Is rat liver affected by non-alcoholic steatosis more susceptible to the acute toxic effect of thioacetamide?

Abstract:

:Non-alcoholic fatty liver disease (NAFLD) is the most common chronic condition of the liver in the western world. There is only little evidence about altered sensitivity of steatotic liver to acute toxic injury. The aim of this project was to test whether hepatic steatosis sensitizes rat liver to acute toxic injury induced by thioacetamide (TAA). Male Sprague-Dawley rats were fed ad libitum a standard pelleted diet (ST-1, 10% energy fat) and high-fat gelled diet (HFGD, 71% energy fat) for 6 weeks and then TAA was applied intraperitoneally in one dose of 100 mg/kg. Animals were sacrificed in 24-, 48- and 72-h interval after TAA administration. We assessed the serum biochemistry, the hepatic reduced glutathione, thiobarbituric acid reactive substances, cytokine concentration, the respiration of isolated liver mitochondria and histopathological samples (H+E, Sudan III, bromodeoxyuridine [BrdU] incorporation). Activities of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase and concentration of serum bilirubin were significantly higher in HFGD groups after application of TAA, compared to ST-1. There were no differences in activities of respiratory complexes I and II. Serum tumour necrosis factor alpha at 24 and 48 h, liver tissue interleukin-6 at 72 h and transforming growth factor β1 at 24 and 48 h were elevated in TAA-administrated rats fed with HFGD, but not ST-1. TAA-induced centrilobular necrosis and subsequent regenerative response of the liver were higher in HFGD-fed rats in comparison with ST-1. Liver affected by NAFLD, compared to non-steatotic liver, is more sensitive to toxic effect of TAA.

journal_name

Int J Exp Pathol

authors

Kučera O,Lotková H,Staňková P,Podhola M,Roušar T,Mezera V,Cervinková Z

doi

10.1111/j.1365-2613.2011.00765.x

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

281-9

issue

4

eissn

0959-9673

issn

1365-2613

journal_volume

92

pub_type

杂志文章
  • Age-related histopathological lesions in the Mongolian gerbil ventral prostate as a good model for studies of spontaneous hormone-related disorders.

    abstract::The Meriones unguiculatus (Mongolian) gerbil has demonstrated significant prostatic responses to hormonal treatments, and to drugs against human prostatic hyperplasia. Spontaneous neoplasia develops in the older animals. Thirty gerbils (age 18 months) were divided into non-affected and prostatic lesion bearers and the...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2007.00550.x

    authors: Campos SG,Zanetoni C,Scarano WR,Vilamaior PS,Taboga SR

    更新日期:2008-02-01 00:00:00

  • Involvement of the EN-2 gene in normal and abnormal development of the human arcuate nucleus.

    abstract::In this study, we wanted to evaluate whether the engrailed EN-2 gene, a homeobox gene with an essential role in the development of the rhombic lip derivatives in different species, is (1) expressed also in man in the differentiation process of the medullary arcuate nucleus (ArcN) and (2) involved in sudden unexplained...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.0959-9673.2005.00408.x

    authors: Lavezzi AM,Ottaviani G,Mauri M,Terni L,Matturri L

    更新日期:2005-02-01 00:00:00

  • 2.5 kDa and 5.0 kDa heparin fragments specifically inhibit microvessel sprouting and network formation in VEGF165-mediated mammalian angiogenesis.

    abstract::Tumour growth is angiogenesis dependent. Thrombosis and thromboembolism are very common in cancer patients. These patients are often treated with heparin as an anti-coagulant. Many tumour angiogens, including VEGF165, and endogenous anti-angiogenesis factors bind heparin tightly. Using the non-surgical mesenteric-wind...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2613.2000.00150.x

    authors: Norrby K

    更新日期:2000-06-01 00:00:00

  • Rat ultraviolet ray B photodermatitis: an experimental model of psoriasis vulgaris.

    abstract::Ultraviolet ray B (UV-B) induced dermatitis in the rat may be a model for human psoriasis vulgaris. Detailed studies of this model are reported. Rat skin responded to UV-B irradiation quite differently from human, guinea-pig, or mouse skin. Rat UV-B dermatitis was characterized by a sharply demarcated brownish-red les...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Nakaguma H,Kambara T,Yamamoto T

    更新日期:1995-02-01 00:00:00

  • Effect of maternal cholestasis on the kinetics of bile acid transport across the canalicular membrane of infant rat livers.

    abstract::A reversible impairment in the ability of the liver to secrete cholephilic compounds has been reported to exist in infant rats born from mothers with surgically induced complete cholestasis during the last third of the pregnancy. Canalicular plasma membranes (CPM) were purified from livers obtained from 4 and 8 week-o...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2613.1997.360372.x

    authors: Serrano MA,Monte MJ,Martinez-Diez MC,Marin JJ

    更新日期:1997-12-01 00:00:00

  • Collagen metabolism disturbances are accompanied by an increase in prolidase activity in lung carcinoma planoepitheliale.

    abstract::One of the consequences of neoplastic transformation is deregulation of tissue collagen metabolism. Although metalloproteinases initiate the breakdown of collagen in lung carcinoma, the final step of collagen degradation is mediated by prolidase (E.C.3.4.13.9). We investigated whether prolidase activity could reflect ...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2000.00168.x

    authors: Karna E,Surazynski A,Palka J

    更新日期:2000-10-01 00:00:00

  • Superficial exudates of neutrophils prevent invasion of Bacillus anthracis bacilli into abraded skin of resistant mice.

    abstract::Skin window procedures in humans have shown rapid accumulation of neutrophils into the exuded fluids above abraded skin. The present study was undertaken to determine if similar epicutaneous neutrophil accumulation might explain the extreme resistance of HRS/J mice, both hairless (hr/hr) and haired (hr/+), to experime...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2008.00584.x

    authors: Hahn BL,Bischof TS,Sohnle PG

    更新日期:2008-06-01 00:00:00

  • From collagen chemistry towards cell therapy - a personal journey.

    abstract::The Fell-Muir Award requires the recipient to deliver a lecture and a review manuscript which provides a personal overview of significant scientific developments in the field of matrix biology over the period of the recipient's career. In this context, this review considers the collagen family of structural proteins a...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2613.2007.00537.x

    authors: Grant ME

    更新日期:2007-08-01 00:00:00

  • Insulin-like growth factor-1 receptor is associated with better prognosis in classical Hodgkin's lymphoma: Correlation with MET expression.

    abstract::The purpose of this study was to examine the prognostic significance of insulin-like growth factor-1 receptor (IGF-1R) expression alone and in relation to the expression of the MET- receptor and the MET-homologous receptor RON, in classical Hodgkin's lymphoma (cHL). Tumour samples from patients with cHL (n = 202; medi...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12128

    authors: Koh YW,Yoon DH,Suh C,Cha HJ,Huh J

    更新日期:2015-08-01 00:00:00

  • Infection of human monocytes by Leishmania results in a defective oxidative burst.

    abstract::The effect of infection by prototypes from the three major species of Leishmania on the oxidative burst of human mononuclear phagocytes in culture was examined. The presence of intracellular parasites of the three species, L.major, L.donovani and L.mexicana decreased hydrogen peroxide (H2O2) and superoxide anion (O2-)...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Passwell JH,Shor R,Smolen J,Jaffe CL

    更新日期:1994-08-01 00:00:00

  • miR-1, regulated by LMP1, suppresses tumour growth and metastasis by targeting K-ras in nasopharyngeal carcinoma.

    abstract::There is evidence to show that downregulation of miR-1 expression is closely related to cancer progression, including in nasopharyngeal carcinoma (NPC). However, the molecular mechanisms underlying miR-1 downregulation in NPC remain largely unknown, especially its association with Epstein-Barr virus (EBV). In this stu...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12162

    authors: Chen X,Shi J,Zhong J,Huang Z,Luo X,Huang Y,Feng S,Shao J,Liu D

    更新日期:2015-12-01 00:00:00

  • Hepatitis B virus and hepatocellular carcinoma.

    abstract::Chronic hepatitis B virus (HBV) infection is a major global cause of hepatocellular carcinoma (HCC). Individuals who are chronic carriers have a greater than 100-fold increased relative risk of developing the tumour. Several mechanisms of HBV-induced HCC have been proposed. Integration of HBV DNA into the genome of he...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2613.2001.iep0082-0077-x

    authors: Arbuthnot P,Kew M

    更新日期:2001-04-01 00:00:00

  • Low-dose metronomic chemotherapy with cisplatin: can it suppress angiogenesis in H22 hepatocarcinoma cells?

    abstract::Low-dose chemotherapy drugs can suppress tumours by restraining tumour vessel growth and preventing the repair of damaged vascular endothelial cells. Cisplatin is a broad-spectrum, cell cycle-non-specific drug, but has serious side effects if used at high doses. There have been few reports on the anti-angiogenic effec...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2009.00684.x

    authors: Shen FZ,Wang J,Liang J,Mu K,Hou JY,Wang YT

    更新日期:2010-02-01 00:00:00

  • Acinar cell apoptosis and the origin of tubular complexes in caerulein-induced pancreatitis.

    abstract::The interrelationship between acinar cell apoptosis and tubular complex formation was examined in caerulein-induced pancreatitis using histology, immunohistochemistry, electron microscopy and DNA gel electrophoresis. Rats were given 8 hourly subcutaneous injections of caerulein, 24 micrograms/kg, for up to 2 days. Mor...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2613.1999.00116.x

    authors: Reid LE,Walker NI

    更新日期:1999-08-01 00:00:00

  • Effect of IL-2-Bax, a novel interleukin-2-receptor-targeted chimeric protein, on bleomycin lung injury.

    abstract::The role of lymphocytes in the pathogenesis of lung fibrosis is not clear, but the weight of the evidence supports a pro-fibrotic effect for lymphocytes. The high-affinity interleukin-2 receptor (haIL-2R) is expressed on activated, but not quiescent, T lymphocytes. This selective expression of haIL-2R provides the bas...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.0959-9673.2005.00436.x

    authors: Segel MJ,Aqeilan R,Zilka K,Lorberboum-Galski H,Wallach-Dayan SB,Conner MW,Christensen TG,Breuer R

    更新日期:2005-10-01 00:00:00

  • Effect of anticoagulation upon nephron obstruction in experimental acute ischaemic renal failure. A morphological study.

    abstract::Ischaemic-reperfusion injury as a model of acute renal failure (ARF) results in increased macromolecular permeability, tubular obstruction, and renal oedema. To investigate the role for coagulation in this model, anticoagulated and saline-pretreated rats were subjected to 60 min unilateral renal artery occlusion (RAO)...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2613.1998.00055.x

    authors: Druid H,Eneström S,Rammer L

    更新日期:1998-02-01 00:00:00

  • Degenerative and regenerative changes in murine skeletal muscle after injection of venom from the snake Bothrops asper: a histochemical and immunocytochemical study.

    abstract::The degenerative and regenerative changes in murine skeletal muscle after injection of Bothrops asper venom were studied by histological, lectin histochemical and immunocytochemical techniques. According to our observations, the process was divided into four main stages: (a) During the first 3 days prominent degenerat...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Arce V,Brenes F,Gutiérrez JM

    更新日期:1991-04-01 00:00:00

  • Induction of macrophage scavenger receptor MARCO in nonalcoholic steatohepatitis indicates possible involvement of endotoxin in its pathogenic process.

    abstract::Nonalcoholic steatohepatitis (NASH) is one of the life-threatening hepatic diseases; however, its pathogenesis is still unknown. To evaluate the causative role of hyperlipidaemia and high-fat diet, we compared C57BL/6 mice with inherited hyperlipidaemic model mice (LDLR(-/-)mice and ApoE(-/-) mice) fed a normal or a h...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.0959-9673.2004.00401.x

    authors: Yoshimatsu M,Terasaki Y,Sakashita N,Kiyota E,Sato H,van der Laan LJ,Takeya M

    更新日期:2004-12-01 00:00:00

  • Adverse effects of the anabolic steroid, boldenone undecylenate, on reproductive functions of male rabbits.

    abstract::This study was conducted to evaluate the adverse effects of the anabolic steroid, boldenone undecylenate (BOL) on reproductive functions of male rabbits. Thirty white New Zealand mature male rabbits were divided into three groups (10 rabbits each). Group A rabbits served as a control group. Group B rabbits received 4....

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2012.00814.x

    authors: Oda SS,El-Ashmawy IM

    更新日期:2012-06-01 00:00:00

  • Recombinant gamma interferon causes neutrophil migration mediated by the release of a macrophage neutrophil chemotactic factor.

    abstract::A dose-dependent neutrophil migration was observed following the injection of purified (Hu IFN-gamma) or recombinant (rIFN-gamma) human gamma interferon into rat peritoneal cavities. This finding contrasts with their inability to cause chemotaxis in vitro in the Boyden chamber. Neutrophil migration into peritoneal cav...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Ribeiro RA,Cunha FQ,Ferreira SH

    更新日期:1990-10-01 00:00:00

  • Endothelial nitric oxide synthase is a critical factor in experimental liver fibrosis.

    abstract::Reduced expression of endothelial nitric oxide synthase (eNOS) in chronic liver disease can reduce hepatic perfusion and accelerate fibrosis. The relationship between eNOS expression and liver fibrogenesis remains unclear. We investigated whether L-arginine attenuated chronic liver fibrosis through eNOS expression. Ch...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2008.00590.x

    authors: Leung TM,Tipoe GL,Liong EC,Lau TY,Fung ML,Nanji AA

    更新日期:2008-08-01 00:00:00

  • The acute phase protein haptoglobin is locally expressed in arthritic and oncological tissues.

    abstract::Haptoglobin is an acute phase protein known to be highly expressed in the liver. Recently, we showed increased local arterial haptoglobin expression after flow-induced arterial remodelling and found that haptoglobin is involved in cell migration and arterial restructuring probably through accumulation of a temporary g...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2613.2003.00336.x

    authors: Smeets MB,Fontijn J,Kavelaars A,Pasterkamp G,De Kleijn DP

    更新日期:2003-04-01 00:00:00

  • Synergistic action of endothelin (ET)-1 on the activation of bronchial fibroblast isolated from normal and asthmatic subjects.

    abstract::Bronchial subepithelial fibrosis is an histological characteristic of asthma. Cytokines and other mediators, such as PDGF-BB, TGF-beta1 and ET-1 found in the asthmatic submucosa can potentially activate a repair process that leads to fibroblast proliferation and collagen synthesis. The mechanisms of modulation of the ...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2613.2000.00173.x

    authors: Dubé J,Chakir J,Dubé C,Grimard Y,Laviolette M,Boulet LP

    更新日期:2000-12-01 00:00:00

  • Endotoxin is angiogenic.

    abstract::The formation of new blood vessels, angiogenesis, is an important event in inflammation, wound healing and tumour growth. Mediators produced by various cells when exposed to endotoxin include cytokines (tumour necrosis factor, interleukins 1 and 6, and basic fibroblast growth factor) which, it has been suggested, stim...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Mattsby-Baltzer I,Jakobsson A,Sörbo J,Norrby K

    更新日期:1994-06-01 00:00:00

  • Matrix metalloproteinase-2, -9 and -13 are involved in fibronectin degradation of rat lung granulomatous fibrosis caused by Angiostrongylus cantonensis.

    abstract::Pulmonary granuloma formation and fibrosis were experimentally induced in Sprague-Dawley strain rats by Angiostrongylus cantonensis. Increased protein levels of matrix metalloproteinase (MMP)-2, -9, -13 and the imbalance between these enzymes and metalloproteinase inhibitors, tissue inhibitors of MMPs (TIMP-1 and -2),...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2007.00554.x

    authors: Hsu CC,Lai SC

    更新日期:2007-12-01 00:00:00

  • Viruria during acute Japanese encephalitis virus infection.

    abstract::In this study, viruria following Japanese encephalitis virus (JEV) infection in mice has been shown to appear earlier in pregnant than in normal mice with proteinuria and haematuria. This was related to the production of splenic macrophage derived neutrophil chemotactic factor (MDF) following JEV infection. Intravenou...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Mathur A,Khanna N,Kulshreshtha R,Maitra SC,Chaturvedi UC

    更新日期:1995-04-01 00:00:00

  • Specific knock-down of tissue non-specific alkaline phosphatase mRNA levels inhibits intracellular lipid accumulation in 3T3-L1 and HepG2 cells.

    abstract::The use of non-specific inhibitors of tissue non-specific alkaline phosphatase (TNSALP) in pre-adipocytes blocks intracellular lipid accumulation. TNSALP is also expressed in hepatocytes, which are known to accumulate lipid in a similar manner to pre-adipocytes. The purpose of this study was to use specific silencing ...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12243

    authors: Chirambo G,van Niekerk C,Crowther NJ

    更新日期:2017-10-01 00:00:00

  • Cyclophilins and their possible role in the stress response.

    abstract::Cyclophilins are proteins which are remarkably conserved through evolution; moreover they have been found in every possible existing organism, which indicates their fundamental importance. Due to their enzymatic properties, multiplicity, cellular localization and role in protein folding they belong to the group of pro...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2613.1999.00128.x

    authors: Andreeva L,Heads R,Green CJ

    更新日期:1999-12-01 00:00:00

  • Cell proliferation and apoptosis in isoprenaline-induced sialosis in the rat submandibular glands.

    abstract::Regression of submandibular acinar cell hyperplasia after withdrawal of the mitogenic stimulus induced by isoprenaline was studied in male Wistar rats. Intraperitoneal administration of 39 mg of isoprenaline, in divided doses over a 9-day period, resulted in a marked increase in gland size and weight. The proportional...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Chisholm DM,Adi MM

    更新日期:1995-08-01 00:00:00

  • Intracellular location of Mycoplasma genitalium in cultured Vero cells as demonstrated by electron microscopy.

    abstract::The original two strains of Mycoplasma genitalium were isolated from the human urogenital tract. No other strains have been isolated from this site since then. We have recently succeeded in propagating a third strain from a urogenital specimen from a patient with urethritis in Vero cell cultures. By electron microscop...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Jensen JS,Blom J,Lind K

    更新日期:1994-04-01 00:00:00