Abstract:
:The generation of ROS and lipid peroxidation has been considered to play an important role in the pathogenesis of chronic fluoride toxicity. In the present study, we observed that fluoride activated BV-2 microglia cell line by observing OX-42 expression in immunocytochemistry. Intracellular superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), reactive oxygen species (ROS), superoxide anions (O(2)(∙-)), nitric oxide synthase (NOS), nitrotyrosine (NT) and nitric oxide (NO), NOS in cell medium were determined for oxidative stress assessment. Our study found that NaF of concentration from 5 to 20 mg/L can stimuli BV-2 cells to change into activated microglia displaying upregulated OX-42 expression. SOD activities significantly decreased in fluoride-treated BV-2 cells as compared with control, and MDA concentrations and contents of ROS and O(2)(∙-) increased in NaF-treated cells. Activities of NOS in cells and medium significantly increased with fluoride concentrations in a dose-dependent manner. NT concentrations also increased significantly in 10 and 50 mg/L NaF-treated cells compared with the control cells. Our present study demonstrated that toxic effects of fluoride on the central nervous system possibly partly ascribed to activiting of microglia, which enhanced oxidative stress induced by ROS and reactive nitrogen species.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Shuhua X,Ziyou L,Ling Y,Fei W,Sun Gdoi
10.1155/2012/102954subject
Has Abstractpub_date
2012-01-01 00:00:00pages
102954eissn
0962-9351issn
1466-1861journal_volume
2012pub_type
杂志文章abstract::It was recently demonstrated that TLR4 activation via dietary lipids triggers inflammatory pathway and alters insulin responsiveness in the fat tissue during obesity. Here, we question whether other TLR family members could participate in the TLR-mediated inflammatory processes occurring in the obese adipose tissue. W...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/823486
更新日期:2010-01-01 00:00:00
abstract::Platelet activating factor (PAF) is a potent inflammatory lipid. In this study we assessed the ability of PAF to impact lymphatic vessel function by altering prenodal lymphatic resistance. Intralymphatic PAF (7.47 x 10(-6), 7.47 x 10(-5) and 7.47 x 10(-4) M) increased lymphatic perfusion pressure at the two highest in...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935192000590
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Infection in the neonatal period is an extremely serious condition and diagnosis is difficult. C-reactive protein (CRP) is widely used as a marker of infection; however, its usefulness is limited in the early phase. The role of soluble intracellular adhesion molecule-1 (sICAM-1), an adhesion molecule, has be...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350220131944
更新日期:2002-04-01 00:00:00
abstract::Plasma GDF15 concentrations were measured in 612 Taiwanese individuals without overt systemic disease. Clinical parameters, GDF15 genetic variants, and 22 biomarker levels were analyzed. We further enrolled 86 patients with PAD and 481 patients with CAD, who received endovascular intervention and coronary angiography,...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/9398401
更新日期:2017-01-01 00:00:00
abstract::Particulate matter with an aerodynamic diameter equal or less than 2.5 micrometers (PM2.5) is associated with the development of chronic obstructive pulmonary disease (COPD). The mechanisms by which PM2.5 accelerates disease progression in COPD are poorly understood. In this study, we aimed to investigate the effect o...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/4260204
更新日期:2020-05-08 00:00:00
abstract::Keloids are characterized by excessive collagen deposition and growth beyond the edges of the initial injury, and cytokines may be related to their formation. The objective of this study was to evaluate the collagen fibers, analyze in situ expression of cytokines in keloid lesions, and compare to the control group. Re...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/6573802
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Severe traumatization induces a complex pathophysiology, driven by the patient's own immune system. The initial activation is a result of damage-associated molecular patterns, which are released from disrupted and dying cells and recognized by immune receptors, for example, RAGE. In this study we aimed to ev...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/691491
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Asthma is a disorder characterized by a predominance of Th2 cells and eosinophilic inflammation. Suppressors of cytokine signaling (SOCS) proteins act as negative regulators of cytokine signaling. In particular, SOCS1 and SOCS3 play an important role in immune response by controlling the balance between Th1 ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2011/823279
更新日期:2011-01-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is considered a multifactorial, multisystem disease in which inflammation and the immune system play important roles in development and progression. The pleiotropic cytokine TNFα is one of the major players governing the inflammation in the central nervous system and peripheral dist...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2017/2985051
更新日期:2017-01-01 00:00:00
abstract::The stalks of Polygonum hydropiper L. (PHL) have been traditionally used in clinical practice for thousands of years in China to treat various inflammatory diseases. However, little research has been conducted to investigate the anti-inflammatory effects of PHL on TNBS-induced intestinal inflammation in rats. The aim ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/6029135
更新日期:2018-05-07 00:00:00
abstract::A family of eleven proteins comprises the Janus kinases (JAK) and signal transducers and activators of transcription (STAT) signaling pathway, which enables transduction of signal from cytokine receptor to the nucleus and activation of transcription of target genes. Irregular functioning of the cascade may contribute ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/6716419
更新日期:2017-01-01 00:00:00
abstract::S. epidermidis is responsible for biofilm-related nonunions. This study compares the response to S. epidermidis-infected fractures in rats systemically or locally injected with vancomycin or bone marrow mesenchymal stem cells (BMSCs) in preventing the nonunion establishment. The 50% of rats receiving BMSCs intravenous...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/9595706
更新日期:2016-01-01 00:00:00
abstract::Despite early recanalization of an occluded infarct artery, tissue reperfusion remains impaired in more than one-third of the acute myocardial infarction (AMI) patients owing to a process of reperfusion injury. The role of systemic inflammation in triggering this phenomenon is unknown. Proinflammatory factors (hs-CRP,...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI.2005.385
更新日期:2005-12-14 00:00:00
abstract::Tumor necrosis factor alpha (TNF-α) is a cytokine which plays opposing roles in the context of infectious disease pathogenesis. TNF-α is essential for the development of a protective immune response to some pathogens, for example, Mycobacterium tuberculosis, by synergizing with other cytokines. However, exorbitant or ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/619480
更新日期:2015-01-01 00:00:00
abstract::Microparticles (MPs) are induced during apoptosis, cell activation, and even "spontaneous" release. Initially MPs were considered to be inert cellular products with no biological function. However, an extensive research and functional characterization have shown that the molecular composition and the effects of MPs de...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/267590
更新日期:2015-01-01 00:00:00
abstract::Chronic inflammation has an important role in the development and progression of most fibrotic diseases, for which no effective treatments exist. Tubulointerstitial fibrosis (TF) is characterized by irreversible deposition of fibrous tissue in chronic kidney diseases. Prolonged injurious stimuli and chronic inflammati...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/5103672
更新日期:2018-10-14 00:00:00
abstract::Specific binding sites for the anti-inflammatory protein annexin I have been detected on the surface of human monocytes and polymorphonuclear leukocytes (PMN). These binding sites are proteinaceous in nature and are sensitive to cleavage by the proteolytic enzymes trypsin, collagenase, elastase and cathepsin G. When m...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359990720
更新日期:1999-01-01 00:00:00
abstract::Trypanosoma cruzi infection was studied in mouse lines selected for maximal (AIRmax) or minimal (AIRmin) acute inflammatory reaction and for high (HIII) or low (LIII) antibody (Ab) responses to complex antigens. Resistance was associated with gender (females) and strain-the high responder lines AIRmax and HIII were re...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/952857
更新日期:2014-01-01 00:00:00
abstract::It is hypothesized that central nervous system inflammation induced by systematic inflammation due to surgical trauma plays a critical role in postoperative cognitive dysfunction. The potential inhibitory effect of nerve blockage with local anesthetics on peripheral inflammatory response has been reported. We hypothes...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/460125
更新日期:2015-01-01 00:00:00
abstract::Thousands of people suffer from severe malaria every year. The innate immune response plays a determinant role in host's defence to malaria. Transient receptor potential vanilloid 1 (TRPV1) modulates macrophage-mediated responses in sepsis, but its role in other pathogenic diseases has never been addressed. We investi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/506450
更新日期:2014-01-01 00:00:00
abstract:Objectives:In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL). Designs:The current cross-sectional analysis was based on data collected within a type 2 diabetes project. Settings. Dietary magnesium intake is associated with peripheral blood leukocyte telomere length (LTL). H...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/7610436
更新日期:2020-05-22 00:00:00
abstract:BACKGROUND:Noncystic fibrosis bronchiectasis (NCFB) is characterized by airway expansion and recurrent acute exacerbations. Macrolide has been shown to exhibit anti-inflammatory effects in some chronic airway diseases. OBJECTIVE:To assess the efficacy of roxithromycin on airway inflammation and remodeling in patients ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/708608
更新日期:2014-01-01 00:00:00
abstract::Sestrin2 (sesn2) is an endogenous antioxidant protein that has recently gained attention for its potential to treat various inflammatory diseases. However, the relationship of sesn2 with cardiomyopathy is still unclear. In H9c2 cells, sesn2 knockdown reduced the level of 5' adenosine monophosphate-activated protein ki...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/6209140
更新日期:2018-07-05 00:00:00
abstract:PURPOSE:To assess FGF-β, TGF-β, and COX2 expression and immunocompetent cells in the orbital tissue of patients with severe and mild Graves' orbitopathy. PATIENTS AND METHODS:Orbital tissue was taken from 27 patients with GO: (1) severe GO (n = 18), the mean clinical activity score (CAS) being 8.5 (SD 2.5); and (2) mi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/412158
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To investigate the Th17/Treg immune balance in the ulcerative colitis (UC) patients in a Chinese Han population. METHODS:Ninety UC patients and 30 healthy subjects were enrolled. The serum IL-17 and TGF-β1 levels of these participants were measured with ELISA; the percentage of Th17 and Treg cells in periphe...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/7089137
更新日期:2016-01-01 00:00:00
abstract::We previously demonstrated that Bothrops jararaca venom (BjV) has an antitumor effect on Ehrlich ascites tumor (EAT) cells and induces an increase of polymorphonuclear leukocytes in early stages of tumor growth. It has been reported that this venom presents an important inflammatory effect when inoculated in animal mo...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/0962935029000041
更新日期:2002-08-01 00:00:00
abstract::Dysregulated inflammation is increasingly considered as the main cause of many diseases on which NOD1/NF-κB pathway plays an important role. Columbianetin (CBT) is derived from the root of the Chinese herb Radix Angelicae Pubescentis for treating inflammatory diseases. Although the anti-inflammatory effect of CBT has ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/9191743
更新日期:2018-04-05 00:00:00
abstract::Acute necrotizing encephalopathy (ANE) is a rare but distinctive type of acute encephalopathy with global distribution. Occurrence of ANE is usually preceded by a virus-associated febrile illness and ensued by rapid deterioration. However, the causal relationship between viral infections and ANE and the exact pathogen...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/792578
更新日期:2015-01-01 00:00:00
abstract::Background. Inflammation mediators related to radiation proctitis are partially elucidated, and neovascularization is thought to play a key role. Objectives. To investigate the expression of vascular endothelial growth factor (VEGF) and CD31 as angiogenetic markers in postradiation rectal tissue. Methods. Rectal mucos...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/515048
更新日期:2013-01-01 00:00:00
abstract::Mechanical ventilation (MV) is a major life support technique for the management of trauma-associated hemorrhagic shock (HS). Ventilator-induced diaphragm dysfunction (VIDD), one of the most common complications of MV, has been well demonstrated in animal and human studies. However, few data are available concerning t...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/3738409
更新日期:2019-11-14 00:00:00