Abstract:
:Active feedback mechanisms in the ears of mammals amplify and tune the auditory response to sound stimuli, allowing these organisms to enjoy both exquisite sensitivity and sharp frequency selectivity. A requisite component of this feedback pathway has recently been identified. Targeted deletion of pres, the gene that encodes the novel membrane-bound motor protein prestin, has revealed a hundred-fold loss in hearing sensitivity suggesting that it might be part of the elusive cochlear amplifier.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Géléoc GS,Holt JRdoi
10.1016/S0166-2236(03)00030-4subject
Has Abstractpub_date
2003-03-01 00:00:00pages
115-7issue
3eissn
0166-2236issn
1878-108Xpii
S0166-2236(03)00030-4journal_volume
26pub_type
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