New histological observations in spontaneously developing osteoarthritis in the STR/ORT mouse questioning its acceptability as a model of human osteoarthritis.

abstract：:p23 is a cochaperone of heat shock protein 90 and also interacts functionally with numerous steroid receptors and kinases. However, the in vivo roles of p23 remain unclear. To explore its in vivo function, we generated the transgenic (TG) mice ubiquitously overexpressing p23. The p23 TG mice spontaneously developed ki...

journal_title：International journal of experimental pathology

authors： Lee J,Kim HJ,Moon JA,Sung YH,Baek IJ,Roh JI,Ha NY,Kim SY,Bahk YY,Lee JE,Yoo TH,Lee HW

更新日期：2011-08-01 00:00:00

abstract：:Dengue type 2 virus (DV) induces a subpopulation of T lymphocytes of mouse spleen to secrete a soluble helper cytokine (HF) which enhances the DV-specific IgM antibody plaque forming cells (PFC). The present study undertaken to purify and characterize HF shows that it can be purified by low pressure liquid chromatogra...

journal_title：International journal of experimental pathology

authors： Chaturvedi P,Mukherjee R,Chaturvedi UC,Mathur A

更新日期：1992-06-01 00:00:00

abstract：:The field of study concerning promotion and/or inhibition of angiogenesis has gathered much attention in the scientific community. A great deal of work has been invested towards defining reproducible assays to gauge for promotion or inhibition of angiogenesis in response to drug treatments or growth conditions. Two co...

journal_title：International journal of experimental pathology

authors： Prigozhina NL,Heisel AJ,Seldeen JR,Cosford ND,Price JH

更新日期：2013-12-01 00:00:00

abstract：:Tumour growth is angiogenesis dependent. Thrombosis and thromboembolism are very common in cancer patients. These patients are often treated with heparin as an anti-coagulant. Many tumour angiogens, including VEGF165, and endogenous anti-angiogenesis factors bind heparin tightly. Using the non-surgical mesenteric-wind...

journal_title：International journal of experimental pathology

authors： Norrby K

更新日期：2000-06-01 00:00:00

abstract：:Heart failure (HF) is characterized by a skeletal muscle myopathy with increased expression of fast myosin heavy chains (MHCs). The skeletal muscle-specific molecular regulatory mechanisms controlling MHC expression during HF have not been described. Myogenic regulatory factors (MRFs), a family of transcriptional fact...

journal_title：International journal of experimental pathology

authors： Carvalho RF,Cicogna AC,Campos GE,Lopes Fda S,Sugizaki MM,Nogueira CR,Pai-Silva MD

更新日期：2006-06-01 00:00:00

abstract：:Mouse phrenic nerve-hemidiaphragms were stimulated in vitro in the presence of the anticholinesterase ecothiopate iodide and prepared for light and electron microscopy at different times during and after the appearance of prolonged contractions localized at the endplate. The earliest changes were at the subsynapse, wi...

journal_title：International journal of experimental pathology

authors： Ferry CB,Cullen MJ

更新日期：1991-06-01 00:00:00

abstract：:Genetically resistant CBA and A/J mice and susceptible BALB/c and C57BL/6 mice were challenged with either an identical infective dose or a minimal lethal dose of Salmonella typhimurium. The histopathological progression of the disease was examined in tissue sections prepared by the JB-4 Plus resin embedding method an...

journal_title：International journal of experimental pathology

authors： Moncure CW,Guo YN,Xu HR,Hsu HS

更新日期：1998-06-01 00:00:00

abstract：:Acute myocardial infarction is one of the major causes of mortality worldwide. For regeneration of the rabbit heart after experimentally induced infarction we used autologous skeletal myoblasts (SMs) due to their high proliferative potential, resistance to ischaemia and absence of immunological and ethical concerns. T...

journal_title：International journal of experimental pathology

authors： Antanavičiūtė I,Ereminienė E,Vysockas V,Račkauskas M,Skipskis V,Rysevaitė K,Treinys R,Benetis R,Jurevičius J,Skeberdis VA

更新日期：2015-02-01 00:00:00

abstract：:Interleukin (IL)-6-related cytokines share gp130 as the signal-transducing protein. Cardiac myocytes produce various kinds of cytokines including IL-6 and cardiotrophin-1. Activation of gp130 transduces hypertrophic and cytoprotective signals in cardiac myocytes via JAK/STAT, MAP kinase and PI-3 kinase pathways. Besid...

journal_title：International journal of experimental pathology

authors： Yamauchi-Takihara K,Kishimoto T

更新日期：2000-02-01 00:00:00

abstract：:There is evidence to show that downregulation of miR-1 expression is closely related to cancer progression, including in nasopharyngeal carcinoma (NPC). However, the molecular mechanisms underlying miR-1 downregulation in NPC remain largely unknown, especially its association with Epstein-Barr virus (EBV). In this stu...

journal_title：International journal of experimental pathology

authors： Chen X,Shi J,Zhong J,Huang Z,Luo X,Huang Y,Feng S,Shao J,Liu D

更新日期：2015-12-01 00:00:00

abstract：:A major translational barrier to the use of stem cell (SC)-based therapy in patients with myocardial infarction (MI) is the lack of a clear understanding of the mechanism(s) underlying the cardioprotective effect of SCs. Numerous paracrine factors from SCs may account for reduction in infarct size, but myocardial salv...

journal_title：International journal of experimental pathology

authors： Karpov AA,Puzanov MV,Ivkin DY,Krasnova MV,Anikin NA,Docshin PM,Moiseeva OM,Galagudza MM

更新日期：2019-04-01 00:00:00

abstract：:Pathological and immunopathological studies were carried out on snake coiled fibres (SCF) which occurred in affected soleus muscle in chloroquine treated rats. The SCF began to appear in denervated soleus muscle by 8 days after chloroquine injection. By day 14, typical SCF were observed with an unusual swirling patter...

journal_title：International journal of experimental pathology

authors： Tsuzuki K,Fukatsu R,Takamaru Y,Yoshida T,Hayashi Y,Kobayashi K,Fujii N,Takahata N

更新日期：1997-02-01 00:00:00

abstract：:The Fell-Muir Award requires the recipient to deliver a lecture and a review manuscript which provides a personal overview of significant scientific developments in the field of matrix biology over the period of the recipient's career. In this context, this review considers the collagen family of structural proteins a...

journal_title：International journal of experimental pathology

authors： Grant ME

更新日期：2007-08-01 00:00:00

abstract：:Administration of mercuric chloride (HgCl(2)) to Brown Norway rats causes Th2-dominated autoimmunity with raised immunoglobulin E concentrations and gut vasculitis, both of which are T-cell dependent, peak at 14 days after starting HgCl(2) and then spontaneously resolve. If animals are re-challenged with HgCl(2) 6 wee...

journal_title：International journal of experimental pathology

authors： Vinen CS,Turner DR,Oliveira DB

更新日期：2004-06-01 00:00:00

abstract：:Pterygium is a surface ocular lesion that is associated with chronic UV exposure. The primary effect is a solar actinic elastosis within the stroma. All the other changes are secondary. Pterygium is characterized by proliferation, inflammatory infiltrates, fibrosis, angiogenesis and extracellular matrix breakdown. The...

journal_title：International journal of experimental pathology

authors： Ribatti D,Nico B,Perra MT,Maxia C,Piras F,Murtas D,Crivellato E,Sirigu P

更新日期：2009-12-01 00:00:00

abstract：:Ischaemic-reperfusion injury as a model of acute renal failure (ARF) results in increased macromolecular permeability, tubular obstruction, and renal oedema. To investigate the role for coagulation in this model, anticoagulated and saline-pretreated rats were subjected to 60 min unilateral renal artery occlusion (RAO)...

journal_title：International journal of experimental pathology

authors： Druid H,Eneström S,Rammer L

更新日期：1998-02-01 00:00:00

abstract：:In this study, viruria following Japanese encephalitis virus (JEV) infection in mice has been shown to appear earlier in pregnant than in normal mice with proteinuria and haematuria. This was related to the production of splenic macrophage derived neutrophil chemotactic factor (MDF) following JEV infection. Intravenou...

journal_title：International journal of experimental pathology

authors： Mathur A,Khanna N,Kulshreshtha R,Maitra SC,Chaturvedi UC

更新日期：1995-04-01 00:00:00

abstract：:Hydroxymethylnitrofurazone (NFOH) is a nitrofurazone prodrug effective in vivo during acute infections, and it has less hepatotoxicity effect than the standard drug benznidazole (BZN) which has been used during short- and long-term treatment. In the present study, we induced the indeterminate form of Chagas disease in...

journal_title：International journal of experimental pathology

authors： Scarim CB,de Andrade CR,da Rosa JA,Dos Santos JL,Chin CM

更新日期：2018-10-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a major global cause of hepatocellular carcinoma (HCC). Individuals who are chronic carriers have a greater than 100-fold increased relative risk of developing the tumour. Several mechanisms of HBV-induced HCC have been proposed. Integration of HBV DNA into the genome of he...

journal_title：International journal of experimental pathology

authors： Arbuthnot P,Kew M

更新日期：2001-04-01 00:00:00

abstract：:This study aimed to characterize matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in relation to changes in left ventricle (LV) geometry and function in a porcine model with streptozotocin (STZ)-induced diabetes. In 15 Chinese Guizhou minipigs with STZ-induced diabetes (diabetic group) and 15 age-m...

journal_title：International journal of experimental pathology

authors： Lu L,Zhang Q,Pu LJ,Peng WH,Yan XX,Wang LJ,Chen QJ,Zhu ZB,Michel JB,Shen WF

更新日期：2008-04-01 00:00:00

abstract：:Ultraviolet ray B (UV-B) induced dermatitis in the rat may be a model for human psoriasis vulgaris. Detailed studies of this model are reported. Rat skin responded to UV-B irradiation quite differently from human, guinea-pig, or mouse skin. Rat UV-B dermatitis was characterized by a sharply demarcated brownish-red les...

journal_title：International journal of experimental pathology

authors： Nakaguma H,Kambara T,Yamamoto T

更新日期：1995-02-01 00:00:00

abstract：:In chronic administration of sodium valproate to rats, significant disorders of structural integrity of the hippocampal gyrus and the neocortex of the temporal lobe, observed in the last two stages of the experiment (after 9 and 12 months), coexisted with increased number of microglial cells and, especially after 12 m...

journal_title：International journal of experimental pathology

authors： Sobaniec-Lotowska ME

更新日期：2005-04-01 00:00:00

abstract：:To confirm the existence of the cervical thymus and the development of cervical thymoma in thymoma-prone BUF/Mna (BUF) rats, we examined cervical organs and adjacent tissues, and thoracic thymic tissues of the three inbred strains, BUF, ACI/NMna (ACI), and WKY/NCrj (WKY), and 11 congenic strains, in which genetic regi...

journal_title：International journal of experimental pathology

authors： Yamada T,Matsuyama M,Yanagida T,Kato K,Sugiura S,Kuroda M

更新日期：2011-04-01 00:00:00

abstract：:Summary K-ras mutations are found in 40-50% of human colorectal adenomas and carcinomas, but their functional contribution remains incompletely understood. Here, we show that a conditional mutant K-ras mouse model (K-ras(Asp12)/Cre), with transient intestinal Cre activation by beta-Naphthoflavone (beta-NF) treatment, ...

journal_title：International journal of experimental pathology

authors： Luo F,Brooks DG,Ye H,Hamoudi R,Poulogiannis G,Patek CE,Winton DJ,Arends MJ

更新日期：2009-10-01 00:00:00

abstract：:Pulmonary granuloma formation and fibrosis were experimentally induced in Sprague-Dawley strain rats by Angiostrongylus cantonensis. Increased protein levels of matrix metalloproteinase (MMP)-2, -9, -13 and the imbalance between these enzymes and metalloproteinase inhibitors, tissue inhibitors of MMPs (TIMP-1 and -2),...

journal_title：International journal of experimental pathology

authors： Hsu CC,Lai SC

更新日期：2007-12-01 00:00:00

abstract：:Minaçu virus was isolated from Ochlerotatus scapularis (Diptera: Culicidae) in Minaçu, Goiás State, Brazil, in 1996. In attempting characterization of virus serological (hemagluttination inhibition, HI; indirect immunofluorescence assay, IFA), physicochemical [test for deoxycholate acid (DCA) sensitivity; polyacrylami...

journal_title：International journal of experimental pathology

authors： Martins LC,Diniz JA,Silva EV,Barros VL,Monteiro HA,Azevedo RS,Quaresma JA,Vasconcelos PF

更新日期：2007-02-01 00:00:00

abstract：:Cyclophilins are proteins which are remarkably conserved through evolution; moreover they have been found in every possible existing organism, which indicates their fundamental importance. Due to their enzymatic properties, multiplicity, cellular localization and role in protein folding they belong to the group of pro...

journal_title：International journal of experimental pathology

authors： Andreeva L,Heads R,Green CJ

更新日期：1999-12-01 00:00:00

abstract：:Polymorphonuclear cells (PMN) are believed to be important effector cells responsible the myocardial damage seen following ischaemia. However, the exact kinetics of their migration remains controversial. Isolated PMN (10 x 10(6) cells) labelled with (51)Cr were injected into four groups of Lewis rats: 0 h (T0h; n = 13...

journal_title：International journal of experimental pathology

authors： Légaré JF,Oxner A,Heimrath O,Issekutz T

更新日期：2007-08-01 00:00:00

abstract：:Low-dose chemotherapy drugs can suppress tumours by restraining tumour vessel growth and preventing the repair of damaged vascular endothelial cells. Cisplatin is a broad-spectrum, cell cycle-non-specific drug, but has serious side effects if used at high doses. There have been few reports on the anti-angiogenic effec...

journal_title：International journal of experimental pathology

authors： Shen FZ,Wang J,Liang J,Mu K,Hou JY,Wang YT

更新日期：2010-02-01 00:00:00

abstract：:The α2-adrenoceptors regulate the sympathetic nervous system, controlling presynaptic catecholamine release. However, the role of the α2-adrenoceptors in cutaneous wound healing is poorly understood. Mice lacking both the α2A/α2C-adrenoceptors were used to evaluate the participation of the α2-adrenoceptor during cutan...

journal_title：International journal of experimental pathology

authors： Romana-Souza B,Nascimento AP,Brum PC,Monte-Alto-Costa A

更新日期：2014-10-01 00:00:00