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Heterogeneity of HPLC profiles of human class II MHC-bound peptides isolated from intestine with inflammatory bowel disease.

Abstract：

:Studies of the T-cell-receptor repertoire and oligoclonal expansion of lamina propria T cells in patients with Crohn's disease suggest restricted antigen processing in this disease. We examined HPLC elution profiles of HLA-DR-bound peptides isolated from human intestine. Surgical samples of colon and ileum were obtained from patients with ulcerative colitis, patients with Crohn's disease, and normal colon from patients undergoing colon carcinoma treatment as controls. Specimens were homogenized and HLA-DR molecules were isolated using anti-HLA-DR antibody-coupled immunoaffinity chromatography. HLA-DR-bound peptides were dissociated from the HLA-DR groove by acid treatment, isolated, and analyzed by reversed-phase HPLC. HPLC elution profiles of HLA-DR-bound peptides were similar in patients with ulcerative colitis and controls. Large peaks were found in patients with Crohn's disease, but the retention times of these peaks differed among individuals. Elution profiles of HLA-DR bound peptides suggest that specific antigen presentation might occur in patients with Crohn's disease, although the specific antigens appear to differ between patients.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Oshitani N,Hato F,Jinno Y,Sawa Y,Hara J,Nakamura S,Matsumoto T,Arakawa T,Kitano A,Kitagawa S,Kuroki T

doi

10.1023/a:1019689332601

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

2088-94

issue

9

eissn

0163-2116

issn

1573-2568

journal_volume

47

pub_type

杂志文章

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