Characterization of the murine model of schistosomal hepatic periportal fibrosis ('pipestem' fibrosis).

Abstract:

:During mild (one to two pairs of worms) and prolonged (23 weeks or more) mouse infections with Schistosoma mansoni, but not with S. japonicum, periovular granulomas and fibrosis were seen to be preferentially located along periportal tissues. This caused fibrotic expansion of the portal spaces on a background of normal-looking hepatic parenchyma, a picture mimicking 'clay pipestem fibrosis' seen in human patients with advanced schistosomiasis. The model was reproduced in outbred and in several strains of inbred mice, and their main characteristics were studied and compared to the human counterpart. A balanced consideration of the similarities and differences between the murine model and human pipestem fibrosis is needed for the adequate utilization of this simple, reproducible and inexpensive experimental model.

journal_name

Int J Exp Pathol

authors

Andrade ZA,Cheever AW

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

195-202

issue

2

eissn

0959-9673

issn

1365-2613

journal_volume

74

pub_type

杂志文章
  • Further evaluation of the interrelationship between the hepatocellular transport of bile acids and endocytosed proteins.

    abstract::Experiments on the relationship between the hepatocellular transport of endogenous or exogenously loaded bile acids (sodium taurocholate, TC, 0.5 mumol/min/100 g body wt) and horseradish peroxidase (HRP) or immunoglobulin A (IgA) (0.5 mg/100 g body wt) were carried out on anaesthetized Wistar rats. The time course of ...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Herrera MC,el-Mir MY,Monte MJ,Perez-Barriocanal F,Marin JJ

    更新日期:1992-04-01 00:00:00

  • Neuropilins: expression and roles in the epithelium.

    abstract::Initially found expressed in neuronal and then later in endothelial cells, it is well established that the transmembrane glycoproteins neuropilin-1 (NRP1) and neuropilin-2 (NRP2) play essential roles in axonal growth and guidance and in physiological and pathological angiogenesis. Neuropilin expression and function in...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2613.2012.00810.x

    authors: Wild JR,Staton CA,Chapple K,Corfe BM

    更新日期:2012-04-01 00:00:00

  • Correlation between NGF/TrkA and microvascular density in human pterygium.

    abstract::Pterygium is a surface ocular lesion that is associated with chronic UV exposure. The primary effect is a solar actinic elastosis within the stroma. All the other changes are secondary. Pterygium is characterized by proliferation, inflammatory infiltrates, fibrosis, angiogenesis and extracellular matrix breakdown. The...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2009.00665.x

    authors: Ribatti D,Nico B,Perra MT,Maxia C,Piras F,Murtas D,Crivellato E,Sirigu P

    更新日期:2009-12-01 00:00:00

  • The acute phase protein haptoglobin is locally expressed in arthritic and oncological tissues.

    abstract::Haptoglobin is an acute phase protein known to be highly expressed in the liver. Recently, we showed increased local arterial haptoglobin expression after flow-induced arterial remodelling and found that haptoglobin is involved in cell migration and arterial restructuring probably through accumulation of a temporary g...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2613.2003.00336.x

    authors: Smeets MB,Fontijn J,Kavelaars A,Pasterkamp G,De Kleijn DP

    更新日期:2003-04-01 00:00:00

  • Time course of bleomycin-induced lung fibrosis.

    abstract::Intratracheal instillation (IT) of bleomycin is a widely used experimental model for lung fibrosis. In this study we describe the time-course of bleomycin-induced lung fibrosis in mice using computer-assisted morphometry. C57Bl/6J mice were treated with a single IT dose of bleomycin or control saline. Animals were kil...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2613.2002.00220.x

    authors: Izbicki G,Segel MJ,Christensen TG,Conner MW,Breuer R

    更新日期:2002-06-01 00:00:00

  • Hydroxymethylnitrofurazone treatment in indeterminate form of chronic Chagas disease: Reduced intensity of tissue parasitism and inflammation-A histopathological study.

    abstract::Hydroxymethylnitrofurazone (NFOH) is a nitrofurazone prodrug effective in vivo during acute infections, and it has less hepatotoxicity effect than the standard drug benznidazole (BZN) which has been used during short- and long-term treatment. In the present study, we induced the indeterminate form of Chagas disease in...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12289

    authors: Scarim CB,de Andrade CR,da Rosa JA,Dos Santos JL,Chin CM

    更新日期:2018-10-01 00:00:00

  • Induction and treatment of anergy in murine leprosy.

    abstract::Leprosy is a disease consisting of a spectrum of clinical, bacteriological, histopathological and immunological manifestations. Tuberculoid leprosy is frequently recognized as the benign polar form of the disease, while lepromatous leprosy is regarded as the malignant form. The different forms of leprosy depend on the...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12108

    authors: Juarez-Ortega M,Hernandez VG,Arce-Paredes P,Villanueva EB,Aguilar-Santelises M,Rojas-Espinosa O

    更新日期:2015-02-01 00:00:00

  • Endothelial nitric oxide synthase is a critical factor in experimental liver fibrosis.

    abstract::Reduced expression of endothelial nitric oxide synthase (eNOS) in chronic liver disease can reduce hepatic perfusion and accelerate fibrosis. The relationship between eNOS expression and liver fibrogenesis remains unclear. We investigated whether L-arginine attenuated chronic liver fibrosis through eNOS expression. Ch...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2008.00590.x

    authors: Leung TM,Tipoe GL,Liong EC,Lau TY,Fung ML,Nanji AA

    更新日期:2008-08-01 00:00:00

  • Juxtaposition of peroxisomes and chromosomes in mitotic hepatocytes following methyl clofenapate administration to rats.

    abstract::Administration of 25 mg/kg/day methyl clofenapate to Alpk/APfSD rats for up to 4 days gave rise to hepatomegaly resulting from a combination of hepatocyte hyperplasia, mainly in the periportal region of the lobule, and centrilobular cell hypertrophy. In hepatocytes undergoing mitosis there was a redistribution of dens...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Soames AR,Foster JR

    更新日期:1994-12-01 00:00:00

  • Cytomegalovirus infection of adipose tissues induces steatitis in adult mice.

    abstract::Young adult mice infected with MCMV were shown to develop inflammatory lesions in the peripancreatic and salivary gland adipose tissues. MCMV replication was detected by immunoperoxidase staining and electron microscopy in adipocytes, fibroblasts, endothelial cells and pericytes in brown and white adipose tissues. Mor...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Price P,Eddy KS,Papadimitriou JM,Robertson TA,Shellam GR

    更新日期:1990-08-01 00:00:00

  • Recombinant gamma interferon causes neutrophil migration mediated by the release of a macrophage neutrophil chemotactic factor.

    abstract::A dose-dependent neutrophil migration was observed following the injection of purified (Hu IFN-gamma) or recombinant (rIFN-gamma) human gamma interferon into rat peritoneal cavities. This finding contrasts with their inability to cause chemotaxis in vitro in the Boyden chamber. Neutrophil migration into peritoneal cav...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Ribeiro RA,Cunha FQ,Ferreira SH

    更新日期:1990-10-01 00:00:00

  • A new fibroblast growth stimulating activity from the human megakaryoblastic leukaemia cell line ELF-153: in vitro and in vivo findings.

    abstract::Although the exact mechanism for the progression of myelofibrosis in acute megakaryoblastic leukaemia is unclear, certain humoral factors released from the proliferating megakaryoblasts that are unable to store these factors in their defective alpha-granules, including platelet derived growth factor (PDGF), fibroblast...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Hassan HT,Hanauske AR,Lux E,Kleine HD,Freund M

    更新日期:1995-10-01 00:00:00

  • Cervical thymuses exist, but no cervical thymomas develop in thoracic thymoma-prone BUF rats.

    abstract::To confirm the existence of the cervical thymus and the development of cervical thymoma in thymoma-prone BUF/Mna (BUF) rats, we examined cervical organs and adjacent tissues, and thoracic thymic tissues of the three inbred strains, BUF, ACI/NMna (ACI), and WKY/NCrj (WKY), and 11 congenic strains, in which genetic regi...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2010.00755.x

    authors: Yamada T,Matsuyama M,Yanagida T,Kato K,Sugiura S,Kuroda M

    更新日期:2011-04-01 00:00:00

  • Effects of dietary fatty acids on the early stages of neoplastic induction in the rat pancreas. Changes in fatty acid composition and development of atypical acinar cell nodules.

    abstract::Diets enriched with fat, especially unsaturated fat, promote experimental pancreatic carcinogenesis, but little is known of the effects of individual fatty acids. The effect of stearic and oleic acid on pancreatic fatty acids and atypical acinar cell nodules (preneoplastic lesions) was studied in 14-day-old weanling m...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Khoo DE,Flaks B,Oztas H,Williamson RC,Habib NA

    更新日期:1991-10-01 00:00:00

  • Long non-coding RNA GAS5 overexpression inhibits M2-like polarization of tumour-associated macrophages in SMCC-7721 cells by promoting PTEN expression.

    abstract::Tumour-associated macrophage (TAM) polarization is associated with hepatocellular carcinoma but the molecular mechanism of this polarization is still unknown. Peripheral blood mononuclear cells were induced to differentiate into M0, M1 and M2 macrophages and TAMs. TAMs were transfected with pcDNA3.1-GAS5, pcDNA3.1-NC,...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12374

    authors: Wang X,Li FY,Zhao W,Gao ZK,Shen B,Xu H,Cui YF

    更新日期:2020-12-01 00:00:00

  • Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper.

    abstract::Blister formation and skin damage can be induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper. Pathological changes in the skin were investigated after intramuscular injections of Bothrops asper haemorrhagic metalloproteinase BaP1. Blisters developed within the first hour, with ...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Rucavado A,Núñez J,Gutiérrez JM

    更新日期:1998-08-01 00:00:00

  • Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma.

    abstract::A recent global gene expression profiling study unexpectedly showed that activated oncogenic NRAS may recruit neural precursor cell expressed, developmentally downregulated 4L (Nedd4L; a human homologue of Nedd4-2) in cultured melanoma cells. However, whether Nedd4L was expressed in melanoma tissues or participated in...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12051

    authors: Kito Y,Bai J,Goto N,Okubo H,Adachi Y,Nagayama T,Takeuchi T

    更新日期:2014-02-01 00:00:00

  • Coronary vessel development and insight towards neovascular therapy.

    abstract::Formation of the coronary arteries consists of a precisely orchestrated series of morphogenetic and molecular events which can be divided into three distinct processes: vasculogenesis, angiogenesis and arteriogenesis (Risau 1997; Carmeliet 2000). Even subtle perturbations in this process may lead to congenital coronar...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2613.2009.00646.x

    authors: Smart N,Dubé KN,Riley PR

    更新日期:2009-06-01 00:00:00

  • Mode of transmission and histology of M. leprae infection in nude mice.

    abstract::Athymic (nude) mice were experimentally infected with Mycobacterium leprae via the alimentary and respiratory tracts and through the skin. Animals were allowed to inhale aerosols of M. leprae or had bacilli instilled into the nostrils or directly into the lungs. Others were fed M. leprae by gastric tube or had bacilli...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: McDermott-Lancaster RD,McDougall AC

    更新日期:1990-10-01 00:00:00

  • Endotoxin is angiogenic.

    abstract::The formation of new blood vessels, angiogenesis, is an important event in inflammation, wound healing and tumour growth. Mediators produced by various cells when exposed to endotoxin include cytokines (tumour necrosis factor, interleukins 1 and 6, and basic fibroblast growth factor) which, it has been suggested, stim...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Mattsby-Baltzer I,Jakobsson A,Sörbo J,Norrby K

    更新日期:1994-06-01 00:00:00

  • Effects of different doses of nandrolone decanoate on estrous cycle and ovarian tissue of rats after treatment and recovery periods.

    abstract::This study tested the hypothesis that different doses of nandrolone decanoate (ND) will cause changes in the estrous cycle and ovarian tissue of adult rats; and investigated the duration of the recovery period that is sufficient to restore the damage in the animals treated with different doses. Wistar rats were treate...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12144

    authors: Simão VA,Berloffa Belardin L,Araújo Leite GA,de Almeida Chuffa LG,Camargo IC

    更新日期:2015-10-01 00:00:00

  • Viruria during acute Japanese encephalitis virus infection.

    abstract::In this study, viruria following Japanese encephalitis virus (JEV) infection in mice has been shown to appear earlier in pregnant than in normal mice with proteinuria and haematuria. This was related to the production of splenic macrophage derived neutrophil chemotactic factor (MDF) following JEV infection. Intravenou...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Mathur A,Khanna N,Kulshreshtha R,Maitra SC,Chaturvedi UC

    更新日期:1995-04-01 00:00:00

  • Collagen metabolism disturbances are accompanied by an increase in prolidase activity in lung carcinoma planoepitheliale.

    abstract::One of the consequences of neoplastic transformation is deregulation of tissue collagen metabolism. Although metalloproteinases initiate the breakdown of collagen in lung carcinoma, the final step of collagen degradation is mediated by prolidase (E.C.3.4.13.9). We investigated whether prolidase activity could reflect ...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2000.00168.x

    authors: Karna E,Surazynski A,Palka J

    更新日期:2000-10-01 00:00:00

  • New histological observations in spontaneously developing osteoarthritis in the STR/ORT mouse questioning its acceptability as a model of human osteoarthritis.

    abstract::Naturally developing spontaneous osteoarthritis (OA) is seen in a number of small animals one of which is the STR/ORT mouse, an accepted model of human OA. A histological evaluation of the patello-femoral joints of 37 male STR/ORT mice has shown features that are inconsistent with the disease in human joints. These in...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Das-Gupta EP,Lyons TJ,Hoyland JA,Lawton DM,Freemont AJ

    更新日期:1993-12-01 00:00:00

  • Circumferential wall tension due to hypertension plays a pivotal role in aorta remodelling.

    abstract::The present study was carried out to investigate the role of hypertension in the genesis and localization of intimal lesions and medial remodelling found in the prestenotic segment in relation to a severe stenosis of the abdominal aorta just below the diaphragm. Male young rats were divided randomly into operated grou...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2006.00506.x

    authors: Prado CM,Rossi MA

    更新日期:2006-12-01 00:00:00

  • Fibroblasts and myofibroblasts in renal fibrosis.

    abstract::Interstitial fibrosis, associated with extensive accumulation of extracellular matrix constituents in the cortical interstitium, is directly correlated to progression of renal disease. The earliest histological marker of this progression is the accumulation in the interstitium of fibroblasts with the phenotypic appear...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2613.2011.00764.x

    authors: Meran S,Steadman R

    更新日期:2011-06-01 00:00:00

  • Comparative histopathology in mouse typhoid among genetically diverse mice.

    abstract::Genetically resistant CBA and A/J mice and susceptible BALB/c and C57BL/6 mice were challenged with either an identical infective dose or a minimal lethal dose of Salmonella typhimurium. The histopathological progression of the disease was examined in tissue sections prepared by the JB-4 Plus resin embedding method an...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2613.1998.00064.x

    authors: Moncure CW,Guo YN,Xu HR,Hsu HS

    更新日期:1998-06-01 00:00:00

  • Fell-Muir Lecture: Heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra.

    abstract::Heparan sulphate (HS) sits at the interface of the cell and the extracellular matrix. It is a member of the glycosaminoglycan family of anionic polysaccharides with unique structural features designed for protein interaction and regulation. Its client proteins include soluble effectors (e.g. growth factors, morphogens...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12135

    authors: Gallagher J

    更新日期:2015-08-01 00:00:00

  • Cytokines and their receptors in cardiovascular diseases--role of gp130 signalling pathway in cardiac myocyte growth and maintenance.

    abstract::Interleukin (IL)-6-related cytokines share gp130 as the signal-transducing protein. Cardiac myocytes produce various kinds of cytokines including IL-6 and cardiotrophin-1. Activation of gp130 transduces hypertrophic and cytoprotective signals in cardiac myocytes via JAK/STAT, MAP kinase and PI-3 kinase pathways. Besid...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2613.2000.00139.x

    authors: Yamauchi-Takihara K,Kishimoto T

    更新日期:2000-02-01 00:00:00

  • Cell proliferation and apoptosis in isoprenaline-induced sialosis in the rat submandibular glands.

    abstract::Regression of submandibular acinar cell hyperplasia after withdrawal of the mitogenic stimulus induced by isoprenaline was studied in male Wistar rats. Intraperitoneal administration of 39 mg of isoprenaline, in divided doses over a 9-day period, resulted in a marked increase in gland size and weight. The proportional...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Chisholm DM,Adi MM

    更新日期:1995-08-01 00:00:00