Elevated activity of the oxidative and non-oxidative pentose phosphate pathway in (pre)neoplastic lesions in rat liver.

abstract：:BALB/c and CBA mice maintained on low (4%) or normal (18%) protein diets for 2 weeks after weaning were infected with a sublethal dose of murine cytomegalovirus, adjusted in proportion to body weight. Viral replication, histopathological changes and humoral responses to the virus were compared between the dietary grou...

journal_title：International journal of experimental pathology

authors： Teo HK,Price P,Papadimitriou JM

更新日期：1991-02-01 00:00:00

abstract：:An important means of determining how amyloid-beta peptide (Abeta) affects cells is to identify specific macromolecular targets and assess how Abeta interaction with such targets impacts on cellular functions. On the one hand, cell surface receptors interacting with extracellular Abeta have been identified, and their ...

journal_title：International journal of experimental pathology

authors： Yan SD,Stern DM

更新日期：2005-06-01 00:00:00

abstract：:We have shown previously that cycloheximide (CHX), a potent protein synthesis inhibitor, induces high levels of apoptosis in Epstein-Barr virus free (EBV(-)) Burkitt's lymphoma (BJA-B) cells, with comparably reduced levels of apoptosis in the EBV positive (EBV(+)) cells. Modulation of CHX-induced apoptosis in EBV(-) a...

journal_title：International journal of experimental pathology

authors： Ishii H,Tamauchi H,Gobe GC

更新日期：1997-06-01 00:00:00

abstract：:Haptoglobin is an acute phase protein known to be highly expressed in the liver. Recently, we showed increased local arterial haptoglobin expression after flow-induced arterial remodelling and found that haptoglobin is involved in cell migration and arterial restructuring probably through accumulation of a temporary g...

journal_title：International journal of experimental pathology

authors： Smeets MB,Fontijn J,Kavelaars A,Pasterkamp G,De Kleijn DP

更新日期：2003-04-01 00:00:00

abstract：:Duchenne's muscular dystrophy (DMD) is a lethal childhood disease caused by mutations of the dystrophin gene, the protein product of which, dystrophin, has a vital role in maintaining muscle structure and function. Homologues of DMD have been identified in several animals including dogs, cats, mice, fish and invertebr...

journal_title：International journal of experimental pathology

authors： Collins CA,Morgan JE

更新日期：2003-08-01 00:00:00

abstract：:Leprosy is a disease consisting of a spectrum of clinical, bacteriological, histopathological and immunological manifestations. Tuberculoid leprosy is frequently recognized as the benign polar form of the disease, while lepromatous leprosy is regarded as the malignant form. The different forms of leprosy depend on the...

journal_title：International journal of experimental pathology

authors： Juarez-Ortega M,Hernandez VG,Arce-Paredes P,Villanueva EB,Aguilar-Santelises M,Rojas-Espinosa O

更新日期：2015-02-01 00:00:00

abstract：:Regression of submandibular acinar cell hyperplasia after withdrawal of the mitogenic stimulus induced by isoprenaline was studied in male Wistar rats. Intraperitoneal administration of 39 mg of isoprenaline, in divided doses over a 9-day period, resulted in a marked increase in gland size and weight. The proportional...

journal_title：International journal of experimental pathology

authors： Chisholm DM,Adi MM

更新日期：1995-08-01 00:00:00

abstract：:Streptozotocin (SZ)-induced insulitis, which is an animal model for insulin-dependent diabetes mellitus, was suppressed by lactic dehydrogenase virus (LDV) infection. There were no differences in degenerative and necrotic changes of islet cells between SZ-treated mice and SZ-treated mice with LDV infection during the ...

journal_title：International journal of experimental pathology

authors： Hayashi T,Hashimoto S,Kawashima A

更新日期：1994-06-01 00:00:00

abstract：:The aim of this study was to estimate the relationship of endothelial dysfunction induced by intracellular S-adenosylhomocysteine (SAH) accumulation and DNA methylation in human umbilical vein endothelial cells (HUVEC). The isolated HUVEC were incubated with 3-deazaadenosine (DZA) to induce experimental intracellular ...

journal_title：International journal of experimental pathology

authors： Yu X,Ling W,Mi M

更新日期：2009-12-01 00:00:00

abstract：:Long-term intragastric administration of the antiepileptic drug sodium valproate (Vuprol Polfa) to rats for 1, 3, 6, 9 and 12 months, once daily at the effective dose of 200 mg/kg body weight showed morphological evidence of encephalopathy, manifested by numerous nonspecific changes within Purkinje cell perikarya and ...

journal_title：International journal of experimental pathology

authors： Sobaniec-Lotowska ME

更新日期：2001-12-01 00:00:00

abstract：:In order to clarify the function of hepatocyte growth factor (HGF) in vivo, we have developed transgenic mice expressing HGF in the liver. The bromodeoxyuridine labelling indices in livers from HGF transgenic mice were doubled, compared to those from wild type mice. Livers of HGF transgenic mice expressed high levels ...

journal_title：International journal of experimental pathology

authors： Shiota G,Kawasaki H

更新日期：1998-10-01 00:00:00

abstract：:Groups of mice were given oestrone acetate or vitamin E subcutaneously to determine how these treatments might modify responses to endotoxic lipopolysaccharide given intraperitoneally. Release of hepatic transaminase and tumour necrosis factor (TNF) into serum and induction of manganous superoxide dismutase in the liv...

journal_title：International journal of experimental pathology

authors： Carbarns NJ,Neale ML,Stark JM

更新日期：1993-06-01 00:00:00

abstract：:The aim of this study was to evaluate the use of flaxseed in animals subjected to ethanol-induced hepatotoxicity. Twenty-four male rats were divided into four groups (n = 6): control group (CG) which received a control diet and water ad libitum; flaxseed group (FG) which received control diet with an addition of 25% f...

journal_title：International journal of experimental pathology

authors： Latini JTP,Vicente GC,Velarde LGC,Benedicto HG,de Castro Resende Â,Teixeira MT,de Almeida KCL,Boaventura GT

更新日期：2018-10-01 00:00:00

abstract：:The aim of the present study was to clarify the therapeutic effects of 1alpha, 25[OH]2 vitamin D3 (calcitriol) pulse injection on bone lesions induced in a rat model of chronic cadmium toxicosis. Ovariectomized (OVX) and control-operated (sham-OVX) rats were given repeated intravenous injections of 0.5 mg/kg/day CdCl2...

journal_title：International journal of experimental pathology

authors： Kurata Y,Katsuta O,Hiratsuka H,Tsuchitani M,Umemura T

更新日期：2001-02-01 00:00:00

abstract：:Minaçu virus was isolated from Ochlerotatus scapularis (Diptera: Culicidae) in Minaçu, Goiás State, Brazil, in 1996. In attempting characterization of virus serological (hemagluttination inhibition, HI; indirect immunofluorescence assay, IFA), physicochemical [test for deoxycholate acid (DCA) sensitivity; polyacrylami...

journal_title：International journal of experimental pathology

authors： Martins LC,Diniz JA,Silva EV,Barros VL,Monteiro HA,Azevedo RS,Quaresma JA,Vasconcelos PF

更新日期：2007-02-01 00:00:00

abstract：:C-cell tumours of the thyroid gland are among the most common spontaneous neoplasms of the laboratory rat. With the exception of calcitonin, little attention has been paid to the secretory peptides of C cells during the development of neoplasia. Of these peptides, somatostatin (SS) is of particular interest because it...

journal_title：International journal of experimental pathology

authors： Pilling A,Jones S,Turton J

更新日期：2004-02-01 00:00:00

abstract：:In this study, the extent of angiogenesis, evaluated as microvascular volume density, immunoreactivity of tumour cells to erythropoietin (Epo) and of endothelial cells to Epo receptor (EpoR) have been correlated in human primary melanoma specimens. Results showed that Epo/EpoR expression correlate with angiogenesis an...

journal_title：International journal of experimental pathology

authors： Ribatti D,Nico B,Perra MT,Longo V,Maxia C,Annese T,Piras F,Murtas D,Sirigu P

更新日期：2010-12-01 00:00:00

abstract：:Osteonecrosis (ON) was produced experimentally in rabbits by intravenous injection of platelet activating factor (PAF) in combination with lipopolysaccharides (LPS) on two occasions separated by a week-long interval. Eleven of 15 rabbits (73%), with administration of both LPS (50 microg/kg) and PAF (10 microg/kg), exh...

journal_title：International journal of experimental pathology

authors： Masuhara K,Nakata K,Yamasaki S,Miki H,Yoshikawa H

更新日期：2001-10-01 00:00:00

abstract：:The preovulatory follicle provides a unique physiological example of rapid growth accompanied by neovascularization, two processes that are generally characteristic of pathologies such as wound repair or malignancy. During the hours preceding ovulation, follicular growth is accompanied by elevated levels of messenger ...

journal_title：International journal of experimental pathology

authors： Neeman M,Abramovitch R,Schiffenbauer YS,Tempel C

更新日期：1997-04-01 00:00:00

abstract：:Blister formation and skin damage can be induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper. Pathological changes in the skin were investigated after intramuscular injections of Bothrops asper haemorrhagic metalloproteinase BaP1. Blisters developed within the first hour, with ...

journal_title：International journal of experimental pathology

authors： Rucavado A,Núñez J,Gutiérrez JM

更新日期：1998-08-01 00:00:00

abstract：:The relationship between donor age and the growth characteristics of normal human smooth muscle cell cultures derived from aorta and stomach was examined in a series of growth studies. A negative correlation was demonstrated between donor age and growth potential of both cell types in primary culture. This decreased g...

journal_title：International journal of experimental pathology

authors： Start RD,Loomes RS,Shortland JR

更新日期：1991-12-01 00:00:00

abstract：:Over the past 40 years there have been giant steps forward in our understanding of cellular and molecular biology that have given us the framework by which to understand tissue organization and tissue function on a range of scales. However, although the progress has been great, the more we have discovered, the more we...

journal_title：International journal of experimental pathology

authors： Hardingham TE

更新日期：2010-06-01 00:00:00

abstract：:In this study we have explored the pathogenesis of the hepatic alterations which occur in diabetes and the modulation of these complications by the combination of metformin adjunct treatment and insulin monotherapy. For this purpose, diabetic rats were treated with insulin (DM + Ins) or metformin plus insulin (DM + Me...

journal_title：International journal of experimental pathology

authors： Silvares RR,Pereira EN,Flores EE,Estato V,Reis PA,Silva IJ,Machado MP,Neto HC,Tibiriça E,Daliry A

更新日期：2016-06-01 00:00:00

abstract：:The role of lymphocytes in the pathogenesis of lung fibrosis is not clear, but the weight of the evidence supports a pro-fibrotic effect for lymphocytes. The high-affinity interleukin-2 receptor (haIL-2R) is expressed on activated, but not quiescent, T lymphocytes. This selective expression of haIL-2R provides the bas...

journal_title：International journal of experimental pathology

authors： Segel MJ,Aqeilan R,Zilka K,Lorberboum-Galski H,Wallach-Dayan SB,Conner MW,Christensen TG,Breuer R

更新日期：2005-10-01 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) is one of the life-threatening hepatic diseases; however, its pathogenesis is still unknown. To evaluate the causative role of hyperlipidaemia and high-fat diet, we compared C57BL/6 mice with inherited hyperlipidaemic model mice (LDLR(-/-)mice and ApoE(-/-) mice) fed a normal or a h...

journal_title：International journal of experimental pathology

authors： Yoshimatsu M,Terasaki Y,Sakashita N,Kiyota E,Sato H,van der Laan LJ,Takeya M

更新日期：2004-12-01 00:00:00

abstract：:Most patients with epithelial ovarian cancer (EOC) are diagnosed at an advanced stage, and therapeutic options for these patients are limited. The identification of suitable biomarkers could be helpful for patients with EOC, who might benefit from targeted therapies even in advanced stages of the disease. Trophoblast ...

journal_title：International journal of experimental pathology

authors： Xu N,Zhang Z,Zhu J,Xu L,Li Y,Duan L,Mao Y,Li H

更新日期：2016-04-01 00:00:00

abstract：:The Epstein-Barr virus (EBV) is a herpes virus which establishes a life-long persistent infection in over 90% of the human adult population world-wide. Based on its association with a variety of lymphoid and epithelial malignancies, EBV has been classified as a group 1 carcinogen by the International Agency for Resear...

journal_title：International journal of experimental pathology

authors： Niedobitek G,Meru N,Delecluse HJ

更新日期：2001-06-01 00:00:00

abstract：:Pathological and immunopathological studies were carried out on snake coiled fibres (SCF) which occurred in affected soleus muscle in chloroquine treated rats. The SCF began to appear in denervated soleus muscle by 8 days after chloroquine injection. By day 14, typical SCF were observed with an unusual swirling patter...

journal_title：International journal of experimental pathology

authors： Tsuzuki K,Fukatsu R,Takamaru Y,Yoshida T,Hayashi Y,Kobayashi K,Fujii N,Takahata N

更新日期：1997-02-01 00:00:00

abstract：:Dengue type 2 virus (DV) induces a subpopulation of T lymphocytes of mouse spleen to secrete a soluble helper cytokine (HF) which enhances the DV-specific IgM antibody plaque forming cells (PFC). The present study undertaken to purify and characterize HF shows that it can be purified by low pressure liquid chromatogra...

journal_title：International journal of experimental pathology

authors： Chaturvedi P,Mukherjee R,Chaturvedi UC,Mathur A

更新日期：1992-06-01 00:00:00

abstract：:Bronchial subepithelial fibrosis is an histological characteristic of asthma. Cytokines and other mediators, such as PDGF-BB, TGF-beta1 and ET-1 found in the asthmatic submucosa can potentially activate a repair process that leads to fibroblast proliferation and collagen synthesis. The mechanisms of modulation of the ...

journal_title：International journal of experimental pathology

authors： Dubé J,Chakir J,Dubé C,Grimard Y,Laviolette M,Boulet LP

更新日期：2000-12-01 00:00:00