Serum and tissue level of insulin-like growth factor-I (IGF-I) and IGF-I binding proteins as an index of pancreatitis and pancreatic cancer.

Abstract:

:Previously we have found deregulation of collagen metabolism in human pancreatitis and pancreatic cancer tissues. Insulin-like growth factor-I (IGF-I) is known to stimulate collagen biosynthesis through interaction with IGF-I receptor. IGF-I binding proteins (BPs) regulate the activity of IGF-I. We investigated whether serum and tissue IGF-I and IGF-BPs as well as tissue IGF-I receptor expression may reflect disturbances of collagen metabolism in patients with pancreatitis and pancreatic cancer. In pancreatitis tissue, a significant increase in IGF-I and IGFBP-3 content was accompanied by a distinct increase in IGF-I receptor expression, compared to control pancreas tissue. In contrast, serum from patients with pancreatitis did not show significant increases in IGF-I and IGFBP-3 levels, however, significant increases in IGFBP-1 level (2.5 fold). Moreover, a distinct decrease in radioactive IGF-binding to the BPs, compared to control serum, was found. Pancreatic cancer tissue and serum of patients with pancreatic cancer showed significant increases in IGF-I, IGFBP-3 and IGFBP-1 content, accompanied by dramatic increases in IGF-I tissue receptor expression, compared to controls. In serum of patients with pancreatic cancer distinct increases in radioactive IGF-binding to 46 kDa BP, compared to control serum, were observed. The data suggest that disturbances in tissue collagen metabolism during pancreatic diseases may result from deregulation of IGF-I homeostasis and that elevated serum levels of IGF-I, IGFBP-3 and IGFBP-1 may serve as markers of pancreatic cancer.

journal_name

Int J Exp Pathol

authors

Karna E,Surazynski A,Orłowski K,Łaszkiewicz J,Puchalski Z,Nawrat P,Pałka J

doi

10.1046/j.1365-2613.2002.00237.x

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

239-45

issue

5

eissn

0959-9673

issn

1365-2613

pii

237

journal_volume

83

pub_type

杂志文章
  • Does an anti-oxidant ascorbic acid improve the condition of hippocampal formation slice preparations? A micro-EEG approach.

    abstract::The objective of this study was to assess whether ascorbic acid (AA), an intracellular anti-oxidant critical for neuronal protection, when added to artificial cerebrospinal fluid (ACSF), is able to protect hippocampal (HPC) formation slice preparations from ageing. In this research, the micro-electroencephalographic (...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2012.00838.x

    authors: Kazmierska P,Grebowski J,Konopacki J

    更新日期:2012-12-01 00:00:00

  • A "Western Diet" promotes symptoms of hepatic steatosis in spontaneously hypertensive rats.

    abstract::Systemic hypertension, characterized by elevated blood pressure ≥140/90 mm Hg, is a major modifiable risk factor for cardiovascular disease. Hypertension also associates with non-alcoholic fatty liver disease (NAFLD), which is becoming common due to a modern diet and lifestyle. The aim of the present study was to exam...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12369

    authors: Cartland SP,Tamer N,Patil MS,Di Bartolo BA,Kavurma MM

    更新日期:2020-10-01 00:00:00

  • The acute phase protein haptoglobin is locally expressed in arthritic and oncological tissues.

    abstract::Haptoglobin is an acute phase protein known to be highly expressed in the liver. Recently, we showed increased local arterial haptoglobin expression after flow-induced arterial remodelling and found that haptoglobin is involved in cell migration and arterial restructuring probably through accumulation of a temporary g...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2613.2003.00336.x

    authors: Smeets MB,Fontijn J,Kavelaars A,Pasterkamp G,De Kleijn DP

    更新日期:2003-04-01 00:00:00

  • A transmission electron microscopic study of microglia/macrophages in the hippocampal cortex and neocortex following chronic exposure to valproate.

    abstract::In chronic administration of sodium valproate to rats, significant disorders of structural integrity of the hippocampal gyrus and the neocortex of the temporal lobe, observed in the last two stages of the experiment (after 9 and 12 months), coexisted with increased number of microglial cells and, especially after 12 m...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.0959-9673.2005.00417.x

    authors: Sobaniec-Lotowska ME

    更新日期:2005-04-01 00:00:00

  • Histopathology of lymphoid organs in experimental leishmaniasis.

    abstract::Hamsters (Mesocricetus auratus) were inoculated with L. (L.) chagasi and killed on days 7, 15, 30, 45 and 60 after infection. The lymphoid organs developed initial proliferation of the B lymphocyte zone with recovery by the 60th day group when pyroninophilic cells were prominent. The T lymphocyte area showed a progres...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Corbett CE,Paes RA,Laurenti MD,Andrade Júnior HF,Duarte MI

    更新日期:1992-08-01 00:00:00

  • Demonstration of variation in chondrocyte activity in different zones of articular cartilage: an assessment of the value of in-situ hybridization.

    abstract::Several methods have been described for investigating chondrocyte metabolism in vitro. In this study, in-situ hybridization (ISH) using an oligonucleotide probe (i.e. a poly-d(T) probe) to detect total messenger RNA (mRNA) in cartilage explants has been compared with radiosulphate and radioleucine uptake studies in an...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Marles PJ,Hoyland JA,Parkinson R,Freemont AJ

    更新日期:1991-04-01 00:00:00

  • Circumferential wall tension due to hypertension plays a pivotal role in aorta remodelling.

    abstract::The present study was carried out to investigate the role of hypertension in the genesis and localization of intimal lesions and medial remodelling found in the prestenotic segment in relation to a severe stenosis of the abdominal aorta just below the diaphragm. Male young rats were divided randomly into operated grou...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2006.00506.x

    authors: Prado CM,Rossi MA

    更新日期:2006-12-01 00:00:00

  • Recombinant gamma interferon causes neutrophil migration mediated by the release of a macrophage neutrophil chemotactic factor.

    abstract::A dose-dependent neutrophil migration was observed following the injection of purified (Hu IFN-gamma) or recombinant (rIFN-gamma) human gamma interferon into rat peritoneal cavities. This finding contrasts with their inability to cause chemotaxis in vitro in the Boyden chamber. Neutrophil migration into peritoneal cav...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Ribeiro RA,Cunha FQ,Ferreira SH

    更新日期:1990-10-01 00:00:00

  • Effects of dietary fatty acids on the early stages of neoplastic induction in the rat pancreas. Changes in fatty acid composition and development of atypical acinar cell nodules.

    abstract::Diets enriched with fat, especially unsaturated fat, promote experimental pancreatic carcinogenesis, but little is known of the effects of individual fatty acids. The effect of stearic and oleic acid on pancreatic fatty acids and atypical acinar cell nodules (preneoplastic lesions) was studied in 14-day-old weanling m...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Khoo DE,Flaks B,Oztas H,Williamson RC,Habib NA

    更新日期:1991-10-01 00:00:00

  • Combined therapy with metformin and insulin attenuates systemic and hepatic alterations in a model of high-fat diet-/streptozotocin-induced diabetes.

    abstract::In this study we have explored the pathogenesis of the hepatic alterations which occur in diabetes and the modulation of these complications by the combination of metformin adjunct treatment and insulin monotherapy. For this purpose, diabetic rats were treated with insulin (DM + Ins) or metformin plus insulin (DM + Me...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12184

    authors: Silvares RR,Pereira EN,Flores EE,Estato V,Reis PA,Silva IJ,Machado MP,Neto HC,Tibiriça E,Daliry A

    更新日期:2016-06-01 00:00:00

  • Neovascularization is prominent in the chronic inflammatory lesions of Sjögren's syndrome.

    abstract::Angiogenesis is a common finding in chronic inflammatory diseases; however, its role in Sjögren's syndrome (SS) remains to be elucidated. Previous SS studies have demonstrated an increase in VEGF-A/VEGFR-2 system expression in minor salivary gland (MSG) biopsies from patients with SS, but differences in the new blood ...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12061

    authors: Sisto M,Lisi S,Ingravallo G,Lofrumento DD,D'Amore M,Ribatti D

    更新日期:2014-04-01 00:00:00

  • Mode of transmission and histology of M. leprae infection in nude mice.

    abstract::Athymic (nude) mice were experimentally infected with Mycobacterium leprae via the alimentary and respiratory tracts and through the skin. Animals were allowed to inhale aerosols of M. leprae or had bacilli instilled into the nostrils or directly into the lungs. Others were fed M. leprae by gastric tube or had bacilli...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: McDermott-Lancaster RD,McDougall AC

    更新日期:1990-10-01 00:00:00

  • Regulation of angiogenesis by hypoxic stress: from solid tumours to the ovarian follicle.

    abstract::The preovulatory follicle provides a unique physiological example of rapid growth accompanied by neovascularization, two processes that are generally characteristic of pathologies such as wound repair or malignancy. During the hours preceding ovulation, follicular growth is accompanied by elevated levels of messenger ...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2613.1997.d01-247.x

    authors: Neeman M,Abramovitch R,Schiffenbauer YS,Tempel C

    更新日期:1997-04-01 00:00:00

  • Time course of bleomycin-induced lung fibrosis.

    abstract::Intratracheal instillation (IT) of bleomycin is a widely used experimental model for lung fibrosis. In this study we describe the time-course of bleomycin-induced lung fibrosis in mice using computer-assisted morphometry. C57Bl/6J mice were treated with a single IT dose of bleomycin or control saline. Animals were kil...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2613.2002.00220.x

    authors: Izbicki G,Segel MJ,Christensen TG,Conner MW,Breuer R

    更新日期:2002-06-01 00:00:00

  • Factors influencing the ability of different mycoplasmas to colonize the genital tract of hormone-treated female mice.

    abstract::Colonization of the genital tract of female mice, mainly BALB/c, by Mycoplasma genitalium, M. pneumoniae and M. pulmonis was enhanced by pretreatment of the mice with progesterone. M. fermentans, M. hominis and M. salivarium, and three serotypes and two untyped strains of Ureaplasma urealyticum colonized under the inf...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Furr PM,Taylor-Robinson D

    更新日期:1993-02-01 00:00:00

  • Amphiphilic suramin dissolves Matrigel, causing an 'inhibition' artefact within in vitro angiogenesis assays.

    abstract::The field of study concerning promotion and/or inhibition of angiogenesis has gathered much attention in the scientific community. A great deal of work has been invested towards defining reproducible assays to gauge for promotion or inhibition of angiogenesis in response to drug treatments or growth conditions. Two co...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12043

    authors: Prigozhina NL,Heisel AJ,Seldeen JR,Cosford ND,Price JH

    更新日期:2013-12-01 00:00:00

  • Infiltration of polymorphonuclear cells into the post-ischaemic myocardium is dependent on beta2 and alpha4 integrins.

    abstract::Polymorphonuclear cells (PMN) are believed to be important effector cells responsible the myocardial damage seen following ischaemia. However, the exact kinetics of their migration remains controversial. Isolated PMN (10 x 10(6) cells) labelled with (51)Cr were injected into four groups of Lewis rats: 0 h (T0h; n = 13...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2007.00541.x

    authors: Légaré JF,Oxner A,Heimrath O,Issekutz T

    更新日期:2007-08-01 00:00:00

  • Transgenic overexpression of p23 induces spontaneous hydronephrosis in mice.

    abstract::p23 is a cochaperone of heat shock protein 90 and also interacts functionally with numerous steroid receptors and kinases. However, the in vivo roles of p23 remain unclear. To explore its in vivo function, we generated the transgenic (TG) mice ubiquitously overexpressing p23. The p23 TG mice spontaneously developed ki...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2011.00762.x

    authors: Lee J,Kim HJ,Moon JA,Sung YH,Baek IJ,Roh JI,Ha NY,Kim SY,Bahk YY,Lee JE,Yoo TH,Lee HW

    更新日期:2011-08-01 00:00:00

  • A central role for the mast cell in early phase vasculitis in the Brown Norway rat model of vasculitis: a histological study.

    abstract::Administration of mercuric chloride (HgCl(2)) to Brown Norway rats causes Th2-dominated autoimmunity with raised immunoglobulin E concentrations and gut vasculitis, both of which are T-cell dependent, peak at 14 days after starting HgCl(2) and then spontaneously resolve. If animals are re-challenged with HgCl(2) 6 wee...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.0959-9673.2004.00382.x

    authors: Vinen CS,Turner DR,Oliveira DB

    更新日期:2004-06-01 00:00:00

  • Expression of somatostatin mRNA and peptides in C-cell tumours of the thyroid gland in Han Wistar rats.

    abstract::C-cell tumours of the thyroid gland are among the most common spontaneous neoplasms of the laboratory rat. With the exception of calcitonin, little attention has been paid to the secretory peptides of C cells during the development of neoplasia. Of these peptides, somatostatin (SS) is of particular interest because it...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.0959-9673.2004.00367.x

    authors: Pilling A,Jones S,Turton J

    更新日期:2004-02-01 00:00:00

  • Involvement of the EN-2 gene in normal and abnormal development of the human arcuate nucleus.

    abstract::In this study, we wanted to evaluate whether the engrailed EN-2 gene, a homeobox gene with an essential role in the development of the rhombic lip derivatives in different species, is (1) expressed also in man in the differentiation process of the medullary arcuate nucleus (ArcN) and (2) involved in sudden unexplained...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.0959-9673.2005.00408.x

    authors: Lavezzi AM,Ottaviani G,Mauri M,Terni L,Matturri L

    更新日期:2005-02-01 00:00:00

  • Comparison of three research models of portal hypertension in mice: macroscopic, histological and portal pressure evaluation.

    abstract::The characterization of mice models of portal hypertension (PHT) is lacking in the literature. Therefore, the aim of the present study was to make a histological approach during development of PHT in two models of cirrhosis with PHT compared with one model of isolated PHT. The model of isolated PHT was developed by pa...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2008.00597.x

    authors: Geerts AM,Vanheule E,Praet M,Van Vlierberghe H,De Vos M,Colle I

    更新日期:2008-08-01 00:00:00

  • 2.5 kDa and 5.0 kDa heparin fragments specifically inhibit microvessel sprouting and network formation in VEGF165-mediated mammalian angiogenesis.

    abstract::Tumour growth is angiogenesis dependent. Thrombosis and thromboembolism are very common in cancer patients. These patients are often treated with heparin as an anti-coagulant. Many tumour angiogens, including VEGF165, and endogenous anti-angiogenesis factors bind heparin tightly. Using the non-surgical mesenteric-wind...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2613.2000.00150.x

    authors: Norrby K

    更新日期:2000-06-01 00:00:00

  • Viruria during acute Japanese encephalitis virus infection.

    abstract::In this study, viruria following Japanese encephalitis virus (JEV) infection in mice has been shown to appear earlier in pregnant than in normal mice with proteinuria and haematuria. This was related to the production of splenic macrophage derived neutrophil chemotactic factor (MDF) following JEV infection. Intravenou...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:

    authors: Mathur A,Khanna N,Kulshreshtha R,Maitra SC,Chaturvedi UC

    更新日期:1995-04-01 00:00:00

  • Fell-Muir lecture: cartilage 2010 - the known unknowns.

    abstract::Over the past 40 years there have been giant steps forward in our understanding of cellular and molecular biology that have given us the framework by which to understand tissue organization and tissue function on a range of scales. However, although the progress has been great, the more we have discovered, the more we...

    journal_title:International journal of experimental pathology

    pub_type:

    doi:10.1111/j.1365-2613.2010.00719.x

    authors: Hardingham TE

    更新日期:2010-06-01 00:00:00

  • Roles of inducible nitric oxide synthase in the development and healing of experimentally induced gastric ulcers.

    abstract::The roles of inducible nitric oxide synthase (iNOS) in the development and healing of gastric ulcers have not been fully characterized. We characterized iNOS expression in experimentally induced ulcers in rat and mouse stomachs and investigated the roles of iNOS using iNOS gene-deficient (iNOS-/-) mice and wildtype mi...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2003.00357.x

    authors: Tatemichi M,Ogura T,Sakurazawa N,Nagata H,Sugita M,Esumi H

    更新日期:2003-10-01 00:00:00

  • Coronary vessel development and insight towards neovascular therapy.

    abstract::Formation of the coronary arteries consists of a precisely orchestrated series of morphogenetic and molecular events which can be divided into three distinct processes: vasculogenesis, angiogenesis and arteriogenesis (Risau 1997; Carmeliet 2000). Even subtle perturbations in this process may lead to congenital coronar...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2613.2009.00646.x

    authors: Smart N,Dubé KN,Riley PR

    更新日期:2009-06-01 00:00:00

  • Oestrogen supplementation following castration promotes stromal remodelling and histopathological alterations in the Mongolian gerbil ventral prostate.

    abstract::The effect of oestradiol on the intact and castrated adult gerbil prostate was evaluated by focussing on stromal and epithelial disorders, and hormonal receptor immunoreactivity. The experimental animals were studied by histological, histochemical and immunohistochemical techniques, morphometric-stereological analysis...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2613.2007.00559.x

    authors: Scarano WR,de Sousa DE,Campos SG,Corradi LS,Vilamaior PS,Taboga SR

    更新日期:2008-02-01 00:00:00

  • Cytokines and their receptors in cardiovascular diseases--role of gp130 signalling pathway in cardiac myocyte growth and maintenance.

    abstract::Interleukin (IL)-6-related cytokines share gp130 as the signal-transducing protein. Cardiac myocytes produce various kinds of cytokines including IL-6 and cardiotrophin-1. Activation of gp130 transduces hypertrophic and cytoprotective signals in cardiac myocytes via JAK/STAT, MAP kinase and PI-3 kinase pathways. Besid...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2613.2000.00139.x

    authors: Yamauchi-Takihara K,Kishimoto T

    更新日期:2000-02-01 00:00:00

  • Long non-coding RNA GAS5 overexpression inhibits M2-like polarization of tumour-associated macrophages in SMCC-7721 cells by promoting PTEN expression.

    abstract::Tumour-associated macrophage (TAM) polarization is associated with hepatocellular carcinoma but the molecular mechanism of this polarization is still unknown. Peripheral blood mononuclear cells were induced to differentiate into M0, M1 and M2 macrophages and TAMs. TAMs were transfected with pcDNA3.1-GAS5, pcDNA3.1-NC,...

    journal_title:International journal of experimental pathology

    pub_type: 杂志文章

    doi:10.1111/iep.12374

    authors: Wang X,Li FY,Zhao W,Gao ZK,Shen B,Xu H,Cui YF

    更新日期:2020-12-01 00:00:00