Abstract:
:A century after the discovery of acetylcholine (ACh), we recognize both ACh receptors, transporters, and synthesizing and degrading enzymes and regulators of their expression as contributors to cognition, metabolism, and immunity. Recent discoveries indicate that pre- and post-transcriptional ACh signaling controllers coordinate the identity, functioning, dynamics, and brain-to-body communication of cholinergic cells. Checks and balances including epigenetic mechanisms, alternative splicing, and miRNAs may all expand or limit the diversity of these cholinergic components by consistently performing genome-related surveillance. This regulatory network enables homeostatic maintenance of brain-to-body ACh signaling as well as reactions to nicotine, Alzheimer's disease anticholinesterase therapeutics, and agricultural pesticides. Here I review recent reports on the functional implications of these controllers of cholinergic signaling in and out of the brain.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Soreq Hdoi
10.1016/j.tins.2015.05.007subject
Has Abstractpub_date
2015-07-01 00:00:00pages
448-58issue
7eissn
0166-2236issn
1878-108Xpii
S0166-2236(15)00121-6journal_volume
38pub_type
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