A new fibroblast growth stimulating activity from the human megakaryoblastic leukaemia cell line ELF-153: in vitro and in vivo findings.

abstract：:An autoimmune kidney disease morphologically and functionally similar to Heymann nephritis (HN) was induced in mature male Sprague Dawley rats by repeated weekly IP injections of a chemically modified azo sonicated ultracentrifuged (u/c) rat kidney fraction 3 (rKF3) antigen in an aqueous medium. The experiment was ter...

journal_title：International journal of experimental pathology

authors： Barabas AZ,Cole CD,Barabas AD,Lafreniere R

更新日期：2004-10-01 00:00:00

abstract：:In this study, the extent of angiogenesis, evaluated as microvascular volume density, immunoreactivity of tumour cells to erythropoietin (Epo) and of endothelial cells to Epo receptor (EpoR) have been correlated in human primary melanoma specimens. Results showed that Epo/EpoR expression correlate with angiogenesis an...

journal_title：International journal of experimental pathology

authors： Ribatti D,Nico B,Perra MT,Longo V,Maxia C,Annese T,Piras F,Murtas D,Sirigu P

更新日期：2010-12-01 00:00:00

abstract：:Diets enriched with fat, especially unsaturated fat, promote experimental pancreatic carcinogenesis, but little is known of the effects of individual fatty acids. The effect of stearic and oleic acid on pancreatic fatty acids and atypical acinar cell nodules (preneoplastic lesions) was studied in 14-day-old weanling m...

journal_title：International journal of experimental pathology

authors： Khoo DE,Flaks B,Oztas H,Williamson RC,Habib NA

更新日期：1991-10-01 00:00:00

abstract：:Athymic (nude) mice were experimentally infected with Mycobacterium leprae via the alimentary and respiratory tracts and through the skin. Animals were allowed to inhale aerosols of M. leprae or had bacilli instilled into the nostrils or directly into the lungs. Others were fed M. leprae by gastric tube or had bacilli...

journal_title：International journal of experimental pathology

authors： McDermott-Lancaster RD,McDougall AC

更新日期：1990-10-01 00:00:00

abstract：:To confirm the existence of the cervical thymus and the development of cervical thymoma in thymoma-prone BUF/Mna (BUF) rats, we examined cervical organs and adjacent tissues, and thoracic thymic tissues of the three inbred strains, BUF, ACI/NMna (ACI), and WKY/NCrj (WKY), and 11 congenic strains, in which genetic regi...

journal_title：International journal of experimental pathology

authors： Yamada T,Matsuyama M,Yanagida T,Kato K,Sugiura S,Kuroda M

更新日期：2011-04-01 00:00:00

abstract：:Hamsters (Mesocricetus auratus) were inoculated with L. (L.) chagasi and killed on days 7, 15, 30, 45 and 60 after infection. The lymphoid organs developed initial proliferation of the B lymphocyte zone with recovery by the 60th day group when pyroninophilic cells were prominent. The T lymphocyte area showed a progres...

journal_title：International journal of experimental pathology

authors： Corbett CE,Paes RA,Laurenti MD,Andrade Júnior HF,Duarte MI

更新日期：1992-08-01 00:00:00

abstract：:We have shown previously that cycloheximide (CHX), a potent protein synthesis inhibitor, induces high levels of apoptosis in Epstein-Barr virus free (EBV(-)) Burkitt's lymphoma (BJA-B) cells, with comparably reduced levels of apoptosis in the EBV positive (EBV(+)) cells. Modulation of CHX-induced apoptosis in EBV(-) a...

journal_title：International journal of experimental pathology

authors： Ishii H,Tamauchi H,Gobe GC

更新日期：1997-06-01 00:00:00

abstract：:The aim of this study was to estimate the relationship of endothelial dysfunction induced by intracellular S-adenosylhomocysteine (SAH) accumulation and DNA methylation in human umbilical vein endothelial cells (HUVEC). The isolated HUVEC were incubated with 3-deazaadenosine (DZA) to induce experimental intracellular ...

journal_title：International journal of experimental pathology

authors： Yu X,Ling W,Mi M

更新日期：2009-12-01 00:00:00

abstract：:Conventional therapies for low back pain (LBP) are purely symptomatic and do not target the cause of LBP, which in approximately 40% of cases is caused by degeneration of the intervertebral disc (DIVD). Targeting therapies to inhibit the process of degeneration would be a potentially valuable treatment for LBP. There ...

journal_title：International journal of experimental pathology

authors： Le Maitre CL,Freemont AJ,Hoyland JA

更新日期：2006-02-01 00:00:00

abstract：:Minaçu virus was isolated from Ochlerotatus scapularis (Diptera: Culicidae) in Minaçu, Goiás State, Brazil, in 1996. In attempting characterization of virus serological (hemagluttination inhibition, HI; indirect immunofluorescence assay, IFA), physicochemical [test for deoxycholate acid (DCA) sensitivity; polyacrylami...

journal_title：International journal of experimental pathology

authors： Martins LC,Diniz JA,Silva EV,Barros VL,Monteiro HA,Azevedo RS,Quaresma JA,Vasconcelos PF

更新日期：2007-02-01 00:00:00

abstract：:The tumour microenvironment, which is largely composed of inflammatory cells, is a crucial participant in the neoplastic process through the promotion of cell proliferation, survival and migration. Neutrophil polymorphonuclear cells (PMNs) induce inflammatory reactions that can be either cytotoxic for tumour cells or ...

journal_title：International journal of experimental pathology

authors： Remedi MM,Donadio AC,Chiabrando GA

更新日期：2009-02-01 00:00:00

abstract：:Long-term intragastric administration of the antiepileptic drug sodium valproate (Vuprol Polfa) to rats for 1, 3, 6, 9 and 12 months, once daily at the effective dose of 200 mg/kg body weight showed morphological evidence of encephalopathy, manifested by numerous nonspecific changes within Purkinje cell perikarya and ...

journal_title：International journal of experimental pathology

authors： Sobaniec-Lotowska ME

更新日期：2001-12-01 00:00:00

abstract：:Tumour-associated macrophage (TAM) polarization is associated with hepatocellular carcinoma but the molecular mechanism of this polarization is still unknown. Peripheral blood mononuclear cells were induced to differentiate into M0, M1 and M2 macrophages and TAMs. TAMs were transfected with pcDNA3.1-GAS5, pcDNA3.1-NC,...

journal_title：International journal of experimental pathology

authors： Wang X,Li FY,Zhao W,Gao ZK,Shen B,Xu H,Cui YF

更新日期：2020-12-01 00:00:00

abstract：:The present study was carried out to investigate the role of hypertension in the genesis and localization of intimal lesions and medial remodelling found in the prestenotic segment in relation to a severe stenosis of the abdominal aorta just below the diaphragm. Male young rats were divided randomly into operated grou...

journal_title：International journal of experimental pathology

authors： Prado CM,Rossi MA

更新日期：2006-12-01 00:00:00

abstract：:Tumour growth is angiogenesis dependent. Thrombosis and thromboembolism are very common in cancer patients. These patients are often treated with heparin as an anti-coagulant. Many tumour angiogens, including VEGF165, and endogenous anti-angiogenesis factors bind heparin tightly. Using the non-surgical mesenteric-wind...

journal_title：International journal of experimental pathology

authors： Norrby K

更新日期：2000-06-01 00:00:00

abstract：:Most patients with epithelial ovarian cancer (EOC) are diagnosed at an advanced stage, and therapeutic options for these patients are limited. The identification of suitable biomarkers could be helpful for patients with EOC, who might benefit from targeted therapies even in advanced stages of the disease. Trophoblast ...

journal_title：International journal of experimental pathology

authors： Xu N,Zhang Z,Zhu J,Xu L,Li Y,Duan L,Mao Y,Li H

更新日期：2016-04-01 00:00:00

abstract：:Two families of the Metzincin clan of metalloproteinases, the matrix metalloproteinases and the disintegrin metalloproteinases have attracted much attention as important effectors of cellular interactions with their environment. They appear to play significant roles in the modulation of components of the extracellular...

journal_title：International journal of experimental pathology

authors： Murphy G

更新日期：2010-08-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a major global cause of hepatocellular carcinoma (HCC). Individuals who are chronic carriers have a greater than 100-fold increased relative risk of developing the tumour. Several mechanisms of HBV-induced HCC have been proposed. Integration of HBV DNA into the genome of he...

journal_title：International journal of experimental pathology

authors： Arbuthnot P,Kew M

更新日期：2001-04-01 00:00:00

abstract：:The formation of new blood vessels, angiogenesis, is an important event in inflammation, wound healing and tumour growth. Mediators produced by various cells when exposed to endotoxin include cytokines (tumour necrosis factor, interleukins 1 and 6, and basic fibroblast growth factor) which, it has been suggested, stim...

journal_title：International journal of experimental pathology

authors： Mattsby-Baltzer I,Jakobsson A,Sörbo J,Norrby K

更新日期：1994-06-01 00:00:00

abstract：:Recently, there have been significant advances toward the development of culture conditions that promote proliferation of primary rodent hepatocytes. There are two major methods for the multiplication of hepatocytes in vitro: one is the use of nicotinamide, the other is the use of a nutrient-rich medium. In the medium...

journal_title：International journal of experimental pathology

authors： Mitaka T

更新日期：1998-12-01 00:00:00

abstract：:Naturally developing spontaneous osteoarthritis (OA) is seen in a number of small animals one of which is the STR/ORT mouse, an accepted model of human OA. A histological evaluation of the patello-femoral joints of 37 male STR/ORT mice has shown features that are inconsistent with the disease in human joints. These in...

journal_title：International journal of experimental pathology

authors： Das-Gupta EP,Lyons TJ,Hoyland JA,Lawton DM,Freemont AJ

更新日期：1993-12-01 00:00:00

abstract：:Administration of mercuric chloride (HgCl(2)) to Brown Norway rats causes Th2-dominated autoimmunity with raised immunoglobulin E concentrations and gut vasculitis, both of which are T-cell dependent, peak at 14 days after starting HgCl(2) and then spontaneously resolve. If animals are re-challenged with HgCl(2) 6 wee...

journal_title：International journal of experimental pathology

authors： Vinen CS,Turner DR,Oliveira DB

更新日期：2004-06-01 00:00:00

abstract：:Pterygium is a surface ocular lesion that is associated with chronic UV exposure. The primary effect is a solar actinic elastosis within the stroma. All the other changes are secondary. Pterygium is characterized by proliferation, inflammatory infiltrates, fibrosis, angiogenesis and extracellular matrix breakdown. The...

journal_title：International journal of experimental pathology

authors： Ribatti D,Nico B,Perra MT,Maxia C,Piras F,Murtas D,Crivellato E,Sirigu P

更新日期：2009-12-01 00:00:00

abstract：:The characterization of mice models of portal hypertension (PHT) is lacking in the literature. Therefore, the aim of the present study was to make a histological approach during development of PHT in two models of cirrhosis with PHT compared with one model of isolated PHT. The model of isolated PHT was developed by pa...

journal_title：International journal of experimental pathology

authors： Geerts AM,Vanheule E,Praet M,Van Vlierberghe H,De Vos M,Colle I

更新日期：2008-08-01 00:00:00

abstract：:Osteonecrosis (ON) was produced experimentally in rabbits by intravenous injection of platelet activating factor (PAF) in combination with lipopolysaccharides (LPS) on two occasions separated by a week-long interval. Eleven of 15 rabbits (73%), with administration of both LPS (50 microg/kg) and PAF (10 microg/kg), exh...

journal_title：International journal of experimental pathology

authors： Masuhara K,Nakata K,Yamasaki S,Miki H,Yoshikawa H

更新日期：2001-10-01 00:00:00

abstract：:In chronic administration of sodium valproate to rats, significant disorders of structural integrity of the hippocampal gyrus and the neocortex of the temporal lobe, observed in the last two stages of the experiment (after 9 and 12 months), coexisted with increased number of microglial cells and, especially after 12 m...

journal_title：International journal of experimental pathology

authors： Sobaniec-Lotowska ME

更新日期：2005-04-01 00:00:00

abstract：:This study was performed to characterize the intestinal lesions in chronic graft-versus-host disease (GVHD) in mice and to determine a possible role of intestinal intraepithelial lymphocytes (ilEL) in the development of these lesions. Chronic GVHD was induced by transfer of DBA/2 lymphocytes into non-irradiated (C57BL...

journal_title：International journal of experimental pathology

authors： de Geus B,Hogenesch H,de Heer E,Bruijn JA,van den Enden M,Rozing J

更新日期：1993-08-01 00:00:00

abstract：:In this study, we wanted to evaluate whether the engrailed EN-2 gene, a homeobox gene with an essential role in the development of the rhombic lip derivatives in different species, is (1) expressed also in man in the differentiation process of the medullary arcuate nucleus (ArcN) and (2) involved in sudden unexplained...

journal_title：International journal of experimental pathology

authors： Lavezzi AM,Ottaviani G,Mauri M,Terni L,Matturri L

更新日期：2005-02-01 00:00:00

abstract：:The preovulatory follicle provides a unique physiological example of rapid growth accompanied by neovascularization, two processes that are generally characteristic of pathologies such as wound repair or malignancy. During the hours preceding ovulation, follicular growth is accompanied by elevated levels of messenger ...

journal_title：International journal of experimental pathology

authors： Neeman M,Abramovitch R,Schiffenbauer YS,Tempel C

更新日期：1997-04-01 00:00:00

abstract：:Over the past 40 years there have been giant steps forward in our understanding of cellular and molecular biology that have given us the framework by which to understand tissue organization and tissue function on a range of scales. However, although the progress has been great, the more we have discovered, the more we...

journal_title：International journal of experimental pathology

authors： Hardingham TE

更新日期：2010-06-01 00:00:00