Mode of transmission and histology of M. leprae infection in nude mice.

abstract：:Conventional therapies for low back pain (LBP) are purely symptomatic and do not target the cause of LBP, which in approximately 40% of cases is caused by degeneration of the intervertebral disc (DIVD). Targeting therapies to inhibit the process of degeneration would be a potentially valuable treatment for LBP. There ...

journal_title：International journal of experimental pathology

authors： Le Maitre CL,Freemont AJ,Hoyland JA

更新日期：2006-02-01 00:00:00

abstract：:Dengue type 2 virus (DV) induces a subpopulation of T lymphocytes of mouse spleen to secrete a soluble helper cytokine (HF) which enhances the DV-specific IgM antibody plaque forming cells (PFC). The present study undertaken to purify and characterize HF shows that it can be purified by low pressure liquid chromatogra...

journal_title：International journal of experimental pathology

authors： Chaturvedi P,Mukherjee R,Chaturvedi UC,Mathur A

更新日期：1992-06-01 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) is one of the life-threatening hepatic diseases; however, its pathogenesis is still unknown. To evaluate the causative role of hyperlipidaemia and high-fat diet, we compared C57BL/6 mice with inherited hyperlipidaemic model mice (LDLR(-/-)mice and ApoE(-/-) mice) fed a normal or a h...

journal_title：International journal of experimental pathology

authors： Yoshimatsu M,Terasaki Y,Sakashita N,Kiyota E,Sato H,van der Laan LJ,Takeya M

更新日期：2004-12-01 00:00:00

abstract：:Long-term intragastric administration of the antiepileptic drug sodium valproate (Vuprol Polfa) to rats for 1, 3, 6, 9 and 12 months, once daily at the effective dose of 200 mg/kg body weight showed morphological evidence of encephalopathy, manifested by numerous nonspecific changes within Purkinje cell perikarya and ...

journal_title：International journal of experimental pathology

authors： Sobaniec-Lotowska ME

更新日期：2001-12-01 00:00:00

abstract：:Genetically resistant CBA and A/J mice and susceptible BALB/c and C57BL/6 mice were challenged with either an identical infective dose or a minimal lethal dose of Salmonella typhimurium. The histopathological progression of the disease was examined in tissue sections prepared by the JB-4 Plus resin embedding method an...

journal_title：International journal of experimental pathology

authors： Moncure CW,Guo YN,Xu HR,Hsu HS

更新日期：1998-06-01 00:00:00

abstract：:Cyclophilins are proteins which are remarkably conserved through evolution; moreover they have been found in every possible existing organism, which indicates their fundamental importance. Due to their enzymatic properties, multiplicity, cellular localization and role in protein folding they belong to the group of pro...

journal_title：International journal of experimental pathology

authors： Andreeva L,Heads R,Green CJ

更新日期：1999-12-01 00:00:00

abstract：:The original two strains of Mycoplasma genitalium were isolated from the human urogenital tract. No other strains have been isolated from this site since then. We have recently succeeded in propagating a third strain from a urogenital specimen from a patient with urethritis in Vero cell cultures. By electron microscop...

journal_title：International journal of experimental pathology

authors： Jensen JS,Blom J,Lind K

更新日期：1994-04-01 00:00:00

abstract：:The tumour microenvironment, which is largely composed of inflammatory cells, is a crucial participant in the neoplastic process through the promotion of cell proliferation, survival and migration. Neutrophil polymorphonuclear cells (PMNs) induce inflammatory reactions that can be either cytotoxic for tumour cells or ...

journal_title：International journal of experimental pathology

authors： Remedi MM,Donadio AC,Chiabrando GA

更新日期：2009-02-01 00:00:00

abstract：:Ultraviolet ray B (UV-B) induced dermatitis in the rat may be a model for human psoriasis vulgaris. Detailed studies of this model are reported. Rat skin responded to UV-B irradiation quite differently from human, guinea-pig, or mouse skin. Rat UV-B dermatitis was characterized by a sharply demarcated brownish-red les...

journal_title：International journal of experimental pathology

authors： Nakaguma H,Kambara T,Yamamoto T

更新日期：1995-02-01 00:00:00

abstract：:Angiogenesis is a common finding in chronic inflammatory diseases; however, its role in Sjögren's syndrome (SS) remains to be elucidated. Previous SS studies have demonstrated an increase in VEGF-A/VEGFR-2 system expression in minor salivary gland (MSG) biopsies from patients with SS, but differences in the new blood ...

journal_title：International journal of experimental pathology

authors： Sisto M,Lisi S,Ingravallo G,Lofrumento DD,D'Amore M,Ribatti D

更新日期：2014-04-01 00:00:00

abstract：:Ischaemic-reperfusion injury as a model of acute renal failure (ARF) results in increased macromolecular permeability, tubular obstruction, and renal oedema. To investigate the role for coagulation in this model, anticoagulated and saline-pretreated rats were subjected to 60 min unilateral renal artery occlusion (RAO)...

journal_title：International journal of experimental pathology

authors： Druid H,Eneström S,Rammer L

更新日期：1998-02-01 00:00:00

abstract：:(Pre)neoplastic lesions in livers of rats induced by diethylnitrosamine are characterized by elevated activity of the first irreversible enzyme of the oxidative branch of the pentose phosphate pathway (PPP), glucose-6-phosphate dehydrogenase (G6PD), for production of NADPH. In the present study, the activity of G6PD, ...

journal_title：International journal of experimental pathology

authors： Frederiks WM,Vizan P,Bosch KS,Vreeling-Sindelárová H,Boren J,Cascante M

更新日期：2008-08-01 00:00:00

abstract：:The present study was carried out to investigate the role of hypertension in the genesis and localization of intimal lesions and medial remodelling found in the prestenotic segment in relation to a severe stenosis of the abdominal aorta just below the diaphragm. Male young rats were divided randomly into operated grou...

journal_title：International journal of experimental pathology

authors： Prado CM,Rossi MA

更新日期：2006-12-01 00:00:00

abstract：:The pathogenesis of dengue haemorrhagic fever (DHF) is incompletely understood but it has been suggested that various cytokines may have a role in the process. In this study the profile of the cytokine Transforming Growth Factor-beta 1 (TGF-beta1) was investigated in the sera of 79 patients with various grades of deng...

journal_title：International journal of experimental pathology

authors： Agarwal R,Elbishbishi EA,Chaturvedi UC,Nagar R,Mustafa AS

更新日期：1999-06-01 00:00:00

abstract：:This study was conducted to evaluate the adverse effects of the anabolic steroid, boldenone undecylenate (BOL) on reproductive functions of male rabbits. Thirty white New Zealand mature male rabbits were divided into three groups (10 rabbits each). Group A rabbits served as a control group. Group B rabbits received 4....

journal_title：International journal of experimental pathology

authors： Oda SS,El-Ashmawy IM

更新日期：2012-06-01 00:00:00

abstract：:Administration of mercuric chloride (HgCl(2)) to Brown Norway rats causes Th2-dominated autoimmunity with raised immunoglobulin E concentrations and gut vasculitis, both of which are T-cell dependent, peak at 14 days after starting HgCl(2) and then spontaneously resolve. If animals are re-challenged with HgCl(2) 6 wee...

journal_title：International journal of experimental pathology

authors： Vinen CS,Turner DR,Oliveira DB

更新日期：2004-06-01 00:00:00

abstract：:Permethrin (PM), a synthetic pyrethroid insecticide, has broad toxicity spectra. We aimed to investigate the effects of PM on the testes of adult albino rats, examine the recovery response and evaluate the efficacy of naringenin (NG) supplementation. Adult male albino rats were randomly assigned to five groups of six ...

journal_title：International journal of experimental pathology

authors： Mostafa Hel-S,Abd El-Baset SA,Kattaia AA,Zidan RA,Al Sadek MM

更新日期：2016-02-01 00:00:00

abstract：:Leprosy is a disease consisting of a spectrum of clinical, bacteriological, histopathological and immunological manifestations. Tuberculoid leprosy is frequently recognized as the benign polar form of the disease, while lepromatous leprosy is regarded as the malignant form. The different forms of leprosy depend on the...

journal_title：International journal of experimental pathology

authors： Juarez-Ortega M,Hernandez VG,Arce-Paredes P,Villanueva EB,Aguilar-Santelises M,Rojas-Espinosa O

更新日期：2015-02-01 00:00:00

abstract：:We determined the feasibility of producing protoporphyric hepatopathy in unrestrained rats by infusing protoporphyrin into their portal circulation via chronic indwelling catheters. Sprague-Dawley rats, 200-300 g, received single (8.5-27.8 mumol) or multiple (64.1-208.7 mumol) infusions of protoporphyrin over 3-240 h....

journal_title：International journal of experimental pathology

authors： Berenson MM,Kimura R,Samowitz W,Bjorkman D

更新日期：1992-10-01 00:00:00

abstract：:Low-dose chemotherapy drugs can suppress tumours by restraining tumour vessel growth and preventing the repair of damaged vascular endothelial cells. Cisplatin is a broad-spectrum, cell cycle-non-specific drug, but has serious side effects if used at high doses. There have been few reports on the anti-angiogenic effec...

journal_title：International journal of experimental pathology

authors： Shen FZ,Wang J,Liang J,Mu K,Hou JY,Wang YT

更新日期：2010-02-01 00:00:00

abstract：:The effect of dengue type 2 virus (DV) and the cytokines induced by it, on the chemiluminescence (CL) response of mouse spleen cells was studied by luminol-dependent CL. Following intracerebral (i.c.) inoculation of DV, an initial increase in CL response was observed which was followed by a sharp decline from the 4th ...

journal_title：International journal of experimental pathology

authors： Dhawan R,Chaturvedi UC,Mashihi KN,Chaturvedi P,Mukherjee R

更新日期：1993-10-01 00:00:00

abstract：:BALB/c and CBA mice maintained on low (4%) or normal (18%) protein diets for 2 weeks after weaning were infected with a sublethal dose of murine cytomegalovirus, adjusted in proportion to body weight. Viral replication, histopathological changes and humoral responses to the virus were compared between the dietary grou...

journal_title：International journal of experimental pathology

authors： Teo HK,Price P,Papadimitriou JM

更新日期：1991-02-01 00:00:00

abstract：:Over the past 40 years there have been giant steps forward in our understanding of cellular and molecular biology that have given us the framework by which to understand tissue organization and tissue function on a range of scales. However, although the progress has been great, the more we have discovered, the more we...

journal_title：International journal of experimental pathology

authors： Hardingham TE

更新日期：2010-06-01 00:00:00

abstract：:In this study, we wanted to evaluate whether the engrailed EN-2 gene, a homeobox gene with an essential role in the development of the rhombic lip derivatives in different species, is (1) expressed also in man in the differentiation process of the medullary arcuate nucleus (ArcN) and (2) involved in sudden unexplained...

journal_title：International journal of experimental pathology

authors： Lavezzi AM,Ottaviani G,Mauri M,Terni L,Matturri L

更新日期：2005-02-01 00:00:00

abstract：:Mitochondrial DNA (mt-DNA) disorders and abnormal regulation of nuclear-derived proteins devoted to the cross-talk between the two cellular genomes have recently interested researchers in the field of neuromuscular diseases. We have identified, isolated and sequenced a new gene, augmenter of liver regeneration (ALR) t...

journal_title：International journal of experimental pathology

authors： Polimeno L,Pesetti B,Giorgio F,Moretti B,Resta L,Rossi R,Annoscia E,Patella V,Notarnicola A,Mallamaci R,Francavilla A

更新日期：2009-08-01 00:00:00

abstract：:Progress in understanding the pathophysiology of abdominal aortic aneurysms (AAA) is dependent in part on the development and application of effective animal models that recapitulate key aspects of the disease. The objective was to produce an experimental model of AAA in rats by combining two potential causes of metal...

journal_title：International journal of experimental pathology

authors： Mata KM,Prudente PS,Rocha FS,Prado CM,Floriano EM,Elias J Jr,Rizzi E,Gerlach RF,Rossi MA,Ramos SG

更新日期：2011-02-01 00:00:00

abstract：:The objectives of this work were to study some pathological aspects of kidneys obtained from dogs naturally infected with Leishmania infantum and from dogs experimentally infected with two different strains of L infantum with special emphasis on fibrotic process. Seventy eight specimens of paraffin-embedded kidney fra...

journal_title：International journal of experimental pathology

authors： Alves AF,Pereira RA,de Andrade HM,Mosser DM,Tafuri WL

更新日期：2019-08-01 00:00:00

abstract：:Most patients with epithelial ovarian cancer (EOC) are diagnosed at an advanced stage, and therapeutic options for these patients are limited. The identification of suitable biomarkers could be helpful for patients with EOC, who might benefit from targeted therapies even in advanced stages of the disease. Trophoblast ...

journal_title：International journal of experimental pathology

authors： Xu N,Zhang Z,Zhu J,Xu L,Li Y,Duan L,Mao Y,Li H

更新日期：2016-04-01 00:00:00

abstract：:The preovulatory follicle provides a unique physiological example of rapid growth accompanied by neovascularization, two processes that are generally characteristic of pathologies such as wound repair or malignancy. During the hours preceding ovulation, follicular growth is accompanied by elevated levels of messenger ...

journal_title：International journal of experimental pathology

authors： Neeman M,Abramovitch R,Schiffenbauer YS,Tempel C

更新日期：1997-04-01 00:00:00

abstract：:Recently, there have been significant advances toward the development of culture conditions that promote proliferation of primary rodent hepatocytes. There are two major methods for the multiplication of hepatocytes in vitro: one is the use of nicotinamide, the other is the use of a nutrient-rich medium. In the medium...

journal_title：International journal of experimental pathology

authors： Mitaka T

更新日期：1998-12-01 00:00:00