Abstract：
:The endoplasmic reticulum responds to stress by initiating a cascade of events known as the 'unfolded-protein response' (UPR). The accumulation of misfolded proteins in the leukodystrophy Pelizaeus-Merzbacher disease activates this stress response, resulting in apoptosis of oligodendrocytes. Although it remains uncertain whether the UPR plays a mechanistic role in prototypical neurodegenerative disorders such as Alzheimer's disease, this is plausible because misfolded proteins are directly implicated in the pathogenesis of these disorders.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Forman MS,Lee VM,Trojanowski JQdoi
10.1016/S0166-2236(03)00197-8subject
Has Abstractpub_date
2003-08-01 00:00:00pages
407-10issue
8eissn
0166-2236issn
1878-108Xpii
S0166-2236(03)00197-8journal_volume
26pub_type
杂志文章,评审abstract：:In adult rodents, subventricular zone (SVZ) astrocytes (B cells) function as primary progenitors in the generation of new neurons that migrate to the olfactory bulb (OB), where they differentiate into multiple types of interneurons. It has been generally considered that individual adult SVZ stem cells are capable of g...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2008.05.006
更新日期：2008-08-01 00:00:00
abstract：:Lyme disease is of interest to the neurologist and neuroscientist for a variety of reasons. As more arthropod hosts throughout the world are infected with the causative organism, Borrelia burgdorferi, the illness in humans is becoming more prevalent; in addition, recognition of the disease in humans and susceptible an...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(89)90065-9
更新日期：1989-05-01 00:00:00
abstract：:The number of neuroscientists in Europe is large enough to match that of the neuroscientific community in North America. However, the degree of cohesiveness in the former is hampered by, among other things, the lack of a common language, the existence of geopolitical boundaries, and the dearth of pan-European funding ...
journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/0166-2236(94)90171-6
更新日期：1994-08-01 00:00:00
abstract：:A defining feature of the vertebrate nervous system is the ensheathment of axons by myelin, a multilamellar membrane containing a small group of proteins and an abundance of the galactolipid galactocerebroside (GalC) and its sulfated derivative sulfatide. Several in vitro studies have suggested that these galactolipid...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(97)01178-8
更新日期：1998-03-01 00:00:00
abstract：:In the mammalian central nervous system (CNS), coupling of neurons by gap junctions (i.e., electrical synapses) and the expression of the neuronal gap junction protein, connexin 36 (Cx36), transiently increase during early postnatal development. The levels of both subsequently decline and remain low in the adult, conf...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2012.11.001
更新日期：2013-04-01 00:00:00
abstract：:Although signs of empathy have now been well documented in non-human primates, only during the past few years have systematic observations suggested that a primal form of empathy exists in rodents. Thus, the study of empathy in animals has started in earnest. Here we review recent studies indicating that rodents are a...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2013.04.009
更新日期：2013-08-01 00:00:00
abstract：:The shapes of the head and ears of mammals are asymmetrical top-to-bottom and front-to-back. Reflections of sounds from these structures differ with the angle of incidence, producing cues for monaural sound localization in the spectra of the stimuli at the eardrum. Neurons in the dorsal cochlear nucleus (DCN) respond ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2003.12.001
更新日期：2004-02-01 00:00:00
abstract：:'Forward models' are increasingly recognized as a crucial explanatory concept in vertebrate motor control. The essential idea is that an important function implemented by nervous systems is prediction of the sensory consequences of action. This is often associated with higher cognitive capabilities; however, many of t...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2004.03.004
更新日期：2004-05-01 00:00:00
abstract：:The discovery of genetic forms of Parkinson's disease (PD) has highlighted the importance of the autophagy/lysosomal and mitochondrial/oxidative stress pathways in disease pathogenesis. However, recently identified PD-linked genes, including DNAJC6 (auxilin), SYNJ1 (synaptojanin 1), and the PD risk gene SH3GL2 (endoph...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2018.11.001
更新日期：2019-02-01 00:00:00
abstract：:Implanted neural probes are among the most important techniques in both fundamental and clinical neuroscience. Despite great successes and promise, neural electrodes are technically limited by their scalability. A recent study by Obaid et al. demonstrated an innovative way to greatly scale up the channel count and den...
journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/j.tins.2020.03.001
更新日期：2020-05-01 00:00:00
abstract：:Inhibitory interneurons comprise a diverse subpopulation of cells that are critical to circuit function. How distinct inhibitory microcircuits control long-range projections remains poorly understood. A recent study by Lu and colleagues uncovered a unidirectional microcircuit of prefrontal chandelier cells that prefer...
journal_title：Trends in neurosciences
pub_type： 评论,杂志文章
doi：10.1016/j.tins.2017.09.005
更新日期：2017-11-01 00:00:00
abstract：:The hippocampus is thought to automatically encode all experience, yet the vast majority of our experiences are not remembered later. Although psychological theories have postulated the existence of decay processes for declarative memory, the corresponding neurobiological mechanisms are unknown. Here we develop the hy...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2013.05.002
更新日期：2013-09-01 00:00:00
abstract：:It has been suggested, on the basis of neuroanatomical and behavioural data, that olfactory discrimination in the rat provides privileged access to higher cognitive processes, involves the acquisition of a learning-set and, importantly, can be used to model human hippocampal function and dysfunction. In this article, ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(93)90043-l
更新日期：1993-01-01 00:00:00
abstract：:The brain includes multiple types of interconnected excitatory and inhibitory neurons that together allow us to move, think, feel, and interact with the environment. Inhibitory interneurons (INs) comprise a small, heterogeneous fraction, but they exert a powerful and tight control over neuronal activity and consequent...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2017.05.004
更新日期：2017-07-01 00:00:00
abstract：:Much research effort into synaptic plasticity has been motivated by the idea that modifications of synaptic weights (or strengths or efficacies) underlie learning and memory. Here, we examine the possibility of exploiting the statistics of experimentally measured synaptic weights to deduce information about the learni...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2007.09.005
更新日期：2007-12-01 00:00:00
abstract：:Resolvins, including D and E series resolvins, are endogenous lipid mediators generated during the resolution phase of acute inflammation from the omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Resolvins have potent anti-inflammatory and pro-resolution actions in severa...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2011.08.005
更新日期：2011-11-01 00:00:00
abstract：:Mitochondrial dysfunction has been implicated in the pathogenesis of almost all neurological diseases, including Alzheimer's disease (AD). Historically, a primary focus in this context has been the link between mitochondrial dynamics and amyloid β toxicity. Recent evidence suggests that dysregulation of mitochondrial ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2020.10.004
更新日期：2021-02-01 00:00:00
abstract：:Huntington's disease (HD) is a fatal, inherited neurodegenerative disorder that gradually robs affected individuals of memory, cognitive skills and normal movements. Although research has identified a single faulty gene, the huntingtin gene, as the cause of the disease, a cure remains elusive. Strong evidence indicate...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2008.09.004
更新日期：2008-12-01 00:00:00
abstract：:In the classical picture of brain function, electrical impulses are initiated in sensory organs and spread rapidly down axons, jumping synaptic clefts by neurochemical transmission. Patterns of electrical activity generated in this way integrate information throughout the brain and result in coordinated motor output. ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(89)90089-1
更新日期：1989-11-01 00:00:00
abstract：:Aging is the most important risk factor for common neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. Aging in the central nervous system has been associated with elevated mutation load in mitochondrial DNA, defects in mitochondrial respiration and increased oxidative damage. These observations ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2008.02.008
更新日期：2008-05-01 00:00:00
abstract：:Huntington's disease is an inherited neurodegenerative disorder, the cause of which is unknown. Excitotoxicity, mitochondrial dysfunction and oxidative stress are all likely to contribute to the striatal cell death that occurs in this disorder. There are accumulating data indicating that under specific circumstances, ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(00)01568-x
更新日期：2000-06-01 00:00:00
abstract：:The precise modulation of regional cerebral blood flow during neural activation is important for matching local energetic demand and supply and clearing brain metabolites. Here we discuss advances facilitated by high-resolution optical in vivo imaging techniques that for the first time have provided direct visualizati...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2019.05.009
更新日期：2019-08-01 00:00:00
abstract：:Microglia provide immune surveillance of the CNS. They display diverse behaviors, including nondirectional and directed motility of their processes, phagocytosis of targets such as dying neurons or superfluous synapses, and generation of reactive oxygen species (ROS) and cytokines. Many of these functions are mediated...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2018.12.007
更新日期：2019-04-01 00:00:00
abstract：:Sleep is widely believed to play an essential role in synaptic plasticity. However, the precise mechanisms governing this presumptive function are largely unknown. There is also evidence for independent circadian oscillations in synaptic strength and morphology. Therefore, synaptic changes observed after sleep reflect...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2014.06.005
更新日期：2014-09-01 00:00:00
abstract：:The proportional relation between circulating vasopressin concentration and plasma osmolality is fundamental for body fluid homeostasis. Although changes in the sensitivity of this relation are associated with pathophysiological conditions, central mechanisms modulating osmoregulatory gain are unknown. Here, we review...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2009.11.004
更新日期：2010-02-01 00:00:00
abstract：:The ability to map functional activity in the living human brain has rekindled interest in the organization of human neural circuitry specifically and in animal neural circuitry generally. Faced with incredible complexity, researchers are turning to the power of computer graphics for two- and three-dimensional interac...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(95)92766-j
更新日期：1995-11-01 00:00:00
abstract：:Tsao et al. have recently used functional magnetic resonance imaging to compare processing for moving stereoscopic forms in macaque and human brains. Most humans exhibited activation in a swath of lateral occipital areas, extending into the intraparietal sulcus, with a limited version of the same pattern in monkeys. H...
journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/j.tins.2003.12.009
更新日期：2004-03-01 00:00:00
abstract：:Schizophrenia (SZ) is primarily an adult psychiatric disorder in which disturbances caused by susceptibility genes and environmental insults during early neurodevelopment initiate neurophysiological changes over a long time course, culminating in the onset of full-blown disease nearly two decades later. Aberrant postn...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2009.05.007
更新日期：2009-09-01 00:00:00
abstract：:Hebbian synaptic learning requires co-activation of presynaptic and postsynaptic neurons. However, under some conditions, information regarding the postsynaptic action potential, carried by backpropagating action potentials, can be strongly degraded before it reaches the distal exhibit Hebbian long-term potentiation (...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2003.12.004
更新日期：2004-02-01 00:00:00
abstract：:The use of Drosophila as a suitable system to answer behavioural questions is usually based on the availability of mutant phenotypes. Indeed, the 'single-gene' approach to behaviour was a very illuminating strategy in practical and conceptual terms, and served to prove that the genetic mechanisms sustaining behaviour ...
journal_title：Trends in neurosciences
pub_type： 杂志文章
doi：10.1016/0166-2236(94)90137-6
更新日期：1994-11-01 00:00:00
