Juxtaposition of peroxisomes and chromosomes in mitotic hepatocytes following methyl clofenapate administration to rats.

Abstract:

:Administration of 25 mg/kg/day methyl clofenapate to Alpk/APfSD rats for up to 4 days gave rise to hepatomegaly resulting from a combination of hepatocyte hyperplasia, mainly in the periportal region of the lobule, and centrilobular cell hypertrophy. In hepatocytes undergoing mitosis there was a redistribution of dense vesicles and some peroxisomes to the perinuclear region of the cytoplasm. With increasing length of exposure to methyl clofenapate the number of peroxisomes located in this region during mitosis increased. Chromosomes observed by electron microscopy were seen to lie in close apposition to these organelles. Immunocytochemical localization of the Phase II conjugating enzymes glutathione-S transferase B, C and E showed a dramatic reduction and redistribution of those enzymes in mitotic cells and their absence in the region of the chromosomes. These events may increase the vulnerability of DNA to damage in specific cells.

journal_name

Int J Exp Pathol

authors

Soames AR,Foster JR

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

405-14

issue

6

eissn

0959-9673

issn

1365-2613

journal_volume

75

pub_type

杂志文章
  • Elevated activity of the oxidative and non-oxidative pentose phosphate pathway in (pre)neoplastic lesions in rat liver.

    abstract::(Pre)neoplastic lesions in livers of rats induced by diethylnitrosamine are characterized by elevated activity of the first irreversible enzyme of the oxidative branch of the pentose phosphate pathway (PPP), glucose-6-phosphate dehydrogenase (G6PD), for production of NADPH. In the present study, the activity of G6PD, ...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2008.00582.x

    authors: Frederiks WM,Vizan P,Bosch KS,Vreeling-Sindelárová H,Boren J,Cascante M

    更新日期:2008-08-01 00:00:00

  • Production of salivary microlithiasis in cats by parasympathectomy: light and electron microscopy.

    abstract::Salivary glands of cat were examined from 1 to 42 days following parasympathectomy and compared with contralateral normal control glands. Microliths were detected by light microscopy in none of 11 parotid, 31 out of 41 submandibular and four out of 22 sublingual glands following parasympathectomy, and one out of 19 pa...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Triantafyllou A,Harrison JD,Garrett JR

    更新日期:1993-02-01 00:00:00

  • Erythropoietin is involved in angiogenesis in human primary melanoma.

    abstract::In this study, the extent of angiogenesis, evaluated as microvascular volume density, immunoreactivity of tumour cells to erythropoietin (Epo) and of endothelial cells to Epo receptor (EpoR) have been correlated in human primary melanoma specimens. Results showed that Epo/EpoR expression correlate with angiogenesis an...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2010.00731.x

    authors: Ribatti D,Nico B,Perra MT,Longo V,Maxia C,Annese T,Piras F,Murtas D,Sirigu P

    更新日期:2010-12-01 00:00:00

  • Involvement of platelet activation in experimental osteonecrosis in rabbits.

    abstract::Osteonecrosis (ON) was produced experimentally in rabbits by intravenous injection of platelet activating factor (PAF) in combination with lipopolysaccharides (LPS) on two occasions separated by a week-long interval. Eleven of 15 rabbits (73%), with administration of both LPS (50 microg/kg) and PAF (10 microg/kg), exh...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2613.2001.00202.x

    authors: Masuhara K,Nakata K,Yamasaki S,Miki H,Yoshikawa H

    更新日期:2001-10-01 00:00:00

  • Infection of human monocytes by Leishmania results in a defective oxidative burst.

    abstract::The effect of infection by prototypes from the three major species of Leishmania on the oxidative burst of human mononuclear phagocytes in culture was examined. The presence of intracellular parasites of the three species, L.major, L.donovani and L.mexicana decreased hydrogen peroxide (H2O2) and superoxide anion (O2-)...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Passwell JH,Shor R,Smolen J,Jaffe CL

    更新日期:1994-08-01 00:00:00

  • Cervical thymuses exist, but no cervical thymomas develop in thoracic thymoma-prone BUF rats.

    abstract::To confirm the existence of the cervical thymus and the development of cervical thymoma in thymoma-prone BUF/Mna (BUF) rats, we examined cervical organs and adjacent tissues, and thoracic thymic tissues of the three inbred strains, BUF, ACI/NMna (ACI), and WKY/NCrj (WKY), and 11 congenic strains, in which genetic regi...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2010.00755.x

    authors: Yamada T,Matsuyama M,Yanagida T,Kato K,Sugiura S,Kuroda M

    更新日期:2011-04-01 00:00:00

  • Dysregulation of matrix metalloproteinases and their tissue inhibitors is related to abnormality of left ventricular geometry and function in streptozotocin-induced diabetic minipigs.

    abstract::This study aimed to characterize matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in relation to changes in left ventricle (LV) geometry and function in a porcine model with streptozotocin (STZ)-induced diabetes. In 15 Chinese Guizhou minipigs with STZ-induced diabetes (diabetic group) and 15 age-m...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2008.00579.x

    authors: Lu L,Zhang Q,Pu LJ,Peng WH,Yan XX,Wang LJ,Chen QJ,Zhu ZB,Michel JB,Shen WF

    更新日期:2008-04-01 00:00:00

  • Impaired rejection and mucosal injury of small intestinal allografts lacking the interferon-gamma receptor.

    abstract::Small intestinal mucosal T cell activation results in villous atrophy and crypt hyperplasia. There is conflicting evidence as to whether a Th1 IFN-gamma response may be involved. Using a murine intestinal transplant model of T cell-mediated enteropathy we aimed to study the role of IFN-gamma on the development of vill...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2613.2003.00342.x

    authors: Veitch AM,Higgins LM,Bajaj-Elliot M,Farthing MJ,MacDonald TT

    更新日期:2003-06-01 00:00:00

  • A transmission electron microscopic study of microglia/macrophages in the hippocampal cortex and neocortex following chronic exposure to valproate.

    abstract::In chronic administration of sodium valproate to rats, significant disorders of structural integrity of the hippocampal gyrus and the neocortex of the temporal lobe, observed in the last two stages of the experiment (after 9 and 12 months), coexisted with increased number of microglial cells and, especially after 12 m...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.0959-9673.2005.00417.x

    authors: Sobaniec-Lotowska ME

    更新日期:2005-04-01 00:00:00

  • Age-related histopathological lesions in the Mongolian gerbil ventral prostate as a good model for studies of spontaneous hormone-related disorders.

    abstract::The Meriones unguiculatus (Mongolian) gerbil has demonstrated significant prostatic responses to hormonal treatments, and to drugs against human prostatic hyperplasia. Spontaneous neoplasia develops in the older animals. Thirty gerbils (age 18 months) were divided into non-affected and prostatic lesion bearers and the...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2007.00550.x

    authors: Campos SG,Zanetoni C,Scarano WR,Vilamaior PS,Taboga SR

    更新日期:2008-02-01 00:00:00

  • Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma.

    abstract::A recent global gene expression profiling study unexpectedly showed that activated oncogenic NRAS may recruit neural precursor cell expressed, developmentally downregulated 4L (Nedd4L; a human homologue of Nedd4-2) in cultured melanoma cells. However, whether Nedd4L was expressed in melanoma tissues or participated in...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12051

    authors: Kito Y,Bai J,Goto N,Okubo H,Adachi Y,Nagayama T,Takeuchi T

    更新日期:2014-02-01 00:00:00

  • Comparative histopathology in mouse typhoid among genetically diverse mice.

    abstract::Genetically resistant CBA and A/J mice and susceptible BALB/c and C57BL/6 mice were challenged with either an identical infective dose or a minimal lethal dose of Salmonella typhimurium. The histopathological progression of the disease was examined in tissue sections prepared by the JB-4 Plus resin embedding method an...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2613.1998.00064.x

    authors: Moncure CW,Guo YN,Xu HR,Hsu HS

    更新日期:1998-06-01 00:00:00

  • Histopathology of lymphoid organs in experimental leishmaniasis.

    abstract::Hamsters (Mesocricetus auratus) were inoculated with L. (L.) chagasi and killed on days 7, 15, 30, 45 and 60 after infection. The lymphoid organs developed initial proliferation of the B lymphocyte zone with recovery by the 60th day group when pyroninophilic cells were prominent. The T lymphocyte area showed a progres...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Corbett CE,Paes RA,Laurenti MD,Andrade Júnior HF,Duarte MI

    更新日期:1992-08-01 00:00:00

  • Fell-Muir Lecture: Heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra.

    abstract::Heparan sulphate (HS) sits at the interface of the cell and the extracellular matrix. It is a member of the glycosaminoglycan family of anionic polysaccharides with unique structural features designed for protein interaction and regulation. Its client proteins include soluble effectors (e.g. growth factors, morphogens...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12135

    authors: Gallagher J

    更新日期:2015-08-01 00:00:00

  • Hepatitis B virus and hepatocellular carcinoma.

    abstract::Chronic hepatitis B virus (HBV) infection is a major global cause of hepatocellular carcinoma (HCC). Individuals who are chronic carriers have a greater than 100-fold increased relative risk of developing the tumour. Several mechanisms of HBV-induced HCC have been proposed. Integration of HBV DNA into the genome of he...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2613.2001.iep0082-0077-x

    authors: Arbuthnot P,Kew M

    更新日期:2001-04-01 00:00:00

  • Specific knock-down of tissue non-specific alkaline phosphatase mRNA levels inhibits intracellular lipid accumulation in 3T3-L1 and HepG2 cells.

    abstract::The use of non-specific inhibitors of tissue non-specific alkaline phosphatase (TNSALP) in pre-adipocytes blocks intracellular lipid accumulation. TNSALP is also expressed in hepatocytes, which are known to accumulate lipid in a similar manner to pre-adipocytes. The purpose of this study was to use specific silencing ...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12243

    authors: Chirambo G,van Niekerk C,Crowther NJ

    更新日期:2017-10-01 00:00:00

  • Effects of different doses of nandrolone decanoate on estrous cycle and ovarian tissue of rats after treatment and recovery periods.

    abstract::This study tested the hypothesis that different doses of nandrolone decanoate (ND) will cause changes in the estrous cycle and ovarian tissue of adult rats; and investigated the duration of the recovery period that is sufficient to restore the damage in the animals treated with different doses. Wistar rats were treate...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12144

    authors: Simão VA,Berloffa Belardin L,Araújo Leite GA,de Almeida Chuffa LG,Camargo IC

    更新日期:2015-10-01 00:00:00

  • Liver sinusoidal endothelial cells and acute non-oxidative hepatic injury induced by Pseudomonas aeruginosa pyocyanin.

    abstract::The liver sinusoidal endothelial cell (LSEC) is damaged by many toxins, including oxidants and bacterial toxins. Any effect on LSECs of the Pseudomonas aeruginosa virulence factor, pyocyanin, may be relevant for systemic pseudomonal infections and liver transplantation. In this study, the effects of pyocyanin on in vi...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2008.00602.x

    authors: Cheluvappa R,Cogger VC,Kwun SY,O'Reilly JN,Le Couteur DG,Hilmer SN

    更新日期:2008-12-01 00:00:00

  • Effect of infection by lactic dehydrogenase virus on expression of intercellular adhesion molecule-1 on vascular endothelial cells of pancreatic islets in streptozotocin-induced insulitis of CD-1 mice.

    abstract::Streptozotocin (SZ)-induced insulitis, which is an animal model for insulin-dependent diabetes mellitus, was suppressed by lactic dehydrogenase virus (LDV) infection. There were no differences in degenerative and necrotic changes of islet cells between SZ-treated mice and SZ-treated mice with LDV infection during the ...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Hayashi T,Hashimoto S,Kawashima A

    更新日期:1994-06-01 00:00:00

  • Protective effect of an oestrogen against endotoxin-induced liver enzyme release.

    abstract::Groups of mice were given oestrone acetate or vitamin E subcutaneously to determine how these treatments might modify responses to endotoxic lipopolysaccharide given intraperitoneally. Release of hepatic transaminase and tumour necrosis factor (TNF) into serum and induction of manganous superoxide dismutase in the liv...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Carbarns NJ,Neale ML,Stark JM

    更新日期:1993-06-01 00:00:00

  • Cell proliferation and apoptosis in isoprenaline-induced sialosis in the rat submandibular glands.

    abstract::Regression of submandibular acinar cell hyperplasia after withdrawal of the mitogenic stimulus induced by isoprenaline was studied in male Wistar rats. Intraperitoneal administration of 39 mg of isoprenaline, in divided doses over a 9-day period, resulted in a marked increase in gland size and weight. The proportional...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Chisholm DM,Adi MM

    更新日期:1995-08-01 00:00:00

  • Fell-Muir Lecture: Metalloproteinases: from demolition squad to master regulators.

    abstract::Two families of the Metzincin clan of metalloproteinases, the matrix metalloproteinases and the disintegrin metalloproteinases have attracted much attention as important effectors of cellular interactions with their environment. They appear to play significant roles in the modulation of components of the extracellular...

    journal_title:International journal of experimental pathology

    pub_type:

    doi:10.1111/j.1365-2613.2010.00736.x

    authors: Murphy G

    更新日期:2010-08-01 00:00:00

  • Hydroxymethylnitrofurazone treatment in indeterminate form of chronic Chagas disease: Reduced intensity of tissue parasitism and inflammation-A histopathological study.

    abstract::Hydroxymethylnitrofurazone (NFOH) is a nitrofurazone prodrug effective in vivo during acute infections, and it has less hepatotoxicity effect than the standard drug benznidazole (BZN) which has been used during short- and long-term treatment. In the present study, we induced the indeterminate form of Chagas disease in...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12289

    authors: Scarim CB,de Andrade CR,da Rosa JA,Dos Santos JL,Chin CM

    更新日期:2018-10-01 00:00:00

  • From collagen chemistry towards cell therapy - a personal journey.

    abstract::The Fell-Muir Award requires the recipient to deliver a lecture and a review manuscript which provides a personal overview of significant scientific developments in the field of matrix biology over the period of the recipient's career. In this context, this review considers the collagen family of structural proteins a...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2613.2007.00537.x

    authors: Grant ME

    更新日期:2007-08-01 00:00:00

  • Effects of dietary fatty acids on the early stages of neoplastic induction in the rat pancreas. Changes in fatty acid composition and development of atypical acinar cell nodules.

    abstract::Diets enriched with fat, especially unsaturated fat, promote experimental pancreatic carcinogenesis, but little is known of the effects of individual fatty acids. The effect of stearic and oleic acid on pancreatic fatty acids and atypical acinar cell nodules (preneoplastic lesions) was studied in 14-day-old weanling m...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Khoo DE,Flaks B,Oztas H,Williamson RC,Habib NA

    更新日期:1991-10-01 00:00:00

  • Degenerative and regenerative changes in murine skeletal muscle after injection of venom from the snake Bothrops asper: a histochemical and immunocytochemical study.

    abstract::The degenerative and regenerative changes in murine skeletal muscle after injection of Bothrops asper venom were studied by histological, lectin histochemical and immunocytochemical techniques. According to our observations, the process was divided into four main stages: (a) During the first 3 days prominent degenerat...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Arce V,Brenes F,Gutiérrez JM

    更新日期:1991-04-01 00:00:00

  • Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper.

    abstract::Blister formation and skin damage can be induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper. Pathological changes in the skin were investigated after intramuscular injections of Bothrops asper haemorrhagic metalloproteinase BaP1. Blisters developed within the first hour, with ...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Rucavado A,Núñez J,Gutiérrez JM

    更新日期:1998-08-01 00:00:00

  • Protoporphyrin overload in unrestrained rats: biochemical and histopathologic characterization of a new model of protoporphyric hepatopathy.

    abstract::We determined the feasibility of producing protoporphyric hepatopathy in unrestrained rats by infusing protoporphyrin into their portal circulation via chronic indwelling catheters. Sprague-Dawley rats, 200-300 g, received single (8.5-27.8 mumol) or multiple (64.1-208.7 mumol) infusions of protoporphyrin over 3-240 h....

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Berenson MM,Kimura R,Samowitz W,Bjorkman D

    更新日期:1992-10-01 00:00:00

  • New histological observations in spontaneously developing osteoarthritis in the STR/ORT mouse questioning its acceptability as a model of human osteoarthritis.

    abstract::Naturally developing spontaneous osteoarthritis (OA) is seen in a number of small animals one of which is the STR/ORT mouse, an accepted model of human OA. A histological evaluation of the patello-femoral joints of 37 male STR/ORT mice has shown features that are inconsistent with the disease in human joints. These in...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Das-Gupta EP,Lyons TJ,Hoyland JA,Lawton DM,Freemont AJ

    更新日期:1993-12-01 00:00:00

  • Does an anti-oxidant ascorbic acid improve the condition of hippocampal formation slice preparations? A micro-EEG approach.

    abstract::The objective of this study was to assess whether ascorbic acid (AA), an intracellular anti-oxidant critical for neuronal protection, when added to artificial cerebrospinal fluid (ACSF), is able to protect hippocampal (HPC) formation slice preparations from ageing. In this research, the micro-electroencephalographic (...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2012.00838.x

    authors: Kazmierska P,Grebowski J,Konopacki J

    更新日期:2012-12-01 00:00:00