Abstract:
:Streptozotocin (SZ)-induced insulitis, which is an animal model for insulin-dependent diabetes mellitus, was suppressed by lactic dehydrogenase virus (LDV) infection. There were no differences in degenerative and necrotic changes of islet cells between SZ-treated mice and SZ-treated mice with LDV infection during the pre-insulitis phase. The degree of insulitis was more severe and the plasma glucose levels were higher in SZ-treated mice than in SZ-treated mice with LDV infection. Severe degenerative and necrotic changes of cells with mononuclear cell infiltration into the islets were seen in the SZ-treated mice. Infiltration of these cells into islets was less in SZ-treated mice with LDV infection. During the pre-insulitis phase, there was slight expression of intercellular adhesion molecule-1 (ICAM-1) on the surface of vascular endothelial cells in and/or around islets in both groups. ICAM-1 expression on vascular endothelial cells increased in parallel to the degree of insulitis. The degree of this expression in SZ-treated mice was higher than in SZ-treated mice with LDV infection. These results suggest that expression of ICAM-1 on vascular endothelial cells in SZ-treated mice may be important for the development of insulitis. Also, decreased expression of ICAM-1 in the islets may be responsible for the inhibition of the development of insulitis seen in SZ-treated mice with LDV infection.
journal_name
Int J Exp Patholjournal_title
International journal of experimental pathologyauthors
Hayashi T,Hashimoto S,Kawashima Asubject
Has Abstractpub_date
1994-06-01 00:00:00pages
211-7issue
3eissn
0959-9673issn
1365-2613journal_volume
75pub_type
杂志文章abstract::Heart failure (HF) is characterized by a skeletal muscle myopathy with increased expression of fast myosin heavy chains (MHCs). The skeletal muscle-specific molecular regulatory mechanisms controlling MHC expression during HF have not been described. Myogenic regulatory factors (MRFs), a family of transcriptional fact...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2006.00475.x
更新日期:2006-06-01 00:00:00
abstract::Ultraviolet ray B (UV-B) induced dermatitis in the rat may be a model for human psoriasis vulgaris. Detailed studies of this model are reported. Rat skin responded to UV-B irradiation quite differently from human, guinea-pig, or mouse skin. Rat UV-B dermatitis was characterized by a sharply demarcated brownish-red les...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract::The formation of new blood vessels, angiogenesis, is an important event in inflammation, wound healing and tumour growth. Mediators produced by various cells when exposed to endotoxin include cytokines (tumour necrosis factor, interleukins 1 and 6, and basic fibroblast growth factor) which, it has been suggested, stim...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract::Systemic hypertension, characterized by elevated blood pressure ≥140/90 mm Hg, is a major modifiable risk factor for cardiovascular disease. Hypertension also associates with non-alcoholic fatty liver disease (NAFLD), which is becoming common due to a modern diet and lifestyle. The aim of the present study was to exam...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12369
更新日期:2020-10-01 00:00:00
abstract::The α2-adrenoceptors regulate the sympathetic nervous system, controlling presynaptic catecholamine release. However, the role of the α2-adrenoceptors in cutaneous wound healing is poorly understood. Mice lacking both the α2A/α2C-adrenoceptors were used to evaluate the participation of the α2-adrenoceptor during cutan...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12093
更新日期:2014-10-01 00:00:00
abstract::Administration of 25 mg/kg/day methyl clofenapate to Alpk/APfSD rats for up to 4 days gave rise to hepatomegaly resulting from a combination of hepatocyte hyperplasia, mainly in the periportal region of the lobule, and centrilobular cell hypertrophy. In hepatocytes undergoing mitosis there was a redistribution of dens...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::Ischaemic-reperfusion injury as a model of acute renal failure (ARF) results in increased macromolecular permeability, tubular obstruction, and renal oedema. To investigate the role for coagulation in this model, anticoagulated and saline-pretreated rats were subjected to 60 min unilateral renal artery occlusion (RAO)...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1046/j.1365-2613.1998.00055.x
更新日期:1998-02-01 00:00:00
abstract::The relationship between donor age and the growth characteristics of normal human smooth muscle cell cultures derived from aorta and stomach was examined in a series of growth studies. A negative correlation was demonstrated between donor age and growth potential of both cell types in primary culture. This decreased g...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract::In this study, the extent of angiogenesis, evaluated as microvascular volume density, immunoreactivity of tumour cells to erythropoietin (Epo) and of endothelial cells to Epo receptor (EpoR) have been correlated in human primary melanoma specimens. Results showed that Epo/EpoR expression correlate with angiogenesis an...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2010.00731.x
更新日期:2010-12-01 00:00:00
abstract::Recently, there have been significant advances toward the development of culture conditions that promote proliferation of primary rodent hepatocytes. There are two major methods for the multiplication of hepatocytes in vitro: one is the use of nicotinamide, the other is the use of a nutrient-rich medium. In the medium...
journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2613.1998.00083.x
更新日期:1998-12-01 00:00:00
abstract::Salivary glands of cat were examined from 1 to 42 days following parasympathectomy and compared with contralateral normal control glands. Microliths were detected by light microscopy in none of 11 parotid, 31 out of 41 submandibular and four out of 22 sublingual glands following parasympathectomy, and one out of 19 pa...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract::C-cell tumours of the thyroid gland are among the most common spontaneous neoplasms of the laboratory rat. With the exception of calcitonin, little attention has been paid to the secretory peptides of C cells during the development of neoplasia. Of these peptides, somatostatin (SS) is of particular interest because it...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.0959-9673.2004.00367.x
更新日期:2004-02-01 00:00:00
abstract::Mitochondrial DNA (mt-DNA) disorders and abnormal regulation of nuclear-derived proteins devoted to the cross-talk between the two cellular genomes have recently interested researchers in the field of neuromuscular diseases. We have identified, isolated and sequenced a new gene, augmenter of liver regeneration (ALR) t...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2009.00639.x
更新日期:2009-08-01 00:00:00
abstract::The acute phase of experimental Chagas' disease in rats is associated with early lesions of the post-ganglionic sympathetic nerve terminals of the heart, the varicosities being the target. In the superior cervical and stellate ganglia the preganglionic fibres showed no signs of lesion in the course of experimental Cha...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1046/j.1365-2613.1996.00971.x
更新日期:1996-06-01 00:00:00
abstract::Nonalcoholic steatohepatitis (NASH) is one of the life-threatening hepatic diseases; however, its pathogenesis is still unknown. To evaluate the causative role of hyperlipidaemia and high-fat diet, we compared C57BL/6 mice with inherited hyperlipidaemic model mice (LDLR(-/-)mice and ApoE(-/-) mice) fed a normal or a h...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.0959-9673.2004.00401.x
更新日期:2004-12-01 00:00:00
abstract::The role of lymphocytes in the pathogenesis of lung fibrosis is not clear, but the weight of the evidence supports a pro-fibrotic effect for lymphocytes. The high-affinity interleukin-2 receptor (haIL-2R) is expressed on activated, but not quiescent, T lymphocytes. This selective expression of haIL-2R provides the bas...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.0959-9673.2005.00436.x
更新日期:2005-10-01 00:00:00
abstract::Blister formation and skin damage can be induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper. Pathological changes in the skin were investigated after intramuscular injections of Bothrops asper haemorrhagic metalloproteinase BaP1. Blisters developed within the first hour, with ...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::Duchenne's muscular dystrophy (DMD) is a lethal childhood disease caused by mutations of the dystrophin gene, the protein product of which, dystrophin, has a vital role in maintaining muscle structure and function. Homologues of DMD have been identified in several animals including dogs, cats, mice, fish and invertebr...
journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2613.2003.00354.x
更新日期:2003-08-01 00:00:00
abstract::Young adult mice infected with MCMV were shown to develop inflammatory lesions in the peripancreatic and salivary gland adipose tissues. MCMV replication was detected by immunoperoxidase staining and electron microscopy in adipocytes, fibroblasts, endothelial cells and pericytes in brown and white adipose tissues. Mor...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1990-08-01 00:00:00
abstract::Up to 40% of children with Reye's syndrome have hypoglycaemia that could contribute to the patient's encephalopathy. We developed a mouse model in which intravenous inoculation of influenza B/Lee virus produced a non-permissive infection of hepatocytes and cerebral endothelial cells and caused many clinical, biochemic...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00
abstract::The present study was carried out to investigate the role of hypertension in the genesis and localization of intimal lesions and medial remodelling found in the prestenotic segment in relation to a severe stenosis of the abdominal aorta just below the diaphragm. Male young rats were divided randomly into operated grou...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2006.00506.x
更新日期:2006-12-01 00:00:00
abstract::The objectives of this work were to study some pathological aspects of kidneys obtained from dogs naturally infected with Leishmania infantum and from dogs experimentally infected with two different strains of L infantum with special emphasis on fibrotic process. Seventy eight specimens of paraffin-embedded kidney fra...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12321
更新日期:2019-08-01 00:00:00
abstract::Athymic (nude) mice were experimentally infected with Mycobacterium leprae via the alimentary and respiratory tracts and through the skin. Animals were allowed to inhale aerosols of M. leprae or had bacilli instilled into the nostrils or directly into the lungs. Others were fed M. leprae by gastric tube or had bacilli...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::Tumour growth is angiogenesis dependent. Thrombosis and thromboembolism are very common in cancer patients. These patients are often treated with heparin as an anti-coagulant. Many tumour angiogens, including VEGF165, and endogenous anti-angiogenesis factors bind heparin tightly. Using the non-surgical mesenteric-wind...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1046/j.1365-2613.2000.00150.x
更新日期:2000-06-01 00:00:00
abstract::Pterygium is a surface ocular lesion that is associated with chronic UV exposure. The primary effect is a solar actinic elastosis within the stroma. All the other changes are secondary. Pterygium is characterized by proliferation, inflammatory infiltrates, fibrosis, angiogenesis and extracellular matrix breakdown. The...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2009.00665.x
更新日期:2009-12-01 00:00:00
abstract::Conventional therapies for low back pain (LBP) are purely symptomatic and do not target the cause of LBP, which in approximately 40% of cases is caused by degeneration of the intervertebral disc (DIVD). Targeting therapies to inhibit the process of degeneration would be a potentially valuable treatment for LBP. There ...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.0959-9673.2006.00449.x
更新日期:2006-02-01 00:00:00
abstract::Although the exact mechanism for the progression of myelofibrosis in acute megakaryoblastic leukaemia is unclear, certain humoral factors released from the proliferating megakaryoblasts that are unable to store these factors in their defective alpha-granules, including platelet derived growth factor (PDGF), fibroblast...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract::Several methods have been described for investigating chondrocyte metabolism in vitro. In this study, in-situ hybridization (ISH) using an oligonucleotide probe (i.e. a poly-d(T) probe) to detect total messenger RNA (mRNA) in cartilage explants has been compared with radiosulphate and radioleucine uptake studies in an...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract::The interradicular region of primary molars is permeated by many foramina, channels and accessories that connect the pulp cavity with the periapical tissues anatomically. Thus, pulp decomposition products or drugs used in endodontic treatment can trigger inflammatory reactions. The aim of this study was to evaluate th...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12292
更新日期:2018-10-01 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) is the most common chronic condition of the liver in the western world. There is only little evidence about altered sensitivity of steatotic liver to acute toxic injury. The aim of this project was to test whether hepatic steatosis sensitizes rat liver to acute toxic injury in...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2011.00765.x
更新日期:2011-08-01 00:00:00