Does an anti-oxidant ascorbic acid improve the condition of hippocampal formation slice preparations? A micro-EEG approach.

abstract：:The aim of this study was to estimate the relationship of endothelial dysfunction induced by intracellular S-adenosylhomocysteine (SAH) accumulation and DNA methylation in human umbilical vein endothelial cells (HUVEC). The isolated HUVEC were incubated with 3-deazaadenosine (DZA) to induce experimental intracellular ...

journal_title：International journal of experimental pathology

authors： Yu X,Ling W,Mi M

更新日期：2009-12-01 00:00:00

abstract：:The characterization of mice models of portal hypertension (PHT) is lacking in the literature. Therefore, the aim of the present study was to make a histological approach during development of PHT in two models of cirrhosis with PHT compared with one model of isolated PHT. The model of isolated PHT was developed by pa...

journal_title：International journal of experimental pathology

authors： Geerts AM,Vanheule E,Praet M,Van Vlierberghe H,De Vos M,Colle I

更新日期：2008-08-01 00:00:00

abstract：:Several methods have been described for investigating chondrocyte metabolism in vitro. In this study, in-situ hybridization (ISH) using an oligonucleotide probe (i.e. a poly-d(T) probe) to detect total messenger RNA (mRNA) in cartilage explants has been compared with radiosulphate and radioleucine uptake studies in an...

journal_title：International journal of experimental pathology

authors： Marles PJ,Hoyland JA,Parkinson R,Freemont AJ

更新日期：1991-04-01 00:00:00

abstract：:The roles of inducible nitric oxide synthase (iNOS) in the development and healing of gastric ulcers have not been fully characterized. We characterized iNOS expression in experimentally induced ulcers in rat and mouse stomachs and investigated the roles of iNOS using iNOS gene-deficient (iNOS-/-) mice and wildtype mi...

journal_title：International journal of experimental pathology

authors： Tatemichi M,Ogura T,Sakurazawa N,Nagata H,Sugita M,Esumi H

更新日期：2003-10-01 00:00:00

abstract：:Amino acid metabolism is a significant metabolic activity in humans, especially of sulphur-containing amino acids, methionine and cysteine (Cys). Cys is cytotoxic and neurotoxic in nature; hence, mammalian cells maintain a constant intracellular level of Cys. Metabolism of Cys is mainly regulated by two thiol dioxygen...

journal_title：International journal of experimental pathology

authors： Sarkar B,Kulharia M,Mantha AK

更新日期：2017-04-01 00:00:00

abstract：:This study was conducted to evaluate the adverse effects of the anabolic steroid, boldenone undecylenate (BOL) on reproductive functions of male rabbits. Thirty white New Zealand mature male rabbits were divided into three groups (10 rabbits each). Group A rabbits served as a control group. Group B rabbits received 4....

journal_title：International journal of experimental pathology

authors： Oda SS,El-Ashmawy IM

更新日期：2012-06-01 00:00:00

abstract：:Progress in understanding the pathophysiology of abdominal aortic aneurysms (AAA) is dependent in part on the development and application of effective animal models that recapitulate key aspects of the disease. The objective was to produce an experimental model of AAA in rats by combining two potential causes of metal...

journal_title：International journal of experimental pathology

authors： Mata KM,Prudente PS,Rocha FS,Prado CM,Floriano EM,Elias J Jr,Rizzi E,Gerlach RF,Rossi MA,Ramos SG

更新日期：2011-02-01 00:00:00

abstract：:Muramyl dipeptide-Lys(L18) given by daily subcutaneous injection for 14 days induced arthritis in male Lewis, Fischer and nude rats, to a lesser degree in the last two than in the first strain. On the other hand, a single intradermal administration of Freund's complete adjuvant induced arthritis in Lewis and Fischer b...

journal_title：International journal of experimental pathology

authors： Sugawara T,Takada S,Furuhama K,Takayama S,Nomura M,Kato M

更新日期：1995-06-01 00:00:00

abstract：:The acute phase of experimental Chagas' disease in rats is associated with early lesions of the post-ganglionic sympathetic nerve terminals of the heart, the varicosities being the target. In the superior cervical and stellate ganglia the preganglionic fibres showed no signs of lesion in the course of experimental Cha...

journal_title：International journal of experimental pathology

authors： Camargos ER,Haertel LR,Machado CR

更新日期：1996-06-01 00:00:00

abstract：:Most patients with epithelial ovarian cancer (EOC) are diagnosed at an advanced stage, and therapeutic options for these patients are limited. The identification of suitable biomarkers could be helpful for patients with EOC, who might benefit from targeted therapies even in advanced stages of the disease. Trophoblast ...

journal_title：International journal of experimental pathology

authors： Xu N,Zhang Z,Zhu J,Xu L,Li Y,Duan L,Mao Y,Li H

更新日期：2016-04-01 00:00:00

abstract：:Small intestinal mucosal T cell activation results in villous atrophy and crypt hyperplasia. There is conflicting evidence as to whether a Th1 IFN-gamma response may be involved. Using a murine intestinal transplant model of T cell-mediated enteropathy we aimed to study the role of IFN-gamma on the development of vill...

journal_title：International journal of experimental pathology

authors： Veitch AM,Higgins LM,Bajaj-Elliot M,Farthing MJ,MacDonald TT

更新日期：2003-06-01 00:00:00

abstract：:Ureteropelvic junction (UPJ) obstruction is the most frequently observed cause of obstructive nephropathy in children. Neonatal and foetal animal models have been developed that mimic closely what is observed in human disease. The purpose of this review is to discuss how obstructive nephropathy alters kidney histology...

journal_title：International journal of experimental pathology

authors： Klein J,Gonzalez J,Miravete M,Caubet C,Chaaya R,Decramer S,Bandin F,Bascands JL,Buffin-Meyer B,Schanstra JP

更新日期：2011-06-01 00:00:00

abstract：:A reversible impairment in the ability of the liver to secrete cholephilic compounds has been reported to exist in infant rats born from mothers with surgically induced complete cholestasis during the last third of the pregnancy. Canalicular plasma membranes (CPM) were purified from livers obtained from 4 and 8 week-o...

journal_title：International journal of experimental pathology

authors： Serrano MA,Monte MJ,Martinez-Diez MC,Marin JJ

更新日期：1997-12-01 00:00:00

abstract：:Plasmodium berghei ANKA (PbA) infection in susceptible inbred mouse strains is the most commonly used experimental model to study pathogenesis of cerebral malaria (CM). Indeed, many concepts on mechanisms related to this complication have arisen from works using this model. Although inbred strains present several adva...

journal_title：International journal of experimental pathology

authors： Martins YC,Smith MJ,Pelajo-Machado M,Werneck GL,Lenzi HL,Daniel-Ribeiro CT,Carvalho LJ

更新日期：2009-04-01 00:00:00

abstract：:p23 is a cochaperone of heat shock protein 90 and also interacts functionally with numerous steroid receptors and kinases. However, the in vivo roles of p23 remain unclear. To explore its in vivo function, we generated the transgenic (TG) mice ubiquitously overexpressing p23. The p23 TG mice spontaneously developed ki...

journal_title：International journal of experimental pathology

authors： Lee J,Kim HJ,Moon JA,Sung YH,Baek IJ,Roh JI,Ha NY,Kim SY,Bahk YY,Lee JE,Yoo TH,Lee HW

更新日期：2011-08-01 00:00:00

abstract：:C-cell tumours of the thyroid gland are among the most common spontaneous neoplasms of the laboratory rat. With the exception of calcitonin, little attention has been paid to the secretory peptides of C cells during the development of neoplasia. Of these peptides, somatostatin (SS) is of particular interest because it...

journal_title：International journal of experimental pathology

authors： Pilling A,Jones S,Turton J

更新日期：2004-02-01 00:00:00

abstract：:Heart failure (HF) is characterized by a skeletal muscle myopathy with increased expression of fast myosin heavy chains (MHCs). The skeletal muscle-specific molecular regulatory mechanisms controlling MHC expression during HF have not been described. Myogenic regulatory factors (MRFs), a family of transcriptional fact...

journal_title：International journal of experimental pathology

authors： Carvalho RF,Cicogna AC,Campos GE,Lopes Fda S,Sugizaki MM,Nogueira CR,Pai-Silva MD

更新日期：2006-06-01 00:00:00

abstract：:Bronchial subepithelial fibrosis is an histological characteristic of asthma. Cytokines and other mediators, such as PDGF-BB, TGF-beta1 and ET-1 found in the asthmatic submucosa can potentially activate a repair process that leads to fibroblast proliferation and collagen synthesis. The mechanisms of modulation of the ...

journal_title：International journal of experimental pathology

authors： Dubé J,Chakir J,Dubé C,Grimard Y,Laviolette M,Boulet LP

更新日期：2000-12-01 00:00:00

abstract：:Pathological and immunopathological studies were carried out on snake coiled fibres (SCF) which occurred in affected soleus muscle in chloroquine treated rats. The SCF began to appear in denervated soleus muscle by 8 days after chloroquine injection. By day 14, typical SCF were observed with an unusual swirling patter...

journal_title：International journal of experimental pathology

authors： Tsuzuki K,Fukatsu R,Takamaru Y,Yoshida T,Hayashi Y,Kobayashi K,Fujii N,Takahata N

更新日期：1997-02-01 00:00:00

abstract：:The objectives of this work were to study some pathological aspects of kidneys obtained from dogs naturally infected with Leishmania infantum and from dogs experimentally infected with two different strains of L infantum with special emphasis on fibrotic process. Seventy eight specimens of paraffin-embedded kidney fra...

journal_title：International journal of experimental pathology

authors： Alves AF,Pereira RA,de Andrade HM,Mosser DM,Tafuri WL

更新日期：2019-08-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is the most common chronic condition of the liver in the western world. There is only little evidence about altered sensitivity of steatotic liver to acute toxic injury. The aim of this project was to test whether hepatic steatosis sensitizes rat liver to acute toxic injury in...

journal_title：International journal of experimental pathology

authors： Kučera O,Lotková H,Staňková P,Podhola M,Roušar T,Mezera V,Cervinková Z

更新日期：2011-08-01 00:00:00

abstract：:In order to clarify the function of hepatocyte growth factor (HGF) in vivo, we have developed transgenic mice expressing HGF in the liver. The bromodeoxyuridine labelling indices in livers from HGF transgenic mice were doubled, compared to those from wild type mice. Livers of HGF transgenic mice expressed high levels ...

journal_title：International journal of experimental pathology

authors： Shiota G,Kawasaki H

更新日期：1998-10-01 00:00:00

abstract：:The interrelationship between acinar cell apoptosis and tubular complex formation was examined in caerulein-induced pancreatitis using histology, immunohistochemistry, electron microscopy and DNA gel electrophoresis. Rats were given 8 hourly subcutaneous injections of caerulein, 24 micrograms/kg, for up to 2 days. Mor...

journal_title：International journal of experimental pathology

authors： Reid LE,Walker NI

更新日期：1999-08-01 00:00:00

abstract：:Heparan sulphate (HS) sits at the interface of the cell and the extracellular matrix. It is a member of the glycosaminoglycan family of anionic polysaccharides with unique structural features designed for protein interaction and regulation. Its client proteins include soluble effectors (e.g. growth factors, morphogens...

journal_title：International journal of experimental pathology

authors： Gallagher J

更新日期：2015-08-01 00:00:00

abstract：:Acute myocardial infarction is one of the major causes of mortality worldwide. For regeneration of the rabbit heart after experimentally induced infarction we used autologous skeletal myoblasts (SMs) due to their high proliferative potential, resistance to ischaemia and absence of immunological and ethical concerns. T...

journal_title：International journal of experimental pathology

authors： Antanavičiūtė I,Ereminienė E,Vysockas V,Račkauskas M,Skipskis V,Rysevaitė K,Treinys R,Benetis R,Jurevičius J,Skeberdis VA

更新日期：2015-02-01 00:00:00

abstract：:Tumour-associated macrophage (TAM) polarization is associated with hepatocellular carcinoma but the molecular mechanism of this polarization is still unknown. Peripheral blood mononuclear cells were induced to differentiate into M0, M1 and M2 macrophages and TAMs. TAMs were transfected with pcDNA3.1-GAS5, pcDNA3.1-NC,...

journal_title：International journal of experimental pathology

authors： Wang X,Li FY,Zhao W,Gao ZK,Shen B,Xu H,Cui YF

更新日期：2020-12-01 00:00:00

abstract：:Over the past 40 years there have been giant steps forward in our understanding of cellular and molecular biology that have given us the framework by which to understand tissue organization and tissue function on a range of scales. However, although the progress has been great, the more we have discovered, the more we...

journal_title：International journal of experimental pathology

authors： Hardingham TE

更新日期：2010-06-01 00:00:00

abstract：:This study tested the hypothesis that different doses of nandrolone decanoate (ND) will cause changes in the estrous cycle and ovarian tissue of adult rats; and investigated the duration of the recovery period that is sufficient to restore the damage in the animals treated with different doses. Wistar rats were treate...

journal_title：International journal of experimental pathology

authors： Simão VA,Berloffa Belardin L,Araújo Leite GA,de Almeida Chuffa LG,Camargo IC

更新日期：2015-10-01 00:00:00

abstract：:Naturally developing spontaneous osteoarthritis (OA) is seen in a number of small animals one of which is the STR/ORT mouse, an accepted model of human OA. A histological evaluation of the patello-femoral joints of 37 male STR/ORT mice has shown features that are inconsistent with the disease in human joints. These in...

journal_title：International journal of experimental pathology

authors： Das-Gupta EP,Lyons TJ,Hoyland JA,Lawton DM,Freemont AJ

更新日期：1993-12-01 00:00:00

abstract：:Nonalcoholic steatohepatitis (NASH) is one of the life-threatening hepatic diseases; however, its pathogenesis is still unknown. To evaluate the causative role of hyperlipidaemia and high-fat diet, we compared C57BL/6 mice with inherited hyperlipidaemic model mice (LDLR(-/-)mice and ApoE(-/-) mice) fed a normal or a h...

journal_title：International journal of experimental pathology

authors： Yoshimatsu M,Terasaki Y,Sakashita N,Kiyota E,Sato H,van der Laan LJ,Takeya M

更新日期：2004-12-01 00:00:00