Heart failure alters MyoD and MRF4 expressions in rat skeletal muscle.

Abstract:

:Heart failure (HF) is characterized by a skeletal muscle myopathy with increased expression of fast myosin heavy chains (MHCs). The skeletal muscle-specific molecular regulatory mechanisms controlling MHC expression during HF have not been described. Myogenic regulatory factors (MRFs), a family of transcriptional factors that control the expression of several skeletal muscle-specific genes, may be related to these alterations. This investigation was undertaken in order to examine potential relationships between MRF mRNA expression and MHC protein isoforms in Wistar rat skeletal muscle with monocrotaline-induced HF. We studied soleus (Sol) and extensor digitorum longus (EDL) muscles from both HF and control Wistar rats. MyoD, myogenin and MRF4 contents were determined using reverse transcription-polymerase chain reaction while MHC isoforms were separated using polyacrylamide gel electrophoresis. Despite no change in MHC composition of Wistar rat skeletal muscles with HF, the mRNA relative expression of MyoD in Sol and EDL muscles and that of MRF4 in Sol muscle were significantly reduced, whereas myogenin was not changed in both muscles. This down-regulation in the mRNA relative expression of MRF4 in Sol was associated with atrophy in response to HF while these alterations were not present in EDL muscle. Taken together, our results show a potential role for MRFs in skeletal muscle myopathy during HF.

journal_name

Int J Exp Pathol

authors

Carvalho RF,Cicogna AC,Campos GE,Lopes Fda S,Sugizaki MM,Nogueira CR,Pai-Silva MD

doi

10.1111/j.1365-2613.2006.00475.x

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

219-25

issue

3

eissn

0959-9673

issn

1365-2613

pii

IEP475

journal_volume

87

pub_type

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