Abstract：
:Permethrin (PM), a synthetic pyrethroid insecticide, has broad toxicity spectra. We aimed to investigate the effects of PM on the testes of adult albino rats, examine the recovery response and evaluate the efficacy of naringenin (NG) supplementation. Adult male albino rats were randomly assigned to five groups of six each: control, NG (50 mg/kg), PM (70 mg/kg), recovery (after subsequent withdrawal of PM) and NG-PM group. All treatments were given by oral gavage for 6 weeks and another 3 weeks for the recovery group. At the time of sacrifice, each testis was weighed. Biochemical analysis of epididymal sperm count and serum testosterone level was performed. Testes were processed for histological, ultrastructural and c-Kit immunohistochemical study. PM toxicity was evidenced by a highly significant decrease in testicular weight, epididymal sperm count and serum testosterone level compared to control. Furthermore, testicular structure abnormalities and reduced c-Kit immunoreactions were observed. Stoppage of PM in the recovery group partially reversed PM-induced changes. There was a mild decrease in testicular weight and biochemical parameters compared to control. The structure of seminiferous tubules was partially retained. The NG-PM group showed an overall improvement in testicular weight and biochemical alterations which were confirmed by light and electron microscopic examination. In conclusion, PM induced testicular toxicity, which was ameliorated by NG co-administration. However, stoppage of PM exposure was associated with partial recovery.
journal_name
Int J Exp Patholjournal_title
International journal of experimental pathologyauthors
Mostafa Hel-S,Abd El-Baset SA,Kattaia AA,Zidan RA,Al Sadek MMdoi
10.1111/iep.12168subject
Has Abstractpub_date
2016-02-01 00:00:00pages
37-49issue
1eissn
0959-9673issn
1365-2613journal_volume
97pub_type
杂志文章abstract：:Reduced expression of endothelial nitric oxide synthase (eNOS) in chronic liver disease can reduce hepatic perfusion and accelerate fibrosis. The relationship between eNOS expression and liver fibrogenesis remains unclear. We investigated whether L-arginine attenuated chronic liver fibrosis through eNOS expression. Ch...
journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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doi：
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journal_title：International journal of experimental pathology
pub_type： 杂志文章
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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更新日期：1992-10-01 00:00:00
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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doi：
更新日期：1994-12-01 00:00:00
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pub_type： 杂志文章
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journal_title：International journal of experimental pathology
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更新日期：1991-06-01 00:00:00
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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更新日期：1992-04-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：International journal of experimental pathology
pub_type： 杂志文章,评审
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journal_title：International journal of experimental pathology
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更新日期：1991-04-01 00:00:00
abstract：:The interradicular region of primary molars is permeated by many foramina, channels and accessories that connect the pulp cavity with the periapical tissues anatomically. Thus, pulp decomposition products or drugs used in endodontic treatment can trigger inflammatory reactions. The aim of this study was to evaluate th...
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pub_type： 杂志文章
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