abstract：:Tumour-associated macrophage (TAM) polarization is associated with hepatocellular carcinoma but the molecular mechanism of this polarization is still unknown. Peripheral blood mononuclear cells were induced to differentiate into M0, M1 and M2 macrophages and TAMs. TAMs were transfected with pcDNA3.1-GAS5, pcDNA3.1-NC,...

journal_title：International journal of experimental pathology

authors： Wang X,Li FY,Zhao W,Gao ZK,Shen B,Xu H,Cui YF

更新日期：2020-12-01 00:00:00

abstract：:Systemic hypertension, characterized by elevated blood pressure ≥140/90 mm Hg, is a major modifiable risk factor for cardiovascular disease. Hypertension also associates with non-alcoholic fatty liver disease (NAFLD), which is becoming common due to a modern diet and lifestyle. The aim of the present study was to exam...

journal_title：International journal of experimental pathology

authors： Cartland SP,Tamer N,Patil MS,Di Bartolo BA,Kavurma MM

更新日期：2020-10-01 00:00:00

abstract：:The objectives of this work were to study some pathological aspects of kidneys obtained from dogs naturally infected with Leishmania infantum and from dogs experimentally infected with two different strains of L infantum with special emphasis on fibrotic process. Seventy eight specimens of paraffin-embedded kidney fra...

journal_title：International journal of experimental pathology

authors： Alves AF,Pereira RA,de Andrade HM,Mosser DM,Tafuri WL

更新日期：2019-08-01 00:00:00

abstract：:A major translational barrier to the use of stem cell (SC)-based therapy in patients with myocardial infarction (MI) is the lack of a clear understanding of the mechanism(s) underlying the cardioprotective effect of SCs. Numerous paracrine factors from SCs may account for reduction in infarct size, but myocardial salv...

journal_title：International journal of experimental pathology

authors： Karpov AA,Puzanov MV,Ivkin DY,Krasnova MV,Anikin NA,Docshin PM,Moiseeva OM,Galagudza MM

更新日期：2019-04-01 00:00:00

abstract：:Hydroxymethylnitrofurazone (NFOH) is a nitrofurazone prodrug effective in vivo during acute infections, and it has less hepatotoxicity effect than the standard drug benznidazole (BZN) which has been used during short- and long-term treatment. In the present study, we induced the indeterminate form of Chagas disease in...

journal_title：International journal of experimental pathology

authors： Scarim CB,de Andrade CR,da Rosa JA,Dos Santos JL,Chin CM

更新日期：2018-10-01 00:00:00

abstract：:The aim of this study was to evaluate the use of flaxseed in animals subjected to ethanol-induced hepatotoxicity. Twenty-four male rats were divided into four groups (n = 6): control group (CG) which received a control diet and water ad libitum; flaxseed group (FG) which received control diet with an addition of 25% f...

journal_title：International journal of experimental pathology

authors： Latini JTP,Vicente GC,Velarde LGC,Benedicto HG,de Castro Resende Â,Teixeira MT,de Almeida KCL,Boaventura GT

更新日期：2018-10-01 00:00:00

abstract：:The interradicular region of primary molars is permeated by many foramina, channels and accessories that connect the pulp cavity with the periapical tissues anatomically. Thus, pulp decomposition products or drugs used in endodontic treatment can trigger inflammatory reactions. The aim of this study was to evaluate th...

journal_title：International journal of experimental pathology

authors： Moura LFAD,Lima MDM,Lima CCB,Bandeira AVL,Moura MS,Conde Júnior AM,Rizzo MDS

更新日期：2018-10-01 00:00:00

abstract：:Integrins are the key mediators of cell-extracellular matrix (ECM) interaction, linking the ECM to the actin cytoskeleton. Besides localizing at the cell surface, they can be internalized and transported back to the plasma membrane (recycled) or delivered to the late endosomes/lysosomes for degradation. We and others ...

journal_title：International journal of experimental pathology

authors： Rainero E

更新日期：2018-02-01 00:00:00

abstract：:The use of non-specific inhibitors of tissue non-specific alkaline phosphatase (TNSALP) in pre-adipocytes blocks intracellular lipid accumulation. TNSALP is also expressed in hepatocytes, which are known to accumulate lipid in a similar manner to pre-adipocytes. The purpose of this study was to use specific silencing ...

journal_title：International journal of experimental pathology

authors： Chirambo G,van Niekerk C,Crowther NJ

更新日期：2017-10-01 00:00:00

abstract：:Amino acid metabolism is a significant metabolic activity in humans, especially of sulphur-containing amino acids, methionine and cysteine (Cys). Cys is cytotoxic and neurotoxic in nature; hence, mammalian cells maintain a constant intracellular level of Cys. Metabolism of Cys is mainly regulated by two thiol dioxygen...

journal_title：International journal of experimental pathology

authors： Sarkar B,Kulharia M,Mantha AK

更新日期：2017-04-01 00:00:00

abstract：:In this study we have explored the pathogenesis of the hepatic alterations which occur in diabetes and the modulation of these complications by the combination of metformin adjunct treatment and insulin monotherapy. For this purpose, diabetic rats were treated with insulin (DM + Ins) or metformin plus insulin (DM + Me...

journal_title：International journal of experimental pathology

authors： Silvares RR,Pereira EN,Flores EE,Estato V,Reis PA,Silva IJ,Machado MP,Neto HC,Tibiriça E,Daliry A

更新日期：2016-06-01 00:00:00

abstract：:Most patients with epithelial ovarian cancer (EOC) are diagnosed at an advanced stage, and therapeutic options for these patients are limited. The identification of suitable biomarkers could be helpful for patients with EOC, who might benefit from targeted therapies even in advanced stages of the disease. Trophoblast ...

journal_title：International journal of experimental pathology

authors： Xu N,Zhang Z,Zhu J,Xu L,Li Y,Duan L,Mao Y,Li H

更新日期：2016-04-01 00:00:00

abstract：:Permethrin (PM), a synthetic pyrethroid insecticide, has broad toxicity spectra. We aimed to investigate the effects of PM on the testes of adult albino rats, examine the recovery response and evaluate the efficacy of naringenin (NG) supplementation. Adult male albino rats were randomly assigned to five groups of six ...

journal_title：International journal of experimental pathology

authors： Mostafa Hel-S,Abd El-Baset SA,Kattaia AA,Zidan RA,Al Sadek MM

更新日期：2016-02-01 00:00:00

abstract：:There is evidence to show that downregulation of miR-1 expression is closely related to cancer progression, including in nasopharyngeal carcinoma (NPC). However, the molecular mechanisms underlying miR-1 downregulation in NPC remain largely unknown, especially its association with Epstein-Barr virus (EBV). In this stu...

journal_title：International journal of experimental pathology

authors： Chen X,Shi J,Zhong J,Huang Z,Luo X,Huang Y,Feng S,Shao J,Liu D

更新日期：2015-12-01 00:00:00

abstract：:This study tested the hypothesis that different doses of nandrolone decanoate (ND) will cause changes in the estrous cycle and ovarian tissue of adult rats; and investigated the duration of the recovery period that is sufficient to restore the damage in the animals treated with different doses. Wistar rats were treate...

journal_title：International journal of experimental pathology

authors： Simão VA,Berloffa Belardin L,Araújo Leite GA,de Almeida Chuffa LG,Camargo IC

更新日期：2015-10-01 00:00:00

abstract：:The purpose of this study was to examine the prognostic significance of insulin-like growth factor-1 receptor (IGF-1R) expression alone and in relation to the expression of the MET- receptor and the MET-homologous receptor RON, in classical Hodgkin's lymphoma (cHL). Tumour samples from patients with cHL (n = 202; medi...

journal_title：International journal of experimental pathology

authors： Koh YW,Yoon DH,Suh C,Cha HJ,Huh J

更新日期：2015-08-01 00:00:00

abstract：:Heparan sulphate (HS) sits at the interface of the cell and the extracellular matrix. It is a member of the glycosaminoglycan family of anionic polysaccharides with unique structural features designed for protein interaction and regulation. Its client proteins include soluble effectors (e.g. growth factors, morphogens...

journal_title：International journal of experimental pathology

authors： Gallagher J

更新日期：2015-08-01 00:00:00

abstract：:Leprosy is a disease consisting of a spectrum of clinical, bacteriological, histopathological and immunological manifestations. Tuberculoid leprosy is frequently recognized as the benign polar form of the disease, while lepromatous leprosy is regarded as the malignant form. The different forms of leprosy depend on the...

journal_title：International journal of experimental pathology

authors： Juarez-Ortega M,Hernandez VG,Arce-Paredes P,Villanueva EB,Aguilar-Santelises M,Rojas-Espinosa O

更新日期：2015-02-01 00:00:00

abstract：:Acute myocardial infarction is one of the major causes of mortality worldwide. For regeneration of the rabbit heart after experimentally induced infarction we used autologous skeletal myoblasts (SMs) due to their high proliferative potential, resistance to ischaemia and absence of immunological and ethical concerns. T...

journal_title：International journal of experimental pathology

authors： Antanavičiūtė I,Ereminienė E,Vysockas V,Račkauskas M,Skipskis V,Rysevaitė K,Treinys R,Benetis R,Jurevičius J,Skeberdis VA

更新日期：2015-02-01 00:00:00

abstract：:The α2-adrenoceptors regulate the sympathetic nervous system, controlling presynaptic catecholamine release. However, the role of the α2-adrenoceptors in cutaneous wound healing is poorly understood. Mice lacking both the α2A/α2C-adrenoceptors were used to evaluate the participation of the α2-adrenoceptor during cutan...

journal_title：International journal of experimental pathology

authors： Romana-Souza B,Nascimento AP,Brum PC,Monte-Alto-Costa A

更新日期：2014-10-01 00:00:00

abstract：:Angiogenesis is a common finding in chronic inflammatory diseases; however, its role in Sjögren's syndrome (SS) remains to be elucidated. Previous SS studies have demonstrated an increase in VEGF-A/VEGFR-2 system expression in minor salivary gland (MSG) biopsies from patients with SS, but differences in the new blood ...

journal_title：International journal of experimental pathology

authors： Sisto M,Lisi S,Ingravallo G,Lofrumento DD,D'Amore M,Ribatti D

更新日期：2014-04-01 00:00:00

abstract：:A recent global gene expression profiling study unexpectedly showed that activated oncogenic NRAS may recruit neural precursor cell expressed, developmentally downregulated 4L (Nedd4L; a human homologue of Nedd4-2) in cultured melanoma cells. However, whether Nedd4L was expressed in melanoma tissues or participated in...

journal_title：International journal of experimental pathology

authors： Kito Y,Bai J,Goto N,Okubo H,Adachi Y,Nagayama T,Takeuchi T

更新日期：2014-02-01 00:00:00

abstract：:The field of study concerning promotion and/or inhibition of angiogenesis has gathered much attention in the scientific community. A great deal of work has been invested towards defining reproducible assays to gauge for promotion or inhibition of angiogenesis in response to drug treatments or growth conditions. Two co...

journal_title：International journal of experimental pathology

authors： Prigozhina NL,Heisel AJ,Seldeen JR,Cosford ND,Price JH

更新日期：2013-12-01 00:00:00

abstract：:The objective of this study was to assess whether ascorbic acid (AA), an intracellular anti-oxidant critical for neuronal protection, when added to artificial cerebrospinal fluid (ACSF), is able to protect hippocampal (HPC) formation slice preparations from ageing. In this research, the micro-electroencephalographic (...

journal_title：International journal of experimental pathology

authors： Kazmierska P,Grebowski J,Konopacki J

更新日期：2012-12-01 00:00:00

abstract：:This study was conducted to evaluate the adverse effects of the anabolic steroid, boldenone undecylenate (BOL) on reproductive functions of male rabbits. Thirty white New Zealand mature male rabbits were divided into three groups (10 rabbits each). Group A rabbits served as a control group. Group B rabbits received 4....

journal_title：International journal of experimental pathology

authors： Oda SS,El-Ashmawy IM

更新日期：2012-06-01 00:00:00

abstract：:Initially found expressed in neuronal and then later in endothelial cells, it is well established that the transmembrane glycoproteins neuropilin-1 (NRP1) and neuropilin-2 (NRP2) play essential roles in axonal growth and guidance and in physiological and pathological angiogenesis. Neuropilin expression and function in...

journal_title：International journal of experimental pathology

authors： Wild JR,Staton CA,Chapple K,Corfe BM

更新日期：2012-04-01 00:00:00

abstract：:p23 is a cochaperone of heat shock protein 90 and also interacts functionally with numerous steroid receptors and kinases. However, the in vivo roles of p23 remain unclear. To explore its in vivo function, we generated the transgenic (TG) mice ubiquitously overexpressing p23. The p23 TG mice spontaneously developed ki...

journal_title：International journal of experimental pathology

authors： Lee J,Kim HJ,Moon JA,Sung YH,Baek IJ,Roh JI,Ha NY,Kim SY,Bahk YY,Lee JE,Yoo TH,Lee HW

更新日期：2011-08-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is the most common chronic condition of the liver in the western world. There is only little evidence about altered sensitivity of steatotic liver to acute toxic injury. The aim of this project was to test whether hepatic steatosis sensitizes rat liver to acute toxic injury in...

journal_title：International journal of experimental pathology

authors： Kučera O,Lotková H,Staňková P,Podhola M,Roušar T,Mezera V,Cervinková Z

更新日期：2011-08-01 00:00:00

abstract：:Interstitial fibrosis, associated with extensive accumulation of extracellular matrix constituents in the cortical interstitium, is directly correlated to progression of renal disease. The earliest histological marker of this progression is the accumulation in the interstitium of fibroblasts with the phenotypic appear...

journal_title：International journal of experimental pathology

authors： Meran S,Steadman R

更新日期：2011-06-01 00:00:00

abstract：:Ureteropelvic junction (UPJ) obstruction is the most frequently observed cause of obstructive nephropathy in children. Neonatal and foetal animal models have been developed that mimic closely what is observed in human disease. The purpose of this review is to discuss how obstructive nephropathy alters kidney histology...

journal_title：International journal of experimental pathology

authors： Klein J,Gonzalez J,Miravete M,Caubet C,Chaaya R,Decramer S,Bandin F,Bascands JL,Buffin-Meyer B,Schanstra JP

更新日期：2011-06-01 00:00:00

abstract：:To confirm the existence of the cervical thymus and the development of cervical thymoma in thymoma-prone BUF/Mna (BUF) rats, we examined cervical organs and adjacent tissues, and thoracic thymic tissues of the three inbred strains, BUF, ACI/NMna (ACI), and WKY/NCrj (WKY), and 11 congenic strains, in which genetic regi...

journal_title：International journal of experimental pathology

authors： Yamada T,Matsuyama M,Yanagida T,Kato K,Sugiura S,Kuroda M

更新日期：2011-04-01 00:00:00

abstract：:Progress in understanding the pathophysiology of abdominal aortic aneurysms (AAA) is dependent in part on the development and application of effective animal models that recapitulate key aspects of the disease. The objective was to produce an experimental model of AAA in rats by combining two potential causes of metal...

journal_title：International journal of experimental pathology

authors： Mata KM,Prudente PS,Rocha FS,Prado CM,Floriano EM,Elias J Jr,Rizzi E,Gerlach RF,Rossi MA,Ramos SG

更新日期：2011-02-01 00:00:00

abstract：:In this study, the extent of angiogenesis, evaluated as microvascular volume density, immunoreactivity of tumour cells to erythropoietin (Epo) and of endothelial cells to Epo receptor (EpoR) have been correlated in human primary melanoma specimens. Results showed that Epo/EpoR expression correlate with angiogenesis an...

journal_title：International journal of experimental pathology

authors： Ribatti D,Nico B,Perra MT,Longo V,Maxia C,Annese T,Piras F,Murtas D,Sirigu P

更新日期：2010-12-01 00:00:00

abstract：:Two families of the Metzincin clan of metalloproteinases, the matrix metalloproteinases and the disintegrin metalloproteinases have attracted much attention as important effectors of cellular interactions with their environment. They appear to play significant roles in the modulation of components of the extracellular...

journal_title：International journal of experimental pathology

authors： Murphy G

更新日期：2010-08-01 00:00:00

abstract：:Over the past 40 years there have been giant steps forward in our understanding of cellular and molecular biology that have given us the framework by which to understand tissue organization and tissue function on a range of scales. However, although the progress has been great, the more we have discovered, the more we...

journal_title：International journal of experimental pathology

authors： Hardingham TE

更新日期：2010-06-01 00:00:00

abstract：:Although it is well known that cadmium (Cd) causes adverse effects on male rat reproductive organs, few studies have quantified alterations caused by its low doses. Quantification of these alterations, especially in the testis, was measured using morphometry. A single dose of cadmium chloride (1 or 1.2 mg/kg BW) was i...

journal_title：International journal of experimental pathology

authors： de Souza Predes F,Diamante MA,Dolder H

更新日期：2010-04-01 00:00:00

abstract：:Low-dose chemotherapy drugs can suppress tumours by restraining tumour vessel growth and preventing the repair of damaged vascular endothelial cells. Cisplatin is a broad-spectrum, cell cycle-non-specific drug, but has serious side effects if used at high doses. There have been few reports on the anti-angiogenic effec...

journal_title：International journal of experimental pathology

authors： Shen FZ,Wang J,Liang J,Mu K,Hou JY,Wang YT

更新日期：2010-02-01 00:00:00

abstract：:The aim of this study was to estimate the relationship of endothelial dysfunction induced by intracellular S-adenosylhomocysteine (SAH) accumulation and DNA methylation in human umbilical vein endothelial cells (HUVEC). The isolated HUVEC were incubated with 3-deazaadenosine (DZA) to induce experimental intracellular ...

journal_title：International journal of experimental pathology

authors： Yu X,Ling W,Mi M

更新日期：2009-12-01 00:00:00

abstract：:Pterygium is a surface ocular lesion that is associated with chronic UV exposure. The primary effect is a solar actinic elastosis within the stroma. All the other changes are secondary. Pterygium is characterized by proliferation, inflammatory infiltrates, fibrosis, angiogenesis and extracellular matrix breakdown. The...

journal_title：International journal of experimental pathology

authors： Ribatti D,Nico B,Perra MT,Maxia C,Piras F,Murtas D,Crivellato E,Sirigu P

更新日期：2009-12-01 00:00:00

abstract：:Summary K-ras mutations are found in 40-50% of human colorectal adenomas and carcinomas, but their functional contribution remains incompletely understood. Here, we show that a conditional mutant K-ras mouse model (K-ras(Asp12)/Cre), with transient intestinal Cre activation by beta-Naphthoflavone (beta-NF) treatment, ...

journal_title：International journal of experimental pathology

authors： Luo F,Brooks DG,Ye H,Hamoudi R,Poulogiannis G,Patek CE,Winton DJ,Arends MJ

更新日期：2009-10-01 00:00:00