Correlation between NGF/TrkA and microvascular density in human pterygium.

abstract：:The tumour microenvironment, which is largely composed of inflammatory cells, is a crucial participant in the neoplastic process through the promotion of cell proliferation, survival and migration. Neutrophil polymorphonuclear cells (PMNs) induce inflammatory reactions that can be either cytotoxic for tumour cells or ...

journal_title：International journal of experimental pathology

authors： Remedi MM,Donadio AC,Chiabrando GA

更新日期：2009-02-01 00:00:00

abstract：:In this study we have explored the pathogenesis of the hepatic alterations which occur in diabetes and the modulation of these complications by the combination of metformin adjunct treatment and insulin monotherapy. For this purpose, diabetic rats were treated with insulin (DM + Ins) or metformin plus insulin (DM + Me...

journal_title：International journal of experimental pathology

authors： Silvares RR,Pereira EN,Flores EE,Estato V,Reis PA,Silva IJ,Machado MP,Neto HC,Tibiriça E,Daliry A

更新日期：2016-06-01 00:00:00

abstract：:Formation of the coronary arteries consists of a precisely orchestrated series of morphogenetic and molecular events which can be divided into three distinct processes: vasculogenesis, angiogenesis and arteriogenesis (Risau 1997; Carmeliet 2000). Even subtle perturbations in this process may lead to congenital coronar...

journal_title：International journal of experimental pathology

authors： Smart N,Dubé KN,Riley PR

更新日期：2009-06-01 00:00:00

abstract：:Small intestinal mucosal T cell activation results in villous atrophy and crypt hyperplasia. There is conflicting evidence as to whether a Th1 IFN-gamma response may be involved. Using a murine intestinal transplant model of T cell-mediated enteropathy we aimed to study the role of IFN-gamma on the development of vill...

journal_title：International journal of experimental pathology

authors： Veitch AM,Higgins LM,Bajaj-Elliot M,Farthing MJ,MacDonald TT

更新日期：2003-06-01 00:00:00

abstract：:While the origin of tumours, whether from one cell or many, has been a source of fascination for experimental oncologists for some time, in recent years there has been a veritable explosion of information about the clonal architecture of tumours and their antecedents, stimulated, in the main, by the ready accessibilit...

journal_title：International journal of experimental pathology

authors： Garcia SB,Novelli M,Wright NA

更新日期：2000-04-01 00:00:00

abstract：:BALB/c and CBA mice maintained on low (4%) or normal (18%) protein diets for 2 weeks after weaning were infected with a sublethal dose of murine cytomegalovirus, adjusted in proportion to body weight. Viral replication, histopathological changes and humoral responses to the virus were compared between the dietary grou...

journal_title：International journal of experimental pathology

authors： Teo HK,Price P,Papadimitriou JM

更新日期：1991-02-01 00:00:00

abstract：:Summary K-ras mutations are found in 40-50% of human colorectal adenomas and carcinomas, but their functional contribution remains incompletely understood. Here, we show that a conditional mutant K-ras mouse model (K-ras(Asp12)/Cre), with transient intestinal Cre activation by beta-Naphthoflavone (beta-NF) treatment, ...

journal_title：International journal of experimental pathology

authors： Luo F,Brooks DG,Ye H,Hamoudi R,Poulogiannis G,Patek CE,Winton DJ,Arends MJ

更新日期：2009-10-01 00:00:00

abstract：:We have shown previously that cycloheximide (CHX), a potent protein synthesis inhibitor, induces high levels of apoptosis in Epstein-Barr virus free (EBV(-)) Burkitt's lymphoma (BJA-B) cells, with comparably reduced levels of apoptosis in the EBV positive (EBV(+)) cells. Modulation of CHX-induced apoptosis in EBV(-) a...

journal_title：International journal of experimental pathology

authors： Ishii H,Tamauchi H,Gobe GC

更新日期：1997-06-01 00:00:00

abstract：:Heparan sulphate (HS) sits at the interface of the cell and the extracellular matrix. It is a member of the glycosaminoglycan family of anionic polysaccharides with unique structural features designed for protein interaction and regulation. Its client proteins include soluble effectors (e.g. growth factors, morphogens...

journal_title：International journal of experimental pathology

authors： Gallagher J

更新日期：2015-08-01 00:00:00

abstract：:The effect of dengue type 2 virus (DV) and the cytokines induced by it, on the chemiluminescence (CL) response of mouse spleen cells was studied by luminol-dependent CL. Following intracerebral (i.c.) inoculation of DV, an initial increase in CL response was observed which was followed by a sharp decline from the 4th ...

journal_title：International journal of experimental pathology

authors： Dhawan R,Chaturvedi UC,Mashihi KN,Chaturvedi P,Mukherjee R

更新日期：1993-10-01 00:00:00

abstract：:The relationship between donor age and the growth characteristics of normal human smooth muscle cell cultures derived from aorta and stomach was examined in a series of growth studies. A negative correlation was demonstrated between donor age and growth potential of both cell types in primary culture. This decreased g...

journal_title：International journal of experimental pathology

authors： Start RD,Loomes RS,Shortland JR

更新日期：1991-12-01 00:00:00

abstract：:Angiogenesis is a common finding in chronic inflammatory diseases; however, its role in Sjögren's syndrome (SS) remains to be elucidated. Previous SS studies have demonstrated an increase in VEGF-A/VEGFR-2 system expression in minor salivary gland (MSG) biopsies from patients with SS, but differences in the new blood ...

journal_title：International journal of experimental pathology

authors： Sisto M,Lisi S,Ingravallo G,Lofrumento DD,D'Amore M,Ribatti D

更新日期：2014-04-01 00:00:00

abstract：:The roles of inducible nitric oxide synthase (iNOS) in the development and healing of gastric ulcers have not been fully characterized. We characterized iNOS expression in experimentally induced ulcers in rat and mouse stomachs and investigated the roles of iNOS using iNOS gene-deficient (iNOS-/-) mice and wildtype mi...

journal_title：International journal of experimental pathology

authors： Tatemichi M,Ogura T,Sakurazawa N,Nagata H,Sugita M,Esumi H

更新日期：2003-10-01 00:00:00

abstract：:Initially found expressed in neuronal and then later in endothelial cells, it is well established that the transmembrane glycoproteins neuropilin-1 (NRP1) and neuropilin-2 (NRP2) play essential roles in axonal growth and guidance and in physiological and pathological angiogenesis. Neuropilin expression and function in...

journal_title：International journal of experimental pathology

authors： Wild JR,Staton CA,Chapple K,Corfe BM

更新日期：2012-04-01 00:00:00

abstract：:Diets enriched with fat, especially unsaturated fat, promote experimental pancreatic carcinogenesis, but little is known of the effects of individual fatty acids. The effect of stearic and oleic acid on pancreatic fatty acids and atypical acinar cell nodules (preneoplastic lesions) was studied in 14-day-old weanling m...

journal_title：International journal of experimental pathology

authors： Khoo DE,Flaks B,Oztas H,Williamson RC,Habib NA

更新日期：1991-10-01 00:00:00

abstract：:The Fell-Muir Award requires the recipient to deliver a lecture and a review manuscript which provides a personal overview of significant scientific developments in the field of matrix biology over the period of the recipient's career. In this context, this review considers the collagen family of structural proteins a...

journal_title：International journal of experimental pathology

authors： Grant ME

更新日期：2007-08-01 00:00:00

abstract：:Several methods have been described for investigating chondrocyte metabolism in vitro. In this study, in-situ hybridization (ISH) using an oligonucleotide probe (i.e. a poly-d(T) probe) to detect total messenger RNA (mRNA) in cartilage explants has been compared with radiosulphate and radioleucine uptake studies in an...

journal_title：International journal of experimental pathology

authors： Marles PJ,Hoyland JA,Parkinson R,Freemont AJ

更新日期：1991-04-01 00:00:00

abstract：:Minaçu virus was isolated from Ochlerotatus scapularis (Diptera: Culicidae) in Minaçu, Goiás State, Brazil, in 1996. In attempting characterization of virus serological (hemagluttination inhibition, HI; indirect immunofluorescence assay, IFA), physicochemical [test for deoxycholate acid (DCA) sensitivity; polyacrylami...

journal_title：International journal of experimental pathology

authors： Martins LC,Diniz JA,Silva EV,Barros VL,Monteiro HA,Azevedo RS,Quaresma JA,Vasconcelos PF

更新日期：2007-02-01 00:00:00

abstract：:Integrins are the key mediators of cell-extracellular matrix (ECM) interaction, linking the ECM to the actin cytoskeleton. Besides localizing at the cell surface, they can be internalized and transported back to the plasma membrane (recycled) or delivered to the late endosomes/lysosomes for degradation. We and others ...

journal_title：International journal of experimental pathology

authors： Rainero E

更新日期：2018-02-01 00:00:00

abstract：:Up to 40% of children with Reye's syndrome have hypoglycaemia that could contribute to the patient's encephalopathy. We developed a mouse model in which intravenous inoculation of influenza B/Lee virus produced a non-permissive infection of hepatocytes and cerebral endothelial cells and caused many clinical, biochemic...

journal_title：International journal of experimental pathology

authors： Davis LE,Woodfin BM,Tran TQ,Caskey LS,Wallace JM,Scremin OU,Blisard KS

更新日期：1993-06-01 00:00:00

abstract：:p23 is a cochaperone of heat shock protein 90 and also interacts functionally with numerous steroid receptors and kinases. However, the in vivo roles of p23 remain unclear. To explore its in vivo function, we generated the transgenic (TG) mice ubiquitously overexpressing p23. The p23 TG mice spontaneously developed ki...

journal_title：International journal of experimental pathology

authors： Lee J,Kim HJ,Moon JA,Sung YH,Baek IJ,Roh JI,Ha NY,Kim SY,Bahk YY,Lee JE,Yoo TH,Lee HW

更新日期：2011-08-01 00:00:00

abstract：:Ultraviolet ray B (UV-B) induced dermatitis in the rat may be a model for human psoriasis vulgaris. Detailed studies of this model are reported. Rat skin responded to UV-B irradiation quite differently from human, guinea-pig, or mouse skin. Rat UV-B dermatitis was characterized by a sharply demarcated brownish-red les...

journal_title：International journal of experimental pathology

authors： Nakaguma H,Kambara T,Yamamoto T

更新日期：1995-02-01 00:00:00

abstract：:Interleukin (IL)-6-related cytokines share gp130 as the signal-transducing protein. Cardiac myocytes produce various kinds of cytokines including IL-6 and cardiotrophin-1. Activation of gp130 transduces hypertrophic and cytoprotective signals in cardiac myocytes via JAK/STAT, MAP kinase and PI-3 kinase pathways. Besid...

journal_title：International journal of experimental pathology

authors： Yamauchi-Takihara K,Kishimoto T

更新日期：2000-02-01 00:00:00

abstract：:Blister formation and skin damage can be induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper. Pathological changes in the skin were investigated after intramuscular injections of Bothrops asper haemorrhagic metalloproteinase BaP1. Blisters developed within the first hour, with ...

journal_title：International journal of experimental pathology

authors： Rucavado A,Núñez J,Gutiérrez JM

更新日期：1998-08-01 00:00:00

abstract：:The present study was carried out to investigate the role of hypertension in the genesis and localization of intimal lesions and medial remodelling found in the prestenotic segment in relation to a severe stenosis of the abdominal aorta just below the diaphragm. Male young rats were divided randomly into operated grou...

journal_title：International journal of experimental pathology

authors： Prado CM,Rossi MA

更新日期：2006-12-01 00:00:00

abstract：:The purpose of this study was to examine the prognostic significance of insulin-like growth factor-1 receptor (IGF-1R) expression alone and in relation to the expression of the MET- receptor and the MET-homologous receptor RON, in classical Hodgkin's lymphoma (cHL). Tumour samples from patients with cHL (n = 202; medi...

journal_title：International journal of experimental pathology

authors： Koh YW,Yoon DH,Suh C,Cha HJ,Huh J

更新日期：2015-08-01 00:00:00

abstract：:The acute phase of experimental Chagas' disease in rats is associated with early lesions of the post-ganglionic sympathetic nerve terminals of the heart, the varicosities being the target. In the superior cervical and stellate ganglia the preganglionic fibres showed no signs of lesion in the course of experimental Cha...

journal_title：International journal of experimental pathology

authors： Camargos ER,Haertel LR,Machado CR

更新日期：1996-06-01 00:00:00

abstract：:Long-term intragastric administration of the antiepileptic drug sodium valproate (Vuprol Polfa) to rats for 1, 3, 6, 9 and 12 months, once daily at the effective dose of 200 mg/kg body weight showed morphological evidence of encephalopathy, manifested by numerous nonspecific changes within Purkinje cell perikarya and ...

journal_title：International journal of experimental pathology

authors： Sobaniec-Lotowska ME

更新日期：2001-12-01 00:00:00

abstract：:Most patients with epithelial ovarian cancer (EOC) are diagnosed at an advanced stage, and therapeutic options for these patients are limited. The identification of suitable biomarkers could be helpful for patients with EOC, who might benefit from targeted therapies even in advanced stages of the disease. Trophoblast ...

journal_title：International journal of experimental pathology

authors： Xu N,Zhang Z,Zhu J,Xu L,Li Y,Duan L,Mao Y,Li H

更新日期：2016-04-01 00:00:00

abstract：:Pulmonary granuloma formation and fibrosis were experimentally induced in Sprague-Dawley strain rats by Angiostrongylus cantonensis. Increased protein levels of matrix metalloproteinase (MMP)-2, -9, -13 and the imbalance between these enzymes and metalloproteinase inhibitors, tissue inhibitors of MMPs (TIMP-1 and -2),...

journal_title：International journal of experimental pathology

authors： Hsu CC,Lai SC

更新日期：2007-12-01 00:00:00