Fibroblasts and myofibroblasts in renal fibrosis.

Abstract:

:Interstitial fibrosis, associated with extensive accumulation of extracellular matrix constituents in the cortical interstitium, is directly correlated to progression of renal disease. The earliest histological marker of this progression is the accumulation in the interstitium of fibroblasts with the phenotypic appearance of myofibroblasts. These myofibroblasts are contractile cells that express alpha smooth muscle actin and incorporate it into intracellular stress fibres. Although fibroblasts are histologically visible in normal kidneys, there are relatively few of them and proximal tubular epithelial cells predominate. In progressive disease, however, the interstitium becomes filled with myofibroblasts. In this review, we will examine the phenotype and function of fibroblasts and myofibroblasts in the cortical interstitium and the processes that may modulate them.

journal_name

Int J Exp Pathol

authors

Meran S,Steadman R

doi

10.1111/j.1365-2613.2011.00764.x

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

158-67

issue

3

eissn

0959-9673

issn

1365-2613

journal_volume

92

pub_type

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