Fear conditioning and extinction: emotional states encoded by distinct signaling pathways.

Abstract:

:Conditioning and extinction of fear have traditionally been viewed as two independent learning processes for encoding representations of contexts or cues (conditioned stimuli, CS), aversive events (unconditioned stimuli, US), and their relationship. Based on the analysis of protein kinase signaling patterns in neurons of the fear circuit, we propose that fear and extinction are best conceptualized as emotional states triggered by a single CS representation with two opposing values: aversive and non-aversive. These values are conferred by the presence or absence of the US and encoded by distinct sets of kinase signaling pathways and their downstream targets. Modulating specific protein kinases thus has the potential to modify emotional states, and hence, may emerge as a promising treatment for anxiety disorders.

journal_name

Trends Neurosci

journal_title

Trends in neurosciences

authors

Tronson NC,Corcoran KA,Jovasevic V,Radulovic J

doi

10.1016/j.tins.2011.10.003

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

145-55

issue

3

eissn

0166-2236

issn

1878-108X

pii

S0166-2236(11)00174-3

journal_volume

35

pub_type

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