Abstract:
:Administration of 25 mg/kg/day methyl clofenapate to Alpk/APfSD rats for up to 4 days gave rise to hepatomegaly resulting from a combination of hepatocyte hyperplasia, mainly in the periportal region of the lobule, and centrilobular cell hypertrophy. In hepatocytes undergoing mitosis there was a redistribution of dense vesicles and some peroxisomes to the perinuclear region of the cytoplasm. With increasing length of exposure to methyl clofenapate the number of peroxisomes located in this region during mitosis increased. Chromosomes observed by electron microscopy were seen to lie in close apposition to these organelles. Immunocytochemical localization of the Phase II conjugating enzymes glutathione-S transferase B, C and E showed a dramatic reduction and redistribution of those enzymes in mitotic cells and their absence in the region of the chromosomes. These events may increase the vulnerability of DNA to damage in specific cells.
journal_name
Int J Exp Patholjournal_title
International journal of experimental pathologyauthors
Soames AR,Foster JRsubject
Has Abstractpub_date
1994-12-01 00:00:00pages
405-14issue
6eissn
0959-9673issn
1365-2613journal_volume
75pub_type
杂志文章abstract::(Pre)neoplastic lesions in livers of rats induced by diethylnitrosamine are characterized by elevated activity of the first irreversible enzyme of the oxidative branch of the pentose phosphate pathway (PPP), glucose-6-phosphate dehydrogenase (G6PD), for production of NADPH. In the present study, the activity of G6PD, ...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2008.00582.x
更新日期:2008-08-01 00:00:00
abstract::Salivary glands of cat were examined from 1 to 42 days following parasympathectomy and compared with contralateral normal control glands. Microliths were detected by light microscopy in none of 11 parotid, 31 out of 41 submandibular and four out of 22 sublingual glands following parasympathectomy, and one out of 19 pa...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract::In this study, the extent of angiogenesis, evaluated as microvascular volume density, immunoreactivity of tumour cells to erythropoietin (Epo) and of endothelial cells to Epo receptor (EpoR) have been correlated in human primary melanoma specimens. Results showed that Epo/EpoR expression correlate with angiogenesis an...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2010.00731.x
更新日期:2010-12-01 00:00:00
abstract::Osteonecrosis (ON) was produced experimentally in rabbits by intravenous injection of platelet activating factor (PAF) in combination with lipopolysaccharides (LPS) on two occasions separated by a week-long interval. Eleven of 15 rabbits (73%), with administration of both LPS (50 microg/kg) and PAF (10 microg/kg), exh...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1046/j.1365-2613.2001.00202.x
更新日期:2001-10-01 00:00:00
abstract::The effect of infection by prototypes from the three major species of Leishmania on the oxidative burst of human mononuclear phagocytes in culture was examined. The presence of intracellular parasites of the three species, L.major, L.donovani and L.mexicana decreased hydrogen peroxide (H2O2) and superoxide anion (O2-)...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract::To confirm the existence of the cervical thymus and the development of cervical thymoma in thymoma-prone BUF/Mna (BUF) rats, we examined cervical organs and adjacent tissues, and thoracic thymic tissues of the three inbred strains, BUF, ACI/NMna (ACI), and WKY/NCrj (WKY), and 11 congenic strains, in which genetic regi...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2010.00755.x
更新日期:2011-04-01 00:00:00
abstract::This study aimed to characterize matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in relation to changes in left ventricle (LV) geometry and function in a porcine model with streptozotocin (STZ)-induced diabetes. In 15 Chinese Guizhou minipigs with STZ-induced diabetes (diabetic group) and 15 age-m...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2008.00579.x
更新日期:2008-04-01 00:00:00
abstract::Small intestinal mucosal T cell activation results in villous atrophy and crypt hyperplasia. There is conflicting evidence as to whether a Th1 IFN-gamma response may be involved. Using a murine intestinal transplant model of T cell-mediated enteropathy we aimed to study the role of IFN-gamma on the development of vill...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1046/j.1365-2613.2003.00342.x
更新日期:2003-06-01 00:00:00
abstract::In chronic administration of sodium valproate to rats, significant disorders of structural integrity of the hippocampal gyrus and the neocortex of the temporal lobe, observed in the last two stages of the experiment (after 9 and 12 months), coexisted with increased number of microglial cells and, especially after 12 m...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.0959-9673.2005.00417.x
更新日期:2005-04-01 00:00:00
abstract::The Meriones unguiculatus (Mongolian) gerbil has demonstrated significant prostatic responses to hormonal treatments, and to drugs against human prostatic hyperplasia. Spontaneous neoplasia develops in the older animals. Thirty gerbils (age 18 months) were divided into non-affected and prostatic lesion bearers and the...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2007.00550.x
更新日期:2008-02-01 00:00:00
abstract::A recent global gene expression profiling study unexpectedly showed that activated oncogenic NRAS may recruit neural precursor cell expressed, developmentally downregulated 4L (Nedd4L; a human homologue of Nedd4-2) in cultured melanoma cells. However, whether Nedd4L was expressed in melanoma tissues or participated in...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12051
更新日期:2014-02-01 00:00:00
abstract::Genetically resistant CBA and A/J mice and susceptible BALB/c and C57BL/6 mice were challenged with either an identical infective dose or a minimal lethal dose of Salmonella typhimurium. The histopathological progression of the disease was examined in tissue sections prepared by the JB-4 Plus resin embedding method an...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1046/j.1365-2613.1998.00064.x
更新日期:1998-06-01 00:00:00
abstract::Hamsters (Mesocricetus auratus) were inoculated with L. (L.) chagasi and killed on days 7, 15, 30, 45 and 60 after infection. The lymphoid organs developed initial proliferation of the B lymphocyte zone with recovery by the 60th day group when pyroninophilic cells were prominent. The T lymphocyte area showed a progres...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract::Heparan sulphate (HS) sits at the interface of the cell and the extracellular matrix. It is a member of the glycosaminoglycan family of anionic polysaccharides with unique structural features designed for protein interaction and regulation. Its client proteins include soluble effectors (e.g. growth factors, morphogens...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12135
更新日期:2015-08-01 00:00:00
abstract::Chronic hepatitis B virus (HBV) infection is a major global cause of hepatocellular carcinoma (HCC). Individuals who are chronic carriers have a greater than 100-fold increased relative risk of developing the tumour. Several mechanisms of HBV-induced HCC have been proposed. Integration of HBV DNA into the genome of he...
journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2613.2001.iep0082-0077-x
更新日期:2001-04-01 00:00:00
abstract::The use of non-specific inhibitors of tissue non-specific alkaline phosphatase (TNSALP) in pre-adipocytes blocks intracellular lipid accumulation. TNSALP is also expressed in hepatocytes, which are known to accumulate lipid in a similar manner to pre-adipocytes. The purpose of this study was to use specific silencing ...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12243
更新日期:2017-10-01 00:00:00
abstract::This study tested the hypothesis that different doses of nandrolone decanoate (ND) will cause changes in the estrous cycle and ovarian tissue of adult rats; and investigated the duration of the recovery period that is sufficient to restore the damage in the animals treated with different doses. Wistar rats were treate...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12144
更新日期:2015-10-01 00:00:00
abstract::The liver sinusoidal endothelial cell (LSEC) is damaged by many toxins, including oxidants and bacterial toxins. Any effect on LSECs of the Pseudomonas aeruginosa virulence factor, pyocyanin, may be relevant for systemic pseudomonal infections and liver transplantation. In this study, the effects of pyocyanin on in vi...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2008.00602.x
更新日期:2008-12-01 00:00:00
abstract::Streptozotocin (SZ)-induced insulitis, which is an animal model for insulin-dependent diabetes mellitus, was suppressed by lactic dehydrogenase virus (LDV) infection. There were no differences in degenerative and necrotic changes of islet cells between SZ-treated mice and SZ-treated mice with LDV infection during the ...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract::Groups of mice were given oestrone acetate or vitamin E subcutaneously to determine how these treatments might modify responses to endotoxic lipopolysaccharide given intraperitoneally. Release of hepatic transaminase and tumour necrosis factor (TNF) into serum and induction of manganous superoxide dismutase in the liv...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00
abstract::Regression of submandibular acinar cell hyperplasia after withdrawal of the mitogenic stimulus induced by isoprenaline was studied in male Wistar rats. Intraperitoneal administration of 39 mg of isoprenaline, in divided doses over a 9-day period, resulted in a marked increase in gland size and weight. The proportional...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1995-08-01 00:00:00
abstract::Two families of the Metzincin clan of metalloproteinases, the matrix metalloproteinases and the disintegrin metalloproteinases have attracted much attention as important effectors of cellular interactions with their environment. They appear to play significant roles in the modulation of components of the extracellular...
journal_title:International journal of experimental pathology
pub_type:
doi:10.1111/j.1365-2613.2010.00736.x
更新日期:2010-08-01 00:00:00
abstract::Hydroxymethylnitrofurazone (NFOH) is a nitrofurazone prodrug effective in vivo during acute infections, and it has less hepatotoxicity effect than the standard drug benznidazole (BZN) which has been used during short- and long-term treatment. In the present study, we induced the indeterminate form of Chagas disease in...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12289
更新日期:2018-10-01 00:00:00
abstract::The Fell-Muir Award requires the recipient to deliver a lecture and a review manuscript which provides a personal overview of significant scientific developments in the field of matrix biology over the period of the recipient's career. In this context, this review considers the collagen family of structural proteins a...
journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2613.2007.00537.x
更新日期:2007-08-01 00:00:00
abstract::Diets enriched with fat, especially unsaturated fat, promote experimental pancreatic carcinogenesis, but little is known of the effects of individual fatty acids. The effect of stearic and oleic acid on pancreatic fatty acids and atypical acinar cell nodules (preneoplastic lesions) was studied in 14-day-old weanling m...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
abstract::The degenerative and regenerative changes in murine skeletal muscle after injection of Bothrops asper venom were studied by histological, lectin histochemical and immunocytochemical techniques. According to our observations, the process was divided into four main stages: (a) During the first 3 days prominent degenerat...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract::Blister formation and skin damage can be induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper. Pathological changes in the skin were investigated after intramuscular injections of Bothrops asper haemorrhagic metalloproteinase BaP1. Blisters developed within the first hour, with ...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::We determined the feasibility of producing protoporphyric hepatopathy in unrestrained rats by infusing protoporphyrin into their portal circulation via chronic indwelling catheters. Sprague-Dawley rats, 200-300 g, received single (8.5-27.8 mumol) or multiple (64.1-208.7 mumol) infusions of protoporphyrin over 3-240 h....
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract::Naturally developing spontaneous osteoarthritis (OA) is seen in a number of small animals one of which is the STR/ORT mouse, an accepted model of human OA. A histological evaluation of the patello-femoral joints of 37 male STR/ORT mice has shown features that are inconsistent with the disease in human joints. These in...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract::The objective of this study was to assess whether ascorbic acid (AA), an intracellular anti-oxidant critical for neuronal protection, when added to artificial cerebrospinal fluid (ACSF), is able to protect hippocampal (HPC) formation slice preparations from ageing. In this research, the micro-electroencephalographic (...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2012.00838.x
更新日期:2012-12-01 00:00:00