Abstract：
:The female reproductive organs (ovary, uterus, and placenta) are some of the few adult tissues that exhibit regular intervals of rapid growth. They also are highly vascular and have high rates of blood flow. Angiogenesis, or vascular growth, is therefore an important component of the growth and function of these tissues. As with many other tissues, vascular endothelial growth factors (VEGFs) and fibroblast growth factors (FGFs) appear to be major angiogenic factors in the female reproductive organs. A variety of pathologies of the female reproductive organs are associated with disturbances of the angiogenic process, including dysfunctional uterine bleeding, endometrial hyperplasia and carcinoma, endometriosis, failed implantation and subnormal foetal growth, myometrial fibroids (uterine leiomyomas) and adenomyosis, ovarian hyperstimulation syndrome, ovarian carcinoma, and polycystic ovary syndrome. These pathologies are also associated with altered expression of VEGFs and/or FGFs. In the near future, angiogenic or antiangiogenic compounds may prove to be effective therapeutic agents for treating these pathologies. In addition, monitoring of angiogenesis or angiogenic factor expression may provide a means of assessing the efficacy of these therapies.
journal_name
Int J Exp Patholjournal_title
International journal of experimental pathologyauthors
Reynolds LP,Grazul-Bilska AT,Redmer DAdoi
10.1046/j.1365-2613.2002.00277.xsubject
Has Abstractpub_date
2002-08-01 00:00:00pages
151-63issue
4eissn
0959-9673issn
1365-2613pii
277journal_volume
83pub_type
杂志文章,评审abstract：:The α2-adrenoceptors regulate the sympathetic nervous system, controlling presynaptic catecholamine release. However, the role of the α2-adrenoceptors in cutaneous wound healing is poorly understood. Mice lacking both the α2A/α2C-adrenoceptors were used to evaluate the participation of the α2-adrenoceptor during cutan...
journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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doi：
更新日期：1990-10-01 00:00:00
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journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：
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journal_title：International journal of experimental pathology
pub_type： 杂志文章,评审
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journal_title：International journal of experimental pathology
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doi：
更新日期：1993-02-01 00:00:00
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
pub_type： 杂志文章,评审
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更新日期：2011-06-01 00:00:00
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journal_title：International journal of experimental pathology
pub_type： 杂志文章,评审
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journal_title：International journal of experimental pathology
pub_type： 杂志文章
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更新日期：1993-12-01 00:00:00
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journal_title：International journal of experimental pathology
pub_type： 杂志文章
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更新日期：2009-02-01 00:00:00
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journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1111/iep.12243
更新日期：2017-10-01 00:00:00
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journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1111/j.1365-2613.2012.00814.x
更新日期：2012-06-01 00:00:00
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journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1046/j.1365-2613.1999.00116.x
更新日期：1999-08-01 00:00:00
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journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1111/j.1365-2613.2007.00550.x
更新日期：2008-02-01 00:00:00
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journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1111/j.1365-2613.2000.00168.x
更新日期：2000-10-01 00:00:00
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journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
pub_type： 杂志文章,评审
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journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：
更新日期：1995-10-01 00:00:00
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journal_title：International journal of experimental pathology
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更新日期：1993-02-01 00:00:00
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journal_title：International journal of experimental pathology
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更新日期：1993-06-01 00:00:00
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journal_title：International journal of experimental pathology
pub_type： 杂志文章
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更新日期：2001-12-01 00:00:00
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journal_title：International journal of experimental pathology
pub_type： 杂志文章
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