Clinical significance of discordant positive hepatitis C virus transcription-mediated amplification following end of treatment response.

Abstract:

BACKGROUND:Polymerase chain reaction (PCR) assays are the standard for detecting hepatitis C virus viremia. The transcription-mediated amplification (TMA)-based assay is more sensitive. METHODS:We retrospectively reviewed the charts of patients with a post-end of treatment (EOT) PCR-/TMA+ result to assess the clinical significance of a positive TMA result after a PCR negative EOT response or sustained viral response (SVR). Patients were divided into Group 1: PCR-/TMA+ after EOT response but during 24 week follow-up (n = 4); and Group 2: PCR-/TMA+ after SVR (n = 11). RESULTS:All Group 1 patients achieved SVR. No Group 2 patients became PCR positive or had a rise in ALT. The TMA subsequently became negative in 6/7 patients with follow-up evaluation. CONCLUSIONS:A discordant positive TMA post-EOT response or SVR did not seem to be clinically significant. This finding supports the possibility that patients with SVR have an acquired immune surveillance that prevents low-level viremia from progressing to clinical relapse.

journal_name

Dig Dis Sci

authors

Thadani A,Harley J,Rubin J,Lebovics E

doi

10.1007/s10620-011-1820-x

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

239-42

issue

1

eissn

0163-2116

issn

1573-2568

journal_volume

57

pub_type

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