Abstract:
:NMDA receptors (NMDARs) are ion channels activated by the excitatory neurotransmitter glutamate and are essential to all aspects of brain function, including learning and memory formation. Missense mutations distributed throughout NMDAR subunits have been associated with an array of neurological disorders. Recent structural, functional, and computational studies have generated many insights into the activation process connecting glutamate binding to ion-channel opening, which is central to NMDAR physiology and pathophysiology. The field appears poised for breakthroughs, including the exciting prospect of resolving the conformations and energetics of elementary steps in the activation process, and atomic-level modeling of the effects of missense mutations on receptor function. The most promising strategy going forward is through strong integration of multiple approaches.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Zhou HX,Wollmuth LPdoi
10.1016/j.tins.2017.01.001subject
Has Abstractpub_date
2017-03-01 00:00:00pages
129-137issue
3eissn
0166-2236issn
1878-108Xpii
S0166-2236(17)30002-4journal_volume
40pub_type
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