Hooked on benzodiazepines: GABAA receptor subtypes and addiction.

Abstract:

:Benzodiazepines are widely used clinically to treat anxiety and insomnia. They also induce muscle relaxation, control epileptic seizures, and can produce amnesia. Moreover, benzodiazepines are often abused after chronic clinical treatment and also for recreational purposes. Within weeks, tolerance to the pharmacological effects can develop as a sign of dependence. In vulnerable individuals with compulsive drug use, addiction will be diagnosed. Here we review recent observations from animal models regarding the cellular and molecular basis that might underlie the addictive properties of benzodiazepines. These data reveal how benzodiazepines, acting through specific GABA(A) receptor subtypes, activate midbrain dopamine neurons, and how this could hijack the mesolimbic reward system. Such findings have important implications for the future design of benzodiazepines with reduced or even absent addiction liability.

journal_name

Trends Neurosci

journal_title

Trends in neurosciences

authors

Tan KR,Rudolph U,Lüscher C

doi

10.1016/j.tins.2011.01.004

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

188-97

issue

4

eissn

0166-2236

issn

1878-108X

pii

S0166-2236(11)00005-1

journal_volume

34

pub_type

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