. Growth arrest-specific (Gas) 6 is one of the endogenous ligands of TAM receptors (Tyro3, Axl, and Mertk), and its role as an immune modulator has been recently emphasized. Naturally occurring CD4+CD25+ regulatory T cells (Tregs) are essential for the active suppression of autoimmunity. The present study wa...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/6848430
更新日期:2017-01-01 00:00:00
abstract::Human periodontal ligament (hPDL) fibroblasts play a major role during periodontitis and orthodontic tooth movement, mediating periodontal inflammation, osteoclastogenesis, and collagen synthesis. The highly COX-2-selective NSAID etoricoxib has a favorable systemic side effect profile and high analgesic efficacy, part...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/2514956
更新日期:2019-03-10 00:00:00
abstract::Previous studies showed little CD137 expressed in normal vascular smooth muscle cells (VSMCs) and it is important to find a valid way to elevate it before studying its function. The level of CD137 was detected by RT-PCR, western blot, and flow cytometry, respectively. CD137 signaling activation was activated by agonis...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/1382805
更新日期:2017-01-01 00:00:00
abstract::L-Arginine is converted to the highly reactive and unstable nitric oxide (NO) and L-citrulline by an enzyme named nitric oxide synthase (NOS). NO decomposes into other nitrogen oxides such as nitrite (NO(2) (-)) and nitrate (NO(2) (-)), and in the presence of superoxide anion to the potent oxidizing agent peroxynitrit...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935195000135
更新日期:1995-01-01 00:00:00
abstract::Paraoxonase 1 (PON1) activity is markedly influenced by coding polymorphisms, Q/R at position 192 and M/L at position 55 of the PON1 gene. We investigated the frequencies of these polymorphisms and their effects on PON1 and antioxidant activities in 844 South African mixed ancestry individuals. Genotyping was done usi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/217019
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Influenza virus is a worldwide health problem with significant economic consequences. To study the gene expression pattern induced by influenza virus infection, it is useful to reveal the pathogenesis of influenza virus infection; but this has not been well examined, especially in vivo study. AIMS:To assess...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/0962935021000051557
更新日期:2002-12-01 00:00:00
abstract::Peptide 204-212 of lipocortin (LC) 5 inhibited porcine pancreatic phospholipase A(2) (PLA(2)) induced rat stomach strip contractions and ADP induced rabbit platelet aggregation in a concentration dependent manner (IC(30) of 10 muM and 400 muM, respectively). The first two amino acids are not necessary since the eptape...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935193000146
更新日期:1993-01-01 00:00:00
abstract::Edelweiss (Leontopodium alpinum Cass.) is traditionally employed in folk medicine as an anti-inflammatory remedy. In nature, the plant is sparsely available and protected; therefore production of callus cultures was established. A concentrated ethanolic extract of culture homogenate, with leontopodic acid representing...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/498373
更新日期:2012-01-01 00:00:00
abstract::Apolipoprotein E (apoE) is a multifunctional glycosylated protein characterized by its wide tissue distribution. Despite its importance in lipid transport and atherosclerosis pathogenesis, apoE is associated with neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson disease, and autoimmune disorde...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2011/949072
更新日期:2011-01-01 00:00:00
abstract::Chemokines (CKs) and chemokine receptors (CKR) promote leukocyte recruitment into cardiac tissue infected by the Trypanosoma cruzi. This study investigated the long-term treatment with subantimicrobial doses of doxycycline (Dox) in association, or not, with benznidazole (Bz) on the expression of CK and CKR in cardiac ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/3694714
更新日期:2016-01-01 00:00:00
abstract::The production of nitric oxide (NO) was measured in cultures of spleen cells stimulated by lipopolysaccharide (LPS), IL-2 or LPS + IL-2. We observed that NO synthesis is increased by IFN-gamma but inhibited by IFN-alpha/beta. This is not the case when IL-2 is present in the cultures, since interferons play a minor rol...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000117
更新日期:1996-01-01 00:00:00
abstract::Severe acute pancreatitis (SAP) characterized by atrocious progression and numerous complications often leads to a high mortality rate due to hypermetabolism, systemic inflammatory response syndrome (SIRS), and multiple organs dysfunction syndrome (MODS). Studies have revealed that both early enteral nutrition (EEN) a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2007/29638
更新日期:2007-01-01 00:00:00
abstract::In respiratory diseases, there is an increased expression of multiple inflammatory proteins in the respiratory tract, including cytokines, chemokines, and adhesion molecules. Chemokines have been shown to regulate inflammation and immune cell differentiation. Moreover, many of the known inflammatory target proteins, s...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/791231
更新日期:2013-01-01 00:00:00
abstract::The apoptosis-associated speck-like protein containing a caspase recruit domain (ASC) is involved in apoptosis and innate immunity and is a major adaptor molecule responsible for procaspase-1 activation. ASC mRNA is encoded by three exons: exons 1 and 3 encode a pyrin domain (PYD) and caspase recruit domain (CARD), re...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2009/287387
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:TRAIL is a potential biomarker of cardiovascular (CV) disease. Ankylosing spondylitis (AS) is a chronic inflammatory disease associated with metabolic syndrome (MeS) and accelerated atherosclerosis. We assessed whether disease activity, systemic inflammation, and MeS features were associated with circulating ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/798060
更新日期:2014-01-01 00:00:00
abstract::Patients with inflammatory bowel disease (IBD) are at an increased risk of developing colorectal cancer (CRC). The risk factors of CRC in IBD patients include long disease duration, extensive colitis, severe histological inflammation, and coexistence with primary sclerosing cholangitis (PSC). Several molecular pathway...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2017/5126048
更新日期:2017-01-01 00:00:00
abstract::This study examined the role of lymphotoxin (LT)-alpha in host defense against airborne infection with Francisella tularensis, a gram-negative facultative intracellular bacterium and the causative agent of tularemia. Following a low-dose aerosol infection with the highly virulent type A strain of F. tularensis, mice d...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2008/239740
更新日期:2008-01-01 00:00:00
abstract::Paricalcitol, a selective vitamin D receptor (VDR) activator used for treatment of secondary hyperparathyroidism in chronic kidney disease (CKD), has been associated with survival advantages, suggesting that this drug, beyond its ability to suppress parathyroid hormone, may have additional beneficial actions. In this ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/670475
更新日期:2014-01-01 00:00:00
abstract::The mechanism of pain reduction involves bidirectional processes of pain blocking (nociception) and reductions in the levels of proinflammatory cytokines in the blood. Does transcutaneous electrical nerve stimulation (TENS) reduce blood levels of proinflammatory cytokines? For this systematic review, we searched in si...
journal_title:Mediators of inflammation
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2018/1094352
更新日期:2018-04-02 00:00:00
abstract::There is some anecdotal evidence that oxygen-ozone therapy may be beneficial in some human diseases. However so far only a few biochemical and pharmacodynamic mechanisms have been elucidated. On the basis of preliminary data we postulated that controlled ozone administration would promote an oxidative preconditioning ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359890983
更新日期:1998-01-01 00:00:00