Abstract：
:The brain includes multiple types of interconnected excitatory and inhibitory neurons that together allow us to move, think, feel, and interact with the environment. Inhibitory interneurons (INs) comprise a small, heterogeneous fraction, but they exert a powerful and tight control over neuronal activity and consequently modulate the magnitude of neuronal output and, ultimately, information processing. IN abnormalities are linked to two pediatric psychiatric disorders with high comorbidity: autism spectrum disorder (ASD) and Tourette syndrome (TS). Studies probing the basis of this link have been contradictory regarding whether the causative mechanism is a reduction in number, dysfunction, or gene aberrant expression (or a combination thereof). Here, we integrate different theories into a more comprehensive view of INs as responsible for the symptomatology observed in these disorders.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Rapanelli M,Frick LR,Pittenger Cdoi
10.1016/j.tins.2017.05.004subject
Has Abstractpub_date
2017-07-01 00:00:00pages
397-407issue
7eissn
0166-2236issn
1878-108Xpii
S0166-2236(17)30092-9journal_volume
40pub_type
杂志文章,评审abstract：:Axonal transport is critical for neuronal homeostasis and relies on motor complexes bound to cargoes via specific adaptors. However, the mechanisms responsible for the spatiotemporal regulation of axonal transport are not completely understood. A recent study by Liao et al. contributes to filling this gap by reporting...
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journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
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journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
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更新日期：2004-02-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2020.07.005
更新日期：2020-10-01 00:00:00
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journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2010.01.003
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journal_title：Trends in neurosciences
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doi：10.1016/j.tins.2018.10.002
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