当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY期刊下所有文献 > Low-dose metronomic chemotherapy with cisplatin: can it suppress angiogenesis in H22 hepatocarcinoma cells?

Low-dose metronomic chemotherapy with cisplatin: can it suppress angiogenesis in H22 hepatocarcinoma cells?

Abstract：

:Low-dose chemotherapy drugs can suppress tumours by restraining tumour vessel growth and preventing the repair of damaged vascular endothelial cells. Cisplatin is a broad-spectrum, cell cycle-non-specific drug, but has serious side effects if used at high doses. There have been few reports on the anti-angiogenic effects of low-dose cisplatin and hence the effect of low-dose metronomic (LDM) chemotherapy on the proliferation and neovascularization of H22 hepatocarcinoma cells is discussed in this research. The influence of LDM chemotherapy with cisplatin on human umbilical vascular endothelial cells (HUVECs) and proliferation of the HepG(2) human hepatocarcinoma cell line were measured using MTT assays. The LDM group was treated with cisplatin 0.6 mg/kg/day; the control group with saline 0.2 ml; the maximum tolerated dose (MTD) group with cisplatin 9 mg/kg/day. Vascular endothelial growth factor (VEGF) and matrix metallopeptidase 2 (MMP-2) were detected using immunohistochemical staining. A chicken chorio-allantoic membrane (CAM) model was used to check the inhibitory effect of LDM chemotherapy with cisplatin on neovascularization in vivo. Low-dose cisplatin inhibited HUVEC proliferation in a dose- and time-dependent manner, but was ineffective in inhibiting HepG(2) cell proliferation. Tumour growth was delayed in mice receiving LDM cisplatin, without apparent body weight loss, compared with mice that received MTD cisplatin. Microvessel density and expression of VEGF and MMP-2 were much lower in mice receiving LDM cisplatin than in the control and MTD groups. Continuous low-dose cisplatin suppressed CAM angiogenesis in vivo. LDM chemotherapy with cisplatin can inhibit the growth of blood vessel endothelial cells in vitro and shows anti-angiogenic ability in vivo.

journal_name

Int J Exp Pathol

journal_title

International journal of experimental pathology

authors

Shen FZ,Wang J,Liang J,Mu K,Hou JY,Wang YT

doi

10.1111/j.1365-2613.2009.00684.x

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

10-6

issue

1

eissn

0959-9673

issn

1365-2613

pii

IEP684

journal_volume

91

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY文献大全
  • Viruria during acute Japanese encephalitis virus infection.

    abstract：:In this study, viruria following Japanese encephalitis virus (JEV) infection in mice has been shown to appear earlier in pregnant than in normal mice with proteinuria and haematuria. This was related to the production of splenic macrophage derived neutrophil chemotactic factor (MDF) following JEV infection. Intravenou...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：

    authors： Mathur A,Khanna N,Kulshreshtha R,Maitra SC,Chaturvedi UC

    更新日期：1995-04-01 00:00:00

  • Inhibition of chick embryo lysyl oxidase by various lathyrogens and the antagonistic effect of pyridoxal.

    abstract：:Lysyl oxidase, which cross-links collagen and elastin, was obtained from chick embryo bone and cartilage and its substrate, elastin, from aorta. The enzyme was studied using an improved assay which enabled the stability of the substrate to be monitored. The enzyme was fully inhibited in vivo by beta-aminopropionitrile...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：

    authors： Levene CI,Sharman DF,Callingham BA

    更新日期：1992-10-01 00:00:00

  • Fibroblasts and myofibroblasts in renal fibrosis.

    abstract：:Interstitial fibrosis, associated with extensive accumulation of extracellular matrix constituents in the cortical interstitium, is directly correlated to progression of renal disease. The earliest histological marker of this progression is the accumulation in the interstitium of fibroblasts with the phenotypic appear...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2613.2011.00764.x

    authors： Meran S,Steadman R

    更新日期：2011-06-01 00:00:00

  • Elevated activity of the oxidative and non-oxidative pentose phosphate pathway in (pre)neoplastic lesions in rat liver.

    abstract：:(Pre)neoplastic lesions in livers of rats induced by diethylnitrosamine are characterized by elevated activity of the first irreversible enzyme of the oxidative branch of the pentose phosphate pathway (PPP), glucose-6-phosphate dehydrogenase (G6PD), for production of NADPH. In the present study, the activity of G6PD, ...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2613.2008.00582.x

    authors： Frederiks WM,Vizan P,Bosch KS,Vreeling-Sindelárová H,Boren J,Cascante M

    更新日期：2008-08-01 00:00:00

  • Non-inferiority of microencapsulated mesenchymal stem cells to free cells in cardiac repair after myocardial infarction: A rationale for using paracrine factor(s) instead of cells.

    abstract：:A major translational barrier to the use of stem cell (SC)-based therapy in patients with myocardial infarction (MI) is the lack of a clear understanding of the mechanism(s) underlying the cardioprotective effect of SCs. Numerous paracrine factors from SCs may account for reduction in infarct size, but myocardial salv...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：10.1111/iep.12312

    authors： Karpov AA,Puzanov MV,Ivkin DY,Krasnova MV,Anikin NA,Docshin PM,Moiseeva OM,Galagudza MM

    更新日期：2019-04-01 00:00:00

  • Adverse effects of the anabolic steroid, boldenone undecylenate, on reproductive functions of male rabbits.

    abstract：:This study was conducted to evaluate the adverse effects of the anabolic steroid, boldenone undecylenate (BOL) on reproductive functions of male rabbits. Thirty white New Zealand mature male rabbits were divided into three groups (10 rabbits each). Group A rabbits served as a control group. Group B rabbits received 4....

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2613.2012.00814.x

    authors： Oda SS,El-Ashmawy IM

    更新日期：2012-06-01 00:00:00

  • Infection of human monocytes by Leishmania results in a defective oxidative burst.

    abstract：:The effect of infection by prototypes from the three major species of Leishmania on the oxidative burst of human mononuclear phagocytes in culture was examined. The presence of intracellular parasites of the three species, L.major, L.donovani and L.mexicana decreased hydrogen peroxide (H2O2) and superoxide anion (O2-)...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：

    authors： Passwell JH,Shor R,Smolen J,Jaffe CL

    更新日期：1994-08-01 00:00:00

  • L-arginine ameliorates experimental autoimmune myocarditis by maintaining extracellular matrix and reducing cytotoxic activity of lymphocytes.

    abstract：:It was previously shown that administration of the nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) aggravated murine viral myocarditis by increasing myocardial virus titres. Experimental autoimmune myocarditis in mice and rats mimics human fulminant myocarditis. The effects of L-arginine, a...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2613.2008.00609.x

    authors： Okabe TA,Hattori M,Yuan Z,Kishimoto C

    更新日期：2008-10-01 00:00:00

  • Dysregulation of matrix metalloproteinases and their tissue inhibitors is related to abnormality of left ventricular geometry and function in streptozotocin-induced diabetic minipigs.

    abstract：:This study aimed to characterize matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in relation to changes in left ventricle (LV) geometry and function in a porcine model with streptozotocin (STZ)-induced diabetes. In 15 Chinese Guizhou minipigs with STZ-induced diabetes (diabetic group) and 15 age-m...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2613.2008.00579.x

    authors： Lu L,Zhang Q,Pu LJ,Peng WH,Yan XX,Wang LJ,Chen QJ,Zhu ZB,Michel JB,Shen WF

    更新日期：2008-04-01 00:00:00

  • Comparative histopathology in mouse typhoid among genetically diverse mice.

    abstract：:Genetically resistant CBA and A/J mice and susceptible BALB/c and C57BL/6 mice were challenged with either an identical infective dose or a minimal lethal dose of Salmonella typhimurium. The histopathological progression of the disease was examined in tissue sections prepared by the JB-4 Plus resin embedding method an...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2613.1998.00064.x

    authors： Moncure CW,Guo YN,Xu HR,Hsu HS

    更新日期：1998-06-01 00:00:00

  • The clonal origin and clonal evolution of epithelial tumours.

    abstract：:While the origin of tumours, whether from one cell or many, has been a source of fascination for experimental oncologists for some time, in recent years there has been a veritable explosion of information about the clonal architecture of tumours and their antecedents, stimulated, in the main, by the ready accessibilit...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2613.2000.00142.x

    authors： Garcia SB,Novelli M,Wright NA

    更新日期：2000-04-01 00:00:00

  • Explantation of mesangial cell 'hillocks': a method for obtaining human mesangial cells in culture.

    abstract：:A simple method is presented for selective cell culture of human mesangial cells using explantation of mesangial cell hillocks. Glomeruli which had been incubated with collagenase were explanted on plastic tissue culture flasks. Three to 6 weeks after explantation, a rapidly growing multilayer of elongated mesangial c...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：

    authors： Muller EW,Kim Y,Michael AF,Vernier RL,van der Hem GK,van der Woude FJ

    更新日期：1992-02-01 00:00:00

  • Cervical thymuses exist, but no cervical thymomas develop in thoracic thymoma-prone BUF rats.

    abstract：:To confirm the existence of the cervical thymus and the development of cervical thymoma in thymoma-prone BUF/Mna (BUF) rats, we examined cervical organs and adjacent tissues, and thoracic thymic tissues of the three inbred strains, BUF, ACI/NMna (ACI), and WKY/NCrj (WKY), and 11 congenic strains, in which genetic regi...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2613.2010.00755.x

    authors： Yamada T,Matsuyama M,Yanagida T,Kato K,Sugiura S,Kuroda M

    更新日期：2011-04-01 00:00:00

  • Effects of dietary fatty acids on the early stages of neoplastic induction in the rat pancreas. Changes in fatty acid composition and development of atypical acinar cell nodules.

    abstract：:Diets enriched with fat, especially unsaturated fat, promote experimental pancreatic carcinogenesis, but little is known of the effects of individual fatty acids. The effect of stearic and oleic acid on pancreatic fatty acids and atypical acinar cell nodules (preneoplastic lesions) was studied in 14-day-old weanling m...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：

    authors： Khoo DE,Flaks B,Oztas H,Williamson RC,Habib NA

    更新日期：1991-10-01 00:00:00

  • The influenza B virus mouse model of Reye's syndrome: pathogenesis of the hypoglycaemia.

    abstract：:Up to 40% of children with Reye's syndrome have hypoglycaemia that could contribute to the patient's encephalopathy. We developed a mouse model in which intravenous inoculation of influenza B/Lee virus produced a non-permissive infection of hepatocytes and cerebral endothelial cells and caused many clinical, biochemic...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：

    authors： Davis LE,Woodfin BM,Tran TQ,Caskey LS,Wallace JM,Scremin OU,Blisard KS

    更新日期：1993-06-01 00:00:00

  • Coronary vessel development and insight towards neovascular therapy.

    abstract：:Formation of the coronary arteries consists of a precisely orchestrated series of morphogenetic and molecular events which can be divided into three distinct processes: vasculogenesis, angiogenesis and arteriogenesis (Risau 1997; Carmeliet 2000). Even subtle perturbations in this process may lead to congenital coronar...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2613.2009.00646.x

    authors： Smart N,Dubé KN,Riley PR

    更新日期：2009-06-01 00:00:00

  • Circumferential wall tension due to hypertension plays a pivotal role in aorta remodelling.

    abstract：:The present study was carried out to investigate the role of hypertension in the genesis and localization of intimal lesions and medial remodelling found in the prestenotic segment in relation to a severe stenosis of the abdominal aorta just below the diaphragm. Male young rats were divided randomly into operated grou...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2613.2006.00506.x

    authors： Prado CM,Rossi MA

    更新日期：2006-12-01 00:00:00

  • Cellular profile of primary molars with pulp necrosis after treatment with antibiotic paste.

    abstract：:The interradicular region of primary molars is permeated by many foramina, channels and accessories that connect the pulp cavity with the periapical tissues anatomically. Thus, pulp decomposition products or drugs used in endodontic treatment can trigger inflammatory reactions. The aim of this study was to evaluate th...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：10.1111/iep.12292

    authors： Moura LFAD,Lima MDM,Lima CCB,Bandeira AVL,Moura MS,Conde Júnior AM,Rizzo MDS

    更新日期：2018-10-01 00:00:00

  • Further evaluation of the interrelationship between the hepatocellular transport of bile acids and endocytosed proteins.

    abstract：:Experiments on the relationship between the hepatocellular transport of endogenous or exogenously loaded bile acids (sodium taurocholate, TC, 0.5 mumol/min/100 g body wt) and horseradish peroxidase (HRP) or immunoglobulin A (IgA) (0.5 mg/100 g body wt) were carried out on anaesthetized Wistar rats. The time course of ...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：

    authors： Herrera MC,el-Mir MY,Monte MJ,Perez-Barriocanal F,Marin JJ

    更新日期：1992-04-01 00:00:00

  • Neuropilins: expression and roles in the epithelium.

    abstract：:Initially found expressed in neuronal and then later in endothelial cells, it is well established that the transmembrane glycoproteins neuropilin-1 (NRP1) and neuropilin-2 (NRP2) play essential roles in axonal growth and guidance and in physiological and pathological angiogenesis. Neuropilin expression and function in...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2613.2012.00810.x

    authors： Wild JR,Staton CA,Chapple K,Corfe BM

    更新日期：2012-04-01 00:00:00

  • Expression of somatostatin mRNA and peptides in C-cell tumours of the thyroid gland in Han Wistar rats.

    abstract：:C-cell tumours of the thyroid gland are among the most common spontaneous neoplasms of the laboratory rat. With the exception of calcitonin, little attention has been paid to the secretory peptides of C cells during the development of neoplasia. Of these peptides, somatostatin (SS) is of particular interest because it...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：10.1111/j.0959-9673.2004.00367.x

    authors： Pilling A,Jones S,Turton J

    更新日期：2004-02-01 00:00:00

  • Immunohistochemical study of renal fibropoiesis associated with dogs naturally and experimentally infected with two different strains of Leishmania (L.) infantum.

    abstract：:The objectives of this work were to study some pathological aspects of kidneys obtained from dogs naturally infected with Leishmania infantum and from dogs experimentally infected with two different strains of L infantum with special emphasis on fibrotic process. Seventy eight specimens of paraffin-embedded kidney fra...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：10.1111/iep.12321

    authors： Alves AF,Pereira RA,de Andrade HM,Mosser DM,Tafuri WL

    更新日期：2019-08-01 00:00:00

  • Combined therapy with metformin and insulin attenuates systemic and hepatic alterations in a model of high-fat diet-/streptozotocin-induced diabetes.

    abstract：:In this study we have explored the pathogenesis of the hepatic alterations which occur in diabetes and the modulation of these complications by the combination of metformin adjunct treatment and insulin monotherapy. For this purpose, diabetic rats were treated with insulin (DM + Ins) or metformin plus insulin (DM + Me...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：10.1111/iep.12184

    authors： Silvares RR,Pereira EN,Flores EE,Estato V,Reis PA,Silva IJ,Machado MP,Neto HC,Tibiriça E,Daliry A

    更新日期：2016-06-01 00:00:00

  • Involvement of the EN-2 gene in normal and abnormal development of the human arcuate nucleus.

    abstract：:In this study, we wanted to evaluate whether the engrailed EN-2 gene, a homeobox gene with an essential role in the development of the rhombic lip derivatives in different species, is (1) expressed also in man in the differentiation process of the medullary arcuate nucleus (ArcN) and (2) involved in sudden unexplained...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：10.1111/j.0959-9673.2005.00408.x

    authors： Lavezzi AM,Ottaviani G,Mauri M,Terni L,Matturri L

    更新日期：2005-02-01 00:00:00

  • Deletion of the α2A/α2C-adrenoceptors accelerates cutaneous wound healing in mice.

    abstract：:The α2-adrenoceptors regulate the sympathetic nervous system, controlling presynaptic catecholamine release. However, the role of the α2-adrenoceptors in cutaneous wound healing is poorly understood. Mice lacking both the α2A/α2C-adrenoceptors were used to evaluate the participation of the α2-adrenoceptor during cutan...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：10.1111/iep.12093

    authors： Romana-Souza B,Nascimento AP,Brum PC,Monte-Alto-Costa A

    更新日期：2014-10-01 00:00:00

  • Involvement of platelet activation in experimental osteonecrosis in rabbits.

    abstract：:Osteonecrosis (ON) was produced experimentally in rabbits by intravenous injection of platelet activating factor (PAF) in combination with lipopolysaccharides (LPS) on two occasions separated by a week-long interval. Eleven of 15 rabbits (73%), with administration of both LPS (50 microg/kg) and PAF (10 microg/kg), exh...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2613.2001.00202.x

    authors： Masuhara K,Nakata K,Yamasaki S,Miki H,Yoshikawa H

    更新日期：2001-10-01 00:00:00

  • Is rat liver affected by non-alcoholic steatosis more susceptible to the acute toxic effect of thioacetamide?

    abstract：:Non-alcoholic fatty liver disease (NAFLD) is the most common chronic condition of the liver in the western world. There is only little evidence about altered sensitivity of steatotic liver to acute toxic injury. The aim of this project was to test whether hepatic steatosis sensitizes rat liver to acute toxic injury in...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2613.2011.00765.x

    authors： Kučera O,Lotková H,Staňková P,Podhola M,Roušar T,Mezera V,Cervinková Z

    更新日期：2011-08-01 00:00:00

  • Regulation of angiogenesis by hypoxic stress: from solid tumours to the ovarian follicle.

    abstract：:The preovulatory follicle provides a unique physiological example of rapid growth accompanied by neovascularization, two processes that are generally characteristic of pathologies such as wound repair or malignancy. During the hours preceding ovulation, follicular growth is accompanied by elevated levels of messenger ...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2613.1997.d01-247.x

    authors： Neeman M,Abramovitch R,Schiffenbauer YS,Tempel C

    更新日期：1997-04-01 00:00:00

  • Cytokines and their receptors in cardiovascular diseases--role of gp130 signalling pathway in cardiac myocyte growth and maintenance.

    abstract：:Interleukin (IL)-6-related cytokines share gp130 as the signal-transducing protein. Cardiac myocytes produce various kinds of cytokines including IL-6 and cardiotrophin-1. Activation of gp130 transduces hypertrophic and cytoprotective signals in cardiac myocytes via JAK/STAT, MAP kinase and PI-3 kinase pathways. Besid...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2613.2000.00139.x

    authors： Yamauchi-Takihara K,Kishimoto T

    更新日期：2000-02-01 00:00:00

  • Effect of chronic graft-versus-host disease on the intestine in adult BDF1 mice.

    abstract：:This study was performed to characterize the intestinal lesions in chronic graft-versus-host disease (GVHD) in mice and to determine a possible role of intestinal intraepithelial lymphocytes (ilEL) in the development of these lesions. Chronic GVHD was induced by transfer of DBA/2 lymphocytes into non-irradiated (C57BL...

    journal_title：International journal of experimental pathology

    pub_type： 杂志文章

    doi：

    authors： de Geus B,Hogenesch H,de Heer E,Bruijn JA,van den Enden M,Rozing J

    更新日期：1993-08-01 00:00:00