Abstract：
:Experiments on the relationship between the hepatocellular transport of endogenous or exogenously loaded bile acids (sodium taurocholate, TC, 0.5 mumol/min/100 g body wt) and horseradish peroxidase (HRP) or immunoglobulin A (IgA) (0.5 mg/100 g body wt) were carried out on anaesthetized Wistar rats. The time course of HRP excretion into bile (acceleration in the secretory peak), but not the total amount of HRP output, was affected by TC infusion. Administration of HRP was found to have no stimulatory effect on either spontaneous or TC-induced bile flow, bile acid, lecithin or cholesterol output. Spontaneous bile acid output was increased (25 and 67%, respectively) in rats that were treated for 12-h fasting or by oral administration of TC (45 mg/100 g body wt, every 12 h, for 2 days). These manoeuvres did not change the inability of HRP and IgA to increase bile acid output. Exogenous TC load had no stimulatory effect on the hepatocellular transport of endogenous bile acid pool, that was labelled by a combination of fasting and oral administration of 14C-glycocholic acid 12 h before the experiments. Therefore, exogenous bile acid load-induced stimulation of transcytosis had no effect on endogenous bile acid output. Moreover, bile secretion of both endogenous and exogenously loaded bile acids is unaffected by the administration of proteins, irrespective of whether they are endocytosed by a receptor or nonreceptor mediated process.
journal_name
Int J Exp Patholjournal_title
International journal of experimental pathologyauthors
Herrera MC,el-Mir MY,Monte MJ,Perez-Barriocanal F,Marin JJsubject
Has Abstractpub_date
1992-04-01 00:00:00pages
203-14issue
2eissn
0959-9673issn
1365-2613journal_volume
73pub_type
杂志文章abstract：:Regression of submandibular acinar cell hyperplasia after withdrawal of the mitogenic stimulus induced by isoprenaline was studied in male Wistar rats. Intraperitoneal administration of 39 mg of isoprenaline, in divided doses over a 9-day period, resulted in a marked increase in gland size and weight. The proportional...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：
更新日期：1995-08-01 00:00:00
abstract：:Acute myocardial infarction is one of the major causes of mortality worldwide. For regeneration of the rabbit heart after experimentally induced infarction we used autologous skeletal myoblasts (SMs) due to their high proliferative potential, resistance to ischaemia and absence of immunological and ethical concerns. T...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1111/iep.12109
更新日期：2015-02-01 00:00:00
abstract：:Non-alcoholic fatty liver disease (NAFLD) is the most common chronic condition of the liver in the western world. There is only little evidence about altered sensitivity of steatotic liver to acute toxic injury. The aim of this project was to test whether hepatic steatosis sensitizes rat liver to acute toxic injury in...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1111/j.1365-2613.2011.00765.x
更新日期：2011-08-01 00:00:00
abstract：:The interrelationship between acinar cell apoptosis and tubular complex formation was examined in caerulein-induced pancreatitis using histology, immunohistochemistry, electron microscopy and DNA gel electrophoresis. Rats were given 8 hourly subcutaneous injections of caerulein, 24 micrograms/kg, for up to 2 days. Mor...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1046/j.1365-2613.1999.00116.x
更新日期：1999-08-01 00:00:00
abstract：:A dose-dependent neutrophil migration was observed following the injection of purified (Hu IFN-gamma) or recombinant (rIFN-gamma) human gamma interferon into rat peritoneal cavities. This finding contrasts with their inability to cause chemotaxis in vitro in the Boyden chamber. Neutrophil migration into peritoneal cav...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:In this study, we wanted to evaluate whether the engrailed EN-2 gene, a homeobox gene with an essential role in the development of the rhombic lip derivatives in different species, is (1) expressed also in man in the differentiation process of the medullary arcuate nucleus (ArcN) and (2) involved in sudden unexplained...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1111/j.0959-9673.2005.00408.x
更新日期：2005-02-01 00:00:00
abstract：:Previously we have found deregulation of collagen metabolism in human pancreatitis and pancreatic cancer tissues. Insulin-like growth factor-I (IGF-I) is known to stimulate collagen biosynthesis through interaction with IGF-I receptor. IGF-I binding proteins (BPs) regulate the activity of IGF-I. We investigated whethe...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1046/j.1365-2613.2002.00237.x
更新日期：2002-10-01 00:00:00
abstract：:The original two strains of Mycoplasma genitalium were isolated from the human urogenital tract. No other strains have been isolated from this site since then. We have recently succeeded in propagating a third strain from a urogenital specimen from a patient with urethritis in Vero cell cultures. By electron microscop...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:Reduced expression of endothelial nitric oxide synthase (eNOS) in chronic liver disease can reduce hepatic perfusion and accelerate fibrosis. The relationship between eNOS expression and liver fibrogenesis remains unclear. We investigated whether L-arginine attenuated chronic liver fibrosis through eNOS expression. Ch...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1111/j.1365-2613.2008.00590.x
更新日期：2008-08-01 00:00:00
abstract：:The α2-adrenoceptors regulate the sympathetic nervous system, controlling presynaptic catecholamine release. However, the role of the α2-adrenoceptors in cutaneous wound healing is poorly understood. Mice lacking both the α2A/α2C-adrenoceptors were used to evaluate the participation of the α2-adrenoceptor during cutan...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1111/iep.12093
更新日期：2014-10-01 00:00:00
abstract：:A reversible impairment in the ability of the liver to secrete cholephilic compounds has been reported to exist in infant rats born from mothers with surgically induced complete cholestasis during the last third of the pregnancy. Canalicular plasma membranes (CPM) were purified from livers obtained from 4 and 8 week-o...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1046/j.1365-2613.1997.360372.x
更新日期：1997-12-01 00:00:00
abstract：:Permethrin (PM), a synthetic pyrethroid insecticide, has broad toxicity spectra. We aimed to investigate the effects of PM on the testes of adult albino rats, examine the recovery response and evaluate the efficacy of naringenin (NG) supplementation. Adult male albino rats were randomly assigned to five groups of six ...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1111/iep.12168
更新日期：2016-02-01 00:00:00
abstract：:Mitochondrial DNA (mt-DNA) disorders and abnormal regulation of nuclear-derived proteins devoted to the cross-talk between the two cellular genomes have recently interested researchers in the field of neuromuscular diseases. We have identified, isolated and sequenced a new gene, augmenter of liver regeneration (ALR) t...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1111/j.1365-2613.2009.00639.x
更新日期：2009-08-01 00:00:00
abstract：:Over the past 40 years there have been giant steps forward in our understanding of cellular and molecular biology that have given us the framework by which to understand tissue organization and tissue function on a range of scales. However, although the progress has been great, the more we have discovered, the more we...
journal_title：International journal of experimental pathology
pub_type：
doi：10.1111/j.1365-2613.2010.00719.x
更新日期：2010-06-01 00:00:00
abstract：:Most patients with epithelial ovarian cancer (EOC) are diagnosed at an advanced stage, and therapeutic options for these patients are limited. The identification of suitable biomarkers could be helpful for patients with EOC, who might benefit from targeted therapies even in advanced stages of the disease. Trophoblast ...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1111/iep.12174
更新日期：2016-04-01 00:00:00
abstract：:Systemic hypertension, characterized by elevated blood pressure ≥140/90 mm Hg, is a major modifiable risk factor for cardiovascular disease. Hypertension also associates with non-alcoholic fatty liver disease (NAFLD), which is becoming common due to a modern diet and lifestyle. The aim of the present study was to exam...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1111/iep.12369
更新日期：2020-10-01 00:00:00
abstract：:This study was performed to characterize the intestinal lesions in chronic graft-versus-host disease (GVHD) in mice and to determine a possible role of intestinal intraepithelial lymphocytes (ilEL) in the development of these lesions. Chronic GVHD was induced by transfer of DBA/2 lymphocytes into non-irradiated (C57BL...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
abstract：:We determined the feasibility of producing protoporphyric hepatopathy in unrestrained rats by infusing protoporphyrin into their portal circulation via chronic indwelling catheters. Sprague-Dawley rats, 200-300 g, received single (8.5-27.8 mumol) or multiple (64.1-208.7 mumol) infusions of protoporphyrin over 3-240 h....
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:Interleukin (IL)-6-related cytokines share gp130 as the signal-transducing protein. Cardiac myocytes produce various kinds of cytokines including IL-6 and cardiotrophin-1. Activation of gp130 transduces hypertrophic and cytoprotective signals in cardiac myocytes via JAK/STAT, MAP kinase and PI-3 kinase pathways. Besid...
journal_title：International journal of experimental pathology
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2613.2000.00139.x
更新日期：2000-02-01 00:00:00
abstract：:Initially found expressed in neuronal and then later in endothelial cells, it is well established that the transmembrane glycoproteins neuropilin-1 (NRP1) and neuropilin-2 (NRP2) play essential roles in axonal growth and guidance and in physiological and pathological angiogenesis. Neuropilin expression and function in...
journal_title：International journal of experimental pathology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2613.2012.00810.x
更新日期：2012-04-01 00:00:00
abstract：:Polymorphonuclear cells (PMN) are believed to be important effector cells responsible the myocardial damage seen following ischaemia. However, the exact kinetics of their migration remains controversial. Isolated PMN (10 x 10(6) cells) labelled with (51)Cr were injected into four groups of Lewis rats: 0 h (T0h; n = 13...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1111/j.1365-2613.2007.00541.x
更新日期：2007-08-01 00:00:00
abstract：:Although the exact mechanism for the progression of myelofibrosis in acute megakaryoblastic leukaemia is unclear, certain humoral factors released from the proliferating megakaryoblasts that are unable to store these factors in their defective alpha-granules, including platelet derived growth factor (PDGF), fibroblast...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：
更新日期：1995-10-01 00:00:00
abstract：:The field of study concerning promotion and/or inhibition of angiogenesis has gathered much attention in the scientific community. A great deal of work has been invested towards defining reproducible assays to gauge for promotion or inhibition of angiogenesis in response to drug treatments or growth conditions. Two co...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1111/iep.12043
更新日期：2013-12-01 00:00:00
abstract：:The formation of new blood vessels, angiogenesis, is an important event in inflammation, wound healing and tumour growth. Mediators produced by various cells when exposed to endotoxin include cytokines (tumour necrosis factor, interleukins 1 and 6, and basic fibroblast growth factor) which, it has been suggested, stim...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：:To confirm the existence of the cervical thymus and the development of cervical thymoma in thymoma-prone BUF/Mna (BUF) rats, we examined cervical organs and adjacent tissues, and thoracic thymic tissues of the three inbred strains, BUF, ACI/NMna (ACI), and WKY/NCrj (WKY), and 11 congenic strains, in which genetic regi...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1111/j.1365-2613.2010.00755.x
更新日期：2011-04-01 00:00:00
abstract：:Using uptake of the fluorescent bile acid derivative cholylglycylamido-fluorescein (FITC-GC) as a measurement of liver cell population size and function, the antiproliferative and toxic effects of the well known cytostatic drug, cisplatin was evaluated on rapidly growing rat hepatoma McA-RH7777 cells and rat hepatocyt...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1046/j.1365-2613.1998.00054.x
更新日期：1998-04-01 00:00:00
abstract：:The roles of inducible nitric oxide synthase (iNOS) in the development and healing of gastric ulcers have not been fully characterized. We characterized iNOS expression in experimentally induced ulcers in rat and mouse stomachs and investigated the roles of iNOS using iNOS gene-deficient (iNOS-/-) mice and wildtype mi...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：10.1111/j.1365-2613.2003.00357.x
更新日期：2003-10-01 00:00:00
abstract：:Colonization of the genital tract of female mice, mainly BALB/c, by Mycoplasma genitalium, M. pneumoniae and M. pulmonis was enhanced by pretreatment of the mice with progesterone. M. fermentans, M. hominis and M. salivarium, and three serotypes and two untyped strains of Ureaplasma urealyticum colonized under the inf...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
abstract：:Reovirus type 2-induced diabetes-like syndrome in suckling mice is considered to be an animal model for human insulin-dependent diabetes mellitus. We have previously demonstrated that immunopathologic pancreatic islet cell damage might be relevant to reovirus type 2 infection. In this study the involvement of adhesion...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:Dengue type 2 virus (DV) induces a subpopulation of T lymphocytes of mouse spleen to secrete a soluble helper cytokine (HF) which enhances the DV-specific IgM antibody plaque forming cells (PFC). The present study undertaken to purify and characterize HF shows that it can be purified by low pressure liquid chromatogra...
journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
