Abstract：
:Blister formation and skin damage can be induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper. Pathological changes in the skin were investigated after intramuscular injections of Bothrops asper haemorrhagic metalloproteinase BaP1. Blisters developed within the first hour, with separation of epidermis from the dermal-epidermal junction, whereas acantholysis of epithelial cells was not observed. After the third hour there was ulceration with formation of a proteinaceous scab and inflammatory infiltrate. By 7 to 14 days there was evidence of a regenerative process in dermis and epidermis. Haemorrhage occurred in both dermis and hypodermis as a consequence of BaP1 injection, together with damage of sebaceous glands and an inflammatory reaction in which enlarged macrophages were the predominant cell type. Zymography assays showed the presence of several endogenous metalloproteinases in the exudate, skin homogenates and plasma. In addition, BaP1 was detected in exudates and plasma by immunoblotting. This technique also demonstrated the presence of components immunologically related to laminin and collagen type IV in exudates. It is suggested that BaP1, and probably endogenous matrix metalloproteinases, degrade some protein components at the dermal-epidermal junction, inducing the formation of blisters.
journal_name
Int J Exp Patholjournal_title
International journal of experimental pathologyauthors
Rucavado A,Núñez J,Gutiérrez JMsubject
Has Abstractpub_date
1998-08-01 00:00:00pages
245-54issue
4eissn
0959-9673issn
1365-2613journal_volume
79pub_type
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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更新日期：1994-12-01 00:00:00
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journal_title：International journal of experimental pathology
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doi：
更新日期：1995-08-01 00:00:00
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
pub_type： 杂志文章,评审
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journal_title：International journal of experimental pathology
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更新日期：1995-10-01 00:00:00
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journal_title：International journal of experimental pathology
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更新日期：1990-10-01 00:00:00
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