Enhanced levels of chemokines and their receptors in the colon of microscopic colitis patients indicate mixed immune cell recruitment.

abstract：:We have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic encephalomyelitis (EAE). Within the frames of the successfully completed phase I clinical trial, we investigated changes in the serum cytokine profile after Xemys admini...

journal_title：Mediators of inflammation

authors： Lomakin Y,Belogurov A Jr,Glagoleva I,Stepanov A,Zakharov K,Okunola J,Smirnov I,Genkin D,Gabibov A

更新日期：2016-01-01 00:00:00

abstract：:The clinical outcome of autologous adipose stem cell (ASC) treatment of patients with multiple sclerosis (MS) was investigated following one year of observation. Methods. The clinical and MRI outcomes of 16 ASC-treated patients with RRMS and SPMS are reported after a one-year follow-up period. Results. At 18 months of...

journal_title：Mediators of inflammation

authors： Stepien A,Dabrowska NL,Maciagowska M,Macoch RP,Zolocinska A,Mazur S,Siennicka K,Frankowska E,Kidzinski R,Chalimoniuk M,Pojda Z

更新日期：2016-01-01 00:00:00

abstract：:Syndecan-1 (CD138) is a transmembrane heparin sulfate proteoglycan expressed on distinct stages of differentiation of B-lymphoid cells. Its prognostic value in B-cell chronic lymphocytic leukemia (B-CLL) has not been evaluated so far. The serum concentration of sCD138 and some angiogenesis-involved cytokines: vascular...

journal_title：Mediators of inflammation

authors： Wołowiec D,Dybko J,Wróbel T,Urbaniak-Kujda D,Jaźwiec B,Tomaszewska-Toporska B,Kapelko-Słowik K,Potoczek S,Kuliczkowski K

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Production of antibodies that are specific for allergens is an important pathological process in inflammatory allergic diseases. These contain the antibodies against antigens of Candida albicans, one of the normal microbial flora in an intestinal tract. We studied the effects of the prednisolone administrati...

journal_title：Mediators of inflammation

authors： Tansho S,Abe S,Ishibashi H,Mitsuya M,Wada K,Ikeda T,Suegara N,Koshio O,Ono Y,Yamaguchi H

更新日期：2004-06-01 00:00:00

abstract：:As one of the ligands of aryl hydrocarbon receptor (AhR), baicalein, isolated from Scutellaria baicalensis Georgi, has been proved to exert potential therapeutic effects on ulcerative colitis (UC), but its therapeutic mechanism remains obscure. Authentically, ulcerative colitis can be alleviated by regulating the diff...

journal_title：Mediators of inflammation

authors： Liu C,Li Y,Chen Y,Huang S,Wang X,Luo S,Su Y,Zhou L,Luo X

更新日期：2020-10-05 00:00:00

abstract：:Delayed rectifier K(+)-channels (Kv1.3) are predominantly expressed in T lymphocytes. Based on patch-clamp studies, the channels play crucial roles in facilitating the calcium influx necessary to trigger lymphocyte activation and proliferation. Using selective channel inhibitors in experimental animal models, in vivo ...

journal_title：Mediators of inflammation

authors： Kazama I

更新日期：2015-01-01 00:00:00

abstract：Background:Inflammation plays a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD). We evaluated the lncRNA and mRNA expression profile of peripheral blood mononuclear cells (PBMCs) from healthy nonsmokers, smokers without airflow limitation, and COPD patients. Methods:lncRNA and mRNA pro...

journal_title：Mediators of inflammation

authors： Qu X,Dang X,Wang W,Li Y,Xu D,Shang D,Chang Y

更新日期：2018-03-13 00:00:00

abstract：:Cytokines and chemokines are proteins that coordinate the immune response throughout the body. The dysregulation of cytokines and chemokines is a central feature in the development of neuroinflammation, neurodegeneration, and demyelination both in the central and peripheral nervous systems and in conditions of neuropa...

journal_title：Mediators of inflammation

authors： Ramesh G,MacLean AG,Philipp MT

更新日期：2013-01-01 00:00:00

abstract：:Monocyte chemotactic protein (MCP-1) is a specific monocyte chemoattractant and activating factor produced by both immune cells (mononuclear phagocytes and lymphocytes) and non-immune cells (parenchymal and stromal cells). In order to define the conditions under which human monocytes express MCP-1, monocytes were expo...

journal_title：Mediators of inflammation

authors： Liebler JM,Kunkel SL,Allen RM,Burdick MD,Strieter RM

更新日期：1994-01-01 00:00:00

abstract：:The present study investigated the frequencies of rs1800450 (MBL ⁎B, G>A), rs1800451 (MBL ⁎C, G>A), and rs5030737 (MBL ⁎D, C>T) polymorphisms in exon 1 of the MBL2 gene among patients with chronic viral hepatitis. Blood samples from patients infected with hepatitis B virus (HBV; n = 65), hepatitis C virus (HCV; n = 92...

journal_title：Mediators of inflammation

authors： Moura TC,Amoras ED,Araújo MS,Freitas Queiroz MA,Conde SR,Demachki S,Martins-Feitosa RN,Machado LF,Cayres-Vallinoto IM,Ishak R,Vallinoto AC

更新日期：2017-01-01 00:00:00

abstract：:Cardiovascular (CV) disease is the most common cause of premature mortality in patients with rheumatoid arthritis (RA). It is the result of an accelerated atherosclerotic process. Both RA and atherosclerosis are complex polygenic diseases. Besides traditional CV risk factors and chronic inflammation, a number of studi...

journal_title：Mediators of inflammation

authors： Rodríguez-Rodríguez L,López-Mejías R,García-Bermúdez M,González-Juanatey C,González-Gay MA,Martín J

更新日期：2012-01-01 00:00:00

abstract：Purpose:To explore the potential of monocyte-to-lymphocyte ratio (MLR) at hospital admission for predicting acute traumatic intraparenchymal hematoma (tICH) expansion in patients with cerebral contusion. Patients and Methods. This multicenter, observational study included patients with available at-hospital admission (...

journal_title：Mediators of inflammation

authors： Sheng J,Li T,Zhuang D,Cai S,Yang J,Ding F,Chen X,Tian F,Huang M,Li L,Li K,Chen W

更新日期：2020-12-28 00:00:00

abstract：:Our understanding of inflammation's role in the pathogenesis of myeloproliferative neoplasm (MPN) is evolving. The impact of chronic inflammation, a characteristic feature of MPN, likely goes far beyond its role as a driver of constitutional symptoms. An inflammatory response to the neoplastic clone may be responsible...

journal_title：Mediators of inflammation

authors： Fleischman AG

更新日期：2015-01-01 00:00:00

abstract：:Adipose tissue produces a wide range of proteins that may influence the immune system. In this study, we assessed the serum levels of leptin, adiponectin, and ghrelin, in association with the measurements of body composition, in 15 female patients with various autoimmune diseases (systemic lupus erythematosus, primary...

journal_title：Mediators of inflammation

authors： Toussirot E,Gaugler B,Bouhaddi M,Nguyen NU,Saas P,Dumoulin G

更新日期：2010-01-01 00:00:00

abstract：:The influence of an anti-allergic agent, suplatast tosilate (IPD-1151T; (+/-)-[2-[4-(3-ethoxy-2-hydroxypropoxy)phenyl-carbamoyl]-ethyl] dimethylsulfonium p-toluenesulfonate) on allergic bronchoconstriction induced by allergen and methacholine (MCh) were examined in mice. BALB/c mice were sensitized by intraperitoneal ...

journal_title：Mediators of inflammation

authors： Asano K,Mizutani T,Shimane T,Hisano M,Hisamitsu T,Suzaki H

更新日期：2000-01-01 00:00:00

abstract：:Atherosclerosis is characterized by interaction between immune and vascular endothelial cells which is mediated by adhesion molecules occurring on the surface of the vascular endothelium leading to massive release of proinflammatory mediators. Ginkgo biloba L. (Ginkgoaceae) standardized extracts showing beneficial eff...

journal_title：Mediators of inflammation

authors： Piazza S,Pacchetti B,Fumagalli M,Bonacina F,Dell'Agli M,Sangiovanni E

更新日期：2019-06-25 00:00:00

abstract：:The aim of this study was to evaluate the effects of moderate-intensity exercise on plasma levels of C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) as markers of low-grade inflammation and endothelial function in diabetic (db/db) mice. Control and db/db mice were divided into sedentary and exercised ...

journal_title：Mediators of inflammation

authors： Sallam N,Khazaei M,Laher I

更新日期：2010-01-01 00:00:00

abstract：:Many therapies are now available for patients with rheumatoid arthritis (RA) who have an inadequate response to methotrexate including tumor necrosis factor inhibitors, abatacept, tocilizumab, and rituximab. Clinical response to drugs varies widely between individuals. A part of this variability is due to the characte...

journal_title：Mediators of inflammation

authors： Daïen CI,Morel J

更新日期：2014-01-01 00:00:00

abstract：:One of the most globally prevalent supraventricular arrhythmias is atrial fibrillation (AF). Knowledge of the structures and functions of messenger RNA (mRNA) has recently increased. It is no longer viewed as solely an intermediate molecule between DNA and proteins but has come to be seen as a dynamic and modifiable g...

journal_title：Mediators of inflammation

authors： Xu X,Zhao Z,Li G

更新日期：2020-03-12 00:00:00

abstract：:Despite early recanalization of an occluded infarct artery, tissue reperfusion remains impaired in more than one-third of the acute myocardial infarction (AMI) patients owing to a process of reperfusion injury. The role of systemic inflammation in triggering this phenomenon is unknown. Proinflammatory factors (hs-CRP,...

journal_title：Mediators of inflammation

authors： Blancke F,Claeys MJ,Jorens P,Vermeiren G,Bosmans J,Wuyts FL,Vrints CJ

更新日期：2005-12-14 00:00:00

abstract：:The close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study. Traditional risk factors for metabolic disorders, including the waist circumstance, body mass index (BMI), triglyceride (TG), and ratio of TG to high density lipoprotein (HDL) chol...

journal_title：Mediators of inflammation

authors： Wang SW,Lin TM,Wang CH,Liu HH,Houng JY

更新日期：2012-01-01 00:00:00

abstract：:Periodontitis is an inflammatory disease characterized by destruction of the tooth-supporting tissues. Obese individuals have an increased risk of periodontitis, and elevated circulating levels of nicotinamide phosphoribosyltransferase (NAMPT) may be a pathomechanistic link between both diseases. Recently, increased l...

journal_title：Mediators of inflammation

authors： Nokhbehsaim M,Keser S,Jäger A,Jepsen S,Deschner J

更新日期：2013-01-01 00:00:00

abstract：:In respiratory diseases, there is an increased expression of multiple inflammatory proteins in the respiratory tract, including cytokines, chemokines, and adhesion molecules. Chemokines have been shown to regulate inflammation and immune cell differentiation. Moreover, many of the known inflammatory target proteins, s...

journal_title：Mediators of inflammation

authors： Lee IT,Yang CM

更新日期：2013-01-01 00:00:00

abstract：:Silica inhalation can induce chronic lung inflammation and fibrosis. Upon silica stimulation, activated macrophages trigger the T-lymphocyte which can differentiate into many different types of Th cells, including the recently discovered Th17 cells. IL-17A, the typical Th17 cytokine, is reported in some inflammatory d...

journal_title：Mediators of inflammation

authors： Tang W,Liu F,Chen Y,Song L,Dai W,Li C,Weng D,Chen J

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To investigate the effects and mechanisms of hydroxytyrosol (HT) during the pathogenesis of myocardial ischemia reperfusion (I/R) in rat hearts. METHODS:The rats were randomized into five groups: sham group, I/R group, HT+I/R group, HT+LY294002+I/R group, and LY+I/R group. Myocardial infarct size, markers of...

journal_title：Mediators of inflammation

authors： Pei YH,Chen J,Xie L,Cai XM,Yang RH,Wang X,Gong JB

更新日期：2016-01-01 00:00:00

abstract：:Metabolic hormones have been associated with reproductive function modulation. Thus, the aim of this study was: (i) to characterize the immunolocalization, mRNA and protein levels of leptin (LEP), Ghrelin (GHR) and respective receptors LEPR and Ghr-R1A, throughout luteal phase; and (ii) to evaluate the role of LEP and...

journal_title：Mediators of inflammation

authors： Galvão A,Tramontano A,Rebordão MR,Amaral A,Bravo PP,Szóstek A,Skarzynski D,Mollo A,Ferreira-Dias G

更新日期：2014-01-01 00:00:00

abstract：:Little is known about the cause and pathophysiology of middermal elastolysis (MDE). In this condition, variable inflammatory infiltrate may be present or not together with loss of elastic fibres in the middermis that spares both papillary and lower reticular dermis. MDE may be a consequence of abnormal extracellular m...

journal_title：Mediators of inflammation

authors： De Cunto G,Lamberti A,de Santi MM,Miracco C,Fimiani M,Lungarella G,Cavarra E

更新日期：2017-01-01 00:00:00

abstract：:Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects. We assessed urinary F2-isoprostanes (F2-IsoPs), prostaglandin E...

journal_title：Mediators of inflammation

authors： Hulgan T,Boger MS,Liao DH,McComsey GA,Wanke CA,Mangili A,Walmsley SL,McCreath H,Milne GL,Sanchez SC,Currier JS,Lake JE

更新日期：2014-01-01 00:00:00

abstract：:Nitrooleic acid (OA-NO2) is an endogenous lipid product which has novel signaling properties, particularly the activation of peroxisome proliferator-activated receptors. The current study aimed to evaluate the protective effects of OA-NO2 against cisplatin-induced kidney injury in mice. Mice were pretreated with OA-NO...

journal_title：Mediators of inflammation

authors： Wang H,Jia Z,Sun J,Xu L,Zhao B,Yu K,Yang M,Yang T,Wang R

更新日期：2015-01-01 00:00:00

abstract：:Shinbaro3, a formulation derived from the hydrolysed roots of Harpagophytum procumbens var. sublobatum (Engl.) Stapf, has been clinically used in the pharamacopuncture treatment of arthritis in Korea. In the present study, Shinbaro3 inhibited NO generation in LPS-induced RAW 264.7 cells in a dose-dependent manner. Shi...

journal_title：Mediators of inflammation

authors： Chung HJ,Koh W,Kim WK,Shin JS,Lee J,Lee SK,Ha IH

更新日期：2018-04-05 00:00:00