Abstract：
:Genetically resistant CBA and A/J mice and susceptible BALB/c and C57BL/6 mice were challenged with either an identical infective dose or a minimal lethal dose of Salmonella typhimurium. The histopathological progression of the disease was examined in tissue sections prepared by the JB-4 Plus resin embedding method and compared between the resistant and susceptible mice. In a fatal disease, the lesions in both animal hosts began with focal abscesses within the first three days post infection. Mononuclear cell infiltration started by day 4 and transformed the lesions into granulomata. Well-formed granulomata were evident by day 7 and persisted in sublethally infected resistant mice. Massive bacterial proliferation and extensive tissue degeneration marked the terminal stage of a lethal challenge. There were no distinguishable features that would identify the tissue response to infection in a resistant host from a susceptible one, except that the lesions in the sublethally infected resistant mice advanced slower and were discrete and self-limiting.
journal_name
Int J Exp Patholjournal_title
International journal of experimental pathologyauthors
Moncure CW,Guo YN,Xu HR,Hsu HSdoi
10.1046/j.1365-2613.1998.00064.xsubject
Has Abstractpub_date
1998-06-01 00:00:00pages
183-92issue
3eissn
0959-9673issn
1365-2613journal_volume
79pub_type
杂志文章abstract：:Pathological and immunopathological studies were carried out on snake coiled fibres (SCF) which occurred in affected soleus muscle in chloroquine treated rats. The SCF began to appear in denervated soleus muscle by 8 days after chloroquine injection. By day 14, typical SCF were observed with an unusual swirling patter...
journal_title：International journal of experimental pathology
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abstract：:While the origin of tumours, whether from one cell or many, has been a source of fascination for experimental oncologists for some time, in recent years there has been a veritable explosion of information about the clonal architecture of tumours and their antecedents, stimulated, in the main, by the ready accessibilit...
journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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abstract：:Mitochondrial DNA (mt-DNA) disorders and abnormal regulation of nuclear-derived proteins devoted to the cross-talk between the two cellular genomes have recently interested researchers in the field of neuromuscular diseases. We have identified, isolated and sequenced a new gene, augmenter of liver regeneration (ALR) t...
journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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更新日期：1995-10-01 00:00:00
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journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2613.1998.00083.x
更新日期：1998-12-01 00:00:00
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journal_title：International journal of experimental pathology
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