Explantation of mesangial cell 'hillocks': a method for obtaining human mesangial cells in culture.

abstract：:The roles of inducible nitric oxide synthase (iNOS) in the development and healing of gastric ulcers have not been fully characterized. We characterized iNOS expression in experimentally induced ulcers in rat and mouse stomachs and investigated the roles of iNOS using iNOS gene-deficient (iNOS-/-) mice and wildtype mi...

journal_title：International journal of experimental pathology

authors： Tatemichi M,Ogura T,Sakurazawa N,Nagata H,Sugita M,Esumi H

更新日期：2003-10-01 00:00:00

abstract：:(Pre)neoplastic lesions in livers of rats induced by diethylnitrosamine are characterized by elevated activity of the first irreversible enzyme of the oxidative branch of the pentose phosphate pathway (PPP), glucose-6-phosphate dehydrogenase (G6PD), for production of NADPH. In the present study, the activity of G6PD, ...

journal_title：International journal of experimental pathology

authors： Frederiks WM,Vizan P,Bosch KS,Vreeling-Sindelárová H,Boren J,Cascante M

更新日期：2008-08-01 00:00:00

abstract：:C-cell tumours of the thyroid gland are among the most common spontaneous neoplasms of the laboratory rat. With the exception of calcitonin, little attention has been paid to the secretory peptides of C cells during the development of neoplasia. Of these peptides, somatostatin (SS) is of particular interest because it...

journal_title：International journal of experimental pathology

authors： Pilling A,Jones S,Turton J

更新日期：2004-02-01 00:00:00

abstract：:In order to clarify the function of hepatocyte growth factor (HGF) in vivo, we have developed transgenic mice expressing HGF in the liver. The bromodeoxyuridine labelling indices in livers from HGF transgenic mice were doubled, compared to those from wild type mice. Livers of HGF transgenic mice expressed high levels ...

journal_title：International journal of experimental pathology

authors： Shiota G,Kawasaki H

更新日期：1998-10-01 00:00:00

abstract：:Experiments on the relationship between the hepatocellular transport of endogenous or exogenously loaded bile acids (sodium taurocholate, TC, 0.5 mumol/min/100 g body wt) and horseradish peroxidase (HRP) or immunoglobulin A (IgA) (0.5 mg/100 g body wt) were carried out on anaesthetized Wistar rats. The time course of ...

journal_title：International journal of experimental pathology

authors： Herrera MC,el-Mir MY,Monte MJ,Perez-Barriocanal F,Marin JJ

更新日期：1992-04-01 00:00:00

abstract：:Lysyl oxidase, which cross-links collagen and elastin, was obtained from chick embryo bone and cartilage and its substrate, elastin, from aorta. The enzyme was studied using an improved assay which enabled the stability of the substrate to be monitored. The enzyme was fully inhibited in vivo by beta-aminopropionitrile...

journal_title：International journal of experimental pathology

authors： Levene CI,Sharman DF,Callingham BA

更新日期：1992-10-01 00:00:00

abstract：:Administration of mercuric chloride (HgCl(2)) to Brown Norway rats causes Th2-dominated autoimmunity with raised immunoglobulin E concentrations and gut vasculitis, both of which are T-cell dependent, peak at 14 days after starting HgCl(2) and then spontaneously resolve. If animals are re-challenged with HgCl(2) 6 wee...

journal_title：International journal of experimental pathology

authors： Vinen CS,Turner DR,Oliveira DB

更新日期：2004-06-01 00:00:00

abstract：:Mitochondrial DNA (mt-DNA) disorders and abnormal regulation of nuclear-derived proteins devoted to the cross-talk between the two cellular genomes have recently interested researchers in the field of neuromuscular diseases. We have identified, isolated and sequenced a new gene, augmenter of liver regeneration (ALR) t...

journal_title：International journal of experimental pathology

authors： Polimeno L,Pesetti B,Giorgio F,Moretti B,Resta L,Rossi R,Annoscia E,Patella V,Notarnicola A,Mallamaci R,Francavilla A

更新日期：2009-08-01 00:00:00

abstract：:Integrins are the key mediators of cell-extracellular matrix (ECM) interaction, linking the ECM to the actin cytoskeleton. Besides localizing at the cell surface, they can be internalized and transported back to the plasma membrane (recycled) or delivered to the late endosomes/lysosomes for degradation. We and others ...

journal_title：International journal of experimental pathology

authors： Rainero E

更新日期：2018-02-01 00:00:00

abstract：:We determined the feasibility of producing protoporphyric hepatopathy in unrestrained rats by infusing protoporphyrin into their portal circulation via chronic indwelling catheters. Sprague-Dawley rats, 200-300 g, received single (8.5-27.8 mumol) or multiple (64.1-208.7 mumol) infusions of protoporphyrin over 3-240 h....

journal_title：International journal of experimental pathology

authors： Berenson MM,Kimura R,Samowitz W,Bjorkman D

更新日期：1992-10-01 00:00:00

abstract：:BALB/c and CBA mice maintained on low (4%) or normal (18%) protein diets for 2 weeks after weaning were infected with a sublethal dose of murine cytomegalovirus, adjusted in proportion to body weight. Viral replication, histopathological changes and humoral responses to the virus were compared between the dietary grou...

journal_title：International journal of experimental pathology

authors： Teo HK,Price P,Papadimitriou JM

更新日期：1991-02-01 00:00:00

abstract：:Recently, there have been significant advances toward the development of culture conditions that promote proliferation of primary rodent hepatocytes. There are two major methods for the multiplication of hepatocytes in vitro: one is the use of nicotinamide, the other is the use of a nutrient-rich medium. In the medium...

journal_title：International journal of experimental pathology

authors： Mitaka T

更新日期：1998-12-01 00:00:00

abstract：:A major translational barrier to the use of stem cell (SC)-based therapy in patients with myocardial infarction (MI) is the lack of a clear understanding of the mechanism(s) underlying the cardioprotective effect of SCs. Numerous paracrine factors from SCs may account for reduction in infarct size, but myocardial salv...

journal_title：International journal of experimental pathology

authors： Karpov AA,Puzanov MV,Ivkin DY,Krasnova MV,Anikin NA,Docshin PM,Moiseeva OM,Galagudza MM

更新日期：2019-04-01 00:00:00

abstract：:The female reproductive organs (ovary, uterus, and placenta) are some of the few adult tissues that exhibit regular intervals of rapid growth. They also are highly vascular and have high rates of blood flow. Angiogenesis, or vascular growth, is therefore an important component of the growth and function of these tissu...

journal_title：International journal of experimental pathology

authors： Reynolds LP,Grazul-Bilska AT,Redmer DA

更新日期：2002-08-01 00:00:00

abstract：:The effect of oestradiol on the intact and castrated adult gerbil prostate was evaluated by focussing on stromal and epithelial disorders, and hormonal receptor immunoreactivity. The experimental animals were studied by histological, histochemical and immunohistochemical techniques, morphometric-stereological analysis...

journal_title：International journal of experimental pathology

authors： Scarano WR,de Sousa DE,Campos SG,Corradi LS,Vilamaior PS,Taboga SR

更新日期：2008-02-01 00:00:00

abstract：:The Fell-Muir Award requires the recipient to deliver a lecture and a review manuscript which provides a personal overview of significant scientific developments in the field of matrix biology over the period of the recipient's career. In this context, this review considers the collagen family of structural proteins a...

journal_title：International journal of experimental pathology

authors： Grant ME

更新日期：2007-08-01 00:00:00

abstract：:Haptoglobin is an acute phase protein known to be highly expressed in the liver. Recently, we showed increased local arterial haptoglobin expression after flow-induced arterial remodelling and found that haptoglobin is involved in cell migration and arterial restructuring probably through accumulation of a temporary g...

journal_title：International journal of experimental pathology

authors： Smeets MB,Fontijn J,Kavelaars A,Pasterkamp G,De Kleijn DP

更新日期：2003-04-01 00:00:00

abstract：:Two families of the Metzincin clan of metalloproteinases, the matrix metalloproteinases and the disintegrin metalloproteinases have attracted much attention as important effectors of cellular interactions with their environment. They appear to play significant roles in the modulation of components of the extracellular...

journal_title：International journal of experimental pathology

authors： Murphy G

更新日期：2010-08-01 00:00:00

abstract：:There is evidence to show that downregulation of miR-1 expression is closely related to cancer progression, including in nasopharyngeal carcinoma (NPC). However, the molecular mechanisms underlying miR-1 downregulation in NPC remain largely unknown, especially its association with Epstein-Barr virus (EBV). In this stu...

journal_title：International journal of experimental pathology

authors： Chen X,Shi J,Zhong J,Huang Z,Luo X,Huang Y,Feng S,Shao J,Liu D

更新日期：2015-12-01 00:00:00

abstract：:The use of non-specific inhibitors of tissue non-specific alkaline phosphatase (TNSALP) in pre-adipocytes blocks intracellular lipid accumulation. TNSALP is also expressed in hepatocytes, which are known to accumulate lipid in a similar manner to pre-adipocytes. The purpose of this study was to use specific silencing ...

journal_title：International journal of experimental pathology

authors： Chirambo G,van Niekerk C,Crowther NJ

更新日期：2017-10-01 00:00:00

abstract：:Muramyl dipeptide-Lys(L18) given by daily subcutaneous injection for 14 days induced arthritis in male Lewis, Fischer and nude rats, to a lesser degree in the last two than in the first strain. On the other hand, a single intradermal administration of Freund's complete adjuvant induced arthritis in Lewis and Fischer b...

journal_title：International journal of experimental pathology

authors： Sugawara T,Takada S,Furuhama K,Takayama S,Nomura M,Kato M

更新日期：1995-06-01 00:00:00

abstract：:It was previously shown that administration of the nitric oxide synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) aggravated murine viral myocarditis by increasing myocardial virus titres. Experimental autoimmune myocarditis in mice and rats mimics human fulminant myocarditis. The effects of L-arginine, a...

journal_title：International journal of experimental pathology

authors： Okabe TA,Hattori M,Yuan Z,Kishimoto C

更新日期：2008-10-01 00:00:00

abstract：:The objectives of this work were to study some pathological aspects of kidneys obtained from dogs naturally infected with Leishmania infantum and from dogs experimentally infected with two different strains of L infantum with special emphasis on fibrotic process. Seventy eight specimens of paraffin-embedded kidney fra...

journal_title：International journal of experimental pathology

authors： Alves AF,Pereira RA,de Andrade HM,Mosser DM,Tafuri WL

更新日期：2019-08-01 00:00:00

abstract：:The aim of the present study was to evaluate the coexpression of very early (CD69), early (CD25) and late (HLADR) antigens and to analyse the mean fluorescence intensity (MFI) of such activation markers on synovial fluid (SF) and peripheral blood (PB) lymphocytes of patients affected by rheumatoid arthritis (RA) and o...

journal_title：International journal of experimental pathology

authors： Afeltra A,Galeazzi M,Sebastiani GD,Ferri GM,Caccavo D,Addessi MA,Marcolongo R,Bonomo L

更新日期：1997-10-01 00:00:00

abstract：:Colonization of the genital tract of female mice, mainly BALB/c, by Mycoplasma genitalium, M. pneumoniae and M. pulmonis was enhanced by pretreatment of the mice with progesterone. M. fermentans, M. hominis and M. salivarium, and three serotypes and two untyped strains of Ureaplasma urealyticum colonized under the inf...

journal_title：International journal of experimental pathology

authors： Furr PM,Taylor-Robinson D

更新日期：1993-02-01 00:00:00

abstract：:This study tested the hypothesis that different doses of nandrolone decanoate (ND) will cause changes in the estrous cycle and ovarian tissue of adult rats; and investigated the duration of the recovery period that is sufficient to restore the damage in the animals treated with different doses. Wistar rats were treate...

journal_title：International journal of experimental pathology

authors： Simão VA,Berloffa Belardin L,Araújo Leite GA,de Almeida Chuffa LG,Camargo IC

更新日期：2015-10-01 00:00:00

abstract：:Naturally developing spontaneous osteoarthritis (OA) is seen in a number of small animals one of which is the STR/ORT mouse, an accepted model of human OA. A histological evaluation of the patello-femoral joints of 37 male STR/ORT mice has shown features that are inconsistent with the disease in human joints. These in...

journal_title：International journal of experimental pathology

authors： Das-Gupta EP,Lyons TJ,Hoyland JA,Lawton DM,Freemont AJ

更新日期：1993-12-01 00:00:00

abstract：:Tumour-associated macrophage (TAM) polarization is associated with hepatocellular carcinoma but the molecular mechanism of this polarization is still unknown. Peripheral blood mononuclear cells were induced to differentiate into M0, M1 and M2 macrophages and TAMs. TAMs were transfected with pcDNA3.1-GAS5, pcDNA3.1-NC,...

journal_title：International journal of experimental pathology

authors： Wang X,Li FY,Zhao W,Gao ZK,Shen B,Xu H,Cui YF

更新日期：2020-12-01 00:00:00

abstract：:Permethrin (PM), a synthetic pyrethroid insecticide, has broad toxicity spectra. We aimed to investigate the effects of PM on the testes of adult albino rats, examine the recovery response and evaluate the efficacy of naringenin (NG) supplementation. Adult male albino rats were randomly assigned to five groups of six ...

journal_title：International journal of experimental pathology

authors： Mostafa Hel-S,Abd El-Baset SA,Kattaia AA,Zidan RA,Al Sadek MM

更新日期：2016-02-01 00:00:00

abstract：:Diets enriched with fat, especially unsaturated fat, promote experimental pancreatic carcinogenesis, but little is known of the effects of individual fatty acids. The effect of stearic and oleic acid on pancreatic fatty acids and atypical acinar cell nodules (preneoplastic lesions) was studied in 14-day-old weanling m...

journal_title：International journal of experimental pathology

authors： Khoo DE,Flaks B,Oztas H,Williamson RC,Habib NA

更新日期：1991-10-01 00:00:00