Epithelial Cells Attenuate Toll-Like Receptor-Mediated Inflammatory Responses in Monocyte-Derived Macrophage-Like Cells to Mycobacterium tuberculosis by Modulating the PI3K/Akt/mTOR Signaling Pathway.

abstract：:Delayed rectifier K(+)-channels (Kv1.3) are predominantly expressed in T lymphocytes. Based on patch-clamp studies, the channels play crucial roles in facilitating the calcium influx necessary to trigger lymphocyte activation and proliferation. Using selective channel inhibitors in experimental animal models, in vivo ...

journal_title：Mediators of inflammation

authors： Kazama I

更新日期：2015-01-01 00:00:00

abstract：:The therapeutic strategies used in the treatment of hepatitis C are essentially based on the combination of direct-acting antiviral agents (DAAs). This therapy has been shown to be very effective in relation to patient adherence to treatment and has shown high rates of sustained virological response (SVR). However, th...

journal_title：Mediators of inflammation

authors： Pereira GL,Tarragô AM,Neves WLL,da Silva Neto PV,de Souza PS,Dos Santos Affonso J,de Sousa KS,da Silva JA,Costa AG,da Silva Victoria F,Victoria MB,Malheiro A

更新日期：2019-11-04 00:00:00

abstract：:TThe molecular mechanisms responsible for the development of hepatic fibrosis are not fully understood. The Nlrc4 inflammasome detects cytosolic presence of bacterial components, activating inflammatory cytokines to facilitate clearance of pathogens and infected cells. We hypothesized that low-grade constitutive activ...

journal_title：Mediators of inflammation

authors： DeSantis DA,Ko CW,Wang L,Lee P,Croniger CM

更新日期：2015-01-01 00:00:00

abstract：:Endoglin is a coreceptor of the TGF-β superfamily predominantly expressed on the vascular endothelium and selective subsets of immune cells. We previously demonstrated that Endoglin heterozygous (Eng (+/-)) mice subjected to dextran sulfate sodium (DSS) developed persistent gut inflammation and pathological angiogenes...

journal_title：Mediators of inflammation

authors： Peter MR,Jerkic M,Sotov V,Douda DN,Ardelean DS,Ghamami N,Lakschevitz F,Khan MA,Robertson SJ,Glogauer M,Philpott DJ,Palaniyar N,Letarte M

更新日期：2014-01-01 00:00:00

abstract：AIM:To determine induced sputum cell counts and interleukin-8 (IL-8), tumor necrosis factor alpha (TNF-alpha) and leukotriene B4 (LTB4) levels as markers of neutrophilic inflammation in moderate persistent asthma, and to evaluate the response to inhaled steroid therapy. METHODS:Forty-five moderate asthmatic patients a...

journal_title：Mediators of inflammation

authors： Basyigit I,Yildiz F,Ozkara SK,Boyaci H,Ilgazli A

更新日期：2004-08-01 00:00:00

abstract：:To test the statistical association of the CRP and SAA1 locus variants with their corresponding circulating levels and metabolic and inflammatory biomarker levels by using mediation analysis, a sample population of 599 Taiwanese subjects was enrolled and five CRP and four SAA1 variants were genotyped. Correlation anal...

journal_title：Mediators of inflammation

authors： Ko YL,Hsu LA,Wu S,Teng MS,Chou HH

更新日期：2016-01-01 00:00:00

abstract：:Vascular complications of diabetes mellitus represent a major public health problem. Although many steps forward have been made to define the causes and to find the best possible therapies, the problem remains crucial. In recent years, more and more evidences have defined a link between microbiota and the initiation, ...

journal_title：Mediators of inflammation

authors： Biscetti F,Nardella E,Cecchini AL,Landolfi R,Flex A

更新日期：2019-05-08 00:00:00

abstract：:Interleukin 35 (IL-35) is a heterodimeric cytokine involved in the development of atherosclerosis. The aim of the present study was to establish if the polymorphisms of IL-12A and EBI3 genes that encode the IL-35 subunits are associated with the development of premature coronary artery disease (CAD) in Mexican individ...

journal_title：Mediators of inflammation

authors： Posadas-Sánchez R,Pérez-Hernández N,Angeles-Martínez J,López-Bautista F,Villarreal-Molina T,Rodríguez-Pérez JM,Fragoso JM,Posadas-Romero C,Vargas-Alarcón G

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Hepatic ischemia-reperfusion (I/R) injury is a pivotal clinical problem occurring in many clinical conditions such as transplantation, trauma, and hepatic failure after hemorrhagic shock. Apoptosis and autophagy have been shown to contribute to cell death in hepatic I/R injury. Ethyl pyruvate, a stable and s...

journal_title：Mediators of inflammation

authors： Shen M,Lu J,Dai W,Wang F,Xu L,Chen K,He L,Cheng P,Zhang Y,Wang C,Wu D,Yang J,Zhu R,Zhang H,Zhou Y,Guo C

更新日期：2013-01-01 00:00:00

abstract：:Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabe...

journal_title：Mediators of inflammation

authors： van den Oever IA,Raterman HG,Nurmohamed MT,Simsek S

更新日期：2010-01-01 00:00:00

abstract：:Schistosomiasis is a chronic inflammatory disease whose macrophages are involved in immunopathology modulation. Although P2X7 receptor signaling plays an important role in inflammatory responses mediated by macrophages, no reports have examined the role of P2X7 receptors in macrophage function during schistosomiasis. ...

journal_title：Mediators of inflammation

authors： Oliveira SD,Nanini HF,Savio LE,Waghabi MC,Silva CL,Coutinho-Silva R

更新日期：2014-01-01 00:00:00

abstract：:To determine the role of mutant SOD1 gene (SOD1(G93A)) on muscle cell differentiation, we derived C2C12 muscle cell lines carrying a stably transfected SOD1(G93A) gene under the control of a myosin light chain (MLC) promoter-enhancer cassette. Expression of MLC/SOD1(G93A) in C2C12 cells resulted in dramatic inhibition...

journal_title：Mediators of inflammation

authors： Martini M,Dobrowolny G,Aucello M,Musarò A

更新日期：2015-01-01 00:00:00

abstract：Aims:To assess the maresin 1 (MaR1) contents in type 2 diabetic patients with or without diabetic foot ulcer and to analyze the association of MaR1 concentrations with several metabolism-related parameters. Methods:Plasma MaR1 concentrations were analyzed in 96 subjects with normal glucose tolerant (NC, n = 43), type ...

journal_title：Mediators of inflammation

authors： Miao T,Huang B,He N,Sun L,Du G,Gong X,Xu Y,Zheng Y,Zheng H,Qu H

更新日期：2020-04-16 00:00:00

abstract：:Psoriasis is a common chronic inflammatory multisystemic disease with a complex pathogenesis consisting of genetic, immunological, and environmental components. It is associated with a number of comorbidities, including diabetes, metabolic syndrome, obesity, and myocardial infarction. In addition, the severity of psor...

journal_title：Mediators of inflammation

authors： Rodríguez-Cerdeira C,Cordeiro-Rodríguez M,Carnero-Gregorio M,López-Barcenas A,Martínez-Herrera E,Fabbrocini G,Sinani A,Arenas-Guzmán R,González-Cespón JL

更新日期：2019-05-28 00:00:00

abstract：:Breast cancer (BC) is potentially life-threatening malignancy that still causes high mortality among women. Scientific research in this field is focused on deeper understanding of pathogenesis and progressing of BC, in order to develop relevant diagnosis and improve therapeutic treatment. Multifunctional cytokine TGF-...

journal_title：Mediators of inflammation

authors： Zarzynska JM

更新日期：2014-01-01 00:00:00

abstract：:To elucidate the role of (1-->3)-beta-D-glucan in pulmonary aspergilloma, serum concentrations of (1-->3)-beta-D-glucan were measured repeatedly for as long as 10 months in eight patients. In four patients with inactive disease, concentrations of (1-->3)-beta-D-glucan were in the normal range.The concentrations of (1-...

journal_title：Mediators of inflammation

authors： Yuasa K,Goto H

更新日期：1997-01-01 00:00:00

abstract：:Interleukin-33 (IL-33) is associated with the development of Th2 responses. This study examined the potential role of IL-33 in the pathogenic process of chronic hepatitis C (CHC) in Chinese patients. The levels of serum IL-33 and sST2 in 154 patients with CHC, 24 with spontaneously resolved HCV (SR-HCV) infection and ...

journal_title：Mediators of inflammation

authors： Wang J,Zhao P,Guo H,Sun X,Jiang Z,Xu L,Feng J,Niu J,Jiang Y

更新日期：2012-01-01 00:00:00

abstract：:Statins exert pleiotropic effects on endothelial cells in addition to lowering cholesterol. 15-Lipoxygenase-1 (ALOX15) has been implicated in vascular inflammation and disease. The relationship between atorvastatin and ALOX15 was investigated using a rat carotid artery balloon-injury model. Hematoxylin and eosin (HE) ...

journal_title：Mediators of inflammation

authors： Zhang P,Xing X,Hu C,Yu H,Dong Q,Chang G,Qin S,Liu J,Zhang D

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Platelet-activating factor (PAF) seems to be implicated in systemic lupus erythematosus (SLE) patients with associated renal diseases. AIMS:In this study, we ensured the role of PAF in SLE patients without renal complications. METHODS:Blood PAF and acetylhydrolase activity, plasma soluble phospholipase A(2...

journal_title：Mediators of inflammation

authors： Denizot Y,Liozon E,Guglielmi L,Ly K,Soria P,Loustaud V,Vidal E,Jauberteau MO

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND/AIM:Coronary artery ectasia (CAE) was thought of as a variant of atherosclerosis. C-reactive protein (CRP) which is among the most sensitive markers of systemic inflammation, and elevation of systemic and local levels of this inflammatory marker which has been associated with an increased risk for cardiovasc...

journal_title：Mediators of inflammation

authors： Ozbay Y,Akbulut M,Balin M,Kayancicek H,Baydas A,Korkmaz H

更新日期：2007-01-01 00:00:00

abstract：:In addition to the spectrum of biological action already known to be exhibited by acetylsalicylic acid (ASA) as an analgesic, anti-inflammatory and platelet aggregation inhibitor, there is growing evidence of a stimulatory effect on the immune system. ASA has been found to increase the production ofcytokines and to in...

journal_title：Mediators of inflammation

authors： Jäpel M,Lötzerich H,Rogalla K

更新日期：1994-01-01 00:00:00

abstract：:Human respiratory syncytial virus (RSV) sometimes causes acute and severe lower respiratory tract illness in infants and young children. RSV strongly upregulates proinflammatory cytokines and the platelet-activating factor (PAF) receptor, which is a receptor for Streptococcus pneumoniae, in the pulmonary epithelial ce...

journal_title：Mediators of inflammation

authors： Yokota S,Okabayashi T,Hirakawa S,Tsutsumi H,Himi T,Fujii N

更新日期：2012-01-01 00:00:00

abstract：:In our previous study, lipopolysaccharide (LPS) significantly reduced the cell viability of primary bovine mammary epithelial cells (bMEC) leading to cell apoptosis, which were prevented by caffeic acid (CA) through inhibiting NF-κB activation and reducing proinflammatory cytokine expression. While the underlying mech...

journal_title：Mediators of inflammation

authors： Liu M,Fang G,Yin S,Zhao X,Zhang C,Li J,Liu Z

更新日期：2019-04-30 00:00:00

abstract：:Surgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-alpha: TNF-alpha), acute phase proteins (C-reactive protein: CRP, leptin). We studied the effects of general and spinal anaesthesia on stress response to haemorrhoidectomy. Patients were assigned to ge...

journal_title：Mediators of inflammation

authors： Buyukkocak U,Caglayan O,Daphan C,Aydinuraz K,Saygun O,Agalar F

更新日期：2006-01-01 00:00:00

abstract：:The effect of L-carnitine and some of its acyl derivatives on serum TNF production and lethality in a murine experimental endotoxin shock model was investigated. In some instances, serum IL-6 production was also evaluated. In this experimental model, C57BL/6 mice received 30 mg/kg LPS (E. cell 055:B5) injected intrape...

journal_title：Mediators of inflammation

authors： Ruggiero V,D'Urso CM,Albertoni C,Campo S,Foresta P,Martelli EA

更新日期：1993-01-01 00:00:00

abstract：:[This retracts the article DOI: 10.1155/2018/4514329.]. ...

journal_title：Mediators of inflammation

authors： Of Inflammation M

更新日期：2020-09-29 00:00:00

abstract：:This study was designated to evaluate the influence of behavioral depression on the airway leukocyte recruitment in allergic animals. To achieve this, total and differential cell counts in bronchoalveolar (BAL) fluid of ovalbumin (OVA)-sensitized and depressed rats was evaluated. Inescapable electric footshock, applie...

journal_title：Mediators of inflammation

authors： Varriano MA,Varriano AA,Datti F,Datti M,Antunes E,Teixeira NA

更新日期：2001-08-01 00:00:00

abstract：:Plasma GDF15 concentrations were measured in 612 Taiwanese individuals without overt systemic disease. Clinical parameters, GDF15 genetic variants, and 22 biomarker levels were analyzed. We further enrolled 86 patients with PAD and 481 patients with CAD, who received endovascular intervention and coronary angiography,...

journal_title：Mediators of inflammation

authors： Hsu LA,Wu S,Juang JJ,Chiang FT,Teng MS,Lin JF,Huang HL,Ko YL

更新日期：2017-01-01 00:00:00

abstract：:Little is known about Yu-Ping-Feng (YPF), a typical Chinese herbal decoction, for its antitumor efficacy in non-small-cell lung cancer (NSCLC). Here, we found that YPF significantly inhibited the growth of Lewis lung cancer, prolonged the survival of tumor-bearing mice, promoted NK cell tumor infiltration, increased t...

journal_title：Mediators of inflammation

authors： Luo Y,Wu J,Zhu X,Gong C,Yao C,Ni Z,Wang L,Ni L,Li Y,Zhu S

更新日期：2016-01-01 00:00:00

abstract：:Despite early recanalization of an occluded infarct artery, tissue reperfusion remains impaired in more than one-third of the acute myocardial infarction (AMI) patients owing to a process of reperfusion injury. The role of systemic inflammation in triggering this phenomenon is unknown. Proinflammatory factors (hs-CRP,...

journal_title：Mediators of inflammation

authors： Blancke F,Claeys MJ,Jorens P,Vermeiren G,Bosmans J,Wuyts FL,Vrints CJ

更新日期：2005-12-14 00:00:00