Abstract:
:Young adult mice infected with MCMV were shown to develop inflammatory lesions in the peripancreatic and salivary gland adipose tissues. MCMV replication was detected by immunoperoxidase staining and electron microscopy in adipocytes, fibroblasts, endothelial cells and pericytes in brown and white adipose tissues. More infected cells were detected in C3H mice than in BALB/c, BALB.B, BALB.K or C57BL/6 mice. Peripancreatic steatitis consisted of a monocytic infiltrate surrounding focal necrosis of adipocytes, the severity of which was influenced by the route of inoculation, virus dose, and genetic susceptibility to disseminated MCMV-disease. C57BL/6 mice showed the greatest susceptibility with severe coalescing focal inflammation around areas of coagulative necrosis. Salivary gland adipose tissues exhibited lymphocytic steatitis, which was reduced in Nu/Nu mice.
journal_name
Int J Exp Patholjournal_title
International journal of experimental pathologyauthors
Price P,Eddy KS,Papadimitriou JM,Robertson TA,Shellam GRsubject
Has Abstractpub_date
1990-08-01 00:00:00pages
557-71issue
4eissn
0959-9673issn
1365-2613journal_volume
71pub_type
杂志文章abstract::A reversible impairment in the ability of the liver to secrete cholephilic compounds has been reported to exist in infant rats born from mothers with surgically induced complete cholestasis during the last third of the pregnancy. Canalicular plasma membranes (CPM) were purified from livers obtained from 4 and 8 week-o...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
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journal_title:International journal of experimental pathology
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journal_title:International journal of experimental pathology
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更新日期:1993-02-01 00:00:00
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1995-08-01 00:00:00
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1046/j.1365-2613.1997.170350.x
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abstract::The use of non-specific inhibitors of tissue non-specific alkaline phosphatase (TNSALP) in pre-adipocytes blocks intracellular lipid accumulation. TNSALP is also expressed in hepatocytes, which are known to accumulate lipid in a similar manner to pre-adipocytes. The purpose of this study was to use specific silencing ...
journal_title:International journal of experimental pathology
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
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更新日期:2008-06-01 00:00:00
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journal_title:International journal of experimental pathology
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journal_title:International journal of experimental pathology
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更新日期:1992-10-01 00:00:00
abstract::Although it is well known that cadmium (Cd) causes adverse effects on male rat reproductive organs, few studies have quantified alterations caused by its low doses. Quantification of these alterations, especially in the testis, was measured using morphometry. A single dose of cadmium chloride (1 or 1.2 mg/kg BW) was i...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1993-04-01 00:00:00
abstract::Tumour-associated macrophage (TAM) polarization is associated with hepatocellular carcinoma but the molecular mechanism of this polarization is still unknown. Peripheral blood mononuclear cells were induced to differentiate into M0, M1 and M2 macrophages and TAMs. TAMs were transfected with pcDNA3.1-GAS5, pcDNA3.1-NC,...
journal_title:International journal of experimental pathology
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abstract::A recent global gene expression profiling study unexpectedly showed that activated oncogenic NRAS may recruit neural precursor cell expressed, developmentally downregulated 4L (Nedd4L; a human homologue of Nedd4-2) in cultured melanoma cells. However, whether Nedd4L was expressed in melanoma tissues or participated in...
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更新日期:2014-02-01 00:00:00
abstract::Hamsters (Mesocricetus auratus) were inoculated with L. (L.) chagasi and killed on days 7, 15, 30, 45 and 60 after infection. The lymphoid organs developed initial proliferation of the B lymphocyte zone with recovery by the 60th day group when pyroninophilic cells were prominent. The T lymphocyte area showed a progres...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract::This study tested the hypothesis that different doses of nandrolone decanoate (ND) will cause changes in the estrous cycle and ovarian tissue of adult rats; and investigated the duration of the recovery period that is sufficient to restore the damage in the animals treated with different doses. Wistar rats were treate...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12144
更新日期:2015-10-01 00:00:00
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journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
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更新日期:2009-06-01 00:00:00
abstract::This study was conducted to evaluate the adverse effects of the anabolic steroid, boldenone undecylenate (BOL) on reproductive functions of male rabbits. Thirty white New Zealand mature male rabbits were divided into three groups (10 rabbits each). Group A rabbits served as a control group. Group B rabbits received 4....
journal_title:International journal of experimental pathology
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abstract::Hydroxymethylnitrofurazone (NFOH) is a nitrofurazone prodrug effective in vivo during acute infections, and it has less hepatotoxicity effect than the standard drug benznidazole (BZN) which has been used during short- and long-term treatment. In the present study, we induced the indeterminate form of Chagas disease in...
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journal_title:International journal of experimental pathology
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journal_title:International journal of experimental pathology
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journal_title:International journal of experimental pathology
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doi:10.1111/j.1365-2613.2008.00622.x
更新日期:2009-04-01 00:00:00
abstract::Previously we have found deregulation of collagen metabolism in human pancreatitis and pancreatic cancer tissues. Insulin-like growth factor-I (IGF-I) is known to stimulate collagen biosynthesis through interaction with IGF-I receptor. IGF-I binding proteins (BPs) regulate the activity of IGF-I. We investigated whethe...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1046/j.1365-2613.2002.00237.x
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journal_title:International journal of experimental pathology
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doi:10.1111/j.1365-2613.2010.00736.x
更新日期:2010-08-01 00:00:00
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journal_title:International journal of experimental pathology
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journal_title:International journal of experimental pathology
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abstract::A major translational barrier to the use of stem cell (SC)-based therapy in patients with myocardial infarction (MI) is the lack of a clear understanding of the mechanism(s) underlying the cardioprotective effect of SCs. Numerous paracrine factors from SCs may account for reduction in infarct size, but myocardial salv...
journal_title:International journal of experimental pathology
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journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00