Regulation of angiogenesis by hypoxic stress: from solid tumours to the ovarian follicle.

abstract：:The liver sinusoidal endothelial cell (LSEC) is damaged by many toxins, including oxidants and bacterial toxins. Any effect on LSECs of the Pseudomonas aeruginosa virulence factor, pyocyanin, may be relevant for systemic pseudomonal infections and liver transplantation. In this study, the effects of pyocyanin on in vi...

journal_title：International journal of experimental pathology

authors： Cheluvappa R,Cogger VC,Kwun SY,O'Reilly JN,Le Couteur DG,Hilmer SN

更新日期：2008-12-01 00:00:00

abstract：:The α2-adrenoceptors regulate the sympathetic nervous system, controlling presynaptic catecholamine release. However, the role of the α2-adrenoceptors in cutaneous wound healing is poorly understood. Mice lacking both the α2A/α2C-adrenoceptors were used to evaluate the participation of the α2-adrenoceptor during cutan...

journal_title：International journal of experimental pathology

authors： Romana-Souza B,Nascimento AP,Brum PC,Monte-Alto-Costa A

更新日期：2014-10-01 00:00:00

abstract：:Blister formation and skin damage can be induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper. Pathological changes in the skin were investigated after intramuscular injections of Bothrops asper haemorrhagic metalloproteinase BaP1. Blisters developed within the first hour, with ...

journal_title：International journal of experimental pathology

authors： Rucavado A,Núñez J,Gutiérrez JM

更新日期：1998-08-01 00:00:00

abstract：:We have shown previously that cycloheximide (CHX), a potent protein synthesis inhibitor, induces high levels of apoptosis in Epstein-Barr virus free (EBV(-)) Burkitt's lymphoma (BJA-B) cells, with comparably reduced levels of apoptosis in the EBV positive (EBV(+)) cells. Modulation of CHX-induced apoptosis in EBV(-) a...

journal_title：International journal of experimental pathology

authors： Ishii H,Tamauchi H,Gobe GC

更新日期：1997-06-01 00:00:00

abstract：:To confirm the existence of the cervical thymus and the development of cervical thymoma in thymoma-prone BUF/Mna (BUF) rats, we examined cervical organs and adjacent tissues, and thoracic thymic tissues of the three inbred strains, BUF, ACI/NMna (ACI), and WKY/NCrj (WKY), and 11 congenic strains, in which genetic regi...

journal_title：International journal of experimental pathology

authors： Yamada T,Matsuyama M,Yanagida T,Kato K,Sugiura S,Kuroda M

更新日期：2011-04-01 00:00:00

abstract：:Diets enriched with fat, especially unsaturated fat, promote experimental pancreatic carcinogenesis, but little is known of the effects of individual fatty acids. The effect of stearic and oleic acid on pancreatic fatty acids and atypical acinar cell nodules (preneoplastic lesions) was studied in 14-day-old weanling m...

journal_title：International journal of experimental pathology

authors： Khoo DE,Flaks B,Oztas H,Williamson RC,Habib NA

更新日期：1991-10-01 00:00:00

abstract：:Polymorphonuclear cells (PMN) are believed to be important effector cells responsible the myocardial damage seen following ischaemia. However, the exact kinetics of their migration remains controversial. Isolated PMN (10 x 10(6) cells) labelled with (51)Cr were injected into four groups of Lewis rats: 0 h (T0h; n = 13...

journal_title：International journal of experimental pathology

authors： Légaré JF,Oxner A,Heimrath O,Issekutz T

更新日期：2007-08-01 00:00:00

abstract：:The aim of this study was to estimate the relationship of endothelial dysfunction induced by intracellular S-adenosylhomocysteine (SAH) accumulation and DNA methylation in human umbilical vein endothelial cells (HUVEC). The isolated HUVEC were incubated with 3-deazaadenosine (DZA) to induce experimental intracellular ...

journal_title：International journal of experimental pathology

authors： Yu X,Ling W,Mi M

更新日期：2009-12-01 00:00:00

abstract：:One of the consequences of neoplastic transformation is deregulation of tissue collagen metabolism. Although metalloproteinases initiate the breakdown of collagen in lung carcinoma, the final step of collagen degradation is mediated by prolidase (E.C.3.4.13.9). We investigated whether prolidase activity could reflect ...

journal_title：International journal of experimental pathology

authors： Karna E,Surazynski A,Palka J

更新日期：2000-10-01 00:00:00

abstract：:The pathogenesis of dengue haemorrhagic fever (DHF) is incompletely understood but it has been suggested that various cytokines may have a role in the process. In this study the profile of the cytokine Transforming Growth Factor-beta 1 (TGF-beta1) was investigated in the sera of 79 patients with various grades of deng...

journal_title：International journal of experimental pathology

authors： Agarwal R,Elbishbishi EA,Chaturvedi UC,Nagar R,Mustafa AS

更新日期：1999-06-01 00:00:00

abstract：:Streptozotocin (SZ)-induced insulitis, which is an animal model for insulin-dependent diabetes mellitus, was suppressed by lactic dehydrogenase virus (LDV) infection. There were no differences in degenerative and necrotic changes of islet cells between SZ-treated mice and SZ-treated mice with LDV infection during the ...

journal_title：International journal of experimental pathology

authors： Hayashi T,Hashimoto S,Kawashima A

更新日期：1994-06-01 00:00:00

abstract：:Summary K-ras mutations are found in 40-50% of human colorectal adenomas and carcinomas, but their functional contribution remains incompletely understood. Here, we show that a conditional mutant K-ras mouse model (K-ras(Asp12)/Cre), with transient intestinal Cre activation by beta-Naphthoflavone (beta-NF) treatment, ...

journal_title：International journal of experimental pathology

authors： Luo F,Brooks DG,Ye H,Hamoudi R,Poulogiannis G,Patek CE,Winton DJ,Arends MJ

更新日期：2009-10-01 00:00:00

abstract：:p23 is a cochaperone of heat shock protein 90 and also interacts functionally with numerous steroid receptors and kinases. However, the in vivo roles of p23 remain unclear. To explore its in vivo function, we generated the transgenic (TG) mice ubiquitously overexpressing p23. The p23 TG mice spontaneously developed ki...

journal_title：International journal of experimental pathology

authors： Lee J,Kim HJ,Moon JA,Sung YH,Baek IJ,Roh JI,Ha NY,Kim SY,Bahk YY,Lee JE,Yoo TH,Lee HW

更新日期：2011-08-01 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) is one of the life-threatening hepatic diseases; however, its pathogenesis is still unknown. To evaluate the causative role of hyperlipidaemia and high-fat diet, we compared C57BL/6 mice with inherited hyperlipidaemic model mice (LDLR(-/-)mice and ApoE(-/-) mice) fed a normal or a h...

journal_title：International journal of experimental pathology

authors： Yoshimatsu M,Terasaki Y,Sakashita N,Kiyota E,Sato H,van der Laan LJ,Takeya M

更新日期：2004-12-01 00:00:00

abstract：:The effect of dengue type 2 virus (DV) and the cytokines induced by it, on the chemiluminescence (CL) response of mouse spleen cells was studied by luminol-dependent CL. Following intracerebral (i.c.) inoculation of DV, an initial increase in CL response was observed which was followed by a sharp decline from the 4th ...

journal_title：International journal of experimental pathology

authors： Dhawan R,Chaturvedi UC,Mashihi KN,Chaturvedi P,Mukherjee R

更新日期：1993-10-01 00:00:00

abstract：:Cyclophilins are proteins which are remarkably conserved through evolution; moreover they have been found in every possible existing organism, which indicates their fundamental importance. Due to their enzymatic properties, multiplicity, cellular localization and role in protein folding they belong to the group of pro...

journal_title：International journal of experimental pathology

authors： Andreeva L,Heads R,Green CJ

更新日期：1999-12-01 00:00:00

abstract：:Low-dose chemotherapy drugs can suppress tumours by restraining tumour vessel growth and preventing the repair of damaged vascular endothelial cells. Cisplatin is a broad-spectrum, cell cycle-non-specific drug, but has serious side effects if used at high doses. There have been few reports on the anti-angiogenic effec...

journal_title：International journal of experimental pathology

authors： Shen FZ,Wang J,Liang J,Mu K,Hou JY,Wang YT

更新日期：2010-02-01 00:00:00

abstract：:The characterization of mice models of portal hypertension (PHT) is lacking in the literature. Therefore, the aim of the present study was to make a histological approach during development of PHT in two models of cirrhosis with PHT compared with one model of isolated PHT. The model of isolated PHT was developed by pa...

journal_title：International journal of experimental pathology

authors： Geerts AM,Vanheule E,Praet M,Van Vlierberghe H,De Vos M,Colle I

更新日期：2008-08-01 00:00:00

abstract：:Angiogenesis is a common finding in chronic inflammatory diseases; however, its role in Sjögren's syndrome (SS) remains to be elucidated. Previous SS studies have demonstrated an increase in VEGF-A/VEGFR-2 system expression in minor salivary gland (MSG) biopsies from patients with SS, but differences in the new blood ...

journal_title：International journal of experimental pathology

authors： Sisto M,Lisi S,Ingravallo G,Lofrumento DD,D'Amore M,Ribatti D

更新日期：2014-04-01 00:00:00

abstract：:In this study, viruria following Japanese encephalitis virus (JEV) infection in mice has been shown to appear earlier in pregnant than in normal mice with proteinuria and haematuria. This was related to the production of splenic macrophage derived neutrophil chemotactic factor (MDF) following JEV infection. Intravenou...

journal_title：International journal of experimental pathology

authors： Mathur A,Khanna N,Kulshreshtha R,Maitra SC,Chaturvedi UC

更新日期：1995-04-01 00:00:00

abstract：:The present study was carried out to investigate the role of hypertension in the genesis and localization of intimal lesions and medial remodelling found in the prestenotic segment in relation to a severe stenosis of the abdominal aorta just below the diaphragm. Male young rats were divided randomly into operated grou...

journal_title：International journal of experimental pathology

authors： Prado CM,Rossi MA

更新日期：2006-12-01 00:00:00

abstract：:The role of lymphocytes in the pathogenesis of lung fibrosis is not clear, but the weight of the evidence supports a pro-fibrotic effect for lymphocytes. The high-affinity interleukin-2 receptor (haIL-2R) is expressed on activated, but not quiescent, T lymphocytes. This selective expression of haIL-2R provides the bas...

journal_title：International journal of experimental pathology

authors： Segel MJ,Aqeilan R,Zilka K,Lorberboum-Galski H,Wallach-Dayan SB,Conner MW,Christensen TG,Breuer R

更新日期：2005-10-01 00:00:00

abstract：:Conventional therapies for low back pain (LBP) are purely symptomatic and do not target the cause of LBP, which in approximately 40% of cases is caused by degeneration of the intervertebral disc (DIVD). Targeting therapies to inhibit the process of degeneration would be a potentially valuable treatment for LBP. There ...

journal_title：International journal of experimental pathology

authors： Le Maitre CL,Freemont AJ,Hoyland JA

更新日期：2006-02-01 00:00:00

abstract：:The constitutive cell types of the two lung cancer cell lines CaLu1 and CaLu3 have been investigated by immunocytochemical staining with markers for cytokeratins, vimentin, carcinoembryonic antigen and the epithelial cell epitope recognized by the monoclonal antibody Ber-EP4. The cells of both lines reacted with vimen...

journal_title：International journal of experimental pathology

authors： Daniel MR,Burnett HE

更新日期：1991-08-01 00:00:00

abstract：:This study was performed to characterize the intestinal lesions in chronic graft-versus-host disease (GVHD) in mice and to determine a possible role of intestinal intraepithelial lymphocytes (ilEL) in the development of these lesions. Chronic GVHD was induced by transfer of DBA/2 lymphocytes into non-irradiated (C57BL...

journal_title：International journal of experimental pathology

authors： de Geus B,Hogenesch H,de Heer E,Bruijn JA,van den Enden M,Rozing J

更新日期：1993-08-01 00:00:00

abstract：:During mild (one to two pairs of worms) and prolonged (23 weeks or more) mouse infections with Schistosoma mansoni, but not with S. japonicum, periovular granulomas and fibrosis were seen to be preferentially located along periportal tissues. This caused fibrotic expansion of the portal spaces on a background of norma...

journal_title：International journal of experimental pathology

authors： Andrade ZA,Cheever AW

更新日期：1993-04-01 00:00:00

abstract：:Muramyl dipeptide-Lys(L18) given by daily subcutaneous injection for 14 days induced arthritis in male Lewis, Fischer and nude rats, to a lesser degree in the last two than in the first strain. On the other hand, a single intradermal administration of Freund's complete adjuvant induced arthritis in Lewis and Fischer b...

journal_title：International journal of experimental pathology

authors： Sugawara T,Takada S,Furuhama K,Takayama S,Nomura M,Kato M

更新日期：1995-06-01 00:00:00

abstract：:Long-term intragastric administration of the antiepileptic drug sodium valproate (Vuprol Polfa) to rats for 1, 3, 6, 9 and 12 months, once daily at the effective dose of 200 mg/kg body weight showed morphological evidence of encephalopathy, manifested by numerous nonspecific changes within Purkinje cell perikarya and ...

journal_title：International journal of experimental pathology

authors： Sobaniec-Lotowska ME

更新日期：2001-12-01 00:00:00

abstract：:Young adult mice infected with MCMV were shown to develop inflammatory lesions in the peripancreatic and salivary gland adipose tissues. MCMV replication was detected by immunoperoxidase staining and electron microscopy in adipocytes, fibroblasts, endothelial cells and pericytes in brown and white adipose tissues. Mor...

journal_title：International journal of experimental pathology

authors： Price P,Eddy KS,Papadimitriou JM,Robertson TA,Shellam GR

更新日期：1990-08-01 00:00:00

abstract：:Several methods have been described for investigating chondrocyte metabolism in vitro. In this study, in-situ hybridization (ISH) using an oligonucleotide probe (i.e. a poly-d(T) probe) to detect total messenger RNA (mRNA) in cartilage explants has been compared with radiosulphate and radioleucine uptake studies in an...

journal_title：International journal of experimental pathology

authors： Marles PJ,Hoyland JA,Parkinson R,Freemont AJ

更新日期：1991-04-01 00:00:00