Non-inferiority of microencapsulated mesenchymal stem cells to free cells in cardiac repair after myocardial infarction: A rationale for using paracrine factor(s) instead of cells.

abstract：:Hamsters (Mesocricetus auratus) were inoculated with L. (L.) chagasi and killed on days 7, 15, 30, 45 and 60 after infection. The lymphoid organs developed initial proliferation of the B lymphocyte zone with recovery by the 60th day group when pyroninophilic cells were prominent. The T lymphocyte area showed a progres...

journal_title：International journal of experimental pathology

authors： Corbett CE,Paes RA,Laurenti MD,Andrade Júnior HF,Duarte MI

更新日期：1992-08-01 00:00:00

abstract：:Permethrin (PM), a synthetic pyrethroid insecticide, has broad toxicity spectra. We aimed to investigate the effects of PM on the testes of adult albino rats, examine the recovery response and evaluate the efficacy of naringenin (NG) supplementation. Adult male albino rats were randomly assigned to five groups of six ...

journal_title：International journal of experimental pathology

authors： Mostafa Hel-S,Abd El-Baset SA,Kattaia AA,Zidan RA,Al Sadek MM

更新日期：2016-02-01 00:00:00

abstract：:Formation of the coronary arteries consists of a precisely orchestrated series of morphogenetic and molecular events which can be divided into three distinct processes: vasculogenesis, angiogenesis and arteriogenesis (Risau 1997; Carmeliet 2000). Even subtle perturbations in this process may lead to congenital coronar...

journal_title：International journal of experimental pathology

authors： Smart N,Dubé KN,Riley PR

更新日期：2009-06-01 00:00:00

abstract：:Tumour growth is angiogenesis dependent. Thrombosis and thromboembolism are very common in cancer patients. These patients are often treated with heparin as an anti-coagulant. Many tumour angiogens, including VEGF165, and endogenous anti-angiogenesis factors bind heparin tightly. Using the non-surgical mesenteric-wind...

journal_title：International journal of experimental pathology

authors： Norrby K

更新日期：2000-06-01 00:00:00

abstract：:Amino acid metabolism is a significant metabolic activity in humans, especially of sulphur-containing amino acids, methionine and cysteine (Cys). Cys is cytotoxic and neurotoxic in nature; hence, mammalian cells maintain a constant intracellular level of Cys. Metabolism of Cys is mainly regulated by two thiol dioxygen...

journal_title：International journal of experimental pathology

authors： Sarkar B,Kulharia M,Mantha AK

更新日期：2017-04-01 00:00:00

abstract：:Haptoglobin is an acute phase protein known to be highly expressed in the liver. Recently, we showed increased local arterial haptoglobin expression after flow-induced arterial remodelling and found that haptoglobin is involved in cell migration and arterial restructuring probably through accumulation of a temporary g...

journal_title：International journal of experimental pathology

authors： Smeets MB,Fontijn J,Kavelaars A,Pasterkamp G,De Kleijn DP

更新日期：2003-04-01 00:00:00

abstract：:The preovulatory follicle provides a unique physiological example of rapid growth accompanied by neovascularization, two processes that are generally characteristic of pathologies such as wound repair or malignancy. During the hours preceding ovulation, follicular growth is accompanied by elevated levels of messenger ...

journal_title：International journal of experimental pathology

authors： Neeman M,Abramovitch R,Schiffenbauer YS,Tempel C

更新日期：1997-04-01 00:00:00

abstract：:Systemic hypertension, characterized by elevated blood pressure ≥140/90 mm Hg, is a major modifiable risk factor for cardiovascular disease. Hypertension also associates with non-alcoholic fatty liver disease (NAFLD), which is becoming common due to a modern diet and lifestyle. The aim of the present study was to exam...

journal_title：International journal of experimental pathology

authors： Cartland SP,Tamer N,Patil MS,Di Bartolo BA,Kavurma MM

更新日期：2020-10-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is the most common chronic condition of the liver in the western world. There is only little evidence about altered sensitivity of steatotic liver to acute toxic injury. The aim of this project was to test whether hepatic steatosis sensitizes rat liver to acute toxic injury in...

journal_title：International journal of experimental pathology

authors： Kučera O,Lotková H,Staňková P,Podhola M,Roušar T,Mezera V,Cervinková Z

更新日期：2011-08-01 00:00:00

abstract：:Blister formation and skin damage can be induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper. Pathological changes in the skin were investigated after intramuscular injections of Bothrops asper haemorrhagic metalloproteinase BaP1. Blisters developed within the first hour, with ...

journal_title：International journal of experimental pathology

authors： Rucavado A,Núñez J,Gutiérrez JM

更新日期：1998-08-01 00:00:00

abstract：:In this study, the extent of angiogenesis, evaluated as microvascular volume density, immunoreactivity of tumour cells to erythropoietin (Epo) and of endothelial cells to Epo receptor (EpoR) have been correlated in human primary melanoma specimens. Results showed that Epo/EpoR expression correlate with angiogenesis an...

journal_title：International journal of experimental pathology

authors： Ribatti D,Nico B,Perra MT,Longo V,Maxia C,Annese T,Piras F,Murtas D,Sirigu P

更新日期：2010-12-01 00:00:00

abstract：:Dengue type 2 virus (DV) induces a subpopulation of T lymphocytes of mouse spleen to secrete a soluble helper cytokine (HF) which enhances the DV-specific IgM antibody plaque forming cells (PFC). The present study undertaken to purify and characterize HF shows that it can be purified by low pressure liquid chromatogra...

journal_title：International journal of experimental pathology

authors： Chaturvedi P,Mukherjee R,Chaturvedi UC,Mathur A

更新日期：1992-06-01 00:00:00

abstract：:A dose-dependent neutrophil migration was observed following the injection of purified (Hu IFN-gamma) or recombinant (rIFN-gamma) human gamma interferon into rat peritoneal cavities. This finding contrasts with their inability to cause chemotaxis in vitro in the Boyden chamber. Neutrophil migration into peritoneal cav...

journal_title：International journal of experimental pathology

authors： Ribeiro RA,Cunha FQ,Ferreira SH

更新日期：1990-10-01 00:00:00

abstract：:In order to clarify the function of hepatocyte growth factor (HGF) in vivo, we have developed transgenic mice expressing HGF in the liver. The bromodeoxyuridine labelling indices in livers from HGF transgenic mice were doubled, compared to those from wild type mice. Livers of HGF transgenic mice expressed high levels ...

journal_title：International journal of experimental pathology

authors： Shiota G,Kawasaki H

更新日期：1998-10-01 00:00:00

abstract：:To confirm the existence of the cervical thymus and the development of cervical thymoma in thymoma-prone BUF/Mna (BUF) rats, we examined cervical organs and adjacent tissues, and thoracic thymic tissues of the three inbred strains, BUF, ACI/NMna (ACI), and WKY/NCrj (WKY), and 11 congenic strains, in which genetic regi...

journal_title：International journal of experimental pathology

authors： Yamada T,Matsuyama M,Yanagida T,Kato K,Sugiura S,Kuroda M

更新日期：2011-04-01 00:00:00

abstract：:Genetically resistant CBA and A/J mice and susceptible BALB/c and C57BL/6 mice were challenged with either an identical infective dose or a minimal lethal dose of Salmonella typhimurium. The histopathological progression of the disease was examined in tissue sections prepared by the JB-4 Plus resin embedding method an...

journal_title：International journal of experimental pathology

authors： Moncure CW,Guo YN,Xu HR,Hsu HS

更新日期：1998-06-01 00:00:00

abstract：:The characterization of mice models of portal hypertension (PHT) is lacking in the literature. Therefore, the aim of the present study was to make a histological approach during development of PHT in two models of cirrhosis with PHT compared with one model of isolated PHT. The model of isolated PHT was developed by pa...

journal_title：International journal of experimental pathology

authors： Geerts AM,Vanheule E,Praet M,Van Vlierberghe H,De Vos M,Colle I

更新日期：2008-08-01 00:00:00

abstract：:The field of study concerning promotion and/or inhibition of angiogenesis has gathered much attention in the scientific community. A great deal of work has been invested towards defining reproducible assays to gauge for promotion or inhibition of angiogenesis in response to drug treatments or growth conditions. Two co...

journal_title：International journal of experimental pathology

authors： Prigozhina NL,Heisel AJ,Seldeen JR,Cosford ND,Price JH

更新日期：2013-12-01 00:00:00

abstract：:Angiogenesis is a common finding in chronic inflammatory diseases; however, its role in Sjögren's syndrome (SS) remains to be elucidated. Previous SS studies have demonstrated an increase in VEGF-A/VEGFR-2 system expression in minor salivary gland (MSG) biopsies from patients with SS, but differences in the new blood ...

journal_title：International journal of experimental pathology

authors： Sisto M,Lisi S,Ingravallo G,Lofrumento DD,D'Amore M,Ribatti D

更新日期：2014-04-01 00:00:00

abstract：:There is evidence to show that downregulation of miR-1 expression is closely related to cancer progression, including in nasopharyngeal carcinoma (NPC). However, the molecular mechanisms underlying miR-1 downregulation in NPC remain largely unknown, especially its association with Epstein-Barr virus (EBV). In this stu...

journal_title：International journal of experimental pathology

authors： Chen X,Shi J,Zhong J,Huang Z,Luo X,Huang Y,Feng S,Shao J,Liu D

更新日期：2015-12-01 00:00:00

abstract：:Muramyl dipeptide-Lys(L18) given by daily subcutaneous injection for 14 days induced arthritis in male Lewis, Fischer and nude rats, to a lesser degree in the last two than in the first strain. On the other hand, a single intradermal administration of Freund's complete adjuvant induced arthritis in Lewis and Fischer b...

journal_title：International journal of experimental pathology

authors： Sugawara T,Takada S,Furuhama K,Takayama S,Nomura M,Kato M

更新日期：1995-06-01 00:00:00

abstract：:The female reproductive organs (ovary, uterus, and placenta) are some of the few adult tissues that exhibit regular intervals of rapid growth. They also are highly vascular and have high rates of blood flow. Angiogenesis, or vascular growth, is therefore an important component of the growth and function of these tissu...

journal_title：International journal of experimental pathology

authors： Reynolds LP,Grazul-Bilska AT,Redmer DA

更新日期：2002-08-01 00:00:00

abstract：:Lysyl oxidase, which cross-links collagen and elastin, was obtained from chick embryo bone and cartilage and its substrate, elastin, from aorta. The enzyme was studied using an improved assay which enabled the stability of the substrate to be monitored. The enzyme was fully inhibited in vivo by beta-aminopropionitrile...

journal_title：International journal of experimental pathology

authors： Levene CI,Sharman DF,Callingham BA

更新日期：1992-10-01 00:00:00

abstract：:Interleukin (IL)-6-related cytokines share gp130 as the signal-transducing protein. Cardiac myocytes produce various kinds of cytokines including IL-6 and cardiotrophin-1. Activation of gp130 transduces hypertrophic and cytoprotective signals in cardiac myocytes via JAK/STAT, MAP kinase and PI-3 kinase pathways. Besid...

journal_title：International journal of experimental pathology

authors： Yamauchi-Takihara K,Kishimoto T

更新日期：2000-02-01 00:00:00

abstract：:It was previously shown that administration of the nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) aggravated murine viral myocarditis by increasing myocardial virus titres. Experimental autoimmune myocarditis in mice and rats mimics human fulminant myocarditis. The effects of L-arginine, a...

journal_title：International journal of experimental pathology

authors： Okabe TA,Hattori M,Yuan Z,Kishimoto C

更新日期：2008-10-01 00:00:00

abstract：:Integrins are the key mediators of cell-extracellular matrix (ECM) interaction, linking the ECM to the actin cytoskeleton. Besides localizing at the cell surface, they can be internalized and transported back to the plasma membrane (recycled) or delivered to the late endosomes/lysosomes for degradation. We and others ...

journal_title：International journal of experimental pathology

authors： Rainero E

更新日期：2018-02-01 00:00:00

abstract：:Administration of 25 mg/kg/day methyl clofenapate to Alpk/APfSD rats for up to 4 days gave rise to hepatomegaly resulting from a combination of hepatocyte hyperplasia, mainly in the periportal region of the lobule, and centrilobular cell hypertrophy. In hepatocytes undergoing mitosis there was a redistribution of dens...

journal_title：International journal of experimental pathology

authors： Soames AR,Foster JR

更新日期：1994-12-01 00:00:00

abstract：:This study was performed to characterize the intestinal lesions in chronic graft-versus-host disease (GVHD) in mice and to determine a possible role of intestinal intraepithelial lymphocytes (ilEL) in the development of these lesions. Chronic GVHD was induced by transfer of DBA/2 lymphocytes into non-irradiated (C57BL...

journal_title：International journal of experimental pathology

authors： de Geus B,Hogenesch H,de Heer E,Bruijn JA,van den Enden M,Rozing J

更新日期：1993-08-01 00:00:00

abstract：:Athymic (nude) mice were experimentally infected with Mycobacterium leprae via the alimentary and respiratory tracts and through the skin. Animals were allowed to inhale aerosols of M. leprae or had bacilli instilled into the nostrils or directly into the lungs. Others were fed M. leprae by gastric tube or had bacilli...

journal_title：International journal of experimental pathology

authors： McDermott-Lancaster RD,McDougall AC

更新日期：1990-10-01 00:00:00

abstract：:Colonization of the genital tract of female mice, mainly BALB/c, by Mycoplasma genitalium, M. pneumoniae and M. pulmonis was enhanced by pretreatment of the mice with progesterone. M. fermentans, M. hominis and M. salivarium, and three serotypes and two untyped strains of Ureaplasma urealyticum colonized under the inf...

journal_title：International journal of experimental pathology

authors： Furr PM,Taylor-Robinson D

更新日期：1993-02-01 00:00:00