Abstract:
:Initially found expressed in neuronal and then later in endothelial cells, it is well established that the transmembrane glycoproteins neuropilin-1 (NRP1) and neuropilin-2 (NRP2) play essential roles in axonal growth and guidance and in physiological and pathological angiogenesis. Neuropilin expression and function in epithelial cells has received little attention when compared with neuronal and endothelial cells. Overexpression of NRPs is shown to enhance growth, correlate with invasion and is associated with poor prognosis in various tumour types, especially those of epithelial origin. The contribution of NRP and its ligands to tumour growth and metastasis has spurred a strong interest in NRPs as novel chemotherapy drug targets. Given NRP's role as a multifunctional co-receptor with an ability to bind with disparate ligand families, this has sparked new areas of research implicating NRPs in diverse biological functions. Here, we review the growing body of research demonstrating NRP expression and role in the normal and neoplastic epithelium.
journal_name
Int J Exp Patholjournal_title
International journal of experimental pathologyauthors
Wild JR,Staton CA,Chapple K,Corfe BMdoi
10.1111/j.1365-2613.2012.00810.xsubject
Has Abstractpub_date
2012-04-01 00:00:00pages
81-103issue
2eissn
0959-9673issn
1365-2613journal_volume
93pub_type
杂志文章,评审abstract::Integrins are the key mediators of cell-extracellular matrix (ECM) interaction, linking the ECM to the actin cytoskeleton. Besides localizing at the cell surface, they can be internalized and transported back to the plasma membrane (recycled) or delivered to the late endosomes/lysosomes for degradation. We and others ...
journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
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journal_title:International journal of experimental pathology
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journal_title:International journal of experimental pathology
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
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journal_title:International journal of experimental pathology
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journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12135
更新日期:2015-08-01 00:00:00
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
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journal_title:International journal of experimental pathology
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1046/j.1365-2613.1997.9950333.x
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
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更新日期:2007-02-01 00:00:00
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1991-02-01 00:00:00
abstract::Interleukin (IL)-6-related cytokines share gp130 as the signal-transducing protein. Cardiac myocytes produce various kinds of cytokines including IL-6 and cardiotrophin-1. Activation of gp130 transduces hypertrophic and cytoprotective signals in cardiac myocytes via JAK/STAT, MAP kinase and PI-3 kinase pathways. Besid...
journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2613.2000.00139.x
更新日期:2000-02-01 00:00:00
abstract::Diets enriched with fat, especially unsaturated fat, promote experimental pancreatic carcinogenesis, but little is known of the effects of individual fatty acids. The effect of stearic and oleic acid on pancreatic fatty acids and atypical acinar cell nodules (preneoplastic lesions) was studied in 14-day-old weanling m...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
abstract::While the origin of tumours, whether from one cell or many, has been a source of fascination for experimental oncologists for some time, in recent years there has been a veritable explosion of information about the clonal architecture of tumours and their antecedents, stimulated, in the main, by the ready accessibilit...
journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
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abstract::Systemic hypertension, characterized by elevated blood pressure ≥140/90 mm Hg, is a major modifiable risk factor for cardiovascular disease. Hypertension also associates with non-alcoholic fatty liver disease (NAFLD), which is becoming common due to a modern diet and lifestyle. The aim of the present study was to exam...
journal_title:International journal of experimental pathology
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
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journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
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abstract::Cyclophilins are proteins which are remarkably conserved through evolution; moreover they have been found in every possible existing organism, which indicates their fundamental importance. Due to their enzymatic properties, multiplicity, cellular localization and role in protein folding they belong to the group of pro...
journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
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abstract::Administration of 25 mg/kg/day methyl clofenapate to Alpk/APfSD rats for up to 4 days gave rise to hepatomegaly resulting from a combination of hepatocyte hyperplasia, mainly in the periportal region of the lobule, and centrilobular cell hypertrophy. In hepatocytes undergoing mitosis there was a redistribution of dens...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2011.00765.x
更新日期:2011-08-01 00:00:00
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
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更新日期:2008-08-01 00:00:00