Abstract:
:Pathological and immunopathological studies were carried out on snake coiled fibres (SCF) which occurred in affected soleus muscle in chloroquine treated rats. The SCF began to appear in denervated soleus muscle by 8 days after chloroquine injection. By day 14, typical SCF were observed with an unusual swirling pattern of the myofibrils, presenting a bizarre appearance. By day 21 or later, the SCF became less remarkable, and were fragmented and broken apart to form large vacuoles. Immunopathological studies demonstrated that the amyloid beta (A beta) and N and C-terminal regions of amyloid precursor protein (APP), and the amyloid associated proteins tested, apolipoprotein E (apoE), SP-40,40, alpha 1-antichymotrypsin (alpha 1-ACT), and ubiquitin, which are known to be components of amyloid depositions found in Alzheimer's disease (AD) affected brains, were present in the SCF. ApoE, SP-40,40, alpha 1-ACT, and ubiquitin are induced following certain cell challenges (e.g. heat shock, various drugs and injury). The significance of APP, A beta, and amyloid associated proteins are discussed in respect to snake coiled fibre formations in chloroquine rat myopathy and in the amyloidogenesis of AD.
journal_name
Int J Exp Patholjournal_title
International journal of experimental pathologyauthors
Tsuzuki K,Fukatsu R,Takamaru Y,Yoshida T,Hayashi Y,Kobayashi K,Fujii N,Takahata Ndoi
10.1046/j.1365-2613.1997.9950333.xsubject
Has Abstractpub_date
1997-02-01 00:00:00pages
1-8issue
1eissn
0959-9673issn
1365-2613journal_volume
78pub_type
杂志文章abstract::Using uptake of the fluorescent bile acid derivative cholylglycylamido-fluorescein (FITC-GC) as a measurement of liver cell population size and function, the antiproliferative and toxic effects of the well known cytostatic drug, cisplatin was evaluated on rapidly growing rat hepatoma McA-RH7777 cells and rat hepatocyt...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1046/j.1365-2613.1998.00054.x
更新日期:1998-04-01 00:00:00
abstract::Reduced expression of endothelial nitric oxide synthase (eNOS) in chronic liver disease can reduce hepatic perfusion and accelerate fibrosis. The relationship between eNOS expression and liver fibrogenesis remains unclear. We investigated whether L-arginine attenuated chronic liver fibrosis through eNOS expression. Ch...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2008.00590.x
更新日期:2008-08-01 00:00:00
abstract::Haptoglobin is an acute phase protein known to be highly expressed in the liver. Recently, we showed increased local arterial haptoglobin expression after flow-induced arterial remodelling and found that haptoglobin is involved in cell migration and arterial restructuring probably through accumulation of a temporary g...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1046/j.1365-2613.2003.00336.x
更新日期:2003-04-01 00:00:00
abstract::Streptozotocin (SZ)-induced insulitis, which is an animal model for insulin-dependent diabetes mellitus, was suppressed by lactic dehydrogenase virus (LDV) infection. There were no differences in degenerative and necrotic changes of islet cells between SZ-treated mice and SZ-treated mice with LDV infection during the ...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract::In this study, we wanted to evaluate whether the engrailed EN-2 gene, a homeobox gene with an essential role in the development of the rhombic lip derivatives in different species, is (1) expressed also in man in the differentiation process of the medullary arcuate nucleus (ArcN) and (2) involved in sudden unexplained...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.0959-9673.2005.00408.x
更新日期:2005-02-01 00:00:00
abstract::The interradicular region of primary molars is permeated by many foramina, channels and accessories that connect the pulp cavity with the periapical tissues anatomically. Thus, pulp decomposition products or drugs used in endodontic treatment can trigger inflammatory reactions. The aim of this study was to evaluate th...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12292
更新日期:2018-10-01 00:00:00
abstract::There is evidence to show that downregulation of miR-1 expression is closely related to cancer progression, including in nasopharyngeal carcinoma (NPC). However, the molecular mechanisms underlying miR-1 downregulation in NPC remain largely unknown, especially its association with Epstein-Barr virus (EBV). In this stu...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12162
更新日期:2015-12-01 00:00:00
abstract::The use of non-specific inhibitors of tissue non-specific alkaline phosphatase (TNSALP) in pre-adipocytes blocks intracellular lipid accumulation. TNSALP is also expressed in hepatocytes, which are known to accumulate lipid in a similar manner to pre-adipocytes. The purpose of this study was to use specific silencing ...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12243
更新日期:2017-10-01 00:00:00
abstract::Ischaemic-reperfusion injury as a model of acute renal failure (ARF) results in increased macromolecular permeability, tubular obstruction, and renal oedema. To investigate the role for coagulation in this model, anticoagulated and saline-pretreated rats were subjected to 60 min unilateral renal artery occlusion (RAO)...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1046/j.1365-2613.1998.00055.x
更新日期:1998-02-01 00:00:00
abstract::Up to 40% of children with Reye's syndrome have hypoglycaemia that could contribute to the patient's encephalopathy. We developed a mouse model in which intravenous inoculation of influenza B/Lee virus produced a non-permissive infection of hepatocytes and cerebral endothelial cells and caused many clinical, biochemic...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00
abstract::One of the consequences of neoplastic transformation is deregulation of tissue collagen metabolism. Although metalloproteinases initiate the breakdown of collagen in lung carcinoma, the final step of collagen degradation is mediated by prolidase (E.C.3.4.13.9). We investigated whether prolidase activity could reflect ...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2000.00168.x
更新日期:2000-10-01 00:00:00
abstract::The constitutive cell types of the two lung cancer cell lines CaLu1 and CaLu3 have been investigated by immunocytochemical staining with markers for cytokeratins, vimentin, carcinoembryonic antigen and the epithelial cell epitope recognized by the monoclonal antibody Ber-EP4. The cells of both lines reacted with vimen...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
abstract::The purpose of this study was to examine the prognostic significance of insulin-like growth factor-1 receptor (IGF-1R) expression alone and in relation to the expression of the MET- receptor and the MET-homologous receptor RON, in classical Hodgkin's lymphoma (cHL). Tumour samples from patients with cHL (n = 202; medi...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12128
更新日期:2015-08-01 00:00:00
abstract::The formation of new blood vessels, angiogenesis, is an important event in inflammation, wound healing and tumour growth. Mediators produced by various cells when exposed to endotoxin include cytokines (tumour necrosis factor, interleukins 1 and 6, and basic fibroblast growth factor) which, it has been suggested, stim...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract::Initially found expressed in neuronal and then later in endothelial cells, it is well established that the transmembrane glycoproteins neuropilin-1 (NRP1) and neuropilin-2 (NRP2) play essential roles in axonal growth and guidance and in physiological and pathological angiogenesis. Neuropilin expression and function in...
journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2613.2012.00810.x
更新日期:2012-04-01 00:00:00
abstract::Minaçu virus was isolated from Ochlerotatus scapularis (Diptera: Culicidae) in Minaçu, Goiás State, Brazil, in 1996. In attempting characterization of virus serological (hemagluttination inhibition, HI; indirect immunofluorescence assay, IFA), physicochemical [test for deoxycholate acid (DCA) sensitivity; polyacrylami...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2006.00516.x
更新日期:2007-02-01 00:00:00
abstract::Permethrin (PM), a synthetic pyrethroid insecticide, has broad toxicity spectra. We aimed to investigate the effects of PM on the testes of adult albino rats, examine the recovery response and evaluate the efficacy of naringenin (NG) supplementation. Adult male albino rats were randomly assigned to five groups of six ...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12168
更新日期:2016-02-01 00:00:00
abstract::Angiogenesis is a common finding in chronic inflammatory diseases; however, its role in Sjögren's syndrome (SS) remains to be elucidated. Previous SS studies have demonstrated an increase in VEGF-A/VEGFR-2 system expression in minor salivary gland (MSG) biopsies from patients with SS, but differences in the new blood ...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12061
更新日期:2014-04-01 00:00:00
abstract::Colonization of the genital tract of female mice, mainly BALB/c, by Mycoplasma genitalium, M. pneumoniae and M. pulmonis was enhanced by pretreatment of the mice with progesterone. M. fermentans, M. hominis and M. salivarium, and three serotypes and two untyped strains of Ureaplasma urealyticum colonized under the inf...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract::Duchenne's muscular dystrophy (DMD) is a lethal childhood disease caused by mutations of the dystrophin gene, the protein product of which, dystrophin, has a vital role in maintaining muscle structure and function. Homologues of DMD have been identified in several animals including dogs, cats, mice, fish and invertebr...
journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2613.2003.00354.x
更新日期:2003-08-01 00:00:00
abstract::Summary K-ras mutations are found in 40-50% of human colorectal adenomas and carcinomas, but their functional contribution remains incompletely understood. Here, we show that a conditional mutant K-ras mouse model (K-ras(Asp12)/Cre), with transient intestinal Cre activation by beta-Naphthoflavone (beta-NF) treatment, ...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2009.00667.x
更新日期:2009-10-01 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) is the most common chronic condition of the liver in the western world. There is only little evidence about altered sensitivity of steatotic liver to acute toxic injury. The aim of this project was to test whether hepatic steatosis sensitizes rat liver to acute toxic injury in...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2011.00765.x
更新日期:2011-08-01 00:00:00
abstract::Hydroxymethylnitrofurazone (NFOH) is a nitrofurazone prodrug effective in vivo during acute infections, and it has less hepatotoxicity effect than the standard drug benznidazole (BZN) which has been used during short- and long-term treatment. In the present study, we induced the indeterminate form of Chagas disease in...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12289
更新日期:2018-10-01 00:00:00
abstract::Heparan sulphate (HS) sits at the interface of the cell and the extracellular matrix. It is a member of the glycosaminoglycan family of anionic polysaccharides with unique structural features designed for protein interaction and regulation. Its client proteins include soluble effectors (e.g. growth factors, morphogens...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/iep.12135
更新日期:2015-08-01 00:00:00
abstract::Osteonecrosis (ON) was produced experimentally in rabbits by intravenous injection of platelet activating factor (PAF) in combination with lipopolysaccharides (LPS) on two occasions separated by a week-long interval. Eleven of 15 rabbits (73%), with administration of both LPS (50 microg/kg) and PAF (10 microg/kg), exh...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1046/j.1365-2613.2001.00202.x
更新日期:2001-10-01 00:00:00
abstract::In order to clarify the function of hepatocyte growth factor (HGF) in vivo, we have developed transgenic mice expressing HGF in the liver. The bromodeoxyuridine labelling indices in livers from HGF transgenic mice were doubled, compared to those from wild type mice. Livers of HGF transgenic mice expressed high levels ...
journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2613.1998.730403.x
更新日期:1998-10-01 00:00:00
abstract::Amino acid metabolism is a significant metabolic activity in humans, especially of sulphur-containing amino acids, methionine and cysteine (Cys). Cys is cytotoxic and neurotoxic in nature; hence, mammalian cells maintain a constant intracellular level of Cys. Metabolism of Cys is mainly regulated by two thiol dioxygen...
journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
doi:10.1111/iep.12222
更新日期:2017-04-01 00:00:00
abstract::The Fell-Muir Award requires the recipient to deliver a lecture and a review manuscript which provides a personal overview of significant scientific developments in the field of matrix biology over the period of the recipient's career. In this context, this review considers the collagen family of structural proteins a...
journal_title:International journal of experimental pathology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2613.2007.00537.x
更新日期:2007-08-01 00:00:00
abstract::The original two strains of Mycoplasma genitalium were isolated from the human urogenital tract. No other strains have been isolated from this site since then. We have recently succeeded in propagating a third strain from a urogenital specimen from a patient with urethritis in Vero cell cultures. By electron microscop...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::The objective of this study was to assess whether ascorbic acid (AA), an intracellular anti-oxidant critical for neuronal protection, when added to artificial cerebrospinal fluid (ACSF), is able to protect hippocampal (HPC) formation slice preparations from ageing. In this research, the micro-electroencephalographic (...
journal_title:International journal of experimental pathology
pub_type: 杂志文章
doi:10.1111/j.1365-2613.2012.00838.x
更新日期:2012-12-01 00:00:00