Abstract：
:Sleep is widely believed to play an essential role in synaptic plasticity. However, the precise mechanisms governing this presumptive function are largely unknown. There is also evidence for independent circadian oscillations in synaptic strength and morphology. Therefore, synaptic changes observed after sleep reflect interactions between state-dependent (e.g., wake versus sleep) and state-independent (circadian) processes. In this review we consider how sleep and biological clocks influence synaptic plasticity. We discuss these findings in the context of current plasticity-based theories of sleep function and propose a new model that integrates circadian and brain-state influences on synaptic plasticity.
journal_name
Trends Neuroscijournal_title
Trends in neurosciencesauthors
Frank MG,Cantera Rdoi
10.1016/j.tins.2014.06.005subject
Has Abstractpub_date
2014-09-01 00:00:00pages
491-501issue
9eissn
0166-2236issn
1878-108Xpii
S0166-2236(14)00105-2journal_volume
37pub_type
杂志文章,评审abstract：:Neuroethics, a recently modernized field at the intersection of bioethics and neuroscience, is founded on centuries of discussion of the ethical issues associated with mind and behavior. Broadly defined, neuroethics is concerned with ethical, legal and social policy implications of neuroscience, and with aspects of ne...
journal_title：Trends in neurosciences
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.tins.2006.07.002
更新日期：2006-09-01 00:00:00
abstract：:Neurobiology was a central concern at the Marine Biological Laboratory (MBL), Woods Hole at the end of the last century, when the director Charles Otis Whitman set up a seminar for discussion of research and general issues in 'neurology', which took place annually from 1896 to 1900 and generated intense interest among...
journal_title：Trends in neurosciences
pub_type： 历史文章,杂志文章,评审
doi：10.1016/0166-2236(90)90118-t
更新日期：1990-10-01 00:00:00
abstract：:To understand the role of a gene in adult behavior, it is necessary to control its expression in four dimensions: space and time. Two recent papers describe implementation of different but related technologies that now provide this missing element in fly behavioral research. ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2004.06.013
更新日期：2004-09-01 00:00:00
abstract：:Inhibitory interneurons comprise a diverse subpopulation of cells that are critical to circuit function. How distinct inhibitory microcircuits control long-range projections remains poorly understood. A recent study by Lu and colleagues uncovered a unidirectional microcircuit of prefrontal chandelier cells that prefer...
journal_title：Trends in neurosciences
pub_type： 评论,杂志文章
doi：10.1016/j.tins.2017.09.005
更新日期：2017-11-01 00:00:00
abstract：:In adult rodents, subventricular zone (SVZ) astrocytes (B cells) function as primary progenitors in the generation of new neurons that migrate to the olfactory bulb (OB), where they differentiate into multiple types of interneurons. It has been generally considered that individual adult SVZ stem cells are capable of g...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2008.05.006
更新日期：2008-08-01 00:00:00
abstract：:There are pluripotent stem cells in the adult brain that might not be very different from those found in bone marrow. Recent and profound advances in the field of neuropoiesis, which often rely on insights from studies of hematopoiesis and in some instances use cross-paradigms with this field, have already revealed th...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(99)01416-2
更新日期：1999-08-01 00:00:00
abstract：:Diverse human disorders, including the majority of neurodegenerative diseases, are thought to arise from the misfolding and aggregation of protein. We have recently described a novel technology to amplify cyclically misfolded proteins in vitro. This procedure, named protein misfolding cyclic amplification (PMCA), is c...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(02)02195-1
更新日期：2002-08-01 00:00:00
abstract：:Although signs of empathy have now been well documented in non-human primates, only during the past few years have systematic observations suggested that a primal form of empathy exists in rodents. Thus, the study of empathy in animals has started in earnest. Here we review recent studies indicating that rodents are a...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2013.04.009
更新日期：2013-08-01 00:00:00
abstract：:Communication is a central theme in biology. Consequently, specialized structures have evolved to permit rapid communication among cells, tissues, organs, and physiological systems, thus enhancing the overall function and adaptation of the organism. A prime example is the neuronal synapse. In the brain, synaptic commu...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2015.06.001
更新日期：2015-08-01 00:00:00
abstract：:Neurodegenerative tauopathies are marked by their common pathologic feature of aggregates formed of hyperphosphorylated tau protein, which are associated with synapse and neuronal loss. Changes in tau conformation result in both loss of normal function and gain of fibrillogenicity that leads to aggregation. Here, we d...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2008.11.007
更新日期：2009-03-01 00:00:00
abstract：:Ejaculation, although mediated by a spinal ejaculation generator, is subject to descending supraspinal modulation from several brain regions. 5-Hydroxytryptamine (5-HT or serotonin) is involved in ejaculatory control, with its ejaculation-retarding effects likely to be attributable to activation of 5-HT1B and 5-HT2C r...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2006.12.002
更新日期：2007-02-01 00:00:00
abstract：:More often than not, action potentials fail to trigger neurotransmitter release. And even when neurotransmitter is released, the resulting change in synaptic conductance is highly variable. Given the energetic cost of generating and propagating action potentials, and the importance of information transmission across s...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2020.03.009
更新日期：2020-06-01 00:00:00
abstract：:Synaptic transmission and plasticity are shaped by the dynamic reorganization of signaling molecules within pre- and postsynaptic compartments. The nanoscale organization of key effector molecules has been revealed by single-particle trajectory (SPT) methods. Interestingly, this nanoscale organization is highly hetero...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2020.01.005
更新日期：2020-03-01 00:00:00
abstract：:ATP-sensitive K+ channels couple cell metabolism to electrical activity in nerve, muscle and endocrine cells, and play important roles in these tissues under both physiological and pathological conditions. The KATP channel is an octameric complex of two unrelated types of subunit: a pore-forming subunit (Kir6.2) and a...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(98)01225-9
更新日期：1998-07-01 00:00:00
abstract：:Dendrites of pyramidal neurons are complex, electrically active structures that can produce local and global Ca(2+) compartments. Recent studies indicate that dendrites of cortical GABAergic interneurons are also highly specialized, and that different subtypes vary in their morphology, in their intrinsic and synaptic ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2005.01.005
更新日期：2005-03-01 00:00:00
abstract：:The marriage of cognitive neurophysiology and mathematical psychology to understand decision-making has been exceptionally productive. This interdisciplinary area is based on the proposition that particular neurons or circuits instantiate the accumulation of evidence specified by mathematical models of sequential samp...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2019.10.001
更新日期：2019-12-01 00:00:00
abstract：:Sensory representations are repeatedly transformed by neural computations that determine which of their attributes can be effectively processed at each stage. Whereas some early computations are common across multiple sensory systems, they can utilize dissimilar underlying mechanisms depending on the properties of eac...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2009.12.004
更新日期：2010-03-01 00:00:00
abstract：:Many behavioral responses are completed too quickly for the underlying sensory processes to rely on estimation of neural firing rates over extended time windows. Theoretically, first-spike times could underlie such rapid responses, but direct evidence has been lacking. Such evidence has now been uncovered in the human...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2004.10.010
更新日期：2005-01-01 00:00:00
abstract：:The majority of Alzheimer's disease is inherited in a complex manner involving environmental factors and several genes. One of these genes is Apolipoprotein E where the polymorphic allele (APOE epsilon 4) has been robustly shown to modify risk and the course of Alzheimer's disease. The epsilon 4 allele however, only a...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(00)01912-3
更新日期：2001-10-01 00:00:00
abstract：:GABA neurotransmission requires a specialized set of proteins to synthesize, transport or respond to GABA. This article reviews results from a genetic strategy in the nematode Caenorhabditis elegans designed to identify the genes responsible for these activities. These studies identified mutations in genes encoding fi...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2004.05.005
更新日期：2004-07-01 00:00:00
abstract：:Navigation depends upon neural systems that monitor spatial location and head orientation. Recent developmental findings have led some to conclude that these systems are innate. Such claims are premature. But also, there are more meaningful ways to arrive at answers about developmental origins than by invoking the out...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2015.01.001
更新日期：2015-02-01 00:00:00
abstract：:The two GluN3 subunits were the last NMDA receptor subunits to be cloned some 15 years ago. Strikingly, despite the steadily growing interest in their function, their physiological role remains elusive. The original billing as dominant-negative modulators of classical NMDA receptors composed of GluN1 and GluN2 subunit...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2011.11.010
更新日期：2012-04-01 00:00:00
abstract：:The precise modulation of regional cerebral blood flow during neural activation is important for matching local energetic demand and supply and clearing brain metabolites. Here we discuss advances facilitated by high-resolution optical in vivo imaging techniques that for the first time have provided direct visualizati...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2019.05.009
更新日期：2019-08-01 00:00:00
abstract：:The nervous system is made up of many specific types of neuron intricately intertwined to form complex networks. Identifying and defining the characteristic features of the many different neuronal types is essential for achieving a cellular understanding of complex activity from perception to cognition. So far, cortic...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2003.08.002
更新日期：2003-10-01 00:00:00
abstract：:The endoplasmic reticulum responds to stress by initiating a cascade of events known as the 'unfolded-protein response' (UPR). The accumulation of misfolded proteins in the leukodystrophy Pelizaeus-Merzbacher disease activates this stress response, resulting in apoptosis of oligodendrocytes. Although it remains uncert...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/S0166-2236(03)00197-8
更新日期：2003-08-01 00:00:00
abstract：:In mature rodents, whisker-related patterns are known to be present in three levels of the brain: the brainstem trigeminal nuclei, the ventrobasal thalamus and the somatosensory cortex. These patterns have been demonstrated using neuroanatomical tracing techniques, histological and histochemical staining methods and e...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/s0166-2236(97)01217-4
更新日期：1998-06-01 00:00:00
abstract：:The complexity and inaccessibility of the vertebrate CNS impede the localization and description of memory traces and the definition of the processes that create them. Recent work has shown that the spinal stretch reflex (SSR), which is produced by a monosynaptic two-neuron pathway, can be operantly conditioned, and t...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(90)90005-u
更新日期：1990-04-01 00:00:00
abstract：:Lyme disease is of interest to the neurologist and neuroscientist for a variety of reasons. As more arthropod hosts throughout the world are infected with the causative organism, Borrelia burgdorferi, the illness in humans is becoming more prevalent; in addition, recognition of the disease in humans and susceptible an...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(89)90065-9
更新日期：1989-05-01 00:00:00
abstract：:Parkinson's disease is a common and disabling disorder of movement owing to dopaminergic denervation of the striatum. However, it is still unclear how this denervation perverts normal functioning to cause slowing of voluntary movements. Recent work using tissue slice preparations, animal models and in humans with Park...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/j.tins.2007.05.004
更新日期：2007-07-01 00:00:00
abstract：:In the classical picture of brain function, electrical impulses are initiated in sensory organs and spread rapidly down axons, jumping synaptic clefts by neurochemical transmission. Patterns of electrical activity generated in this way integrate information throughout the brain and result in coordinated motor output. ...
journal_title：Trends in neurosciences
pub_type： 杂志文章,评审
doi：10.1016/0166-2236(89)90089-1
更新日期：1989-11-01 00:00:00
