Abstract:
:With the development of culture-independent techniques, numerous studies have demonstrated that the lower airway is not sterile in health and harbors diverse microbial communities. Furthermore, new evidence suggests that there is a distinct lower airway microbiome in those with chronic respiratory disease. To understand the role of lower airway dysbiosis in the pathogenesis of asthma, in this article, we review the published reports about the lung microbiome of healthy controls, provide an outlook on the contribution of lower airway dysbiosis to asthma, especially steroid-resistant asthma, and discuss the potential therapies targeted for lower airway dysbiosis.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Lu J,Xiong L,Zhang X,Liu Z,Wang S,Zhang C,Zheng J,Wang G,Zheng R,Simpson JL,Wang Fdoi
10.1155/2017/3890601subject
Has Abstractpub_date
2017-01-01 00:00:00pages
3890601eissn
0962-9351issn
1466-1861journal_volume
2017pub_type
杂志文章,评审abstract::Systemic and intraplaque biomarkers have been widely investigated in clinical cohorts as promising surrogate parameters of cardiovascular vulnerability. In this pilot study, we investigated if systemic and intraplaque levels of calcification biomarkers were affected by treatment with a statin in a cohort of patients w...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/720987
更新日期:2014-01-01 00:00:00
abstract::Increased insulin resistance and inflammatory action are observed in pregnancy-induced hypertension (PIH), but similar insulin resistance is observed also in successful pregnancy. To estimate insulin resistance and inflammatory activity in normal pregnancy and PIH, serum concentrations of free fatty acids (FFA; correc...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/432575
更新日期:2012-01-01 00:00:00
abstract::The development of an acidic tissue environment is a hallmark of a variety of inflammatory processes and solid tumors. However, little attention has been paid so far to analyze the influence exerted by extracellular pH on the immune response. Tissue acidosis (pH 6.0 to 7.0) is usually associated with the course of inf...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2018/1218297
更新日期:2018-12-30 00:00:00
abstract::Many therapies are now available for patients with rheumatoid arthritis (RA) who have an inadequate response to methotrexate including tumor necrosis factor inhibitors, abatacept, tocilizumab, and rituximab. Clinical response to drugs varies widely between individuals. A part of this variability is due to the characte...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2014/386148
更新日期:2014-01-01 00:00:00
abstract::High-fructose diet induced changes in gut microbiota structure and function, which have been linked to inflammatory response. However, the effect of small or appropriate doses of fructose on gut microbiota and inflammatory cytokines is not fully understood. Hence, the abundance changes of gut microbiota in fructose-tr...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/6672636
更新日期:2020-11-30 00:00:00
abstract::Tissue engineering cell-based therapy using induced pluripotent stem cells and adipose-derived stem cells (ASCs) may be promising tools for therapeutic applications in tissue engineering because of their abundance, relatively easy harvesting, and high proliferation potential. The purpose of this study was to investiga...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/4267158
更新日期:2018-03-18 00:00:00
abstract::The causes of retinal hypoxia are many and varied. Under hypoxic conditions, a variety of soluble factors are secreted into the vitreous cavity including growth factors, cytokines, and chemokines. Cytokines, which usually serve as signals between neighboring cells, are involved in essentially every important biologica...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/935301
更新日期:2013-01-01 00:00:00
abstract::Thousands of people suffer from severe malaria every year. The innate immune response plays a determinant role in host's defence to malaria. Transient receptor potential vanilloid 1 (TRPV1) modulates macrophage-mediated responses in sepsis, but its role in other pathogenic diseases has never been addressed. We investi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/506450
更新日期:2014-01-01 00:00:00
abstract::Statins exert pleiotropic effects on endothelial cells in addition to lowering cholesterol. 15-Lipoxygenase-1 (ALOX15) has been implicated in vascular inflammation and disease. The relationship between atorvastatin and ALOX15 was investigated using a rat carotid artery balloon-injury model. Hematoxylin and eosin (HE) ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/6769032
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIM:Coronary artery ectasia (CAE) was thought of as a variant of atherosclerosis. C-reactive protein (CRP) which is among the most sensitive markers of systemic inflammation, and elevation of systemic and local levels of this inflammatory marker which has been associated with an increased risk for cardiovasc...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2007/89649
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Icariin (ICA) is an active compound extracted from Epimedium brevicornum Maxim. Previous reports have shown that icariin has a clinically significant therapeutic effect on rheumatoid arthritis. However, little is known about the mechanism by which icariin inhibits cartilage and bone degradation. METHODS:New...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/9529630
更新日期:2016-01-01 00:00:00
abstract::Thymosin beta(4) is a polypeptide isolated from thymosin fraction 5. This peptide exhibits important activities in the regulation and differentiation of thymus-dependent lymphocytes. An analogue of thymosin beta(4), [Phe(4F)(12)] deacetyl- thymosin beta(4), was synthesized by a solution method, followed by deprotectio...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S096293519200019X
更新日期:1992-01-01 00:00:00
abstract::Crohn's disease (CD) is a multifactorial chronic inflammatory bowel disease of unknown cause. The aim of the present study was to explore if mRNA over-expression of SSTR5 and CCR7 found in CD patients could be correlated to respective protein expression. When compared to healthy donors, SSTR5 was over-expressed 417 +/...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2009/285812
更新日期:2009-01-01 00:00:00
abstract::Although the initiating events of Crohn's disease are unknown, models of experimental colitis have provided new insights in the immunologically mediated pathways of mucosal inflammation. In Crohn's disease activated mucosal T lymphocytes produce proinflammatory cytokines within the mucosal compartment. With this under...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1080/09629359891063
更新日期:1998-01-01 00:00:00
abstract::Lysophosphatidic acid (LPA) is a bioactive phospholipid playing an important role in various inflammatory diseases by inducing expression and secretion of many inflammatory cytokines/chemokines. Here we report in a murine air pouch model of inflammation that LPA induced CXCL13 secretion in a time-dependent manner and ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/248492
更新日期:2015-01-01 00:00:00
abstract::Sarcoidosis is an inflammatory granulomatous disease with unknown etiology driven by cytokines and chemokines. There is limited information regarding the regulation of cytokine/chemokine-receptor network in bronchoalveolar lavage (BAL) cells in pulmonary sarcoidosis, suggesting contribution of miRNAs and transcription...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/121378
更新日期:2015-01-01 00:00:00
abstract::Cathepsin G is a serine protease secreted by activated neutrophils that play a role in the inflammatory response. Because neutrophils are known to be invading leukocytes in various tumors, their products may influence the characteristics of tumor cells such as the growth state, motility, and the adhesiveness between c...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2009/850940
更新日期:2009-01-01 00:00:00
abstract::In addition to its well-established effect on T cells, cyclosporin A (CsA) also inhibits inflammatory cytokine production by macrophages. However, little is known about the mechanism of action of CsA on macrophage cytokine production. We measured the effect of CsA on basal and phorbol-myristate-acetate (PMA)-stimulate...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359990423
更新日期:1999-01-01 00:00:00
abstract::Silica inhalation can induce chronic lung inflammation and fibrosis. Upon silica stimulation, activated macrophages trigger the T-lymphocyte which can differentiate into many different types of Th cells, including the recently discovered Th17 cells. IL-17A, the typical Th17 cytokine, is reported in some inflammatory d...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/570894
更新日期:2014-01-01 00:00:00
abstract::Adipose tissue produces a wide range of proteins that may influence the immune system. In this study, we assessed the serum levels of leptin, adiponectin, and ghrelin, in association with the measurements of body composition, in 15 female patients with various autoimmune diseases (systemic lupus erythematosus, primary...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/938408
更新日期:2010-01-01 00:00:00
abstract::Inflammatory mediators play a critical role in ulcerative colitis immune and inflammatory processes. The aim of the study was to investigate the effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-alpha, NF-kappaBp65, IL-6) in TNBS-induced colitis in rats. Colitis in rats was induced by colonic a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI/2006/92642
更新日期:2006-01-01 00:00:00
abstract::Autism is a neurodevelopmental disorder characterized by problems in communication, social skills, and repetitive behavior. Recent studies suggest that apoptotic and inflammatory mechanisms may contribute to the pathogenesis of this disorder. Nuclear factor-κB (NF-κB) is an important gene transcriptional factor involv...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2011/785265
更新日期:2011-01-01 00:00:00
abstract:UNLABELLED:The aim of this study was to investigate the relationship between urinary eosinophil protein X (uEPX) and asthma symptoms, lung function, and other markers of eosinophilic airway inflammation in asthmatic school children. METHODS:A cross-sectional study was performed in 180 steroid dependent atopic children...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2007/49240
更新日期:2007-01-01 00:00:00
abstract::The generation of ROS and lipid peroxidation has been considered to play an important role in the pathogenesis of chronic fluoride toxicity. In the present study, we observed that fluoride activated BV-2 microglia cell line by observing OX-42 expression in immunocytochemistry. Intracellular superoxide dismutase (SOD),...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/102954
更新日期:2012-01-01 00:00:00
abstract::The destruction of joints caused by rheumatoid arthritis and osteoarthritis is characterized by an imbalance of enzyme catalysed cartilage breakdown and regeneration. A complex cytokine network perpetuates joint conditions by direct regulation of metalloproteases, by indirect recruitment of cells that secrete degradat...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935194000359
更新日期:1994-01-01 00:00:00
abstract::Extracellular bacterial ribonucleases such as binase from Bacillus pumilus possess cytotoxic activity against tumor cells with a potential for clinical application. Moreover, they may induce activation of tumor-derived macrophages either into the M1-phenotype with well-documented functions in the regulation of the ant...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/4029641
更新日期:2017-01-01 00:00:00
abstract::Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune disease...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/834831
更新日期:2014-01-01 00:00:00
abstract::The effects of intravenous injection of Porphyromonas gingivalis (Pg) on rabbit inflammatory immune response and atherosclerosis were evaluated by establishing a microamount Pg bacteremia model combined with high-fat diet. Twenty-four New Zealand rabbits were randomly divided into Groups A-D (n = 6). After 14 weeks, l...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/364391
更新日期:2015-01-01 00:00:00
abstract::The purpose of this paper is to evaluate the chronic effect of sitagliptin on metabolic profile, inflammation, and redox status in the Zucker Diabetic Fatty (ZDF) rat, an animal model of obese type 2 diabetes. Diabetic and obese ZDF (fa/fa) rats and their controls (ZDF +/+) were treated during 6 weeks with vehicle (co...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/592760
更新日期:2010-01-01 00:00:00
abstract::In this study the question was addressed whether cAMP mediated drugs induce a differential reduction of branches of the arachidonic acid metabolism rather than a global reduction of eicosanoid synthesis. The isolated lungs of actively sensitized rats were employed to study prostaglandin and leukotriene release in the ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935192000395
更新日期:1992-01-01 00:00:00