Abstract:
:BALB/c and CBA mice maintained on low (4%) or normal (18%) protein diets for 2 weeks after weaning were infected with a sublethal dose of murine cytomegalovirus, adjusted in proportion to body weight. Viral replication, histopathological changes and humoral responses to the virus were compared between the dietary groups 2-42 days post infection (p.i.). Higher numbers of viral antigen-positive cells and/or more prominent tissue necrosis were noted in the livers, spleens, hearts, adrenal glands, kidneys and bone marrows of infected protein-deficient mice. These mice also showed a delayed onset of leucocytic exudation in their livers and salivary glands, relative to infected mice on the normal diet. Second peaks of viral replication were detected by plaque assays in livers and spleens from protein-deficient mice and in livers from normal mice 12-18 days p.i., but few antigen-positive cells and no tissue necrosis were observed. Virus also persisted at higher titres in the salivary glands from protein-deficient mice. Although cellular immunity may be defective in these mice, humoral IgG and IgM responses to the virus were not inhibited. The influence of genetic factors on the pathogenesis of murine cytomegalovirus disease in protein-deficient mice is discussed.
journal_name
Int J Exp Patholjournal_title
International journal of experimental pathologyauthors
Teo HK,Price P,Papadimitriou JMsubject
Has Abstractpub_date
1991-02-01 00:00:00pages
67-82issue
1eissn
0959-9673issn
1365-2613journal_volume
72pub_type
杂志文章abstract::The aim of the present study was to evaluate the coexpression of very early (CD69), early (CD25) and late (HLADR) antigens and to analyse the mean fluorescence intensity (MFI) of such activation markers on synovial fluid (SF) and peripheral blood (PB) lymphocytes of patients affected by rheumatoid arthritis (RA) and o...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1046/j.1365-2613.1997.290360.x
更新日期:1997-10-01 00:00:00
abstract::Tumour-associated macrophage (TAM) polarization is associated with hepatocellular carcinoma but the molecular mechanism of this polarization is still unknown. Peripheral blood mononuclear cells were induced to differentiate into M0, M1 and M2 macrophages and TAMs. TAMs were transfected with pcDNA3.1-GAS5, pcDNA3.1-NC,...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12374
更新日期:2020-12-01 00:00:00
abstract::In this study, we wanted to evaluate whether the engrailed EN-2 gene, a homeobox gene with an essential role in the development of the rhombic lip derivatives in different species, is (1) expressed also in man in the differentiation process of the medullary arcuate nucleus (ArcN) and (2) involved in sudden unexplained...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
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更新日期:2005-02-01 00:00:00
abstract::An autoimmune kidney disease morphologically and functionally similar to Heymann nephritis (HN) was induced in mature male Sprague Dawley rats by repeated weekly IP injections of a chemically modified azo sonicated ultracentrifuged (u/c) rat kidney fraction 3 (rKF3) antigen in an aqueous medium. The experiment was ter...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.0959-9673.2004.00389.x
更新日期:2004-10-01 00:00:00
abstract::The use of non-specific inhibitors of tissue non-specific alkaline phosphatase (TNSALP) in pre-adipocytes blocks intracellular lipid accumulation. TNSALP is also expressed in hepatocytes, which are known to accumulate lipid in a similar manner to pre-adipocytes. The purpose of this study was to use specific silencing ...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12243
更新日期:2017-10-01 00:00:00
abstract::Amino acid metabolism is a significant metabolic activity in humans, especially of sulphur-containing amino acids, methionine and cysteine (Cys). Cys is cytotoxic and neurotoxic in nature; hence, mammalian cells maintain a constant intracellular level of Cys. Metabolism of Cys is mainly regulated by two thiol dioxygen...
journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
doi:10.1111/iep.12222
更新日期:2017-04-01 00:00:00
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journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
doi:10.1111/iep.12265
更新日期:2018-02-01 00:00:00
abstract::The relationship between donor age and the growth characteristics of normal human smooth muscle cell cultures derived from aorta and stomach was examined in a series of growth studies. A negative correlation was demonstrated between donor age and growth potential of both cell types in primary culture. This decreased g...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract::Ureteropelvic junction (UPJ) obstruction is the most frequently observed cause of obstructive nephropathy in children. Neonatal and foetal animal models have been developed that mimic closely what is observed in human disease. The purpose of this review is to discuss how obstructive nephropathy alters kidney histology...
journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
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更新日期:2011-06-01 00:00:00
abstract::Administration of 25 mg/kg/day methyl clofenapate to Alpk/APfSD rats for up to 4 days gave rise to hepatomegaly resulting from a combination of hepatocyte hyperplasia, mainly in the periportal region of the lobule, and centrilobular cell hypertrophy. In hepatocytes undergoing mitosis there was a redistribution of dens...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::Lysyl oxidase, which cross-links collagen and elastin, was obtained from chick embryo bone and cartilage and its substrate, elastin, from aorta. The enzyme was studied using an improved assay which enabled the stability of the substrate to be monitored. The enzyme was fully inhibited in vivo by beta-aminopropionitrile...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract::Blister formation and skin damage can be induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper. Pathological changes in the skin were investigated after intramuscular injections of Bothrops asper haemorrhagic metalloproteinase BaP1. Blisters developed within the first hour, with ...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::A simple method is presented for selective cell culture of human mesangial cells using explantation of mesangial cell hillocks. Glomeruli which had been incubated with collagenase were explanted on plastic tissue culture flasks. Three to 6 weeks after explantation, a rapidly growing multilayer of elongated mesangial c...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1992-02-01 00:00:00
abstract::Genetically resistant CBA and A/J mice and susceptible BALB/c and C57BL/6 mice were challenged with either an identical infective dose or a minimal lethal dose of Salmonella typhimurium. The histopathological progression of the disease was examined in tissue sections prepared by the JB-4 Plus resin embedding method an...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1046/j.1365-2613.1998.00064.x
更新日期:1998-06-01 00:00:00
abstract::Acute myocardial infarction is one of the major causes of mortality worldwide. For regeneration of the rabbit heart after experimentally induced infarction we used autologous skeletal myoblasts (SMs) due to their high proliferative potential, resistance to ischaemia and absence of immunological and ethical concerns. T...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12109
更新日期:2015-02-01 00:00:00
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2008.00584.x
更新日期:2008-06-01 00:00:00
abstract::The acute phase of experimental Chagas' disease in rats is associated with early lesions of the post-ganglionic sympathetic nerve terminals of the heart, the varicosities being the target. In the superior cervical and stellate ganglia the preganglionic fibres showed no signs of lesion in the course of experimental Cha...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1046/j.1365-2613.1996.00971.x
更新日期:1996-06-01 00:00:00
abstract::A reversible impairment in the ability of the liver to secrete cholephilic compounds has been reported to exist in infant rats born from mothers with surgically induced complete cholestasis during the last third of the pregnancy. Canalicular plasma membranes (CPM) were purified from livers obtained from 4 and 8 week-o...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1046/j.1365-2613.1997.360372.x
更新日期:1997-12-01 00:00:00
abstract::The Meriones unguiculatus (Mongolian) gerbil has demonstrated significant prostatic responses to hormonal treatments, and to drugs against human prostatic hyperplasia. Spontaneous neoplasia develops in the older animals. Thirty gerbils (age 18 months) were divided into non-affected and prostatic lesion bearers and the...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2007.00550.x
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abstract::Plasmodium berghei ANKA (PbA) infection in susceptible inbred mouse strains is the most commonly used experimental model to study pathogenesis of cerebral malaria (CM). Indeed, many concepts on mechanisms related to this complication have arisen from works using this model. Although inbred strains present several adva...
journal_title:International journal of experimental pathology
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journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
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journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2613.1997.d01-247.x
更新日期:1997-04-01 00:00:00
abstract::Hydroxymethylnitrofurazone (NFOH) is a nitrofurazone prodrug effective in vivo during acute infections, and it has less hepatotoxicity effect than the standard drug benznidazole (BZN) which has been used during short- and long-term treatment. In the present study, we induced the indeterminate form of Chagas disease in...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12289
更新日期:2018-10-01 00:00:00
abstract::Muramyl dipeptide-Lys(L18) given by daily subcutaneous injection for 14 days induced arthritis in male Lewis, Fischer and nude rats, to a lesser degree in the last two than in the first strain. On the other hand, a single intradermal administration of Freund's complete adjuvant induced arthritis in Lewis and Fischer b...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::The formation of new blood vessels, angiogenesis, is an important event in inflammation, wound healing and tumour growth. Mediators produced by various cells when exposed to endotoxin include cytokines (tumour necrosis factor, interleukins 1 and 6, and basic fibroblast growth factor) which, it has been suggested, stim...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract::The liver sinusoidal endothelial cell (LSEC) is damaged by many toxins, including oxidants and bacterial toxins. Any effect on LSECs of the Pseudomonas aeruginosa virulence factor, pyocyanin, may be relevant for systemic pseudomonal infections and liver transplantation. In this study, the effects of pyocyanin on in vi...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2008.00602.x
更新日期:2008-12-01 00:00:00
abstract::Angiogenesis is a common finding in chronic inflammatory diseases; however, its role in Sjögren's syndrome (SS) remains to be elucidated. Previous SS studies have demonstrated an increase in VEGF-A/VEGFR-2 system expression in minor salivary gland (MSG) biopsies from patients with SS, but differences in the new blood ...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12061
更新日期:2014-04-01 00:00:00
abstract::To confirm the existence of the cervical thymus and the development of cervical thymoma in thymoma-prone BUF/Mna (BUF) rats, we examined cervical organs and adjacent tissues, and thoracic thymic tissues of the three inbred strains, BUF, ACI/NMna (ACI), and WKY/NCrj (WKY), and 11 congenic strains, in which genetic regi...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2010.00755.x
更新日期:2011-04-01 00:00:00
abstract::Young adult mice infected with MCMV were shown to develop inflammatory lesions in the peripancreatic and salivary gland adipose tissues. MCMV replication was detected by immunoperoxidase staining and electron microscopy in adipocytes, fibroblasts, endothelial cells and pericytes in brown and white adipose tissues. Mor...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1990-08-01 00:00:00
abstract::Recently, there have been significant advances toward the development of culture conditions that promote proliferation of primary rodent hepatocytes. There are two major methods for the multiplication of hepatocytes in vitro: one is the use of nicotinamide, the other is the use of a nutrient-rich medium. In the medium...
journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2613.1998.00083.x
更新日期:1998-12-01 00:00:00