Abstract：
:We determined the feasibility of producing protoporphyric hepatopathy in unrestrained rats by infusing protoporphyrin into their portal circulation via chronic indwelling catheters. Sprague-Dawley rats, 200-300 g, received single (8.5-27.8 mumol) or multiple (64.1-208.7 mumol) infusions of protoporphyrin over 3-240 h. Single protoporphyrin infusions increased the hepatic protoporphyrin concentration from < 1 nmol/g up to 1368 nmol/g; multiple infusions up to 3908 nmol/g. The maximal non-hepatic tissue concentrations averaged 243 nmol/g in the spleen. Hepatocanalicular and ductular birefringent pigmented deposits were found in all livers, generally proportional to the protoporphyrin load. Aggregates of crystalline protoporphyrin were detected in biliary ductules, canaliculi, hepatocytes, Kupffer cells and fat-storage cells by electron microscopy. Laboratory abnormalities included elevations of the transaminases, LDH, GGTP and bilirubin and a modest fall in the haematocrit suggesting a mixture of red blood cell and hepatic injury. Thus, protoporphyric hepatopathy was produced by infusions of protoporphyrin into the portal circulation. This model may aid in understanding the pathogenesis and pathophysiology of liver disease in protoporphyria.
journal_name
Int J Exp Patholjournal_title
International journal of experimental pathologyauthors
Berenson MM,Kimura R,Samowitz W,Bjorkman Dsubject
Has Abstractpub_date
1992-10-01 00:00:00pages
665-73issue
5eissn
0959-9673issn
1365-2613journal_volume
73pub_type
杂志文章abstract：:During mild (one to two pairs of worms) and prolonged (23 weeks or more) mouse infections with Schistosoma mansoni, but not with S. japonicum, periovular granulomas and fibrosis were seen to be preferentially located along periportal tissues. This caused fibrotic expansion of the portal spaces on a background of norma...
journal_title：International journal of experimental pathology
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更新日期：1993-04-01 00:00:00
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journal_title：International journal of experimental pathology
pub_type： 杂志文章,评审
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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pub_type： 杂志文章,评审
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journal_title：International journal of experimental pathology
pub_type： 杂志文章
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
pub_type： 杂志文章,评审
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更新日期：2011-06-01 00:00:00
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journal_title：International journal of experimental pathology
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
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pub_type： 杂志文章
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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doi：
更新日期：1993-06-01 00:00:00
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journal_title：International journal of experimental pathology
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更新日期：1991-02-01 00:00:00
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journal_title：International journal of experimental pathology
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journal_title：International journal of experimental pathology
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更新日期：1990-08-01 00:00:00
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更新日期：1993-08-01 00:00:00
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journal_title：International journal of experimental pathology
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