Cytokines and their receptors in cardiovascular diseases--role of gp130 signalling pathway in cardiac myocyte growth and maintenance.

abstract：:There is evidence to show that downregulation of miR-1 expression is closely related to cancer progression, including in nasopharyngeal carcinoma (NPC). However, the molecular mechanisms underlying miR-1 downregulation in NPC remain largely unknown, especially its association with Epstein-Barr virus (EBV). In this stu...

journal_title：International journal of experimental pathology

authors： Chen X,Shi J,Zhong J,Huang Z,Luo X,Huang Y,Feng S,Shao J,Liu D

更新日期：2015-12-01 00:00:00

abstract：:In this study, we wanted to evaluate whether the engrailed EN-2 gene, a homeobox gene with an essential role in the development of the rhombic lip derivatives in different species, is (1) expressed also in man in the differentiation process of the medullary arcuate nucleus (ArcN) and (2) involved in sudden unexplained...

journal_title：International journal of experimental pathology

authors： Lavezzi AM,Ottaviani G,Mauri M,Terni L,Matturri L

更新日期：2005-02-01 00:00:00

abstract：:Leprosy is a disease consisting of a spectrum of clinical, bacteriological, histopathological and immunological manifestations. Tuberculoid leprosy is frequently recognized as the benign polar form of the disease, while lepromatous leprosy is regarded as the malignant form. The different forms of leprosy depend on the...

journal_title：International journal of experimental pathology

authors： Juarez-Ortega M,Hernandez VG,Arce-Paredes P,Villanueva EB,Aguilar-Santelises M,Rojas-Espinosa O

更新日期：2015-02-01 00:00:00

abstract：:Systemic hypertension, characterized by elevated blood pressure ≥140/90 mm Hg, is a major modifiable risk factor for cardiovascular disease. Hypertension also associates with non-alcoholic fatty liver disease (NAFLD), which is becoming common due to a modern diet and lifestyle. The aim of the present study was to exam...

journal_title：International journal of experimental pathology

authors： Cartland SP,Tamer N,Patil MS,Di Bartolo BA,Kavurma MM

更新日期：2020-10-01 00:00:00

abstract：:Progress in understanding the pathophysiology of abdominal aortic aneurysms (AAA) is dependent in part on the development and application of effective animal models that recapitulate key aspects of the disease. The objective was to produce an experimental model of AAA in rats by combining two potential causes of metal...

journal_title：International journal of experimental pathology

authors： Mata KM,Prudente PS,Rocha FS,Prado CM,Floriano EM,Elias J Jr,Rizzi E,Gerlach RF,Rossi MA,Ramos SG

更新日期：2011-02-01 00:00:00

abstract：:The interrelationship between acinar cell apoptosis and tubular complex formation was examined in caerulein-induced pancreatitis using histology, immunohistochemistry, electron microscopy and DNA gel electrophoresis. Rats were given 8 hourly subcutaneous injections of caerulein, 24 micrograms/kg, for up to 2 days. Mor...

journal_title：International journal of experimental pathology

authors： Reid LE,Walker NI

更新日期：1999-08-01 00:00:00

abstract：:The field of study concerning promotion and/or inhibition of angiogenesis has gathered much attention in the scientific community. A great deal of work has been invested towards defining reproducible assays to gauge for promotion or inhibition of angiogenesis in response to drug treatments or growth conditions. Two co...

journal_title：International journal of experimental pathology

authors： Prigozhina NL,Heisel AJ,Seldeen JR,Cosford ND,Price JH

更新日期：2013-12-01 00:00:00

abstract：:Reovirus type 2-induced diabetes-like syndrome in suckling mice is considered to be an animal model for human insulin-dependent diabetes mellitus. We have previously demonstrated that immunopathologic pancreatic islet cell damage might be relevant to reovirus type 2 infection. In this study the involvement of adhesion...

journal_title：International journal of experimental pathology

authors： Hayashi T,Yamamoto S,Onodera T

更新日期：1995-12-01 00:00:00

abstract：:Administration of 25 mg/kg/day methyl clofenapate to Alpk/APfSD rats for up to 4 days gave rise to hepatomegaly resulting from a combination of hepatocyte hyperplasia, mainly in the periportal region of the lobule, and centrilobular cell hypertrophy. In hepatocytes undergoing mitosis there was a redistribution of dens...

journal_title：International journal of experimental pathology

authors： Soames AR,Foster JR

更新日期：1994-12-01 00:00:00

abstract：:Athymic (nude) mice were experimentally infected with Mycobacterium leprae via the alimentary and respiratory tracts and through the skin. Animals were allowed to inhale aerosols of M. leprae or had bacilli instilled into the nostrils or directly into the lungs. Others were fed M. leprae by gastric tube or had bacilli...

journal_title：International journal of experimental pathology

authors： McDermott-Lancaster RD,McDougall AC

更新日期：1990-10-01 00:00:00

abstract：:In this study, the extent of angiogenesis, evaluated as microvascular volume density, immunoreactivity of tumour cells to erythropoietin (Epo) and of endothelial cells to Epo receptor (EpoR) have been correlated in human primary melanoma specimens. Results showed that Epo/EpoR expression correlate with angiogenesis an...

journal_title：International journal of experimental pathology

authors： Ribatti D,Nico B,Perra MT,Longo V,Maxia C,Annese T,Piras F,Murtas D,Sirigu P

更新日期：2010-12-01 00:00:00

abstract：:The constitutive cell types of the two lung cancer cell lines CaLu1 and CaLu3 have been investigated by immunocytochemical staining with markers for cytokeratins, vimentin, carcinoembryonic antigen and the epithelial cell epitope recognized by the monoclonal antibody Ber-EP4. The cells of both lines reacted with vimen...

journal_title：International journal of experimental pathology

authors： Daniel MR,Burnett HE

更新日期：1991-08-01 00:00:00

abstract：:Angiogenesis is a common finding in chronic inflammatory diseases; however, its role in Sjögren's syndrome (SS) remains to be elucidated. Previous SS studies have demonstrated an increase in VEGF-A/VEGFR-2 system expression in minor salivary gland (MSG) biopsies from patients with SS, but differences in the new blood ...

journal_title：International journal of experimental pathology

authors： Sisto M,Lisi S,Ingravallo G,Lofrumento DD,D'Amore M,Ribatti D

更新日期：2014-04-01 00:00:00

abstract：:Polymorphonuclear cells (PMN) are believed to be important effector cells responsible the myocardial damage seen following ischaemia. However, the exact kinetics of their migration remains controversial. Isolated PMN (10 x 10(6) cells) labelled with (51)Cr were injected into four groups of Lewis rats: 0 h (T0h; n = 13...

journal_title：International journal of experimental pathology

authors： Légaré JF,Oxner A,Heimrath O,Issekutz T

更新日期：2007-08-01 00:00:00

abstract：:Using uptake of the fluorescent bile acid derivative cholylglycylamido-fluorescein (FITC-GC) as a measurement of liver cell population size and function, the antiproliferative and toxic effects of the well known cytostatic drug, cisplatin was evaluated on rapidly growing rat hepatoma McA-RH7777 cells and rat hepatocyt...

journal_title：International journal of experimental pathology

authors： El-Mir MY,Serrano MA,Macias RI,Dominguez MF,Monte MJ,Marin JJ

更新日期：1998-04-01 00:00:00

abstract：:Ureteropelvic junction (UPJ) obstruction is the most frequently observed cause of obstructive nephropathy in children. Neonatal and foetal animal models have been developed that mimic closely what is observed in human disease. The purpose of this review is to discuss how obstructive nephropathy alters kidney histology...

journal_title：International journal of experimental pathology

authors： Klein J,Gonzalez J,Miravete M,Caubet C,Chaaya R,Decramer S,Bandin F,Bascands JL,Buffin-Meyer B,Schanstra JP

更新日期：2011-06-01 00:00:00

abstract：:During mild (one to two pairs of worms) and prolonged (23 weeks or more) mouse infections with Schistosoma mansoni, but not with S. japonicum, periovular granulomas and fibrosis were seen to be preferentially located along periportal tissues. This caused fibrotic expansion of the portal spaces on a background of norma...

journal_title：International journal of experimental pathology

authors： Andrade ZA,Cheever AW

更新日期：1993-04-01 00:00:00

abstract：:Although it is well known that cadmium (Cd) causes adverse effects on male rat reproductive organs, few studies have quantified alterations caused by its low doses. Quantification of these alterations, especially in the testis, was measured using morphometry. A single dose of cadmium chloride (1 or 1.2 mg/kg BW) was i...

journal_title：International journal of experimental pathology

authors： de Souza Predes F,Diamante MA,Dolder H

更新日期：2010-04-01 00:00:00

abstract：:The aim of the present study was to evaluate the coexpression of very early (CD69), early (CD25) and late (HLADR) antigens and to analyse the mean fluorescence intensity (MFI) of such activation markers on synovial fluid (SF) and peripheral blood (PB) lymphocytes of patients affected by rheumatoid arthritis (RA) and o...

journal_title：International journal of experimental pathology

authors： Afeltra A,Galeazzi M,Sebastiani GD,Ferri GM,Caccavo D,Addessi MA,Marcolongo R,Bonomo L

更新日期：1997-10-01 00:00:00

abstract：:Cyclophilins are proteins which are remarkably conserved through evolution; moreover they have been found in every possible existing organism, which indicates their fundamental importance. Due to their enzymatic properties, multiplicity, cellular localization and role in protein folding they belong to the group of pro...

journal_title：International journal of experimental pathology

authors： Andreeva L,Heads R,Green CJ

更新日期：1999-12-01 00:00:00

abstract：:The use of non-specific inhibitors of tissue non-specific alkaline phosphatase (TNSALP) in pre-adipocytes blocks intracellular lipid accumulation. TNSALP is also expressed in hepatocytes, which are known to accumulate lipid in a similar manner to pre-adipocytes. The purpose of this study was to use specific silencing ...

journal_title：International journal of experimental pathology

authors： Chirambo G,van Niekerk C,Crowther NJ

更新日期：2017-10-01 00:00:00

abstract：:Pathological and immunopathological studies were carried out on snake coiled fibres (SCF) which occurred in affected soleus muscle in chloroquine treated rats. The SCF began to appear in denervated soleus muscle by 8 days after chloroquine injection. By day 14, typical SCF were observed with an unusual swirling patter...

journal_title：International journal of experimental pathology

authors： Tsuzuki K,Fukatsu R,Takamaru Y,Yoshida T,Hayashi Y,Kobayashi K,Fujii N,Takahata N

更新日期：1997-02-01 00:00:00

abstract：:The roles of inducible nitric oxide synthase (iNOS) in the development and healing of gastric ulcers have not been fully characterized. We characterized iNOS expression in experimentally induced ulcers in rat and mouse stomachs and investigated the roles of iNOS using iNOS gene-deficient (iNOS-/-) mice and wildtype mi...

journal_title：International journal of experimental pathology

authors： Tatemichi M,Ogura T,Sakurazawa N,Nagata H,Sugita M,Esumi H

更新日期：2003-10-01 00:00:00

abstract：:The tumour microenvironment, which is largely composed of inflammatory cells, is a crucial participant in the neoplastic process through the promotion of cell proliferation, survival and migration. Neutrophil polymorphonuclear cells (PMNs) induce inflammatory reactions that can be either cytotoxic for tumour cells or ...

journal_title：International journal of experimental pathology

authors： Remedi MM,Donadio AC,Chiabrando GA

更新日期：2009-02-01 00:00:00

abstract：:The female reproductive organs (ovary, uterus, and placenta) are some of the few adult tissues that exhibit regular intervals of rapid growth. They also are highly vascular and have high rates of blood flow. Angiogenesis, or vascular growth, is therefore an important component of the growth and function of these tissu...

journal_title：International journal of experimental pathology

authors： Reynolds LP,Grazul-Bilska AT,Redmer DA

更新日期：2002-08-01 00:00:00

abstract：:Experiments on the relationship between the hepatocellular transport of endogenous or exogenously loaded bile acids (sodium taurocholate, TC, 0.5 mumol/min/100 g body wt) and horseradish peroxidase (HRP) or immunoglobulin A (IgA) (0.5 mg/100 g body wt) were carried out on anaesthetized Wistar rats. The time course of ...

journal_title：International journal of experimental pathology

authors： Herrera MC,el-Mir MY,Monte MJ,Perez-Barriocanal F,Marin JJ

更新日期：1992-04-01 00:00:00

abstract：:The effect of dengue type 2 virus (DV) and the cytokines induced by it, on the chemiluminescence (CL) response of mouse spleen cells was studied by luminol-dependent CL. Following intracerebral (i.c.) inoculation of DV, an initial increase in CL response was observed which was followed by a sharp decline from the 4th ...

journal_title：International journal of experimental pathology

authors： Dhawan R,Chaturvedi UC,Mashihi KN,Chaturvedi P,Mukherjee R

更新日期：1993-10-01 00:00:00

abstract：:BALB/c and CBA mice maintained on low (4%) or normal (18%) protein diets for 2 weeks after weaning were infected with a sublethal dose of murine cytomegalovirus, adjusted in proportion to body weight. Viral replication, histopathological changes and humoral responses to the virus were compared between the dietary grou...

journal_title：International journal of experimental pathology

authors： Teo HK,Price P,Papadimitriou JM

更新日期：1991-02-01 00:00:00

abstract：:In this study we have explored the pathogenesis of the hepatic alterations which occur in diabetes and the modulation of these complications by the combination of metformin adjunct treatment and insulin monotherapy. For this purpose, diabetic rats were treated with insulin (DM + Ins) or metformin plus insulin (DM + Me...

journal_title：International journal of experimental pathology

authors： Silvares RR,Pereira EN,Flores EE,Estato V,Reis PA,Silva IJ,Machado MP,Neto HC,Tibiriça E,Daliry A

更新日期：2016-06-01 00:00:00

abstract：:Up to 40% of children with Reye's syndrome have hypoglycaemia that could contribute to the patient's encephalopathy. We developed a mouse model in which intravenous inoculation of influenza B/Lee virus produced a non-permissive infection of hepatocytes and cerebral endothelial cells and caused many clinical, biochemic...

journal_title：International journal of experimental pathology

authors： Davis LE,Woodfin BM,Tran TQ,Caskey LS,Wallace JM,Scremin OU,Blisard KS

更新日期：1993-06-01 00:00:00